Full Text Journal Articles by
Author Marilyn J Hockenberry

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Symptom Clusters, Physical Activity, and Quality of Life: A Latent Class Analysis of Children During Maintenance Therapy for Leukemia.

Mary C Hooke, Michelle A Mathiason, Audrey Blommer, Jessica Hutter, Pauline Mitby, Olga Taylor, Michael E Scheurer, Alicia S Kunin-Batson, Wei Pan, Marilyn J Hockenberry,

<h4>Background</h4>Children undergoing treatment for acute lymphocytic leukemia (ALL) report co-occurring symptoms of fatigue, sleep disturbances, and depression as a symptom cluster. Physical activity (PA) may influence symptom severity and quality of life (QOL).<h4>Objectives</h4>This study examined changes in symptoms and QOL during ALL maintenance in children categorized by symptom cluster and ... Read more >>

Cancer Nurs (Cancer nursing)
[2021, :]

Cited: 0 times

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Prospective patient-reported symptom profiles associated with pediatric acute lymphoblastic leukemia relapse.

Austin L Brown, Kimberly P Raghubar, Olga A Taylor, Melanie Brooke Bernhardt, Lisa S Kahalley, Wei Pan, Philip J Lupo, Marilyn J Hockenberry, Michael E Scheurer,

<h4>Purpose</h4>Despite improvements in frontline pediatric acute lymphoblastic leukemia (ALL) treatment, relapse remains a concern. Research in adult cancer patients suggests that patient-reported symptoms may predict survival, but the relationship between symptoms and relapse for pediatric ALL has received little attention.<h4>Methods</h4>Pediatric patients with ALL (age 2-18 years) and/or their primary caregivers completed ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2021, 29(5):2455-2464]

Cited: 0 times

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Cerebrospinal Fluid Metabolomic Profiles Associated With Fatigue During Treatment for Pediatric Acute Lymphoblastic Leukemia.

Austin L Brown, Pagna Sok, Olga Taylor, John P Woodhouse, M Brooke Bernhardt, Kimberly P Raghubar, Lisa S Kahalley, Philip J Lupo, Marilyn J Hockenberry, Michael E Scheurer,

<h4>Context</h4>Cancer-related fatigue (CRF) is one of the most distressing and persistent symptoms reported during pediatric acute lymphoblastic leukemia (ALL) therapy; however, information on the pathways underlying CRF severity is limited.<h4>Objectives</h4>We conducted global metabolomics profiling of cerebrospinal fluid (CSF) samples to provide insight into the underlying mechanisms of CRF.<h4>Methods</h4>Fatigue in pediatric ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2021, 61(3):464-473]

Cited: 3 times

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The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia.

Mary C Hooke, Daniel Hatch, Marilyn J Hockenberry, Susan Whitman, Ida Moore, David Montgomery, Kari Marano, Pauline Mitby, Michael E Scheurer, Olga Taylor, Wei Pan,

<b>Background:</b> During treatment for acute lymphoblastic leukemia (ALL), children report co-occurring symptoms of fatigue, sleep disturbance, pain, nausea, and depression as a symptom cluster. Central nervous system-directed ALL therapies also put children at risk for cognitive impairments. Cancer therapies can cause an increase in oxidative stress, which may contribute to ... Read more >>

J Pediatr Oncol Nurs (Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses)
[2020, 37(4):244-254]

Cited: 0 times

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Impact of Childhood Leukemia Treatment on Attention Measured by the Continuous Performance Test Factor Structure.

Kari M Koerner, Kathleen C Insel, Marilyn J Hockenberry, Lynnette L Harris, Olga A Taylor, Ida M Moore,

<h4>Objectives</h4>To describe the impact of central nervous system-directed treatment on attention and its relation to academic outcomes in childhood acute lymphoblastic leukemia (ALL) survivors.<h4>Sample &amp; setting</h4>51 children diagnosed with ALL at two pediatric oncology treatment centers in the southwestern United States.<h4>Methods &amp; variables</h4>A prospective, longitudinal design measured attention after a ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2019, 46(4):E98-E106]

Cited: 0 times

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Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia.

Marilyn J Hockenberry, Wei Pan, Michael E Scheurer, Mary C Hooke, Olga Taylor, Kari Koerner, David Montgomery, Susan Whitman, Pauline Mitby, Ida Moore,

<h4>Purpose</h4>The purpose of this study was to explore the influence of oxidative stress (F2-isoprostanes) and inflammatory (interleukin [IL]-8) biomarkers on symptom trajectories during the first 18 months of childhood leukemia treatment.<h4>Method</h4>A repeated-measures design was used to evaluate symptoms experienced by 218 children during treatment. A symptom cluster (fatigue, pain, and ... Read more >>

Biol Res Nurs (Biological research for nursing)
[2019, 21(5):458-465]

Cited: 1 time

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Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life.

