Full Text Journal Articles by
Author Mario M Leitao

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Treatment of Extramammary Paget Disease and the Role of Reflectance Confocal Microscopy: A Prospective Study.

Cristian Navarrete-Dechent, Saud Aleissa, Miguel Cordova, Brian P Hibler, Andres M Erlendsson, Max Polansky, Frank Cordova, Erica H Lee, Klaus J Busam, Travis Hollmann, Cecilia Lezcano, Andrea Moy, Melissa Pulitzer, Mario M Leitao, Anthony M Rossi,

<h4>Background</h4>Extramammary Paget disease (EMPD) poses treatment challenges. Invasive and noninvasive treatment modalities exist with variable success reported. Reflectance confocal microscopy (RCM) is emerging as an adjuvant diagnostic tool.<h4>Objective</h4>To evaluate the treatment of EMPD patients and the role of RCM.<h4>Methods</h4>Prospective study. Demographic and tumor characteristics were recorded. Handheld-RCM was performed and ... Read more >>

Dermatol Surg (Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.])
[2021, 47(4):473-479]

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Multiparametric magnetic resonance imaging facilitates the selection of patients prior to fertility-sparing management of endometrial cancer.

Yuki Himoto, Yulia Lakhman, Shinya Fujii, Satoshi Morita, Jennifer J Mueller, Mario M Leitao, Aki Kido,

<h4>Purpose</h4>To compare the diagnostic performance of biparametric magnetic resonance imaging (bpMRI) versus multiparametric MRI (mpMRI) for the staging of well-differentiated endometrioid endometrial cancer (EC) in potential candidates for fertility-sparing management.<h4>Methods</h4>This multi-center retrospective study included 48 potential candidates for fertility-sparing management (age <46 years, grade 1 endometroid EC) who did not ... Read more >>

Abdom Radiol (NY) (Abdominal radiology (New York))
[2021, :]

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Global disparities in oncology: Pinpointing and addressing the causes.

Mario M Leitao,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 153(2):188-189]

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Quality of Life and Adverse Events: Prognostic Relationships in Long-Term Ovarian Cancer Survival.

Lari Wenzel, Kathryn Osann, Chelsea McKinney, David Cella, Giulia Fulci, Mary J Scroggins, Heather A Lankes, Victoria Wang, Kenneth P Nephew, George L Maxwell, Samuel C Mok, Thomas P Conrads, Austin Miller, Robert S Mannel, Heidi J Gray, Parviz Hanjani, Warner K Huh, Nick Spirtos, Mario M Leitao, Gretchen Glaser, Sudarshan K Sharma, Alessandro D Santin, Paul Sperduto, Shashikant B Lele, Robert A Burger, Bradley J Monk, Michael Birrer,

<h4>Background</h4>There is a critical need to identify patient characteristics associated with long-term ovarian cancer survival.<h4>Methods</h4>Quality of life (QOL), measured by the Functional Assessment of Cancer Therapy-Ovarian-Trial Outcome Index (FACT-O-TOI), including physical, functional and ovarian-specific subscales, was compared between long-term (LTS) (8+ years) and short-term (STS) (<5 years) survivors of GOG 218 ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2021, :]

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Genetic and molecular subtype heterogeneity in newly diagnosed early- and advanced-stage endometrial cancer.

Arnaud Da Cruz Paula, Deborah F DeLair, Lorenzo Ferrando, Daniel J Fix, Robert A Soslow, Kay J Park, Sarah Chiang, Jorge S Reis-Filho, Ahmet Zehir, Mark T A Donoghue, Michelle Wu, David N Brown, Rajmohan Murali, Claire F Friedman, Dmitriy Zamarin, Vicky Makker, Jennifer J Mueller, Mario M Leitao, Nadeem R Abu-Rustum, Carol Aghajanian, Britta Weigelt,

<h4>Objective</h4>To characterize and compare the molecular subtypes and profiles of prospectively-accrued newly-diagnosed early- and advanced-stage endometrial cancers (ECs).<h4>Methods</h4>EC patients consented to an IRB-approved protocol of massively parallel sequencing of 410-468 cancer-related genes; 175 ECs of 7 histologic types (n = 135 FIGO stages I/II, n = 40 FIGO stages III/IV) were included. Previously reported ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Monitoring vulvar melanoma response to combined immunotherapy and radiotherapy with in vivo reflectance confocal microscopy.

Cristian Navarrete-Dechent, Miguel Cordova, Saud Aleissa, Alexander Shoushtari, Travis J Hollmann, Mario M Leitao, Anthony M Rossi,

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2021, :]

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Post-LACC era: critical assessment not "all-or-none" is needed.

