Full Text Journal Articles by
Author Mark E Alexander

Advertisement

Find full text journal articles






Clinical and Genetic Findings in Children Presenting With Ventricular Fibrillation as the First Manifestation of Cardiovascular Disease.

Robyn J Hylind, Stephanie F Chandler, Virginie Beausejour Ladouceur, Shelina M Jamal, Mark E Alexander, Douglas Y Mah, Emily A Phaneuf, Elizabeth S DeWitt, Vassilios J Bezzerides, Dominic J Abrams,

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(10):e016322]

Cited: 0 times

View full text PDF listing >>



Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery.

Audrey Dionne, John N Kheir, Kimberlee Gauvreau, John K Triedman, Dominic J Abrams, Mark E Alexander, Elizabeth S DeWitt, Douglas Y Mah, Edward P Walsh, Vassilios J Bezzerides,

OBJECTIVE:To determine the impact of provocative electrophysiology testing in post-operative congenital heart disease (CHD) patients on the management of supraventricular tachycardia (SVT) and clinical outcomes. METHODS:This is a retrospective study including patients < 18 years of age with surgery for CHD who had post-operative SVT between 2006-2017. Post-operative outcomes were ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Low mortality in fetal supraventricular tachycardia: Outcomes in a 30-year single-institution experience.

Edward T O'Leary, Mark E Alexander, Vassilios J Bezzerides, Monika Drogosz, Katherine E Economy, Kevin G Friedman, Sarah S Pickard, Wayne Tworetzky, Douglas Y Mah,

OBJECTIVES:To describe a single institutional experience managing fetuses with supraventricular tachycardia (SVT) and to identify associations between patient characteristics and fetal and postnatal outcomes. BACKGROUND:Sustained fetal SVT is associated with significant morbidity and mortality if untreated, yet the optimal management strategy remains unclear. METHODS:Retrospective cohort study including fetuses diagnosed with ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2020, 31(5):1105-1113]

Cited: 0 times

View full text PDF listing >>



Adverse event rate during inpatient sotalol initiation for the management of supraventricular and ventricular tachycardia in the pediatric and young adult population.

Stephanie F Chandler, Esther Chu, Robert D Whitehill, Laura M Bevilacqua, Vassilios J Bezzerides, Elizabeth S DeWitt, Mark E Alexander, Dominic J Abrams, John K Triedman, Edward P Walsh, Douglas Y Mah,

BACKGROUND:Sotalol is an important antiarrhythmic drug in the pediatric population. Given the risk of proarrhythmia, sotalol is initiated in inpatient settings, with adult studies as recent as 2015 supporting this practice. OBJECTIVE:The purpose of this study was to determine the frequency of adverse events (AEs) during sotalol initiation for the ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(6):984-990]

Cited: 0 times

View full text PDF listing >>



Ultra-rapid atrial pacing as a form of rate control in postoperative automatic arrhythmias in patients with congenital heart disease.

Stephanie F Chandler, Robert D Whitehill, Elizabeth S DeWitt, Mark E Alexander, Francis Fynn Thompson, Douglas Y Mah,

HeartRhythm Case Rep (HeartRhythm case reports)
[2020, 6(4):215-218]

Cited: 0 times

View full text PDF listing >>



Outcomes of catheter ablation of anteroseptal and midseptal accessory pathways in pediatric patients.

Joshua R Kovach, Douglas Y Mah, Dominic J Abrams, Mark E Alexander, Frank Cecchin, John K Triedman, Edward P Walsh,

BACKGROUND:Outcomes for catheter ablation of accessory pathways in pediatric patients have steadily improved, with the exception of pathways located in the anteroseptal (AS) and midseptal (MS) regions, where success is limited by the close proximity of normal atrioventricular conduction. OBJECTIVE:The purpose of this study was to evaluate the efficacy of ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(5 Pt A):759-767]

Cited: 0 times

View full text PDF listing >>



Interdigitating Myocardial Tongues in Pediatric Cardiac Fibromas: Plausible Substrate for Ventricular Tachycardia and Cardiac Arrest.

