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Author Mariusz Z Ratajczak

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Paper of the August Issue of Stem Cell Reviews and Reports Reveals a Novel Role of Bone Marrow Stroma Cells Expressed CXCR4 in Preventing Aging of Hematopoietic Stem/Progenitor Cells.

Mariusz Z Ratajczak,

Stem Cell Rev Rep (Stem cell reviews and reports)
[2020, :]

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Pannexin-1 channel "fuels" by releasing ATP from bone marrow cells a state of sterile inflammation required for optimal mobilization and homing of hematopoietic stem cells.

Monika Cymer, Katarzyna Brzezniakiewicz-Janus, Kamila Bujko, Arjun Thapa, Janina Ratajczak, Krzysztof Anusz, Michał Tracz, Agnieszka Jackowska-Tracz, Mariusz Z Ratajczak, Mateusz Adamiak,

An efficient harvest of hematopoietic stem/progenitor cells (HSPCs) after pharmacological mobilization from the bone marrow (BM) into peripheral blood (PB) and subsequent proper homing and engraftment of these cells are crucial for clinical outcomes from hematopoietic transplants. Since extracellular adenosine triphosphate (eATP) plays an important role in both processes as ... Read more >>

Purinergic Signal. (Purinergic signalling)
[2020, :]

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SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells.

Mariusz Z Ratajczak, Magda Kucia,

The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine "storm," which in many cases ends in severe acute respiratory syndrome, fulminant myocarditis ... Read more >>

Leukemia (Leukemia)
[2020, 34(7):1726-1729]

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Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling-an update.

Mariusz Z Ratajczak, Mateusz Adamiak, Kamila Bujko, Arjun Thapa, Valentina Pensato, Magda Kucia, Janina Ratajczak, Henning Ulrich,

Bone marrow (BM) as an active hematopoietic organ is highly sensitive to changes in body microenvironments and responds to external physical stimuli from the surrounding environment. In particular, BM tissue responds to several cues related to infections, strenuous exercise, tissue/organ damage, circadian rhythms, and physical challenges such as irradiation. These ... Read more >>

Purinergic Signal. (Purinergic signalling)
[2020, :]

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How to "Detronize" Virus in Crown - Questions to Current Stem Cell Therapies.

Mariusz Z Ratajczak,

Stem Cell Rev Rep (Stem cell reviews and reports)
[2020, 16(3):425-426]

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A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem Progenitor Cells (HSPCs).

Mateusz Adamiak, Monika Cymer, Krzysztof Anusz, Michał Tracz, Mariusz Z Ratajczak,

Delayed homing and engraftment of hematopoietic stem progenitor cells (HSPCs) or even failure to engraft at all is significant clinical problem after hematopoietic transplant. Therefore, in order to develop more efficient homing and engraftment facilitating strategies it is important to learn more about this process. Our team has postulated that ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2020, :]

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The Nlrp3 inflammasome as a "rising star" in studies of normal and malignant hematopoiesis.

Mariusz Z Ratajczak, Kamila Bujko, Monika Cymer, Arjun Thapa, Mateusz Adamiak, Janina Ratajczak, Ahmed K Abdel-Latif, Magda Kucia,

Recent investigations indicate that hematopoiesis is coregulated by innate immunity signals and by pathways characteristic of the activation of innate immunity cells that also operate in normal hematopoietic stem progenitor cells (HSPCs). This should not be surprising because of the common developmental origin of these cells from a hemato/lymphopoietic stem ... Read more >>

Leukemia (Leukemia)
[2020, 34(6):1512-1523]

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Valproic Acid Decreases Endothelial Colony Forming Cells Differentiation and Induces Endothelial-to-Mesenchymal Transition-like Process.

Nathalie Nevo, Severine Lecourt, Ivan Bièche, Magda Kucia, Audrey Cras, Adeline Blandinieres, Sophie Vacher, Nicolas Gendron, Coralie L Guerin, Mariusz Z Ratajczak, David M Smadja,

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor is a widely used anticonvulsant drug. VPA is also under clinical evaluation to be employed in anticancer therapy, as an antithrombotic agent or a molecule to be used in the stem cells expansion protocols. Since endothelial colony forming cells (ECFC) has been ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2020, 16(2):357-368]

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Novel Evidence that Purinergic Signaling - Nlrp3 Inflammasome Axis Regulates Circadian Rhythm of Hematopoietic Stem/Progenitor Cells Circulation in Peripheral Blood.

