Full Text Journal Articles by
Author Marie Agnes Dragon Durey

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Quality and best practice in medical laboratories: specific requests for autoimmunity testing.

Ulrich Sack, Xavier Bossuyt, Hristina Andreeva, Péter Antal-Szalmás, Nicola Bizzaro, Dimitrios Bogdanos, Elena Borzova, Karsten Conrad, Marie-Agnes Dragon-Durey, Catharina Eriksson, Katarzyna Fischer, Anna-Maija Haapala, Ingmar Heijnen, Manfred Herold, Werner Klotz, Ana Kozmar, Andrea Tesija Kuna, Marcos López Hoyos, Vladimir A Malkov, Lucile Musset, Eszter Nagy, Johan Rönnelid, Yehuda Shoenfeld, Tatjana Sundic, Alexandra Tsirogianni, Raivo Uibo, Maria José Rego Sousa, Jan Damoiseaux, ,

Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical device regulation (IVD-R). In addition, international recommendations, guidelines and disease criteria are poorly defined with respect to requirements on autoantibody testing. Laboratory specialists ... Read more >>

Auto Immun Highlights (Auto- immunity highlights)
[2020, 11(1):12]

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Precision of autoantibody assays in clinical diagnostic laboratories: What is the reality?

Marie Senant, Lucile Musset, Georges Chyderiotis, Laurence Guis-Cabanne, Jan Damoiseaux, Nicole Fabien, Marie-Agnès Dragon-Durey,

BACKGROUND:ISO 15189 accreditation remains a challenge for specialized laboratories. In the field of autoimmunity, beside the crucial problem of absence of standardization, laboratories have to manage the analytical performances of the large panel of assays in terms of sensitivity and specificity, but also on their measurement precision for which no ... Read more >>

Clin. Biochem. (Clinical biochemistry)
[2020, 83:57-64]

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Interstitial Lung Disease-Complicated Anti-MDA5 Antibody in Clinically Amyopathic Dermatomyositis Patients: Report of Two Cases With Distinct Clinical Features.

Laurence Pacot, Jacques Pouchot, Nicolas De Prost, Marie Senant, Eric Tartour, Françoise Le Pimpec-Barthes, Dominique Israel-Biet, Marie-Agnes Dragon-Durey,

Two patients presented simultaneously to our hospital with distinct clinical features associated with the presence of anti-MDA5 antibodies: the first one was admitted for a skin rash resembling to a toxic epidermal necrosis (Lyell syndrome) and the second one presented with pulmonary manifestations attributed to a diffuse fibrosing interstitial pneumonitis ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:77]

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A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors.

Luis Teixeira, Jacques Medioni, Julie Garibal, Olivier Adotevi, Ludovic Doucet, Marie-Agnès Dragon Durey, Zineb Ghrieb, Jean-Jacques Kiladjian, Mara Brizard, Caroline Laheurte, Maria Wehbe, Elodie Pliquet, Marie Escande, Rémy Defrance, Stephane Culine, Stephane Oudard, Simon Wain-Hobson, Valérie Doppler, Thierry Huet, Pierre Langlade-Demoyen,

PURPOSE:Human telomerase reverse transcriptase (hTERT) is highly expressed in >85% of human tumors and is thus considered as a good tumor-associated antigen candidate for vaccine development. We conducted a phase I study to investigate the safety, tolerability, clinical response, and immunogenicity of INVAC-1, a DNA plasmid encoding a modified hTERT ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(3):588-597]

Cited: 3 times

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Hemolytic uremic syndrome in a developing country: Consensus guidelines.

Arvind Bagga, Priyanka Khandelwal, Kirtisudha Mishra, Ranjeet Thergaonkar, Anil Vasudevan, Jyoti Sharma, Saroj Kumar Patnaik, Aditi Sinha, Sidharth Sethi, Pankaj Hari, Marie-Agnes Dragon-Durey, ,

BACKGROUND:Hemolytic uremic syndrome (HUS) is a leading cause of acute kidney injury in children. Although international guidelines emphasize comprehensive evaluation and treatment with eculizumab, access to diagnostic and therapeutic facilities is limited in most developing countries. The burden of Shiga toxin-associated HUS in India is unclear; school-going children show high ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(8):1465-1482]

Cited: 2 times

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Autoantibodies Against C3b-Functional Consequences and Disease Relevance.