Mario M Leitao, Se Ik Kim, Jae Weon Kim,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e47]

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Prophylactic Negative Pressure Wound Therapy After Laparotomy for Gynecologic Surgery: A Randomized Controlled Trial.

Mario M Leitao, Qin C Zhou, Maria B Schiavone, Renee A Cowan, Evan S Smith, Alexia Iasonos, Mitchell Veith, Michael Rafizadeh, Katherine Curran, Bhavani Ramesh, Kaity Chang, Dennis S Chi, Yukio Sonoda, Amy K Brown, Jonathan A Cosin, Nadeem R Abu-Rustum, Martin A Martino, Jennifer J Mueller, Kara Long Roche, Elizabeth L Jewell, Vance Broach, Nicholas C Lambrou, John P Diaz, Oliver Zivanovic,

<h4>Objective</h4>To estimate the effectiveness of prophylactic negative pressure wound therapy in patients undergoing laparotomy for gynecologic surgery.<h4>Methods</h4>We conducted a randomized controlled trial. Eligible, consenting patients, regardless of body mass index (BMI), who were undergoing laparotomy for presumed gynecologic malignancy were randomly allocated to standard gauze or negative pressure wound therapy. ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2021, 137(2):334-341]

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Angiosarcoma of the vulva following radiation for colorectal cancer.

Madison Meyer, Evan S Smith, Mario M Leitao,

Gynecol Oncol Rep (Gynecologic oncology reports)
[2021, 36:100711]

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The Landmark Series: Minimally Invasive Surgery for Cervical Cancer.

Derman Basaran, Mario M Leitao,

Cervical cancer incidence and mortality have declined in developed countries during the past few decades as a result of screening programs and vaccination. However, it remains a significant cause of cancer-related mortality in young women. Early-stage cervical cancer, defined as disease limited to the cervix, has traditionally been treated with ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(1):204-211]

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Targeted RNA expression profiling identifies high-grade endometrial stromal sarcoma as a clinically relevant molecular subtype of uterine sarcoma.

Amir Momeni-Boroujeni, Nissreen Mohammad, Robert Wolber, Stephen Yip, Martin Köbel, Brendan C Dickson, Martee L Hensley, Mario M Leitao, Cristina R Antonescu, Ryma Benayed, Marc Ladanyi, Cheng-Han Lee, Sarah Chiang,

High-grade endometrial stromal sarcoma (HGESS) may harbor YWHAE-NUTM2A/B fusion, ZC3H7B-BCOR fusion, and BCOR internal tandem duplication (ITD). NTRK3 upregulation and pan-Trk expression were reported in soft tissue lesions that share similar morphology and genetic abnormalities. To confirm these findings in HGESS, differential expression analysis was performed at gene level comparing ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, :]

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The impact of tumor fragmentation in patients with stage I uterine leiomyosarcoma on patterns of recurrence and oncologic outcome.

Silvana Pedra Nobre, Martee L Hensley, Melody So, Qin C Zhou, Alexia Iasonos, Mario M Leitao, Jennifer Ducie, Sarah Chiang, Jennifer J Mueller, Nadeem R Abu-Rustum, Oliver Zivanovic,

<h4>Objective</h4>To evaluate the impact of tumor fragmentation on oncologic outcomes in patients with stage I uterine leiomyosarcoma (uLMS).<h4>Methods</h4>We identified all patients diagnosed with stage I uLMS presenting to our institution within three months of primary surgery, 1/2000-1/2019. Patients with recurrent disease were excluded. The non-morcellated group had total hysterectomy without ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 160(1):99-105]

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Machine learning-based prediction of microsatellite instability and high tumor mutation burden from contrast-enhanced computed tomography in endometrial cancers.

Harini Veeraraghavan, Claire F Friedman, Deborah F DeLair, Josip Ninčević, Yuki Himoto, Silvio G Bruni, Giovanni Cappello, Iva Petkovska, Stephanie Nougaret, Ines Nikolovski, Ahmet Zehir, Nadeem R Abu-Rustum, Carol Aghajanian, Dmitriy Zamarin, Karen A Cadoo, Luis A Diaz, Mario M Leitao, Vicky Makker, Robert A Soslow, Jennifer J Mueller, Britta Weigelt, Yulia Lakhman,

To evaluate whether radiomic features from contrast-enhanced computed tomography (CE-CT) can identify DNA mismatch repair deficient (MMR-D) and/or tumor mutational burden-high (TMB-H) endometrial cancers (ECs). Patients who underwent targeted massively parallel sequencing of primary ECs between 2014 and 2018 and preoperative CE-CT were included (n = 150). Molecular subtypes of EC were ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):17769]

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Radical Trachelectomy for the Treatment of Early-Stage Cervical Cancer: A Systematic Review.