Mateusz Adamiak, Andrzej Ciechanowicz, Marta Skoda, Monika Cymer, Michal Tracz, Bing Xu, Mariusz Z Ratajczak,

We found that circadian changes in ATP level in peripheral blood (PB) activate the Nlrp3 inflammasome, which triggers diurnal release of hematopoietic stem/progenitor cells (HSPCs) from murine bone marrow (BM) into PB. Consistent with this finding, we observed circadian changes in expression of mRNA for Nlrp3 inflammasome-related genes, including Nlrp3, ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2020, 16(2):335-343]

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Stem Cell Reviews and Reports Enters 16th Year of Publishing.

Mariusz Z Ratajczak,

Stem Cell Rev Rep (Stem cell reviews and reports)
[2020, 16(1):1-2]

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Identification of Human Very Small Embryonic like Stem Cells (VSELS) in Human Heart Tissue Among Young and Old Individuals.

Mohamed El-Helw, Lakshman Chelvarajan, Mohamed Abo-Aly, Mohanad Soliman, Greg Milburn, Autumn L Conger, Kenneth Campbell, Mariusz Z Ratajczak, Ahmed Abdel-Latif,

Very Small Embryonic-Like (VSEL) stem cells are a proposed pluripotent population, residing in adult tissues. VSELs have been described in multiple tissues including bone marrow, cord blood, and gonads. They exhibit multiple characteristics of embryonic stem cells including the ability to differentiate into cellular lineages of all three germ layers, ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2020, 16(1):181-185]

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The Inhibition of CD39 and CD73 Cell Surface Ectonucleotidases by Small Molecular Inhibitors Enhances the Mobilization of Bone Marrow Residing Stem Cells by Decreasing the Extracellular Level of Adenosine.

Mateusz Adamiak, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Magda Kucia, Janina Ratajczak, Mariusz Z Ratajczak,

We have recently demonstrated that purinergic signaling in bone marrow (BM) microenvironment regulates mobilization of hematopoietic stem progenitor cells (HSPCs), mesenchymal stroma cells (MSCs), endothelial progenitor cells (EPCs), and very small embryonic like stem cells (VSELs) into the peripheral blood (PB). While extracellular adenosine triphosphate (ATP) promotes mobilization, its metabolite ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2019, 15(6):892-899]

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An Overview of Novel Unconventional Mechanisms of Hematopoietic Development and Regulators of Hematopoiesis - a Roadmap for Future Investigations.

Kamila Bujko, Monika Cymer, Mateusz Adamiak, Mariusz Z Ratajczak,

Hematopoietic stem cells (HSCs) are the best-characterized stem cells in adult tissues. Nevertheless, as of today, many open questions remain. First, what is the phenotype of the most primitive "pre-HSC" able to undergo asymmetric divisions during ex vivo expansion that gives rise to HSC for all hemato-lymphopoietic lineages. Next, most ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2019, 15(6):785-794]

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Review of animal models of bipolar disorder that alter ion regulation.

Aaron A Mack, Yonglin Gao, Mariusz Z Ratajczak, Sham Kakar, Rif S El-Mallakh,

BACKGROUND:Accurate modeling of psychiatric disorders in animals is essential for advancement in our understanding and treatment of the severe mental illnesses. Of the multiple models available for bipolar illness, the ones that disrupt ion flux are currently the only ones that meet the three criteria for validity: face validity, construct ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2019, 107:208-214]

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Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 inflammasome-dependent manner.

Mateusz Adamiak, Anna M Lenkiewicz, Monika Cymer, Magda Kucia, Janina Ratajczak, Mariusz Z Ratajczak,

Leukemia (Leukemia)
[2019, 33(12):2967-2970]

Cited: 1 time

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ATP-Nlrp3 Inflammasome-Complement Cascade Axis in Sterile Brain Inflammation in Psychiatric Patients and its Impact on Stem Cell Trafficking.

Mariusz Z Ratajczak, Aaron Mack, Kamila Bujko, Alison Domingues, Daniel Pedziwiatr, Magda Kucia, Janina Ratajczak, Henning Ulrich, Jolanta Kucharska-Mazur, Jerzy Samochowiec,

Recent evidence indicates that the occurrence of psychiatric disorders in patients is linked to a local "sterile" inflammation of brain or due to a systemic inflammation process that affects the central nervous system. This is supported by the observation that in peripheral blood of psychotic patients are detectable several mediators ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2019, 15(4):497-505]

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The Complement Cascade as a Mediator of Human Malignant Hematopoietic Cell Trafficking.

Anna Lenkiewicz, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Bing Xu, Mariusz Z Ratajczak,

The complement cascade (ComC) cleavage fragments C3a and C5a regulate the trafficking of normal, differentiated hematopoietic cells, although they do not chemoattract more primitive hematopoietic stem/progenitor cells (HSPCs). By contrast, human myeloid and lymphoid leukemia cell lines and clonogenic blasts from chronic myelogenous leukemia (CML) and acute myelogenous leukemia (AML) ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:1292]

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The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood.

