Full Text Journal Articles by
Author Mario Manto

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Pharmacotherapy of cerebellar and vestibular disorders.

João Lemos, Mario Manto,

<h4>Purpose of review</h4>Major therapeutic advances have been made in patients with episodic and progressive cerebellar ataxias, downbeat nystagmus and some vestibular disorders. We provide an update review on this subject highlighting important research findings from the last two years.<h4>Recent findings</h4>Recently, the use of omaveloxolone for 2 years significantly improved upright stability ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2022, 35(1):118-125]

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Consensus Paper: Novel Directions and Next Steps of Non-invasive Brain Stimulation of the Cerebellum in Health and Disease.

Mario Manto, Georgios P D Argyropoulos, Tommaso Bocci, Pablo A Celnik, Louise A Corben, Matteo Guidetti, Giacomo Koch, Alberto Priori, John C Rothwell, Anna Sadnicka, Danny Spampinato, Yoshikazu Ugawa, Maximilian J Wessel, Roberta Ferrucci,

The cerebellum is involved in multiple closed-loops circuitry which connect the cerebellar modules with the motor cortex, prefrontal, temporal, and parietal cortical areas, and contribute to motor control, cognitive processes, emotional processing, and behavior. Among them, the cerebello-thalamo-cortical pathway represents the anatomical substratum of cerebellum-motor cortex inhibition (CBI). However, the ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, :]

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"A Great Reinforcing Organ": the Cerebellum According to Silas Weir Mitchell.

Lazaros C Triarhou, Mario Manto,

This Cerebellar Classic highlights a work by the physician and novelist, Silas Weir Mitchell (1829-1914), a pupil of Claude Bernard and a founding father of American neurology. Published in the aftermath of the American Civil War, the article reported observations on cerebellar physiology based on ablation and tissue freezing experiments ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, :]

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Postnatal Neurogenesis Beyond Rodents: the Groundbreaking Research of Joseph Altman and Gopal Das.

Lazaros C Triarhou, Mario Manto,

An integral component of neural ontogeny and plasticity is the ongoing generation of new neurons from precursor cells throughout the lifespan in virtually all animals with a nervous system. In mammals, postnatal neurogenesis has been documented in the cerebellum, olfactory bulb, hippocampus, striatum, substantia nigra, hypothalamus, and amygdala. Germinal centers ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, :]

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Using Narrow Band CE-Chirps to Elicit Cervical Vestibular Evoked Myogenic Potentials.

Quentin Mat, Naïma Deggouj, Jean-Pierre Duterme, Sophie Tainmont, Christophe Lelubre, Mario Manto,

<h4>Objectives</h4>To compare the effects of Narrow band CE-Chirps (NB CE-Chirps) and tone bursts (TBs) at 500 Hz and 1000 Hz on the amplitudes and latencies in cervical vestibular evoked myogenic potentials (cVEMPs).<h4>Design</h4>Thirty-one healthy adult volunteers of varying ages were tested by air conduction at 95 dB nHL. Recording conditions were ... Read more >>

Ear Hear (Ear and hearing)
[2021, :]

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Identification of the Prodromal Symptoms and Pre-Ataxic Stage in Cerebellar Disorders: The Next Challenge.

Mario Manto, Aasef G Shaikh, Hiroshi Mitoma,

Cerebellar ataxias (CAs) manifest with a combination of motor incoordination, cognitive, affective and recently identified social symptoms. Novel therapies aim to stop the progression of the subgroup of the degenerative ataxias, or even to cure the disease with a functional and anatomical restoration of the cerebellar circuitry in the near ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(19):]

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Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the Cerebellum.

Hiroshi Mitoma, Mario Manto, Aasef G Shaikh,

Ethanol consumption remains a major concern at a world scale in terms of transient or irreversible neurological consequences, with motor, cognitive, or social consequences. Cerebellum is particularly vulnerable to ethanol, both during development and at the adult stage. In adults, chronic alcoholism elicits, in particular, cerebellar vermis atrophy, the anterior ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(16):]

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Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications.

Jan Cendelin, Marija Cvetanovic, Mandi Gandelman, Hirokazu Hirai, Harry T Orr, Stefan M Pulst, Michael Strupp, Filip Tichanek, Jan Tuma, Mario Manto,

Spinocerebellar ataxias (SCAs) represent a large group of hereditary degenerative diseases of the nervous system, in particular the cerebellum, and other systems that manifest with a variety of progressive motor, cognitive, and behavioral deficits with the leading symptom of cerebellar ataxia. SCAs often lead to severe impairments of the patient's ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, :]

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Exploring Subcellular Cerebellar Fractions with the Electron Microscope.

