Full Text Journal Articles by
Author Mark A Lawson

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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.

Olivia Molinar-Inglis, Cierra A Birch, Dequina Nicholas, Lennis Orduña-Castillo, Metztli Cisneros-Aguirre, Anand Patwardhan, Buxin Chen, Neil J Grimsey, Luisa J Coronel, Huilan Lin, Patrick K Gomez Menzies, Mark A Lawson, Hemal H Patel, JoAnn Trejo,

Endothelial dysfunction is associated with vascular disease and results in disruption of endothelial barrier function and increased sensitivity to apoptosis. Currently, there are limited treatments for improving endothelial dysfunction. Activated protein C (aPC), a promising therapeutic, signals via protease-activated receptor-1 (PAR1) and mediates several cytoprotective responses, including endothelial barrier stabilization ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(49):]

Cited: 0 times

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Modification of ventriculo-arterial coupling by spironolactone in nonischemic dilated cardiomyopathy.

Mark A Lawson, David E Hansen, Deepak K Gupta, Susan P Bell, Douglas W Adkisson, Ravinder R Mallugari, Douglas B Sawyer, Henry Ooi, Marvin W Kronenberg,

<h4>Aims</h4>We sought to clarify the role of ventriculo-arterial (V-A) coupling in the treatment of nonischemic dilated cardiomyopathy (NIDCM) by adding a mineralocorticoid receptor antagonist (MRA) to conventional anti-failure therapy.<h4>Methods and results</h4>We employed cardiac magnetic resonance imaging to quantify left ventricular (LV) contractility and V-A coupling in normal subjects at rest ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(2):1156-1166]

Cited: 2 times

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Androgen Suppresses In Vivo and In Vitro LH Pulse Secretion and Neural Kiss1 and Tac2 Gene Expression in Female Mice.

Lourdes A Esparza, Tomohiro Terasaka, Mark A Lawson, Alexander S Kauffman,

Androgens can affect the reproductive axis of both sexes. In healthy women, as in men, elevated exogenous androgens decrease gonad function and lower gonadotropin levels; such circumstances occur with anabolic steroid abuse or in transgender men (genetic XX individuals) taking androgen supplements. The neuroendocrine mechanisms by which endogenous or exogenous ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(12):]

Cited: 2 times

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MON-009 GLUT1-Mediated Glycolysis Facilitates GnRH-Induced Secretion of Luteinizing Hormone

Dequina Nicholas, Vashti Knight, Karen Tonsfeldt, Tomohiro Terasaka, Olivia Molinar-Inglis, Shannon Brooke Zoe Stephens, Joann Trejo, Alexander S Kauffman, Pamela L Mellon, Mark A Lawson,

Abstract Reproduction requires intensive energy expenditure, and energy availability impacts the function of the reproductive endocrine HPG-axis. Accordingly, the reproductive axis is suppressed during hypoglycemia. Circulating blood glucose can directly interact with gonadotropes within the highly vascular pituitary. Therefore, it is possible that gonadotropes may sense energy availability via the ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

Cited: 0 times

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Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome.

Michael V Homer, Tannaz Toloubeydokhti, Mark A Lawson, Gabriel Garzo, Antoni J Duleba, R Jeffrey Chang,

Context:In women with polycystic ovary syndrome (PCOS), 17-hydroxyprogesterone (17-OHP) responses to gonadotropin stimulation vary from increased to indistinguishable compared with normal controls. Objective:To determine whether 17-OHP responses to recombinant-human chorionic gonadotropin (r-hCG) are individually correlated to the size of antral follicles among women with PCOS. Design Setting and Participants:A prospective ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2019, 3(4):687-698]

Cited: 1 time

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Absence of Fibrosis and Inflammation by Cardiac Magnetic Resonance Imaging in Rheumatoid Arthritis Patients with Low to Moderate Disease Activity.