Chrystalle Katte Carreon, Stephen P Sanders, Antonio R Perez-Atayde, Pedro J Del Nido, Edward P Walsh, Tal Geva, Mark E Alexander,

OBJECTIVES:This study sought to evaluate for the presence of and characterize the interdigitating and entrapped myocardium within cardiac fibromas (CF) and correlate tissue findings with symptoms and surgical outcomes. BACKGROUND:The mechanism of ventricular tachycardia (VT) in CF is unclear. The authors hypothesized that CF harbor tongues of interdigitating myocardium, which ... Read more >>

JACC Clin Electrophysiol (Jacc. Clinical Electrophysiology)
[2019, 5(5):563-575]

Cited: 0 times

View full text PDF listing >>



The Real-World Utility of the LINQ Implantable Loop Recorder in Pediatric and Adult Congenital Heart Patients.

Vassilios J Bezzerides, Amy Walsh, Maria Martuscello, Carolina A Escudero, Kimberlee Gauvreau, Geralyn Lam, Dominic J Abrams, John K Triedman, Mark E Alexander, Laura Bevilacqua, Douglas Y Mah,

OBJECTIVES:This study sought to determine the practical use of the recently introduced LINQ implantable loop recorder (LINQ-ILR) in a cohort of pediatric and adult congenital arrhythmia patients. BACKGROUND:Correlating symptoms to a causative arrhythmia is a key aspect of diagnosis and management in clinical electrophysiology. METHODS:Retrospective review of clinical data, implantation ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2019, 5(2):245-251]

Cited: 0 times

View full text PDF listing >>



Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study.

Charles Mackin, Elizabeth S DeWitt, Katherine J Black, Xiaoqi Tang, Brian D Polizzotti, Sarah J van den Bosch, Mark E Alexander, John N Kheir,

INTRODUCTION:Direct comparison of the effects of antiarrhythmic agents on myocardial performance may be useful in choosing between medications in critically ill patients. Studies directly comparing multiple antiarrhythmic medications are lacking. The use of an experimental heart preparation permits examination of myocardial performance under constant loading conditions. METHODS:Hearts of Sprague Dawley ... Read more >>

J. Cardiovasc. Pharmacol. Ther. (Journal of cardiovascular pharmacology and therapeutics)
[2019, 24(3):288-297]

Cited: 0 times

View full text PDF listing >>



Dual-Site Ventricular Pacing in Patients With Fontan Physiology and Heart Block: Does it Mitigate the Detrimental Effects of Single-Site Ventricular Pacing?

Edward T O'Leary, Kimberlee Gauvreau, Mark E Alexander, Puja Banka, Vassilios J Bezzerides, Francis Fynn-Thompson, John K Triedman, Edward P Walsh, Douglas Y Mah,

OBJECTIVES:This study sought to determine the long-term effect of dual-site ventricular pacing (i.e., cardiac resynchronization therapy [CRT]) versus single-site pacing in patients with Fontan physiology and high-grade atrioventricular block (AVB). BACKGROUND:Chronic single-site ventricular pacing in Fontan patients is associated with significant morbidity and mortality. METHODS:The study conducted a retrospective review ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2018, 4(10):1289-1297]

Cited: 0 times

View full text PDF listing >>



Evaluation of left ventricular false tendons in children with idiopathic left ventricular tachycardia.

Anthony Merlocco, David W Brown, Kimberlee Gauvreau, Douglas Y Mah, John K Triedman, Mark E Alexander, Edward P Walsh,

BACKGROUND:Left ventricular false tendons (FT) traverse the ventricular cavity and are thought to have some association with idiopathic left ventricular tachycardia (ILVT). However, reported prevalence of FT varies widely, making correlation difficult. Superior echocardiographic windows of pediatric patients may permit better analysis of FT in ILVT. Our study describes the ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2018, 41(9):1143-1149]

Cited: 0 times

View full text PDF listing >>



Incidence and Predictors of Clinically Important and Dangerous Arrhythmias During Exercise Tests in Pediatric and Congenital Heart Disease Patients.

Oliver M Barry, Kimberlee Gauvreau, Jonathan Rhodes, Jeffrey R Reichman, Laura Bourette, Tracy Curran, Julieann O'Neill, Jennifer L Pymm, Mark E Alexander,

OBJECTIVES:This study quantified the incidence of arrhythmias during pediatric exercise stress tests (ESTs) and evaluated criteria to identify patients at risk of clinically important arrhythmias. BACKGROUND:The incidence of clinically important arrhythmias during pediatric ESTs and criteria for identifying high-risk patients are poorly characterized. METHODS:A retrospective review of ESTs performed from ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2018, 4(10):1319-1327]

Cited: 0 times

View full text PDF listing >>



Electrocardiograms in Healthy North American Children in the Digital Age.