Anna M Lenkiewicz, Mateusz Adamiak, Arjun Thapa, Kamila Bujko, Daniel Pedziwiatr, Ahmed K Abdel-Latif, Magda Kucia, Janina Ratajczak, Mariusz Z Ratajczak,

Mobilization of stem cells from bone marrow (BM) into peripheral blood (PB) in response to tissue or organ injury, infections, strenuous exercise, or mobilization-inducing drugs is as we postulated result of a "sterile inflammation" in the BM microenvironment that triggers activation of the Complement Cascade (ComC). Therefore, we became interested ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2019, 15(3):391-403]

Cited: 2 times

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Correction: Cancer from the perspective of stem cells and misappropriated tissue regeneration mechanisms.

Mariusz Z Ratajczak, Kamila Bujko, Aaron Mack, Magda Kucia, Janina Ratajczak,

The original version of this Article omitted the following from the Acknowledgements. ... Read more >>

Leukemia (Leukemia)
[2019, 33(4):1058]

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Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survival.

Zachariah Payne Sellers, Lukasz Bolkun, Janusz Kloczko, Marzena Liliana Wojtaszewska, Krzysztof Lewandowski, Marcin Moniuszko, Mariusz Z Ratajczak, Gabriela Schneider,

BACKGROUND:The delta-like non-canonical Notch ligand 1 (DLK1)-maternally expressed 3(MEG3) locus (DLK1-MEG3 locus) plays a critical role in the maintenance and differentiation of hematopoietic stem cells. Accumulating evidence implicates the imprinted genes from this locus, DLK1 and MEG3, in the development and progression of acute myeloid leukemia (AML). However, the contribution ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2019, 11(1):50]

Cited: 3 times

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NLRP3 inflammasome couples purinergic signaling with activation of the complement cascade for the optimal release of cells from bone marrow.

Mariusz Z Ratajczak, Mateusz Adamiak, Arjun Thapa, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Anna M Lenkiewicz,

The mechanisms that regulate egress of hematopoietic stem/progenitor cells (HSPCs) into peripheral blood (PB) in response to stress, inflammation, tissue/organ injury, or administration of mobilization-inducing drugs are still not well understood, and because of the importance of stem cell trafficking in maintaining organism homeostasis, several complementary pathways are believed to ... Read more >>

Leukemia (Leukemia)
[2019, 33(4):815-825]

Cited: 2 times

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Correction: Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells.

Mateusz Adamiak, Kamila Bujko, Monika Cymer, Monika Plonka, Talita Glaser, Magda Kucia, Janina Ratajczak, Henning Ulrich, Ahmed Abdel-Latif, Mariusz Z Ratajczak,

Following the publication of this article, the authors noted that the following should be included in the Acknowledgements section: "MA is the recipient of a START scholarship (0785) from FNP". The authors wish to apologise for any inconvenience caused. ... Read more >>

Leukemia (Leukemia)
[2019, 33(4):1057]

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Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner.

Ahmed Abdelbaset-Ismail, Monika Cymer, Sylwia Borkowska-Rzeszotek, Katarzyna Brzeźniakiewicz-Janus, Pranela Rameshwar, Sham S Kakar, Janina Ratajczak, Mariusz Z Ratajczak,

Bioactive phospholipids, including sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), lysophosphatidylcholine (LPC), and its derivative lysophosphatidic acid (LPA), have emerged as important mediators regulating the trafficking of normal and cancer cells. While the role of S1P in regulating migration of hematopoietic cells is well established, in this work we compared its biological effects ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2019, 15(1):139-154]

Cited: 2 times

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What is in Store for 2019 in Stem Cell Reviews and Reports.

Mariusz Z Ratajczak,

Stem Cell Rev Rep (Stem cell reviews and reports)
[2019, 15(1):1-2]

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[Corrigendum] Pituitary sex hormones enhance the pro‑metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase‑1.

Ahmed Abdelbaset-Ismail, Daniel Pedziwiatr, Gabriela Schneider, Jacek Niklinski, Radoslaw Charkiewicz, Marcin Moniuszko, Magda Kucia, Mariusz Z Ratajczak,

After the publication of the article, the authors realize that they overlooked stating that the author Magda Kucia was the recipient of an OPUS grant (grant no. UMO‑2016/21/B/NZ4/00201). Therefore, the Acknowledgements section of the paper should have read as follows (the added text is highlighted in bold): "This study was supported ... Read more >>

Int. J. Oncol. (International journal of oncology)
[2019, 54(3):1134]

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