William Bradham, Michelle J Ormseth, Comfort Elumogo, Srikanth Palanisamy, Chia-Ying Liu, Mark A Lawson, Jonathan H Soslow, Nadine Kawel-Boehm, David A Bluemke, C Michael Stein,

OBJECTIVE:The prevalence of heart failure is increased 2-fold in patients with rheumatoid arthritis (RA); this is not explained by ischemic heart disease or other risk factors for heart failure. We hypothesized that in patients with RA without known heart disease, cardiac magnetic resonance imaging (cMRI) would detect altered cardiac structure, ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2018, 45(8):1078-1084]

Cited: 5 times

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A Young Man With Cardiomegaly and Edema.

Sushan Yang, Jared O'Leary, Mark A Lawson,

JAMA Cardiol (JAMA cardiology)
[2018, 3(8):777-778]

Cited: 0 times

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Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes.

Song Li, Ekaette F Mbong, Denise T John, Tomohiro Terasaka, Danmei Li, Mark A Lawson,

An emerging body of evidence supports the concept that the pituitary is a site for integration of multiple physiological and metabolic signals that inform and modulate endocrine pathways. Multiple endocrine mediators of energy balance and adiposity are known to impinge on the neuroendocrine axis regulating reproduction. Observations in humans show ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(2):1074-1087]

Cited: 6 times

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Timing of Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy.

William S Bradham, Susan P Bell, Shi Huang, Frank E Harrell, Douglas W Adkisson, Mark A Lawson, Douglas B Sawyer, Henry Ooi, Marvin W Kronenberg,

<h4>Background</h4>Mineralocorticoid receptor antagonist (MRA) treatment produces beneficial left ventricular (LV) remodeling in nonischemic dilated cardiomyopathy (NIDCM). This study addressed the timing of maximal beneficial LV remodeling in NIDCM when adding MRA.<h4>Materials and methods</h4>We studied 12 patients with NIDCM on stable β-blocker and angiotensin-converting enzyme inhibitor/angiotensin receptor-blocking therapy who underwent cardiac ... Read more >>

Am J Med Sci (The American journal of the medical sciences)
[2018, 356(3):262-267]

Cited: 1 time

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Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope.

Tomohiro Terasaka, Mary E Adakama, Song Li, Taeshin Kim, Eri Terasaka, Danmei Li, Mark A Lawson,

Biological rhythms lie at the center of regulatory schemes that control many aspects of living systems. At the cellular level, meaningful responses to external stimuli depend on propagation and quenching of a signal to maintain vigilance for subsequent stimulation or changes that serve to shape and modulate the response. The ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2017, 8:286]

Cited: 5 times

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Myocardial T1 Measurement Predicts Beneficial LV Remodeling After Long-Term Heart Failure Therapy.

William S Bradham, Susan P Bell, Douglas W Adkisson, Holly M Smith, Frank E Harrell, Mark A Lawson, Henry Ooi, Douglas B Sawyer, Marvin W Kronenberg,

<h4>Background</h4>The myocardial longitudinal relaxation time (T1) on cardiac magnetic resonance imaging (CMR) can quantify myocardial fibrosis in the presence or absence of visually detectable late gadolinium (Gd) enhancement (LGE). Mineralocorticoid receptor antagonist (MRA) treatment produces beneficial remodeling in nonischemic dilated cardiomyopathy (NIDCM). We assessed the hypothesis that interstitial myocardial fibrosis ... Read more >>

J Card Fail (Journal of cardiac failure)
[2017, 23(3):262-265]

Cited: 2 times

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Increased myocardial native T1 and extracellular volume in patients with Duchenne muscular dystrophy.

Jonathan H Soslow, Stephen M Damon, Kimberly Crum, Mark A Lawson, James C Slaughter, Meng Xu, Andrew E Arai, Douglas B Sawyer, David A Parra, Bruce M Damon, Larry W Markham,

<h4>Background</h4>Duchenne muscular dystrophy (DMD) cardiomyopathy is a progressive disease for which there is no cure. Disease-specific therapies are needed that can be initiated before irreversible myocardial damage ensues. In order to evaluate therapeutic efficacy, surrogate endpoints other than ejection fraction must be found. The hypothesis of this study is that ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2016, 18:5]

Cited: 27 times

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Antifailure therapy including spironolactone improves left ventricular energy supply-demand relations in nonischemic dilated cardiomyopathy.

