Full Text Journal Articles by
Author Marjorie M Walker

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Antibiotic use but not gastrointestinal infection frequently precedes first diagnosis of functional gastrointestinal disorders.

Michael P Jones, Ayesha Shah, Marjorie M Walker, Natasha A Koloski, Gerald Holtmann, Nicholas J Talley,

<h4>Introduction</h4>While the etiopathogenesis of functional gastrointestinal disorders (FGIDs) is not completely understood, alterations of the intestinal microbiome have been observed. Antibiotics can induce dysbiosis, but whether antibiotics are a risk factor for the onset of FGIDs is uncertain. Antibiotics have been reported as both a risk factor for new onset ... Read more >>

United European Gastroenterol J (United European gastroenterology journal)
[2021, :]

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Electroencephalographic evidence of unconscious and conscious attentional bias in people with functional gastrointestinal disorders: A pilot study.

Anastasia Ejova, Nicholas A Badcock, Sarah McKerchar, Alissa P Beath, Claire Swift, Nicholas J Talley, Gerald Holtmann, Marjorie M Walker, Michael P Jones,

Debate continues as to whether an attentional bias towards threat displayed by sufferers of functional gastrointestinal disorders (FGIDs) is conscious and, thus, more amenable to change through psychological therapy. We compared the amplitudes of early (unconscious) and later (conscious) electroencephalographic (EEG) event-related potentials following silent reading of symptom-related, emotionally neutral, ... Read more >>

Int J Psychophysiol (International journal of psychophysiology : official journal of the International Organization of Psychophysiology)
[2021, 170:30-42]

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Prevalence, symptoms and risk factor profile of rumination syndrome and functional dyspepsia: a population-based study.

Mudar Zand Irani, Michael P Jones, Magnus Halland, Linda Herrick, Rok Seon Choung, Yuri A Saito Loftus, Marjorie M Walker, Joseph A Murray, Nicholas J Talley,

<h4>Background</h4>Rumination syndrome is a functional gastroduodenal disorder characterised by effortless regurgitation of recently ingested food. Emerging evidence reports duodenal eosinophilic inflammation in a subset, suggesting a shared pathophysiology with functional dyspepsia (FD).<h4>Aim</h4>To assess the clinical features of rumination syndrome and FD in a community-based study.<h4>Methods</h4>We mailed a survey assessing gastrointestinal ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Mortality in Eosinophilic Esophagitis - a nationwide, population-based matched cohort study from 2005 to 2017.

Lovisa Röjler, John J Garber, Bjorn Roelstraete, Marjorie M Walker, Jonas F Ludvigsson,

<h4>Background</h4>There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE.<h4>Methods</h4>A nationwide, population-based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (<i>n</i> = 1,625) were identified ... Read more >>

Ups J Med Sci (Upsala journal of medical sciences)
[2021, 126:]

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Serum L-arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case-control study.

Mark A McEvoy, John R Attia, Christopher Oldmeadow, Elizabeth Holliday, Wayne T Smith, Arduino A Mangoni, Roseanne Peel, Stephen J Hancock, Marjorie M Walker, Nicholas J Talley,

BACKGROUND & AIMS: Nitric oxide, a major inhibitory nonadrenergic, noncholinergic neurotransmitter that relaxes smooth muscle, may be implicated in the pathophysiology of visceral hypersensitivity in irritable bowel syndrome (IBS). Impaired bioavailability of the nitric oxide precursor molecule L-arginine and higher concentrations of methylarginines (endogenous inhibitors of nitric oxide synthesis) are known ... Read more >>

United European Gastroenterol J (United European gastroenterology journal)
[2021, :]

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Validation of the diagnosis of eosinophilic esophagitis based on histopathology reports in Sweden.

Lovisa Röjler, Ida Glimberg, Marjorie M Walker, John J Garber, Jonas F Ludvigsson,

<h4>Background</h4>Eosinophilic esophagitis (EoE) is a relatively new diagnosis, where until recently a specific international classification of disease code was missing. One way to identify patients with EoE is to use histopathology codes. We validated the clinicopathological EoE diagnosis based on histopathology reports and patient charts to establish these data sources ... Read more >>

Ups J Med Sci (Upsala journal of medical sciences)
[2021, 126:]

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Concomitant Irritable Bowel Syndrome Does Not Influence the Response to Antimicrobial Therapy in Patients with Functional Dyspepsia.

