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Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the Cerebellum.

Hiroshi Mitoma, Mario Manto, Aasef G Shaikh,

Ethanol consumption remains a major concern at a world scale in terms of transient or irreversible neurological consequences, with motor, cognitive, or social consequences. Cerebellum is particularly vulnerable to ethanol, both during development and at the adult stage. In adults, chronic alcoholism elicits, in particular, cerebellar vermis atrophy, the anterior ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(16):]

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Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications.

Jan Cendelin, Marija Cvetanovic, Mandi Gandelman, Hirokazu Hirai, Harry T Orr, Stefan M Pulst, Michael Strupp, Filip Tichanek, Jan Tuma, Mario Manto,

Spinocerebellar ataxias (SCAs) represent a large group of hereditary degenerative diseases of the nervous system, in particular the cerebellum, and other systems that manifest with a variety of progressive motor, cognitive, and behavioral deficits with the leading symptom of cerebellar ataxia. SCAs often lead to severe impairments of the patient's ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, :]

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Exploring Subcellular Cerebellar Fractions with the Electron Microscope.

Lazaros C Triarhou, Mario Manto,

Differential ultracentrifugation and subcellular fractionation historically helped to study the components of the cell, to discover new cellular organelles, and to decipher their morphological and molecular properties. In neuroscience, the technique has yielded important results on neuron biochemistry and the mechanisms of synaptic transmission. This Cerebellar Classic is devoted to ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, 20(4):492-494]

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Correction to: From Cerebellar Apoplexy in 1849 to Cerebellar Stroke in the 2020s: Robert Dunn's Contribution.

Mario Manto, Lazaros C Triarhou,

Cerebellum (Cerebellum (London, England))
[2021, 20(4):671]

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Friedreich's Ataxia and Auditory Processing Disorder.

Helio Ag Teive, Vasiliki Maria Iliadou, Mario Manto,

Cerebellum (Cerebellum (London, England))
[2021, 20(4):495-496]

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Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.

Shinji Kakei, Mario Manto, Hirokazu Tanaka, Hiroshi Mitoma,

Lesions in the Guillain-Mollaret (G-M) triangle frequently cause various types of tremors or tremor-like movements. Nevertheless, we know relatively little about their generation mechanisms. The deep cerebellar nuclei (DCN), which is a primary node of the triangle, has two main output paths: the primary excitatory path to the thalamus, the ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:694653]

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Part I: The Complex Spikes as One of the Cerebellar Secrets.

Mario Manto, Lazaros C Triarhou,

The olivocerebellar tract has unique morphological, physiological, and developmental properties. Olivocerebellar axons are the source of multiple climbing fibers (CFs). The synapse between CFs and the Purkinje neuron is one of the most powerful excitatory in the central nervous system. Complex spikes are composed of an initial large amplitude spike ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, 20(3):327-329]

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Physiology of Cerebellar Reserve: Redundancy and Plasticity of a Modular Machine.

Hiroshi Mitoma, Shinji Kakei, Kazuhiko Yamaguchi, Mario Manto,

The cerebellum is endowed with the capacity for compensation and restoration after pathological injury, a property known as cerebellar reserve. Such capacity is attributed to two unique morphological and physiological features of the cerebellum. First, mossy fibers that convey peripheral and central information run mediolaterally over a wide area of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(9):]

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Optimizing Ocular Vestibular Evoked Myogenic Potentials With Narrow Band CE-Chirps.

Quentin Mat, Jean-Pierre Duterme, Sophie Tainmont, Christophe Lelubre, Mario Manto,

<h4>Objectives</h4>To evaluate the effects of narrow band CE-Chirp (NB CE-Chirp) on the amplitudes and latencies in ocular vestibular evoked myogenic potentials (oVEMPs) at 500 and 1000 Hz in comparison with tone burst (TB).<h4>Design</h4>Twenty-one healthy volunteers were included in the study and tested in air conduction with a "belly-tendon" montage. Recording ... Read more >>

Ear Hear (Ear and hearing)
[2021, 42(5):1373-1380]

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LTDpathies: a Novel Clinical Concept.

Hiroshi Mitoma, Jerome Honnorat, Kazuhiko Yamaguchi, Mario Manto,

Cerebellum (Cerebellum (London, England))
[2021, :]

Cited: 1 time

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Corrigendum: CSF HIV RNA Escape in Opsoclonus-Myoclonus-Ataxia Syndrome: Case Report and Review of the Literature.

Pierre Cabaraux, Arthur Poncelet, Jérome Honnorat, Remy Demeester, Soraya Cherifi, Mario Manto,

[This corrects the article DOI: 10.3389/fneur.2020.585527.]. ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:665996]

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From Cerebellar Apoplexy in 1849 to Cerebellar Stroke in the 2020s: Robert Dunn's Contribution.

