Full Text Journal Articles by
Author Marie Jeanne Marion

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Diversity of hepatocellular carcinoma clones bearing hematopoietic malignancies-related chromosomal translocation.

Romain Parent, Marie-Laure Plissonnier, Brigitte Bancel, Wan-Li Liao, Sylvie Rumin, Remal Asaad, Marianne Till, Damien Sanlaville, Fabien Zoulim, Christian Trépo, Marie-Jeanne Marion,

Interpatient heterogeneity of hepatocellular carcinoma has been in-depth addressed. Intrapatient heterogeneity is less known. Four clones were freshly isolated from an Edmondson grade I HCV-associated hepatocellular carcinoma. Biochemical approaches, functional assays and cytogenetics were used. Albumin inducibility was uncoupled from canonical cytokeratin profiles, suggesting pathological combinations of hepatospecific and biliary ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2014, 115(4):666-677]

Cited: 0 times

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An immortalized human liver endothelial sinusoidal cell line for the study of the pathobiology of the liver endothelium.

Romain Parent, David Durantel, Thomas Lahlali, Aurélie Sallé, Marie-Laure Plissonnier, Daniel DaCosta, Gaëtan Lesca, Fabien Zoulim, Marie-Jeanne Marion, Birke Bartosch,

BACKGROUND: The endothelium lines blood and lymph vessels and protects underlying tissues against external agents such as viruses, bacteria and parasites. Yet, microbes and particularly viruses have developed sophisticated ways to bypass the endothelium in order to gain access to inner organs. De novo infection of the liver parenchyma by ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2014, 450(1):7-12]

Cited: 12 times

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Plastics and carcinogenesis: The example of vinyl chloride.

Paul Wesley Brandt-Rauf, Yongliang Li, Changmin Long, Regina Monaco, Gopala Kovvali, Marie-Jeanne Marion,

The manufacture, use and disposal of various plastics can pose numerous health risks, including the risk of cancer. A model example of carcinogenic risk from plastics is provided by polyvinyl chloride, since it is composed of the known human carcinogen vinyl chloride (VC). In recent years, much has been learned ... Read more >>

J Carcinog (Journal of carcinogenesis)
[2012, 11:5]

Cited: 5 times

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Effect of the XRCC1 codon 399 polymorphism on the repair of vinyl chloride metabolite-induced DNA damage.

Yongliang Li, Changmin Long, George Lin, Marie-Jeanne Marion, Greg Freyer, Regina M Santella, Paul W Brandt-Rauf,

Recent epidemiologic evidence suggests that the common polymorphism at amino acid residue 399 of the x-ray cross complementing-1 (XRCC1) protein, a key component of the base excision repair (BER) pathway for DNA damage, plays a significant role in the genetic variability of individuals in terms of the mutagenic damage they ... Read more >>

J Carcinog (Journal of carcinogenesis)
[2009, 8:14]

Cited: 5 times

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Gene-environment interactions between DNA repair polymorphisms and exposure to the carcinogen vinyl chloride.

Yongliang Li, Marie-Jeanne Marion, Jennifer Zipprich, Regina M Santella, Greg Freyer, Paul W Brandt-Rauf,

We have recently suggested that polymorphisms in metabolism and repair pathways may play a role in modulating the effects of exposure to the carcinogen vinyl chloride in the production of biomarkers of its mutagenic damage. The aim of the present study was to extend these observations by examining gene-environment interactions ... Read more >>

Biomarkers (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals)
[2009, 14(3):148-155]

Cited: 9 times

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The role of XRCC1 polymorphisms in base excision repair of etheno-DNA adducts in French vinyl chloride workers.

Yongliang Li, Marie-Jeanne Marion, Jennifer Zipprich, Greg Freyer, Regina M Santella, Chisaka Kanki, Paul W Brandt-Rauf,

OBJECTIVES:The purpose of this study was to examine whether polymorphisms in the XRCC1 DNA-repair protein can affect the base excision repair capacity to remove etheno-DNA adducts induced by vinyl chloride exposure that account for the occurrence of mutant biomarkers of effect seen in exposed workers. MATERIALS AND METHODS:Using polymerase chain ... Read more >>

Int J Occup Med Environ Health (International journal of occupational medicine and environmental health)
[2006, 19(1):45-52]

Cited: 11 times

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Distribution of ENG and ACVRL1 (ALK1) mutations in French HHT patients.