Lazaros C Triarhou, Mario Manto,

Differential ultracentrifugation and subcellular fractionation historically helped to study the components of the cell, to discover new cellular organelles, and to decipher their morphological and molecular properties. In neuroscience, the technique has yielded important results on neuron biochemistry and the mechanisms of synaptic transmission. This Cerebellar Classic is devoted to ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, 20(4):492-494]

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Correction to: From Cerebellar Apoplexy in 1849 to Cerebellar Stroke in the 2020s: Robert Dunn's Contribution.

Mario Manto, Lazaros C Triarhou,

Cerebellum (Cerebellum (London, England))
[2021, 20(4):671]

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Friedreich's Ataxia and Auditory Processing Disorder.

Helio Ag Teive, Vasiliki Maria Iliadou, Mario Manto,

Cerebellum (Cerebellum (London, England))
[2021, 20(4):495-496]

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Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.

Shinji Kakei, Mario Manto, Hirokazu Tanaka, Hiroshi Mitoma,

Lesions in the Guillain-Mollaret (G-M) triangle frequently cause various types of tremors or tremor-like movements. Nevertheless, we know relatively little about their generation mechanisms. The deep cerebellar nuclei (DCN), which is a primary node of the triangle, has two main output paths: the primary excitatory path to the thalamus, the ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:694653]

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Part I: The Complex Spikes as One of the Cerebellar Secrets.

Mario Manto, Lazaros C Triarhou,

The olivocerebellar tract has unique morphological, physiological, and developmental properties. Olivocerebellar axons are the source of multiple climbing fibers (CFs). The synapse between CFs and the Purkinje neuron is one of the most powerful excitatory in the central nervous system. Complex spikes are composed of an initial large amplitude spike ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, 20(3):327-329]

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Physiology of Cerebellar Reserve: Redundancy and Plasticity of a Modular Machine.

Hiroshi Mitoma, Shinji Kakei, Kazuhiko Yamaguchi, Mario Manto,

The cerebellum is endowed with the capacity for compensation and restoration after pathological injury, a property known as cerebellar reserve. Such capacity is attributed to two unique morphological and physiological features of the cerebellum. First, mossy fibers that convey peripheral and central information run mediolaterally over a wide area of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(9):]

Cited: 1 time

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Optimizing Ocular Vestibular Evoked Myogenic Potentials With Narrow Band CE-Chirps.

Quentin Mat, Jean-Pierre Duterme, Sophie Tainmont, Christophe Lelubre, Mario Manto,

<h4>Objectives</h4>To evaluate the effects of narrow band CE-Chirp (NB CE-Chirp) on the amplitudes and latencies in ocular vestibular evoked myogenic potentials (oVEMPs) at 500 and 1000 Hz in comparison with tone burst (TB).<h4>Design</h4>Twenty-one healthy volunteers were included in the study and tested in air conduction with a "belly-tendon" montage. Recording ... Read more >>

Ear Hear (Ear and hearing)
[2021, 42(5):1373-1380]

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LTDpathies: a Novel Clinical Concept.

Hiroshi Mitoma, Jerome Honnorat, Kazuhiko Yamaguchi, Mario Manto,

Cerebellum (Cerebellum (London, England))
[2021, 20(6):948-951]

Cited: 1 time

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Corrigendum: CSF HIV RNA Escape in Opsoclonus-Myoclonus-Ataxia Syndrome: Case Report and Review of the Literature.

Pierre Cabaraux, Arthur Poncelet, Jérome Honnorat, Remy Demeester, Soraya Cherifi, Mario Manto,

[This corrects the article DOI: 10.3389/fneur.2020.585527.]. ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:665996]

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Consensus on Virtual Management of Vestibular Disorders: Urgent Versus Expedited Care.

Aasef G Shaikh, Adolfo Bronstein, Sergio Carmona, Yoon-Hee Cha, Catherine Cho, Fatema F Ghasia, Daniel Gold, Kemar E Green, Christoph Helmchen, Richard T Ibitoye, Jorge Kattah, Ji-Soo Kim, Sudhir Kothari, Mario Manto, Barry M Seemungal, Dominik Straumann, Michael Strupp, David Szmulewicz, Alexander Tarnutzer, Ali Tehrani, Caroline Tilikete, Miriam Welgampola, Guillermo Zalazar, Amir Kheradmand,

The virtual practice has made major advances in the way that we care for patients in the modern era. The culture of virtual practice, consulting, and telemedicine, which had started several years ago, took an accelerated leap as humankind was challenged by the novel coronavirus pandemic (COVID19). The social distancing ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, 20(1):4-8]

Cited: 7 times

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From Cerebellar Apoplexy in 1849 to Cerebellar Stroke in the 2020s: Robert Dunn's Contribution.