Ayesha Shah, Saravana Ruban Gurusamy, Teressa Hansen, Gavin Callaghan, Nicholas J Talley, Natasha Koloski, Marjorie M Walker, Michael P Jones, Mark Morrison, Gerald J Holtmann,

<h4>Background and aims</h4>Antimicrobial therapy improves symptoms in patients with irritable bowel syndrome (IBS), but the efficacy in functional dyspepsia (FD) is largely unknown. While FD and IBS frequently overlap, it is unknown if concomitant IBS in FD alters the response to antimicrobial therapy in FD. Thus, we aimed to assess ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, :]

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Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS).

, Christopher Ma, Alain M Schoepfer, Evan S Dellon, Albert J Bredenoord, Mirna Chehade, Margaret H Collins, Brian G Feagan, Glenn T Furuta, Sandeep K Gupta, Ikuo Hirano, Vipul Jairath, David A Katzka, Rish K Pai, Marc E Rothenberg, Alex Straumann, Seema S Aceves, Jeffrey A Alexander, Nicoleta C Arva, Dan Atkins, Luc Biedermann, Carine Blanchard, Antonella Cianferoni, Constanza Ciriza de Los Rios, Frederic Clayton, Carla M Davis, Nicola de Bortoli, Jorge A Dias, Gary W Falk, Robert M Genta, Gisoo Ghaffari, Nirmala Gonsalves, Thomas Greuter, Russell Hopp, Karen S Hsu Blatman, Elizabeth T Jensen, Doug Johnston, Amir F Kagalwalla, Helen M Larsson, John Leung, Hubert Louis, Joanne C Masterson, Calies Menard-Katcher, Paul A Menard-Katcher, Fouad J Moawad, Amanda B Muir, Vincent A Mukkada, Roberto Penagini, Robert D Pesek, Kathryn Peterson, Philip E Putnam, Alberto Ravelli, Edoardo V Savarino, Christoph Schlag, Philipp Schreiner, Dagmar Simon, Thomas C Smyrk, Jonathan M Spergel, Tiffany H Taft, Ingrid Terreehorst, Tim Vanuytsel, Carina Venter, Mario C Vieira, Michael Vieth, Berber Vlieg-Boerstra, Ulrike von Arnim, Marjorie M Walker, Joshua B Wechsler, Philip Woodland, John T Woosley, Guang-Yu Yang, Noam Zevit, Ekaterina Safroneeva,

<h4>Background</h4>End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments.<h4>Objective</h4>We sought to develop a core outcome set (COS) for controlled and observational studies of ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Editorial: tobacco use in functional dyspepsia-another smoking gun? Authors' reply.

Nicholas J Talley, Marjorie M Walker, Lars Agreus, Anna Andreasson,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(1):79]

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Neutrophils, eosinophils, and intraepithelial lymphocytes in the squamous esophagus in subjects with and without gastroesophageal reflux symptoms.

Mudar Zand Irani, Nicholas J Talley, Jukka Ronkainen, Pertti Aro, Anna Andreasson, Lars Agreus, Michael Vieth, Mike P Jones, Marjorie M Walker,

Whilst intraepithelial lymphocytes (IELs) are considered normal within the distal esophageal mucosa, they have an increasingly recognised role in the pathogenesis of reflux esophagitis, and IEL quantification establishes the diagnosis of lymphocytic esophagitis. Knowledge regarding the upper limit of a normal IEL count in health is lacking. We studied 117 ... Read more >>

Hum Pathol (Human pathology)
[2021, 115:112-122]

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Clusters of community-dwelling individuals empirically derived from stool diaries correspond with clinically meaningful outcomes.

Michael P Jones, Susanna Walter, Nicholas J Talley, Marjorie M Walker, Gerald J Holtmann, Ayesha Shah, Mauro D'Amato, Lars Agréus, Anna Andreasson,

<h4>Background</h4>Functional gastrointestinal disorders (FGIDs) are diagnosed according to expert consensus criteria based on recall of symptoms over periods of 3 months or longer. Whether the expert opinion concords with underlying disease process and whether individual recall is accurate are both in doubt. This study aimed to identify naturally occurring clusters of ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, :]

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Sleep disturbances in the irritable bowel syndrome and functional dyspepsia are independent of psychological distress: a population-based study of 1322 Australians.