Cheryl C Rodgers, Mary C Hooke, Olga A Taylor, Kari M Koerner, Pauline A Mitby, Ida M Moore, Michael E Scheurer, Marilyn J Hockenberry, Wei Pan,

<h4>Objectives</h4>To examine the relationship of the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L) with health-related quality of life (HRQOL).<h4>Sample &amp; setting</h4>327 children receiving treatment for acute lymphoblastic leukemia from four pediatric oncology programs across the United States.<h4>Methods &amp; variables</h4>Participants completed fatigue, sleep disturbance, pain, nausea, and depression symptom questionnaires at four time ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2019, 46(2):228-237]

Cited: 2 times

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Improving Transitional Care: The Role of Handoffs and Discharge Checklists in Hematologic Malignancies.

Mariah Prince, Deborah Allen, Sarah Chittenden, Joey Misuraca, Marilyn J Hockenberry,

BACKGROUND:Transitional care from inpatient to outpatient settings is a high-risk time for medical errors and missed follow-up appointments. Discharge checklists and handoffs are effective tools that lead to improved quality of care and outcomes. OBJECTIVES:The purpose of this project was to implement an evidence-based discharge checklist and handoff template to ... Read more >>

Clin J Oncol Nurs (Clinical journal of oncology nursing)
[2019, 23(1):36-42]

Cited: 2 times

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Physical Activity, the Childhood Cancer Symptom Cluster-Leukemia, and Cognitive Function: A Longitudinal Mediation Analysis.

Mary C Hooke, Cheryl Rodgers, Olga Taylor, Kari M Koerner, Pauline Mitby, Ida Moore, Michael E Scheurer, Marilyn J Hockenberry, Wei Pan,

BACKGROUND:Children undergoing leukemia treatment report co-occurring symptoms of fatigue, sleep disturbances, pain, nausea, and depression as a symptom cluster. Physical activity (PA) is essential for development and may influence symptom severity. Children with leukemia are at risk of cognitive impairments from central nervous system therapies. Using a longitudinal parallel-process model, ... Read more >>

Cancer Nurs (Cancer nursing)
[2018, 41(6):434-440]

Cited: 8 times

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Disparities in Neurotoxicity Risk and Outcomes among Pediatric Acute Lymphoblastic Leukemia Patients.

Olga A Taylor, Austin L Brown, Julienne Brackett, ZoAnn E Dreyer, Ida Ki Moore, Pauline Mitby, Mary C Hooke, Marilyn J Hockenberry, Philip J Lupo, Michael E Scheurer,

<b>Purpose:</b> Methotrexate chemotherapy can be associated with neurologic complications during therapy and long-term neurologic deficits. This study evaluated demographic and clinical factors associated with incidence of methotrexate neurotoxicity and described the impact of neurotoxicity on acute lymphoblastic leukemia (ALL) therapy in pediatric patients.<b>Experimental Design:</b> Patients were enrolled between 2012 and ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2018, 24(20):5012-5017]

Cited: 3 times

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Peripheral neuropathy in children and adolescents treated for cancer.

Kari L Bjornard, Laura S Gilchrist, Hiroto Inaba, Barthelemy Diouf, Marilyn J Hockenberry, Nina S Kadan-Lottick, Daniel C Bowers, M Eileen Dolan, Nicole J Ullrich, William E Evans, Kirsten K Ness,

Peripheral neuropathy is a well recognised treatment-related toxicity in children with cancer, associated with exposure to neurotoxic chemotherapy agents. Acute damage can occur in sensory, motor, or autonomic neurons, with symptoms that are rarely life threatening, but often severe enough to interfere with function during therapy and after treatment ends. ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2018, 2(10):744-754]

Cited: 6 times

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Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment.

Marilyn J Hockenberry, Ida M Ki Moore, Michael E Scheurer, Mary C Hooke, Olga A Taylor, Kari M Koerner, Patricia M Gundy, Wei Pan,

The focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reductions. Compromise ... Read more >>

Biol Res Nurs (Biological research for nursing)
[2018, 20(4):403-409]

Cited: 2 times

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Changes in Oxidant Defense, Apoptosis, and Cognitive Abilities During Treatment for Childhood Leukemia.