Susan P Bell, Douglas W Adkisson, Mark A Lawson, Li Wang, Henry Ooi, Douglas B Sawyer, Marvin W Kronenberg,

<h4>Background</h4>Left ventricular (LV) energy supply-demand imbalance is postulated to cause "energy starvation" and contribute to heart failure (HF) in nonischemic dilated cardiomyopathy (NIDCM). Using cardiac magnetic resonance (CMR) and [(11)C] acetate positron emission tomography (PET), we evaluated LV perfusion and oxidative metabolism in NIDCM and the effects of spironolactone on ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2014, 3(4):]

Cited: 6 times

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Evaluation of post-contrast myocardial t1 in duchenne muscular dystrophy using cardiac magnetic resonance imaging.

Jonathan H Soslow, Bruce M Damon, Benjamin R Saville, Zengqi Lu, W Bryan Burnette, Mark A Lawson, David A Parra, Douglas B Sawyer, Larry W Markham,

The objective of the study was to perform a retrospective pilot study to evaluate the potential of myocardial T1 in assessment of Duchenne muscular dystrophy (DMD) cardiomyopathy. Early identification of DMD cardiac disease, particularly myocardial fibrosis, would allow earlier therapy, potentially improving outcomes. Shortened myocardial T1 measured by cardiac MRI ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2015, 36(1):49-56]

Cited: 18 times

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Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.

Buxin Chen, David P Siderovski, Richard R Neubig, Mark A Lawson, Joann Trejo,

The G protein-coupled protease-activated receptor 1 (PAR1) is irreversibly proteolytically activated by thrombin. Hence, the precise regulation of PAR1 signaling is important for proper cellular responses. In addition to desensitization, internalization and lysosomal sorting of activated PAR1 are critical for the termination of signaling. Unlike most G protein-coupled receptors, PAR1 ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2014, 289(3):1580-1591]

Cited: 8 times

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Translational control of gene expression in the gonadotrope.

Taeshin Kim, Minh-Ha T Do, Mark A Lawson,

The study of gene expression in gonadotropes has largely focused on the variety of mechanisms regulating transcription of the gonadotropin genes and ancillary factors that contribute to the overall phenotype and function of these cells in reproduction. However, there are aspects of the response to GNRH signaling that are not ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2014, 385(1-2):78-87]

Cited: 10 times

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Aortic insufficiency following transcatheter aortic valve replacement is underestimated by echocardiography compared with cardiac MRI

Wissam M Abdallah, Chris A Semder, Evan L Brittain, Michael T Baker, Lisa A Mendes, Marshall H Crenshaw, Joseph L Fredi, Mark A Robbins, Sonia L Scalf, William S Bradham, Sean G Hughes, Mark A Lawson, David X Zhao,

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2014, 16(Suppl 1):O101-O101]

Cited: 0 times

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Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling.

Minh-Ha T Do, Taeshin Kim, Feng He, Hiral Dave, Rachel E Intriago, Uriah A Astorga, Sonia Jain, Mark A Lawson,

The neuropeptide gonadotropin-releasing hormone stimulates synthesis and secretion of the glycoprotein gonadotropic hormones and activates the unfolded protein response, which causes a transient reduction of endoplasmic reticulum-associated mRNA translation. Hormone-treated cell extracts were fractionated to resolve mRNA in active polyribosomes from mRNA in inactive complexes. Quantitative real-time PCR and expression ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2014, 382(1):346-357]

Cited: 9 times

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hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis.