Natasha A Koloski, Michael Jones, Marjorie M Walker, Simon Keely, Gerald Holtmann, Nicholas J Talley,

<h4>Background</h4>Psychological distress, strongly associated with functional gastrointestinal disorders (FGIDS), likely plays a central role in the pathophysiology. The role of sleep disturbances in FGIDs is unclear, and an association with psychological factors is uncertain.<h4>Aim</h4>To determine whether sleep disturbances are associated with irritable bowel syndrome (IBS) and functional dyspepsia (FD) and ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(5):627-636]

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A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus.

Christopher Ma, Alain M Schoepfer, Ekaterina Safroneeva, ,

Gastroenterology (Gastroenterology)
[2021, 161(3):778-784]

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Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus.

Christopher Ma, Alain M Schoepfer, Ekaterina Safroneeva, , ,

Gastroenterology (Gastroenterology)
[2021, 161(3):748-755]

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Role of smoking in functional dyspepsia and irritable bowel syndrome: three random population-based studies.

Nicholas J Talley, Nicholas Powell, Marjorie M Walker, Mike P Jones, Jukka Ronkainen, Anna Forsberg, Lars Kjellström, Per M Hellström, Pertti Aro, Bengt Wallner, Lars Agréus, Anna Andreasson,

<h4>Background</h4>It is uncertain if functional dyspepsia (FD) or irritable bowel syndrome (IBS) are linked to smoking, and smoking cessation is not part of the routine advice provided to these patients.<h4>Aim</h4>To assess if smoking is an independent risk factor for FD and IBS.<h4>Methods</h4>Three population-based endoscopy studies in Sweden with 2560 community ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(1):32-42]

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Small Intestinal Bacterial Overgrowth in Functional Dyspepsia: A Systematic Review and Meta-Analysis.

Saravana Ruban Gurusamy, Ayesha Shah, Nicholas J Talley, Natasha Koloski, Michael P Jones, Marjorie M Walker, Mark Morrison, Gerald Holtmann,

<h4>Introduction</h4>This systematic review and meta-analysis aimed to determine the role of small intestinal bacterial overgrowth (SIBO) in patients with functional dyspepsia (FD).<h4>Methods</h4>Electronic databases were searched until July 2020 for studies reporting prevalence of SIBO in FD. The prevalence rates, odds ratio, and 95% confidence intervals (CIs) of SIBO in FD ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(5):935-942]

Cited: 2 times

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Duodenal eosinophilia and the link to anxiety: A population-based endoscopic study.

Jukka Ronkainen, Pertti Aro, Mike Jones, Marjorie M Walker, Lars Agréus, Anna Andreasson, Nicholas J Talley,

<h4>Introduction</h4>The concept of gut-to-brain communication via microbial or inflammatory pathways is gaining increased attention but genuine pathology directly linking gut perturbation to anxiety is lacking. We hypothesized that duodenal eosinophilia, as known to occur in functional dyspepsia (FD), may be an underlying cause of anxiety and may help explain the ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(10):e14109]

Cited: 1 time

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Routine assessment of gastrointestinal symptom using a validated questionnaire in the clinical setting to assess the probability of organic or functional gastrointestinal diseases.

Michael P Jones, Ayesha Shah, Ronen Ben-Jacob, Nicholas J Talley, Teressa Hansen, Marjorie M Walker, Marcus Gray, Natasha A Koloski, Gerald Holtmann,

<h4>Background</h4>Patients presenting with gastrointestinal symptoms can be challenging in terms of determining etiology and management strategies. Identifying likely organic pathology is important since it can be treated and may result in further, long-term harm to the patient if not treated. Currently, organic pathology is often identified via invasive procedures such ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(8):e14091]

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Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function.

Bridie J Goggins, Kyra Minahan, Simonne Sherwin, Wai S Soh, Jennifer Pryor, Jessica Bruce, Gang Liu, Andrea Mathe, Darryl Knight, Jay C Horvat, Marjorie M Walker, Simon Keely,

Intestinal epithelia are critical for maintaining gastrointestinal homeostasis. Epithelial barrier injury, causing inflammation and vascular damage, results in inflammatory hypoxia, and thus, healing occurs in an oxygen-restricted environment. The transcription factor hypoxia-inducible factor (HIF)-1 regulates genes important for cell survival and repair, including the cell adhesion protein β1-integrin. Integrins function ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, 320(4):G420-G438]

Cited: 2 times

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Ileocolonic Histopathological and Microbial Alterations in the Irritable Bowel Syndrome: A Nested Community Case-Control Study.