Mario Manto, Lazaros C Triarhou,

Stroke of the cerebellum represents about 10% of strokes of the brain. Both infarction and hemorrhage manifest with symptoms related to the location and extent of the lesion(s). Bilateral cerebellar infarcts constitute up to one third of all cerebellar infarctions. The leading cause of cerebellar infarcts is emboli of cardiac ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, 20(3):340-345]

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Consensus on Virtual Management of Vestibular Disorders: Urgent Versus Expedited Care.

Aasef G Shaikh, Adolfo Bronstein, Sergio Carmona, Yoon-Hee Cha, Catherine Cho, Fatema F Ghasia, Daniel Gold, Kemar E Green, Christoph Helmchen, Richard T Ibitoye, Jorge Kattah, Ji-Soo Kim, Sudhir Kothari, Mario Manto, Barry M Seemungal, Dominik Straumann, Michael Strupp, David Szmulewicz, Alexander Tarnutzer, Ali Tehrani, Caroline Tilikete, Miriam Welgampola, Guillermo Zalazar, Amir Kheradmand,

The virtual practice has made major advances in the way that we care for patients in the modern era. The culture of virtual practice, consulting, and telemedicine, which had started several years ago, took an accelerated leap as humankind was challenged by the novel coronavirus pandemic (COVID19). The social distancing ... Read more >>

Cerebellum (Cerebellum (London, England))
[2021, 20(1):4-8]

Cited: 4 times

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Immune-Mediated Cerebellar Ataxias: Clinical Diagnosis and Treatment Based on Immunological and Physiological Mechanisms.

Hiroshi Mitoma, Mario Manto, Marios Hadjivassiliou,

Since the first description of immune-mediated cerebellar ataxias (IMCAs) by Charcot in 1868, several milestones have been reached in our understanding of this group of neurological disorders. IMCAs have diverse etiologies, such as gluten ataxia, postinfectious cerebellitis, paraneoplastic cerebellar degeneration, opsoclonus myoclonus syndrome, anti-GAD ataxia, and primary autoimmune cerebellar ataxia. ... Read more >>

J Mov Disord (Journal of movement disorders)
[2021, 14(1):10-28]

Cited: 1 time

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The critical need to develop tools assessing cerebellar reserve for the delivery and assessment of non-invasive cerebellar stimulation.

Mario Manto, Shinji Kakei, Hiroshi Mitoma,

Non-invasive cerebellar stimulation (NICS) aims to modulate cerebello-cerebral loops and cerebro-spinal loops, both for research and clinical applications. It is of paramount importance to establish and validate morphological and functional tools to quantify cerebellar reserve, defined as the capacity for restoration and compensation to pathology of the cerebellum. Using NICS ... Read more >>

Cerebellum Ataxias (Cerebellum & ataxias)
[2021, 8(1):2]

Cited: 3 times

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CSF HIV RNA Escape in Opsoclonus-Myoclonus-Ataxia Syndrome: Case Report and Review of the Literature.

Pierre Cabaraux, Arthur Poncelet, Jérome Honnorat, Remy Demeester, Soraya Cherifi, Mario Manto,

<b>Background:</b> Human immunodeficiency viruses (HIV) infection is associated with a broad range of neurological manifestations, including opsoclonus-myoclonus ataxia syndrome (OMAS) occurring in primary infection, immune reconstitution syndrome or in case of opportunistic co-infection. <b>Case:</b> We report the exceptional case of a 43-year-old female under HIV treatment for 10 years who ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:585527]

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Consensus Paper: Cerebellum and Social Cognition.

Frank Van Overwalle, Mario Manto, Zaira Cattaneo, Silvia Clausi, Chiara Ferrari, John D E Gabrieli, Xavier Guell, Elien Heleven, Michela Lupo, Qianying Ma, Marco Michelutti, Giusy Olivito, Min Pu, Laura C Rice, Jeremy D Schmahmann, Libera Siciliano, Arseny A Sokolov, Catherine J Stoodley, Kim van Dun, Larry Vandervert, Maria Leggio,

The traditional view on the cerebellum is that it controls motor behavior. Although recent work has revealed that the cerebellum supports also nonmotor functions such as cognition and affect, only during the last 5 years it has become evident that the cerebellum also plays an important social role. This role is ... Read more >>

Cerebellum (Cerebellum (London, England))
[2020, 19(6):833-868]

Cited: 10 times

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Cerebellar transcranial direct current stimulation reconfigurates static and dynamic functional connectivity of the resting-state networks

Fatma Grami, Giovanni de Marco, Florian Bodranghien, Mario Manto, Habas,

<h4>Background: </h4> Transcranial direct current stimulation (tDCS) of the cerebellum dynamically modulates cerebello-thalamo-cortical excitability in a polarity-specific manner during motor, visuo- motor and cognitive tasks. It remains to be established whether tDCS of the cerebellum impact also on resting-state intrinsically connected networks (ICNs). Such impact would open novel research and ... Read more >>

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Dysmetria and Errors in Predictions: The Role of Internal Forward Model.