Sun-Ji Park, Tae-Shin Kim, Choon-Keun Park, Sang-Hee Lee, Jin-Man Kim, Kyu-Sun Lee, In-Kyu Lee, Jeen-Woo Park, Mark A Lawson, Dong-Seok Lee,

Endoplasmic reticulum (ER) stress generally occurs in secretory cell types. It has been reported that Leydig cells, which produce testosterone in response to human chorionic gonadotropin (hCG), express key steroidogenic enzymes for the regulation of testosterone synthesis. In this study, we analyzed whether hCG induces ER stress via three unfolded ... Read more >>

J Mol Endocrinol (Journal of molecular endocrinology)
[2013, 50(2):151-166]

Cited: 26 times

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Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells.

Tomohiro Terasaka, Fumio Otsuka, Naoko Tsukamoto, Eri Nakamura, Kenichi Inagaki, Kishio Toma, Kanako Ogura-Ochi, Christine Glidewell-Kenney, Mark A Lawson, Hirofumi Makino,

Reproduction is integrated by interaction of neural and hormonal signals converging on hypothalamic neurons for controlling gonadotropin-releasing hormone (GnRH). Kisspeptin, the peptide product of the kiss1 gene and the endogenous agonist for the GRP54 receptor, plays a key role in the regulation of GnRH secretion. In the present study, we ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2013, 381(1-2):8-15]

Cited: 20 times

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Commentary: meeting the challenge to train the next generation of endocrinologists: filling, diversifying, and plugging leaks in the career pipeline.

Mark A Lawson,

Endocrinology (Endocrinology)
[2013, 154(8):2581-2585]

Cited: 0 times

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Biventricular noncompaction cardiomyopathy in a patient presenting with new onset seizure: case report.

Oghenerukevwe Odiete, Ramanna Nagendra, Mark A Lawson, Henry Okafor,

Ventricular noncompaction (VNC) of the myocardium is a rare genetic cardiomyopathy caused by a disorder during endocardial morphogenesis and could be accompanied by life-threatening complications. The major clinical manifestations of VNC are heart failure, arrhythmias, and embolic events. The left ventricle is the most commonly reported affected site, but a ... Read more >>

Case Rep Cardiol (Case reports in cardiology)
[2012, 2012:924865]

Cited: 1 time

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Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes.

Kathryn A Nguyen, Rachel E Intriago, Hiral C Upadhyay, Sharon J Santos, Nicholas J G Webster, Mark A Lawson,

As the regulator of pituitary reproductive hormone synthesis, the hypothalamic neuropeptide GnRH is the central regulator of reproduction. A hallmark of GnRH action is the differential control of gene expression in pituitary gonadotropes through varied pulsatile stimulation. Among other signaling events, GnRH activation of the ERK family of MAPKs plays ... Read more >>

Endocrinology (Endocrinology)
[2010, 151(10):4882-4893]

Cited: 16 times

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Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells.

Masaya Takeda, Fumio Otsuka, Hiroaki Takahashi, Kenichi Inagaki, Tomoko Miyoshi, Naoko Tsukamoto, Hirofumi Makino, Mark A Lawson,

It is known that bone morphogenetic proteins (BMPs) regulate gonadotropin transcription and production by pituitary gonadotrope cells. However, the role of BMPs in gonadotropin-releasing hormone (GnRH)-induced FSH production remains uncertain. Here, we describe a functional link between BMP-6 and BMP-7 signals and FSH transcriptional activity induced by GnRH using mouse ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2012, 348(1):147-154]

Cited: 9 times

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Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1.

Devendra S Mistry, Rie Tsutsumi, Marina Fernandez, Shweta Sharma, Steven A Cardenas, Mark A Lawson, Nicholas J G Webster,

Gonadotropin synthesis and release is dependent on pulsatile stimulation by the hypothalamic neuropeptide GnRH. Generally, slow GnRH pulses promote FSH production, whereas rapid pulses favor LH, but the molecular mechanism underlying this pulse sensitivity is poorly understood. In this study, we developed and tested a model for FSHβ regulation in ... Read more >>

Mol Endocrinol (Molecular endocrinology (Baltimore, Md.))
[2011, 25(8):1387-1403]

Cited: 25 times

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