Gaëtan Lesca, Nelly Burnichon, Grégory Raux, Mario Tosi, Stéphane Pinson, Marie-Jeanne Marion, Emmanuel Babin, Brigitte Gilbert-Dussardier, Sophie Rivière, Cyril Goizet, Laurence Faivre, Henri Plauchu, Thierry Frébourg, Alain Calender, Sophie Giraud, ,

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disease characterized by arteriovenous malformations and resulting from mutations in two major genes: ENG and ACVRL1. The aim of the present study was to estimate the prevalence of the mutations of ENG and ACVRL1 in HHT, based on the largest series of ... Read more >>

Hum. Mutat. (Human mutation)
[2006, 27(6):598]

Cited: 38 times

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The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk.

Jennifer Schindler, Yongliang Li, Marie-Jeanne Marion, Arianne Paroly, Paul W Brandt-Rauf,

Vinyl chloride (VC) is a human carcinogen known to undergo metabolism by cytochrome P450 2E1 (CYP2E1) to reactive intermediates that can cause oncogene and tumor suppressor gene mutations and that are further metabolized by acetaldehyde dehydrogenase (ALDH2) and glutathione-S-transferases (GSTs) to non-mutagenic end products. These metabolic enzymes have known polymorphisms ... Read more >>

J. Hum. Genet. (Journal of human genetics)
[2007, 52(5):448-455]

Cited: 13 times

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Glutathione S-transferase M1 and GST T1 genetic polymorphisms and Raynaud's phenomenon in French vinyl chloride monomer-exposed workers.

Luc Fontana, Marie-Jeanne Marion, Sylvie Ughetto, Pierre Catilina,

Occupational vinyl chloride monomer (VCM) exposure can induce Raynaud's phenomenon (RP). However, not all VCM workers developed RP, which suggests an underlying genetic susceptibility. Genetic polymorphisms of glutathione S-transferases (GSTs), involved in VCM metabolism, have been shown to influence certain VCM-related health effects. We have conducted a case-control study of ... Read more >>

J. Hum. Genet. (Journal of human genetics)
[2006, 51(10):879-886]

Cited: 8 times

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Liver involvement in hereditary hemorrhagic telangiectasia: consensus recommendations.

Elisabetta Buscarini, Henry Plauchu, Guadalupe Garcia Tsao, Robert I White, Carlo Sabbà, Franklin Miller, Jean Cristophe Saurin, Jean Pierre Pelage, Gaetan Lesca, Marie Jeanne Marion, Annalisa Perna, Marie E Faughnan,

STUDY PURPOSE: To formulate recommendations about clinical management of liver involvement in hereditary hemorrhagic telangiectasia (HHT), using a formal consensus development process. CONSENSUS PROCESS: A nominal group technique was used. A list of main clinical, diagnostic and therapeutic issues about liver involvement in HHT was generated by the organizing committee. ... Read more >>

Liver Int. (Liver international : official journal of the International Association for the Study of the Liver)
[2006, 26(9):1040-1046]

Cited: 75 times

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Polymorphisms of microsomal epoxide hydrolase in French vinyl chloride workers.

Yongliang Li, Stephen Lee, Marie-Jeanne Marion, Paul W Brandt-Rauf,

OBJECTIVES: The purpose of this study was to determine if polymorphisms in microsomal epoxide hydrolase, an enzyme involved in the metabolism of reactive intermediates of vinyl chloride (VC), contribute to the variable susceptibility to the mutagenic effects of vinyl chloride among exposed workers. MATERIALS AND METHODS: Polymorphisms at codons 113 ... Read more >>

Int J Occup Med Environ Health (International journal of occupational medicine and environmental health)
[2005, 18(2):133-138]

Cited: 1 time

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Origin and characterization of a human bipotent liver progenitor cell line.

Romain Parent, Marie-Jeanne Marion, Laetitia Furio, Christian Trépo, Marie-Anne Petit,

BACKGROUND & AIMS:Liver progenitor cells may be important in carcinogenesis resulting from human chronic liver diseases. The HepaRG cell line has been established from a liver tumor associated with chronic hepatitis C. We observed that these cells showed an evident morphological heterogeneity, displaying both hepatocyte-like and biliary-like epithelial phenotypes. Our ... Read more >>

Gastroenterology (Gastroenterology)
[2004, 126(4):1147-1156]

Cited: 104 times

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A common polymorphism in XRCC1 as a biomarker of susceptibility for chemically induced genetic damage.

Yongliang Li, Marie-Jeanne Marion, Andrew Rundle, Paul W Brandt-Rauf,

We have recently demonstrated a significant dose-response relationship between vinyl chloride exposure and mutant p53 biomarkers in humans. The aim of this study was to examine a common polymorphism in the DNA repair gene XRCC1 as a potential biomarker of susceptibility modifying this relationship, consistent with the known mechanism of ... Read more >>

Biomarkers (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals)
[2003, 8(5):408-414]

Cited: 14 times

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