Pierre Cabaraux, Jordi Gandini, Shinji Kakei, Mario Manto, Hiroshi Mitoma, Hirokazu Tanaka,

The terminology of cerebellar dysmetria embraces a ubiquitous symptom in motor deficits, oculomotor symptoms, and cognitive/emotional symptoms occurring in cerebellar ataxias. Patients with episodic ataxia exhibit recurrent episodes of ataxia, including motor dysmetria. Despite the consensus that cerebellar dysmetria is a cardinal symptom, there is still no agreement on its ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(18):]

Cited: 2 times

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Management of Patients with Cerebellar Ataxia During the COVID-19 Pandemic: Current Concerns and Future Implications.

Mario Manto, Nicolas Dupre, Marios Hadjivassiliou, Elan D Louis, Hiroshi Mitoma, Marco Molinari, Aasef G Shaikh, Bing-Wen Soong, Michael Strupp, Frank Van Overwalle, Jeremy D Schmahmann,

The current worldwide severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that causes coronavirus disease 2019 (COVID-19) has brought some medical systems to the brink of collapse. This crisis is also negatively impacting the care of patients with non-COVID-19 conditions, including those with cerebellar ataxia (CA). Older patients with CA ... Read more >>

Cerebellum (Cerebellum (London, England))
[2020, 19(4):562-568]

Cited: 6 times

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Transcranial direct current stimulation and attention skills in burnout patients: a randomized blinded sham-controlled pilot study

Pia Van Noppen, Kim van Dun, Siel Depestele, Stefanie Verstraelen, Raf Meesen, Mario Manto,

<ns3:p> <h4>Background: </h4> Burnout is characterized by deficiencies in attention and several components of the working memory. It has been shown that cognitive behavioral therapy can have a positive effect on burnout and depressive symptoms, however, the lingering effects of impaired attention and executive functions are the most frustrating. We ... Read more >>

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Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia-Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias.

Marios Hadjivassiliou, Francesc Graus, Jerome Honnorat, Sven Jarius, Maarten Titulaer, Mario Manto, Nigel Hoggard, Ptolemaios Sarrigiannis, Hiroshi Mitoma,

Aside from well-characterized immune-mediated ataxias with a clear trigger and/or association with specific neuronal antibodies, a large number of idiopathic ataxias are suspected to be immune mediated but remain undiagnosed due to lack of diagnostic biomarkers. Primary autoimmune cerebellar ataxia (PACA) is the term used to describe this later group. ... Read more >>

Cerebellum (Cerebellum (London, England))
[2020, 19(4):605-610]

Cited: 9 times

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Fundamental Mechanisms of Autoantibody-Induced Impairments on Ion Channels and Synapses in Immune-Mediated Cerebellar Ataxias.

Hiroshi Mitoma, Jerome Honnorat, Kazuhiko Yamaguchi, Mario Manto,

In the last years, different kinds of limbic encephalitis associated with autoantibodies against ion channels and synaptic receptors have been described. Many studies have demonstrated that such autoantibodies induce channel or receptor dysfunction. The same mechanism is discussed in immune-mediated cerebellar ataxias (IMCAs), but the pathogenesis has been less investigated. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(14):]

Cited: 1 time

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Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019.

Jerome R Lechien, Carlos M Chiesa-Estomba, Sammy Place, Yves Van Laethem, Pierre Cabaraux, Quentin Mat, Kathy Huet, Jan Plzak, Mihaela Horoi, Stéphane Hans, Maria Rosaria Barillari, Giovanni Cammaroto, Nicolas Fakhry, Delphine Martiny, Tareck Ayad, Lionel Jouffe, Claire Hopkins, Sven Saussez, ,

<h4>Background</h4>The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown.<h4>Objective</h4>To study the clinical presentation of COVID-19 in Europe.<h4>Methods</h4>Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship ... Read more >>

J Intern Med (Journal of internal medicine)
[2020, 288(3):335-344]

Cited: 185 times

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Genome-Wide Association Study Points New Direction for Downbeat Nystagmus Research.

Aasef G Shaikh, Mario Manto,

Cerebellum (Cerebellum (London, England))
[2020, 19(3):345-347]

Cited: 1 time

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