Ida M Ki Moore, Kari M Koerner, Patricia M Gundy, David W Montgomery, Kathleen C Insel, Lynnette L Harris, Olga A Taylor, Marilyn J Hockenberry,

Aggressive central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia (ALL), the most prevalent cancer among children and adolescents, prevents metastasis of leukemia cells into the brain. Up to 60% of survivors experience cognitive problems, but knowledge about risk factors for and mechanisms of neurologic injury is lacking. Objectives of ... Read more >>

Biol Res Nurs (Biological research for nursing)
[2018, 20(4):393-402]

Cited: 3 times

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Declines Noted in Cognitive Processes and Association With Achievement Among Children With Leukemia.

Kathleen C Insel, Marilyn J Hockenberry, Lynette L Harris, Kari M Koerner, Zhenqiang Lu, Kristin B Adkins, Olga A Taylor, Patricia M Gundy, Ida M Moore,

<h4>Purpose/objectives</h4>To assess change in specific cognitive processes during treatment with chemotherapy only among children with acute lymphoblastic leukemia (ALL). 
.<h4>Design</h4>A prospective, repeated measures design.
.<h4>Setting</h4>Pediatric oncology treatment centers at Banner-University Medical Center Tucson/Banner Children's-Diamond Medical Center (University of Arizona) and Texas Children's Cancer and Hematology centers (Baylor College of Medicine) in ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2017, 44(4):503-511]

Cited: 1 time

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Symptom Trajectories in Children Receiving Treatment for Leukemia: A Latent Class Growth Analysis With Multitrajectory Modeling.

Marilyn J Hockenberry, Mary C Hooke, Cheryl Rodgers, Olga Taylor, Kari M Koerner, Pauline Mitby, Ida Moore, Michael E Scheurer, Wei Pan,

<h4>Context</h4>Cancer treatment symptoms play a major role in determining the health of children with cancer. Symptom toxicity often results in complications, treatment delays, and therapy dose reductions that can compromise leukemia therapy and jeopardize chances for long-term survival. Critical to understanding symptom experiences during treatment is the need for exploration ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2017, 54(1):1-8]

Cited: 17 times

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Neurocognitive Predictors of Academic Outcomes Among Childhood Leukemia Survivors.

Ida M Ki Moore, Philip J Lupo, Kathleen Insel, Lynnette L Harris, Alice Pasvogel, Kari M Koerner, Kristin B Adkins, Olga A Taylor, Marilyn J Hockenberry,

<h4>Background</h4>Acute lymphoblastic leukemia is the most common pediatric cancer, and survival approaches 90%. Acute lymphoblastic leukemia survivors are more likely than healthy peers or siblings to experience academic underachievement, yet little is known about neurocognitive predictors of academic outcomes.<h4>Objectives</h4>Objectives were to compare neurocognitive abilities to age-adjusted standardized norms, examine change ... Read more >>

Cancer Nurs (Cancer nursing)
[2016, 39(4):255-262]

Cited: 5 times

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Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment.

Cheryl Rodgers, Chelse Sanborn, Olga Taylor, Patricia Gundy, Alice Pasvogel, Ida M Ki Moore, Marilyn J Hockenberry,

Fatigue is a frequent and distressing symptom in children undergoing leukemia treatment; however, little is known about factors influencing this symptom. Antioxidants such as glutathione can decrease symptom severity in adult oncology patients, but no study has evaluated antioxidants' effects on symptoms in pediatric oncology patients. This study describes fatigue ... Read more >>

Biol Res Nurs (Biological research for nursing)
[2016, 18(5):515-520]

Cited: 10 times

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Health Professions Education Research and the Institutional Review Board.

Mitchell T Heflin, Stephen DeMeo, Alisa Nagler, Marilyn J Hockenberry,

The growth in health professions education (HPE) and a desire on the part of nurse and medical educators to disseminate their work have raised important questions about the ethical conduct of education research. At the center of the debate is the institutional review board (IRB) and its proper role in ... Read more >>

Nurse Educ (Nurse educator)
[2016, 41(2):55-59]

Cited: 0 times

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Oxidative Stress, Motor Abilities, and Behavioral Adjustment in Children Treated for Acute Lymphoblastic Leukemia.

Marilyn J Hockenberry, Kevin R Krull, Kathleen C Insel, Lynnette L Harris, Patricia M Gundy, Kristin B Adkins, Alice E Pasvogel, Olga A Taylor, Kari M Koerner, David W Montgomery, Adam K Ross, Adam Hill, Ida M Moore,

<h4>Purpose/objectives</h4>To examine associations among oxidative stress, fine and visual-motor abilities, and behavioral adjustment in children receiving chemotherapy for acute lymphoblastic leukemia (ALL)
.<h4>Design</h4>A prospective, repeated-measures design
.<h4>Setting</h4>Two pediatric oncology settings in the southwestern United States.<h4>Sample</h4>89 children with ALL were followed from diagnosis to the end of chemotherapy.<h4>Methods</h4>Serial cerebrospinal fluid samples were collected ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2015, 42(5):542-549]

Cited: 1 time

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Trajectories of Obesity and Overweight Rates Among Survivors of Childhood Acute Lymphoblastic Leukemia.