Nicholas J Talley, James L Alexander, Marjorie M Walker, Michael P Jones, Luisa W Hugerth, Lars Engstrand, Lars Agréus, Nicholas Powell, Anna Andreasson,

<h4>Introduction</h4>Histopathological alterations in the ileum and colon in irritable bowel syndrome (IBS) are controversial, and normal values are poorly established. We hypothesized that changes in mucosal immune cells characterize IBS and key changes in immune composition are associated with the mucosa-associated microbiota (MaM).<h4>Methods</h4>A nested case-control study (48 IBS and 106 ... Read more >>

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2020, 12(1):e00296]

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An Increasing Incidence of Upper Gastrointestinal Disorders Over 23 Years: A Prospective Population-Based Study in Sweden.

Anna Andreasson, Nicholas J Talley, Marjorie M Walker, Michael P Jones, Loretta G Platts, Bengt Wallner, Lars Kjellström, Per M Hellström, Anna Forsberg, Lars Agréus,

<h4>Introduction</h4>We hypothesized that the prevalence of functional dyspepsia and gastroesophageal reflux disease in the community may be increasing.<h4>Methods</h4>Randomly selected adults were surveyed on 4 occasions: 1988 (n = 1,151, 21-79 years, response rate [rr] = 90%), 1989 (n = 1,097, 22-80 years, rr = 87%), 1995 (n = 1,139, 20-85 ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(1):210-213]

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Functional Dyspepsia and Duodenal Eosinophil Count and Degranulation: A Multiethnic US Veteran Cohort Study.

M Ellionore Järbrink-Sehgal, Jordan Sparkman, Alexander Damron, Marjorie M Walker, Linda K Green, Daniel G Rosen, David Y Graham, Hashem E El-Serag,

<h4>Background</h4>Duodenal eosinophilia may play a role in functional dyspepsia (FD), but existing study results are conflicted. We investigated the association between duodenal eosinophils (count and degranulation) and FD symptoms, accounting for atopic conditions, medications, and seasonal variations.<h4>Methods</h4>In a cross-sectional study conducted in the Michael E. DeBakey VA Medical Center in ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(10):3482-3489]

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A Role for Primary Care Pharmacists in the Management of Inflammatory Bowel Disease? Lessons from Chronic Disease: A Systematic Review.

Sharmila S Prasad, Kerith Duncanson, Simon Keely, Nicholas J Talley, Therése Kairuz, Gerald J Holtmann, Ayesha Shah, Marjorie M Walker,

<b>Background and aims:</b> Chronic disease, particularly inflammatory bowel disease (IBD), requires a multifaceted approach to managing patients, but it is apparent that primary care pharmacists are being underutilized. To demonstrate the benefits of pharmacist interventions in primary care, a systematic review was conducted of interventions in asthma and type 2 ... Read more >>

Pharmacy (Basel) (Pharmacy (Basel, Switzerland))
[2020, 8(4):]

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The neurotrophic tyrosine kinase receptor 1 (TrkA) is overexpressed in oesophageal squamous cell carcinoma.

Nathan Griffin, Fangfang Gao, Phillip Jobling, Christopher Oldmeadow, Vanessa Wills, Marjorie M Walker, Sam Faulkner, Hubert Hondermarck,

Nerve growth factor (NGF) and its receptors, the neurotrophic receptor tyrosine kinase 1 (NTRK1/TrkA) and the common neurotrophin receptor (NGFR/p75<sup>NTR</sup>), are increasingly implicated in cancer progression, but their clinicopathological significance in oesophageal cancer is unclear. In this study, the expression of NGF, NTRK1 and NGFR were analysed by immunohistochemistry in ... Read more >>

Pathology (Pathology)
[2021, 53(4):470-477]

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The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer.

Nathan Griffin, Mark Marsland, Severine Roselli, Christopher Oldmeadow, John Attia, Marjorie M Walker, Hubert Hondermarck, Sam Faulkner,

The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear. In this study, TrkA expression was assessed via immunohistochemistry of 158 invasive ductal carcinomas (IDC), 158 invasive lobular carcinomas (ILC) and 50 ... Read more >>

Biomolecules (Biomolecules)
[2020, 10(9):]

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