Elizabeth V Saarel, Suzanne Granger, Jonathan R Kaltman, L LuAnn Minich, Martin Tristani-Firouzi, Jeffrey J Kim, Kathleen Ash, Sabrina S Tsao, Charles I Berul, Elizabeth A Stephenson, David G Gamboa, Felicia Trachtenberg, Peter Fischbach, Victoria L Vetter, Richard J Czosek, Tiffanie R Johnson, Jack C Salerno, Nicole B Cain, Robert H Pass, Ilana Zeltser, Eric S Silver, Joshua R Kovach, Mark E Alexander, ,

BACKGROUND:Interpretation of pediatric ECGs is limited by lack of accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, to evaluate the effects of sex and race, and to compare our results ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2018, 11(7):e005808]

Cited: 0 times

View full text PDF listing >>



Utility of incomplete right bundle branch block as an isolated ECG finding in children undergoing initial cardiac evaluation.

Omar Meziab, Dominic J Abrams, Mark E Alexander, Laura Bevilacqua, Vassilios Bezzerides, Doug Y Mah, Edward P Walsh, John K Triedman,

This study evaluates the ability of experienced pediatric electrophysiologists (EPs) to reliably classify incomplete right bundle branch block (IRBBB) and assesses its clinical utility as an isolated ECG finding in a group of healthy outpatient children without prior cardiac evaluation.We performed a retrospective analysis of all electrocardiographic and echocardiographic records ... Read more >>

Congenit Heart Dis (Congenital heart disease)
[2018, 13(3):419-427]

Cited: 0 times

View full text PDF listing >>



Placebo-controlled crossover assessment of mecasermin for the treatment of Rett syndrome.

Heather M O'Leary, Walter E Kaufmann, Katherine V Barnes, Kshitiz Rakesh, Kush Kapur, Daniel C Tarquinio, Nicole G Cantwell, Katherine J Roche, Suzanne A Rose, Alexandra C Walco, Natalie M Bruck, Grace A Bazin, Ingrid A Holm, Mark E Alexander, Lindsay C Swanson, Lauren M Baczewski, Chi‐Sang Poon, Juan M Mayor Torres, Charles A Nelson, Mustafa Sahin,

Objective:To measure the efficacy of mecasermin (recombinant human insulin-like growth factor 1, rhIGF-1), for treating symptoms of Rett syndrome (RTT) in a pediatric population using a double-blind crossover study design. Methods:Thirty girls with classic RTT in postregression stage were randomly assigned to placebo or rhIGF-1 in treatment period 1 and ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(3):323-332]

Cited: 9 times

View full text PDF listing >>



Cardiac Events During Competitive, Recreational, and Daily Activities in Children and Adolescents With Long QT Syndrome.

Kristina D Chambers, Virginie Beausejour Ladouceur, Mark E Alexander, Robyn J Hylind, Laura Bevilacqua, Douglas Y Mah, Vassilios Bezzerides, John K Triedman, Edward P Walsh, Dominic J Abrams,

The 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients.Long QT syndrome patients aged ≥4 years treated with anti-adrenergic therapy were included. Demographics included mechanism of presentation, corrected ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(9):]

Cited: 1 time

View full text PDF listing >>



Finding the next good thing.

Mark E Alexander,

J. Thorac. Cardiovasc. Surg. (The Journal of thoracic and cardiovascular surgery)
[2017, 153(6):1555-1556]

Cited: 1 time

View full text PDF listing >>



Pausing With the Gauze: Inhibition of Temporary Pacemakers by Radiofrequency Scan During Cardiac Surgery.

Matthew R Williams, Douglas B Atkinson, Vassilios J Bezzerides, Koichi Yuki, Kathryn Franklin, Alfonso Casta, Mark E Alexander,

Radiofrequency identification (RFID) detection systems are used to detect retained surgical sponges and may cause electromagnetic interference (EMI), altering intended function of cardiac pacing systems. Three pediatric patients requiring temporary pacing for postoperative atrioventricular block experienced transient inhibition of ventricular pacing during the use of RFID detection system. Bench testing ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2016, 123(5):1143-1148]

Cited: 1 time

View full text PDF listing >>



Transvenous approach to pacemaker lead implantation for sinus node dysfunction after extracardiac lateral tunnel Fontan conduit placement.