Megan R Winkler, Marilyn J Hockenberry, Kathy S McCarthy, Susan G Silva,

<h4>Purpose/objectives</h4>To describe the trajectories of obesity/overweight rates by age group among survivors of childhood acute lymphoblastic leukemia (ALL) from diagnosis through several years post-therapy.<h4>Design</h4>Longitudinal, descriptive.<h4>Setting</h4>Hematology/oncology clinic in the southwestern United States.<h4>Sample</h4>62 child and adolescent ALL survivors receiving treatment and follow-up care from 1999-2013.<h4>Methods</h4>Retrospective chart review of height, weight, and body ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2015, 42(4):E287-93]

Cited: 4 times

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Increase in oxidative stress as measured by cerebrospinal fluid lipid peroxidation during treatment for childhood acute lymphoblastic leukemia.

Ida M Ki Moore, Patricia Gundy, Alice Pasvogel, David W Montgomery, Olga A Taylor, Kari M Koerner, Kathy McCarthy, Marilyn J Hockenberry,

Five-year survival from childhood acute lymphoblastic leukemia (ALL) approaches 90%, but 40% of survivors experience central nervous system (CNS) treatment-related cognitive problems. Despite considerable evidence for cognitive problems, less is known about mechanisms of neurological injury. Our purpose was to investigate oxidative stress, measured by lipid peroxidation, as a mechanism ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2015, 37(2):e86-93]

Cited: 6 times

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Implementing a Daily Maintenance Care Bundle to Prevent Central Line-Associated Bloodstream Infections in Pediatric Oncology Patients.

Elizabeth A Duffy, Cheryl C Rodgers, Leah L Shever, Marilyn J Hockenberry,

Eliminating central line-associated bloodstream infection (CLABSI) is a national priority. Central venous catheter (CVC) care bundles are composed of a series of interventions that, when used together, are effective in preventing CLABSI. A CVC daily maintenance care bundle includes procedural guidelines for hygiene, dressing changes, and access as well as ... Read more >>

J Pediatr Oncol Nurs (Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses)
[2015, 32(6):394-400]

Cited: 12 times

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Evaluation of Biomarkers of Oxidative Stress and Apoptosis in Patients With Severe Methotrexate Neurotoxicity: A Case Series.

Olga A Taylor, Marilyn J Hockenberry, Kathy McCarthy, Patricia Gundy, David Montgomery, Adam Ross, Michael E Scheurer, Ida M Moore,

Central nervous system (CNS) treatment is an essential part of acute lymphocytic leukemia (ALL) therapy, and the most common CNS treatment is intrathecal (IT) and high-dose intravenous (IV) methotrexate (MTX). Treatment with MTX may cause neurotoxicity, which is often accompanied by neurologic changes, delays in treatment, and prolonged hospital stays. ... Read more >>

J Pediatr Oncol Nurs (Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses)
[2015, 32(5):320-325]

Cited: 7 times

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Fatigue and carnitine levels over multiple cycles of chemotherapy in children and adolescents.

Mary C Hooke, Kathleen McCarthy, Olga Taylor, Marilyn J Hockenberry,

<h4>Purpose</h4>Fatigue in childhood cancer is a pervasive and distressing symptom described as a "lack of energy". Carnitine is a micronutrient used to transport long chain fatty acids into muscle mitochondria. Some chemotherapy drugs interfere with the carnitine network. Both carnitine and fatigue relate to physical energy and may be influenced ... Read more >>

Eur J Oncol Nurs (European journal of oncology nursing : the official journal of European Oncology Nursing Society)
[2015, 19(1):7-12]

Cited: 3 times

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The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.

Marilyn J Hockenberry, Olga A Taylor, Alice Pasvogel, Cheryl Rodgers, Kathy McCarthy, Patricia Gundy, David W Montgomery, Phillip Ribbeck, Michael E Scheurer, Ida M Ki Moore,

<h4>Purpose/objectives</h4>To explore the symptom trajectory during the first 16 months of childhood leukemia treatment and any associations with the oxidative stress pathway measured by cerebrospinal fluid (CSF) concentration of oxidized phosphatidylcholine (PC), the predominant glycerophospholipid in the brain and cell membranes.<h4>Design</h4>Prospective, longitudinal design.<h4>Setting</h4>Two cancer centers in the southwestern United States.<h4>Sample</h4>36 ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2014, 41(4):E238-47]

Cited: 11 times

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