Mario Manto, Lazaros C Triarhou,

Stroke of the cerebellum represents about 10% of strokes of the brain. Both infarction and hemorrhage manifest with symptoms related to the location and extent of the lesion(s). Bilateral cerebellar infarcts constitute up to one third of all cerebellar infarctions. The leading cause of cerebellar infarcts is emboli of cardiac ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, 20(3):340-345]

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Cerebellar long-term depression and auto-immune target of auto-antibodies: the concept of LTDpathies.

Hiroshi Mitoma, Jerome Honnorat, Kazuhiko Yamaguchi, Mario Manto,

There is general agreement that auto-antibodies against ion channels and synaptic machinery proteins can induce limbic encephalitis. In immune-mediated cerebellar ataxias (IMCAs), various synaptic proteins, such as GAD65, voltage-gated Ca channel (VGCC), metabotropic glutamate receptor type 1 (mGluR1), and glutamate receptor delta (GluR delta) are auto-immune targets. Among them, the ... Read more >>

Mol Biomed (Molecular biomedicine)
[2021, 2(1):2]

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Immune-Mediated Cerebellar Ataxias: Clinical Diagnosis and Treatment Based on Immunological and Physiological Mechanisms.

Hiroshi Mitoma, Mario Manto, Marios Hadjivassiliou,

Since the first description of immune-mediated cerebellar ataxias (IMCAs) by Charcot in 1868, several milestones have been reached in our understanding of this group of neurological disorders. IMCAs have diverse etiologies, such as gluten ataxia, postinfectious cerebellitis, paraneoplastic cerebellar degeneration, opsoclonus myoclonus syndrome, anti-GAD ataxia, and primary autoimmune cerebellar ataxia. ... Read more >>

J Mov Disord (Journal of movement disorders)
[2021, 14(1):10-28]

Cited: 1 time

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The critical need to develop tools assessing cerebellar reserve for the delivery and assessment of non-invasive cerebellar stimulation.

Mario Manto, Shinji Kakei, Hiroshi Mitoma,

Non-invasive cerebellar stimulation (NICS) aims to modulate cerebello-cerebral loops and cerebro-spinal loops, both for research and clinical applications. It is of paramount importance to establish and validate morphological and functional tools to quantify cerebellar reserve, defined as the capacity for restoration and compensation to pathology of the cerebellum. Using NICS ... Read more >>

Cerebellum Ataxias (Cerebellum & ataxias)
[2021, 8(1):2]

Cited: 4 times

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CSF HIV RNA Escape in Opsoclonus-Myoclonus-Ataxia Syndrome: Case Report and Review of the Literature.

Pierre Cabaraux, Arthur Poncelet, Jérome Honnorat, Remy Demeester, Soraya Cherifi, Mario Manto,

<b>Background:</b> Human immunodeficiency viruses (HIV) infection is associated with a broad range of neurological manifestations, including opsoclonus-myoclonus ataxia syndrome (OMAS) occurring in primary infection, immune reconstitution syndrome or in case of opportunistic co-infection. <b>Case:</b> We report the exceptional case of a 43-year-old female under HIV treatment for 10 years who ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:585527]

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Consensus Paper: Cerebellum and Social Cognition.

Frank Van Overwalle, Mario Manto, Zaira Cattaneo, Silvia Clausi, Chiara Ferrari, John D E Gabrieli, Xavier Guell, Elien Heleven, Michela Lupo, Qianying Ma, Marco Michelutti, Giusy Olivito, Min Pu, Laura C Rice, Jeremy D Schmahmann, Libera Siciliano, Arseny A Sokolov, Catherine J Stoodley, Kim van Dun, Larry Vandervert, Maria Leggio,

The traditional view on the cerebellum is that it controls motor behavior. Although recent work has revealed that the cerebellum supports also nonmotor functions such as cognition and affect, only during the last 5 years it has become evident that the cerebellum also plays an important social role. This role is ... Read more >>

Cerebellum (Cerebellum (London, England))
[2020, 19(6):833-868]

Cited: 15 times

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Cerebellar transcranial direct current stimulation reconfigurates static and dynamic functional connectivity of the resting-state networks

Fatma Grami, Giovanni de Marco, Florian Bodranghien, Mario Manto, Habas,

<h4>Background: </h4> Transcranial direct current stimulation (tDCS) of the cerebellum dynamically modulates cerebello-thalamo-cortical excitability in a polarity-specific manner during motor, visuo- motor and cognitive tasks. It remains to be established whether tDCS of the cerebellum impact also on resting-state intrinsically connected networks (ICNs). Such impact would open novel research and ... Read more >>

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