Full Text Journal Articles by
Author Marie Laure Plissonnier


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Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri,

OBJECTIVE:The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN:We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA ... Read more >>

Gut (Gut)
[2020, 69(11):2016-2024]

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Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.

Romain Barnault, Thomas Lahlali, Marie-Laure Plissonnier, Cristina Romero-López, Noémie Laverdure, Benjamin Ducarouge, Michel Rivoire, Patrick Mehlen, Fabien Zoulim, Romain Parent,

In the liver, HBV and HCV infections, exposure to toxics, genetic and metabolic disorders may induce endoplasmic reticulum (ER) stress and the unfolding protein response (UPR). The UPR allows cells to reach ER homeostasis after lumen overload, but also fosters survival of damaged cells and therefore HCC onset. Dependence receptors ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2018, 495(4):2425-2431]

Cited: 1 time

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Cell death and restoration of TRAIL-sensitivity by ciglitazone in resistant cervical cancer cells.

Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Christiane Mougin, Jean Rommelaere, Isabelle Lascombe,

Known activators of the Peroxisome Proliferator-Activated Receptor γ (PPARγ), thiazolidinediones (TZD) induce apoptosis in a variety of cancer cells through dependent and/or independent mechanisms of the receptor. We tested a panel of TZD (Rosiglitazone, Pioglitazone, Ciglitazone) to shed light on their potential therapeutic effects on three cervical cancer cell lines ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(64):107744-107762]

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[Hepatitis C, EGFR, cirrhosis and netrin-1: potential implications for HCC onset].

Marie-Laure Plissonnier, Thomas Lahlali, Patrick Mehlen, Romain Parent,

Med Sci (Paris) (Medecine sciences : M/S)
[2016, 32(6-7):566-568]

Cited: 0 times

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An immortalized human liver endothelial sinusoidal cell line for the study of the pathobiology of the liver endothelium.

Romain Parent, David Durantel, Thomas Lahlali, Aurélie Sallé, Marie-Laure Plissonnier, Daniel DaCosta, Gaëtan Lesca, Fabien Zoulim, Marie-Jeanne Marion, Birke Bartosch,

BACKGROUND: The endothelium lines blood and lymph vessels and protects underlying tissues against external agents such as viruses, bacteria and parasites. Yet, microbes and particularly viruses have developed sophisticated ways to bypass the endothelium in order to gain access to inner organs. De novo infection of the liver parenchyma by ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2014, 450(1):7-12]

Cited: 12 times

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Diversity of hepatocellular carcinoma clones bearing hematopoietic malignancies-related chromosomal translocation.

Romain Parent, Marie-Laure Plissonnier, Brigitte Bancel, Wan-Li Liao, Sylvie Rumin, Remal Asaad, Marianne Till, Damien Sanlaville, Fabien Zoulim, Christian Trépo, Marie-Jeanne Marion,

Interpatient heterogeneity of hepatocellular carcinoma has been in-depth addressed. Intrapatient heterogeneity is less known. Four clones were freshly isolated from an Edmondson grade I HCV-associated hepatocellular carcinoma. Biochemical approaches, functional assays and cytogenetics were used. Albumin inducibility was uncoupled from canonical cytokeratin profiles, suggesting pathological combinations of hepatospecific and biliary ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2014, 115(4):666-677]

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The antidiabetic drug ciglitazone induces high grade bladder cancer cells apoptosis through the up-regulation of TRAIL.

Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe,

Ciglitazone belongs to the thiazolidinediones class of antidiabetic drug family and is a high-affinity ligand for the Peroxisome Proliferator-Activated Receptor γ (PPARγ). Apart from its antidiabetic activity, this molecule shows antineoplastic effectiveness in numerous cancer cell lines.Using RT4 (derived from a well differentiated grade I papillary tumor) and T24 (derived ... Read more >>

PLoS ONE (PloS one)
[2011, 6(12):e28354]

Cited: 16 times

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Insights on distinct pathways of thiazolidinediones (PPARgamma ligand)-promoted apoptosis in TRAIL-sensitive or -resistant malignant urothelial cells.

Marie Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe,

Thiazolidinediones, including rosiglitazone and troglitazone, are insulin-sensitizing drugs and high-affinity ligands for the peroxisome proliferator-activated receptor gamma (PPARgamma). Apart from their antidiabetic activity, these molecules possess antitumor properties. We investigated their potential apoptotic effects on RT4 (derived from a well-differentiated Grade I papillary tumor) and T24 (derived from an undifferentiated ... Read more >>

Int. J. Cancer (International journal of cancer)
[2010, 127(8):1769-1784]

Cited: 12 times

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Sodium butyrate with UCN-01 has marked antitumour activity against cervical cancer cells.

Anne-Zélie Decrion-Barthod, Matthieu Bosset, Marie-Laure Plissonnier, Antonio Marchini, Magalie Nicolier, Sophie Launay, Jean-Luc Prétet, Jean Rommelaere, Christiane Mougin,

AIM: The effect of combining sodium butyrate (NaB), a histone deacetylase inhibitor, and 7-hydroxy-staurosporine (UCN-01) on cytotoxicity in human cervical carcinoma cells was evaluated. MATERIALS AND METHODS: HeLa and CaSki cells were treated using NaB alone or in combination with staurosporine (STS) or its analog UCN-01. Cytotoxicity was determined by ... Read more >>

Anticancer Res. (Anticancer research)
[2010, 30(10):4049-4061]

Cited: 4 times

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A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells.

Guillaume Boiteux, Isabelle Lascombe, Emmanuelle Roche, Marie-Laure Plissonnier, Anne Clairotte, Hugues Bittard, Sylvie Fauconnet,

Superficial pT1 bladder tumors are characterized by a high risk of recurrence and progression in grade and stage. Few studies provided evidence that loss of adipocyte-fatty acid binding protein (A-FABP) expression was associated with bladder cancer progression. A-FABP is a lipid binding protein playing a role in intracellular lipid transport ... Read more >>

Int. J. Cancer (International journal of cancer)
[2009, 124(8):1820-1828]

Cited: 36 times

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The human papillomavirus type 18 E6 oncoprotein induces Vascular Endothelial Growth Factor 121 (VEGF121) transcription from the promoter through a p53-independent mechanism.

Nicolas Clere, Laurent Bermont, Sylvie Fauconnet, Isabelle Lascombe, Maëlle Saunier, Lucie Vettoretti, Marie-Laure Plissonnier, Christiane Mougin,

Altered angiogenic response is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular Endothelial Growth Factor (VEGF) is one of the most potent inducers of angiogenesis and is up-regulated in carcinoma of the cervix. Infection by high-risk human papillomavirus and persistent expression of viral oncogene ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2007, 313(15):3239-3250]

Cited: 17 times

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Exploration and Swiss field-testing of a viral gene for specific quantitative resistance against smuts and bunts in wheat.

Thomas Schlaich, Bartosz Urbaniak, Marie-Laure Plissonnier, Nicole Malgras, Christof Sautter,

The viral gene for the killer protein 4 (KP4) has been explored for its antifungal effect in genetically modified wheat to defeat specifically the seed-transmitted smut and bunt diseases. In vitro both important seed-transmitted diseases of wheat, loose smut (Ustilago tritici) and stinking smut (Tilletia caries), are susceptible to KP4, ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2007, 107:97-112]

Cited: 2 times

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