Evan S Smith, Ashley S Moon, Robin O'Hanlon, Mario M Leitao, Yukio Sonoda, Nadeem R Abu-Rustum, Jennifer J Mueller,

<h4>Objective</h4>To assess surgical, oncologic, and pregnancy outcomes in patients undergoing radical vaginal, abdominal, or laparoscopic trachelectomy for the treatment of early-stage cervical cancer, using a methodic review of published literature.<h4>Data sources</h4>PubMed, EMBASE, and Cochrane Library sources, including ClinicalTrials.gov, were searched from 1990-2019 with terms "cervical cancer" and "(vaginal, abdominal, open, ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2020, 136(3):533-542]

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State of the science: Uterine sarcomas: From pathology to practice.

Alexander Shushkevich, Premal H Thaker, Ramey D Littell, Naishadh A Shah, Sarah Chiang, Katherine Thornton, Martee L Hensley, Brian M Slomovitz, Kevin M Holcomb, Mario M Leitao, Michael D Toboni, Matthew A Powell, Douglas A Levine, Sean C Dowdy, Ann Klopp, Jubilee Brown,

Gynecol Oncol (Gynecologic oncology)
[2020, 159(1):3-7]

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Genomic Alterations as Potential Therapeutic Targets in Extramammary Paget's Disease of the Vulva.

Marina Stasenko, Gowtham Jayakumaran, Renee Cowan, Vance Broach, Dennis S Chi, Anthony Rossi, Travis J Hollman, Ahmet Zehir, Nadeem R Abu-Rustum, Mario M Leitao,

<h4>Purpose</h4>To identify genomic alterations as potential therapeutic targets in extramammary Paget disease (EMPD) of the vulva.<h4>Methods</h4>We identified all patients with primary vulvar EMPD who were treated at our institution and underwent paired tumor-normal massively parallel sequencing of 410-468 cancer-related genes (MSK-IMPACT assay). EMPD of the vulva samples sequenced from 2014 ... Read more >>

JCO Precis Oncol (JCO precision oncology)
[2020, 4:]

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Circulating Tumor Cells In Advanced Cervical Cancer: NRG Oncology-Gynecologic Oncology Group Study 240 (NCT 00803062).

Krishnansu S Tewari, Michael W Sill, Bradley J Monk, Richard T Penson, David H Moore, Heather A Lankes, Lois M Ramondetta, Lisa M Landrum, Leslie M Randall, Ana Oaknin, Mario M Leitao, Eric L Eisenhauer, Paul DiSilvestro, Linda Van Le, Michael L Pearl, James J Burke, Ritu Salani, Debra L Richardson, Helen E Michael, David W Kindelberger, Michael J Birrer,

To isolate circulating tumor cells (CTC) from women with advanced cervical cancer and estimate the impact of CTCs and treatment on overall survival and progression-free survival (PFS). A total of 7.5 mL of whole blood was drawn pre-cycle 1 and 36 days post-cycle 1 from patients enrolled on Gynecologic Oncology ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2020, :]

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Impact of provider volume on front-line chemotherapy guideline compliance and overall survival in elderly patients with advanced ovarian cancer.

Emeline M Aviki, Jessica A Lavery, Kara Long Roche, Renee Cowan, Kimberly Dessources, Derman Basaran, Angela K Green, Carol A Aghajanian, Roisin O'Cearbhaill, Elizabeth L Jewell, Mario M Leitao, Ginger J Gardner, Nadeem R Abu-Rustum, Paul Sabbatini, Peter B Bach,

<h4>Purpose</h4>We sought to evaluate whether provider volume or other factors are associated with chemotherapy guideline compliance in elderly patients with epithelial ovarian cancer (EOC).<h4>Methods</h4>We queried the SEER-Medicare database for patients ≥66 years, diagnosed with FIGO stage II-IV EOC from 2004 to 2013 who underwent surgery and received chemotherapy within 7 months of ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(2):418-425]

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Electronic patient-reported symptom monitoring in patients recovering from ambulatory minimally invasive gynecologic surgery: A prospective pilot study.

