Full Text Journal Articles by
Author Marina Sindichakis

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Fasting hypoglycemia is associated with disease progression in presymptomatic early stage type 1 diabetes.

Melanie Heinrich, Nicole Maison, Peter Achenbach, Robin Assfalg, Sonja Braig, Dominik Böcker, Desiree Dunstheimer, Uwe Ermer, Antonia Gavazzeni, Eva-Maria Gerstl, Sandra Hummel, Kerstin Kick, Herbert Müller, Nicole Nellen-Hellmuth, Christian Ockert, Marina Sindichakis, Stefanie Tretter, Katharina Warncke, Anette-Gabriele Ziegler, Andreas Beyerlein, ,

<h4>Objective</h4>In children with presymptomatic type 1 diabetes, intermittent hyperglycemia and rising hemoglobin A1c levels are a known signal of progression toward insulin-dependency. Episodes of hypoglycemia, however, have also been reported in one published case. We investigated the prevalence of hypoglycemia and its association with disease progression in children with presymptomatic ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2018, 19(7):1238-1242]

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Recruiting young pre-symptomatic children for a clinical trial in type 1 diabetes: Insights from the Fr1da insulin intervention study.

Kerstin Kick, Robin Assfalg, Susanne Aydin, Susanne Bechtold-Dalla Pozza, Dominik Böcker, Sonja Braig, Melanie Bunk, Desiree Dunstheimer, Alevtina Durmashkina, Uwe Ermer, Antonia Gavazzeni, Eva-Maria Gerstl, Melanie Heinrich, Melanie Herbst, Yvonne Kriesen, Ursula Kuhnle-Krahl, Herbert Müller, Nicole Nellen-Hellmuth, Christian Ockert, Claudia Ramminger, Marina Sindichakis, Stefanie Tretter, Katharina Warncke, Peter Achenbach, Anette-G Ziegler, Verena S Hoffmann,

<h4>Background</h4>Although detection of children at high risk of developing type 1 diabetes and diagnosis of early stages is possible, up to now there exists no approved therapy to delay or prevent type 1 diabetes. Thus it is vital to develop evidence-based interventions. For this a sufficient number of trial participants ... Read more >>

Contemp Clin Trials Commun (Contemporary clinical trials communications)
[2018, 11:170-173]

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Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study.

Jennifer Raab, Florian Haupt, Marlon Scholz, Claudia Matzke, Katharina Warncke, Karin Lange, Robin Assfalg, Katharina Weininger, Susanne Wittich, Stephanie Löbner, Andreas Beyerlein, Uta Nennstiel-Ratzel, Martin Lang, Otto Laub, Desiree Dunstheimer, Ezio Bonifacio, Peter Achenbach, Christiane Winkler, Anette-G Ziegler, ,

<h4>Introduction</h4>Type 1 diabetes can be diagnosed at an early presymptomatic stage by the detection of islet autoantibodies. The Fr1da study aims to assess whether early staging of type 1 diabetes (1) is feasible at a population-based level, (2) prevents severe metabolic decompensation observed at the clinical manifestation of type 1 ... Read more >>

BMJ Open (BMJ open)
[2016, 6(5):e011144]

Cited: 37 times

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Simultaneous radiochemotherapy in pediatric patients with high-grade glioma: a phase I study.

Johannes E A Wolff, Sabine Wagner, Marina Sindichakis, Thorsten Pietsch, Astrid Gnekow, Rolf-Dieter Kortmann, Ronald Sträter, Joachim Kuehl,

BACKGROUND: Sandwich chemotherapy as first postoperative treatment might cause resistance to ensuing irradiation. Simultaneous radiochemotherapy might prevent this. PATIENTS AND METHODS: Twenty-nine children with high-grade glioma were treated from 1997-1999. The median age was 11.1 years. Tumor locations included: cerebral cortex 12, deep cerebral locations 11, cerebellum 3, spinal cord ... Read more >>

Anticancer Res (Anticancer research)
[2002, 22(6B):3569-3572]

Cited: 17 times

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