Edward O'Leary, Mark E Alexander, Francis Fynn-Thompson, Douglas Mah,

HeartRhythm Case Rep (HeartRhythm case reports)
[2016, 2(6):495-498]

Cited: 3 times

View full text PDF listing >>



Relation of Left Atrial Size to Atrial Fibrillation in Patients Aged ≤22 Years.

Douglas Y Mah, Divya Shakti, Kimberlee Gauvreau, Steven D Colan, Mark E Alexander, Dominic J Abrams, David W Brown,

Left atrial (LA) dilation has been shown to be associated with atrial fibrillation (AF) in the adult population, with some studies indicating that larger LAs are more prone to AF recurrence. The relation of LA size to AF in the pediatric and young adult population has not been investigated. In ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2017, 119(1):52-56]

Cited: 1 time

View full text PDF listing >>



Pushing back the cliff (but there probably still is a cliff): Arrhythmia, late outcome, and uncertainty in Fontan patients.

Mark E Alexander,

J. Thorac. Cardiovasc. Surg. (The Journal of thoracic and cardiovascular surgery)
[2016, 152(5):1364-1365]

Cited: 1 time

View full text PDF listing >>



Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias.

Barry D Kussman, Christopher M Aasted, Meryem A Yücel, Sarah C Steele, Mark E Alexander, David A Boas, David Borsook, Lino Becerra,

The predictability of pain makes surgery an ideal model for the study of pain and the development of strategies for analgesia and reduction of perioperative pain. As functional near-infrared spectroscopy reproduces the known functional magnetic resonance imaging activations in response to a painful stimulus, we evaluated the feasibility of functional ... Read more >>

PLoS ONE (PloS one)
[2016, 11(7):e0158975]

Cited: 10 times

View full text PDF listing >>



Heart block following stage 1 palliation of hypoplastic left heart syndrome.

Douglas Y Mah, Henry Cheng, Mark E Alexander, Lynn Sleeper, Jane W Newburger, Pedro J Del Nido, Ravi R Thiagarajan, Satish K Rajagopal,

Publicly available data from the Pediatric Heart Network's Single Ventricle Reconstruction Trial was analyzed to determine the prevalence, timing, risk factors for, and impact of second- and third-degree heart block (HB) on outcomes in patients who underwent stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS).The presence and date ... Read more >>

J. Thorac. Cardiovasc. Surg. (The Journal of thoracic and cardiovascular surgery)
[2016, 152(1):189-194]

Cited: 5 times

View full text PDF listing >>



Regional Implementation of a Pediatric Cardiology Syncope Algorithm Using Standardized Clinical Assessment and Management Plans (SCAMPS) Methodology.

Yvonne Paris, Olga H Toro-Salazar, Naomi S Gauthier, Kathleen M Rotondo, Lucy Arnold, Rose Hamershock, David E Saudek, David R Fulton, Ashley Renaud, Mark E Alexander, ,

Pediatric syncope is common. Cardiac causes are rarely found. We describe and assess a pragmatic approach to these patients first seen by a pediatric cardiologist in the New England region, using Standardized Clinical Assessment and Management Plans (SCAMPs).Ambulatory patients aged 7 to 21 years initially seen for syncope at participating ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2016, 5(2):]

Cited: 1 time

View full text PDF listing >>



A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia.

Kimberly Lobo, Carolina Donado, Laura Cornelissen, Joseph Kim, Rebeca Ortiz, Roy W A Peake, Mark Kellogg, Mark E Alexander, David Zurakowski, Katherine E Kurgansky, James Peyton, Aykut Bilge, Karen Boretsky, Mary Ellen McCann, Charles B Berde, Joseph Cravero,

Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, the authors evaluated safety and efficacy of NeoSTX alone and combined with 0.2% bupivacaine (Bup) with and without epinephrine.The authors conducted ... Read more >>

Anesthesiology (Anesthesiology)
[2015, 123(4):873-885]

Cited: 15 times

View full text PDF listing >>



Advertisement

Disclaimer
1.5339 s