Oliver Zivanovic, Ling Y Chen, Andrew Vickers, Alli Straubhar, Raymond Baser, Mitchell Veith, Nate Aiken, Jeanne Carter, Katherine Curran, Brett Simon, Jennifer Mueller, Elizabeth Jewell, Dennis S Chi, Yukio Sonoda, Nadeem R Abu-Rustum, Mario M Leitao,

<h4>Objective</h4>To evaluate the feasibility of an electronic symptom-tracking platform for patients recovering from ambulatory surgery.<h4>Method</h4>We assessed user response to an electronic system designed to self-report symptoms. Endpoints included compliance, postoperative symptoms, patient satisfaction. An 8-item symptom inventory (pain, nausea, vomiting, shortness of breath, fever, swelling, discharge, redness) was developed and ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(1):187-194]

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Comparison of minimally invasive versus open surgery in the treatment of endometrial carcinosarcoma.

Silvana Pedra Nobre, Jennifer J Mueller, Ginger J Gardner, Kara Long Roche, Carol L Brown, Robert A Soslow, Kaled M Alektiar, Yukio Sonoda, Vance A Broach, Elizabeth L Jewell, Oliver Zivanovic, Dennis S Chi, Nadeem R Abu-Rustum, Mario M Leitao,

<h4>Objective</h4>The aim of this study was to compare perioperative and oncologic outcomes between minimally invasive and open surgery in the treatment of endometrial carcinosarcoma.<h4>Methods</h4>We retrospectively identified all patients with newly diagnosed endometrial carcinosarcoma who underwent primary surgery via any approach at our institution from January 2009 to January 2018. Patients ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(8):1162-1168]

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ASO Author Reflections: Robotically Assisted Gynecologic Surgery in the Frail Elderly: Analysis of Perioperative Outcomes.

Alessia Aloisi, Mario M Leitao,

Ann Surg Oncol (Annals of surgical oncology)
[2020, 27(10):3781-3782]

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The current clinical approach to newly diagnosed uterine cancer.

Olga T Filippova, Mario M Leitao,

<h4>Introduction</h4>Uterine cancer is the most common gynecologic malignancy, although fortunately, 75% of women present with early-stage disease. A major area of controversy regarding the management of the disease concerns postoperative therapy for both women with early- and advanced-stage endometrial carcinoma. Here, we review landmark evidence that can help guide clinical ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2020, 20(7):581-590]

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Clinical patterns and genomic profiling of recurrent 'ultra-low risk' endometrial cancer.

Marina Stasenko, Noah Feit, Simon S K Lee, Cassandra Shepherd, Robert A Soslow, Karen A Cadoo, Kaled Alektiar, Edaise M Da Silva, Ana Paula Martins Sebastião, Mario M Leitao, Ginger Gardner, Pier Selenica, Nadeem R Abu-Rustum, Britta Weigelt, Jennifer J Mueller,

OBJECTIVE:Despite good prognosis for patients with low-risk endometrial cancer, a small subset of women with low-grade/low-stage endometrial cancer experience disease recurrence and death. The aim of this study was to characterize clinical features and mutational profiles of recurrent, low-grade, non-myoinvasive, 'ultra-low risk' endometrioid endometrial adenocarcinomas. METHODS:We retrospectively identified patients with ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(6):717-723]

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The impact of near-infrared angiography and proctoscopy after rectosigmoid resection and anastomosis performed during surgeries for gynecologic malignancies.

Lea A Moukarzel, Maureen E Byrne, Stephanie Leiva, Michelle Wu, Qin C Zhou, Alexia Iasonos, Nadeem R Abu-Rustum, Yukio Sonoda, Ginger Gardner, Mario M Leitao, Vance A Broach, Dennis S Chi, Kara Long Roche, Oliver Zivanovic,

<h4>Objectives</h4>Reducing anastomotic leak rates after rectosigmoid resection and anastomosis is a priority in patients undergoing gynecologic oncology surgery. Therefore, we investigated the implications of performing near-infrared angiography (NIR) via proctoscopy to assess anastomotic perfusion at the time of rectosigmoid resection and anastomosis.<h4>Methods</h4>We identified all patients who underwent rectosigmoid resection and ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 158(2):397-401]

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Surveillance patterns of cervical cancer patients treated with conization alone.

Silvana Pedra Nobre, Varvara Mazina, Alexia Iasonos, Qin C Zhou, Yukio Sonoda, Ginger Gardner, Kara Long-Roche, Mario M Leitao, Nadeem R Abu-Rustum, Jennifer J Mueller,

<h4>Objectives</h4>To determine surveillance patterns of stage I cervical cancer after cervical conization.<h4>Methods</h4>A 25-question electronic survey was sent to members of the Society of Gynecologic Oncology. Provider demographics, surveillance during year 1, years 1-3, and >3 years after cervical conization, use of pelvic examination, cytology, Human papillomavirus testing, colposcopy, and endocervical ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(8):1129-1135]

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