Vasil V Vasilev, Maria Radanova, Valentin J Lazarov, Marie-Agnes Dragon-Durey, Veronique Fremeaux-Bacchi, Lubka T Roumenina,

The complement component C3 is at the heart of the complement cascade. It is a complex protein, which generates different functional activated fragments (C3a, C3b, iC3b, C3c, C3d). C3b is a constituent of the alternative pathway C3 convertase (C3bBb), binds multiple regulators, and receptors, affecting thus the functioning of the ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:64]

Cited: 2 times

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Detection of Autoantibodies to Complement Components by Surface Plasmon Resonance-Based Technology.

Remi Noe, Sophie Chauvet, Shambhuprasad K Togarsimalemath, Maria Chiara Marinozzi, Maria Radanova, Vasil V Vasilev, Veronique Fremeaux-Bacchi, Marie-Agnes Dragon-Durey, Lubka T Roumenina,

The innate immune complement system is a powerful defense cascade against pathogens, but can induce host tissue damage when overactivated. In pathological conditions, mainly but not restricted to renal diseases, such as lupus nephritis, atypical hemolytic uremic syndrome, and C3 glomerulopathies, complement is overactivated or dysregulated by autoantibodies directed against ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2019, 1901:271-280]

Cited: 1 time

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Anti-factor H Autoantibodies Assay by ELISA.

Marie Sénant, Marie-Agnes Dragon-Durey,

The complement system is a part of the immune system implicated in host defense against pathogens and damaged cells and Factor H is the main regulatory protein of this powerful enzymatic cascade. Autoantibodies directed against Factor H (anti-FH antibodies) are implicated in different pathologies mainly atypical hemolytic and uremic syndrome ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2019, 1901:191-196]

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Prevalence and Significance of Non-conventional Antiphospholipid Antibodies in Patients With Clinical APS Criteria.

Elena Litvinova, Luc Darnige, Amos Kirilovsky, Yann Burnel, Gonzalo de Luna, Marie-Agnes Dragon-Durey,

Background: The biological diagnostics of antiphospholipid syndrome (APS) takes into account the persistent positivity for anticardiolipin and/or anti-β2GP1 antibodies and/or presence of lupus anticoagulant (LA). However, some non-conventional antiphospholipid antibodies have emerged that could help in the diagnosis of APS. Objectives: To study the potential usefulness of non-conventional antiphospholipid antibodies ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:2971]

Cited: 2 times

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Analytical validation of an alternative method to quantify specific antibodies in 3 applications.

Marie Senant, Pauline Bordereau, Eric Tartour, Marie-Agnès Dragon-Durey,

The detection and the quantification of specific antibodies represent essential tools for the diagnosis and for the biological monitoring of immune humoral response in many clinical situations in particular in autoimmune diseases or in the context of immunotherapy using monoclonal antibodies. This article focuses on the development of a specific ... Read more >>

J. Immunol. Methods (Journal of immunological methods)
[2019, 464:40-46]

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Both Monoclonal and Polyclonal Immunoglobulin Contingents Mediate Complement Activation in Monoclonal Gammopathy Associated-C3 Glomerulopathy.

Sophie Chauvet, Lubka T Roumenina, Pierre Aucouturier, Maria-Chiara Marinozzi, Marie-Agnès Dragon-Durey, Alexandre Karras, Yahsou Delmas, Moglie Le Quintrec, Dominique Guerrot, Noémie Jourde-Chiche, David Ribes, Pierre Ronco, Frank Bridoux, Véronique Fremeaux-Bacchi,

C3 glomerulopathy (C3G) results from acquired or genetic abnormalities in the complement alternative pathway (AP). C3G with monoclonal immunoglobulin (MIg-C3G) was recently included in the spectrum of "monoclonal gammopathy of renal significance." However, mechanisms of complement dysregulation in MIg-C3G are not described and the pathogenic effect of the monoclonal immunoglobulin ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:2260]

Cited: 3 times

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Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome.

Shambhuprasad K Togarsimalemath, Ali Si-Mohammed, Mamta Puraswani, Aarti Gupta, Astrid Vabret, Sandrine Liguori, Patricia Mariani-Kurkdjian, Arvind Bagga, Marie-Agnes Dragon-Durey,

BACKGROUND:Prodromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS. METHODS:The presence of 15 gastrointestinal (GI) ... Read more >>

Pediatr. Res. (Pediatric research)
[2018, 84(1):118-124]

Cited: 3 times

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Routinely used immunoassays do not detect circulating anti-GBM antibodies against native NC1 hexamer and EA epitope of the α3 chain of type IV collagen.

Giovanna Clavarino, Arnaud Gauthier, Thomas Hellmark, Pierre-Louis Carron, Diane Giovannini, Sophie Colliard, Marie-Agnès Dragon-Durey, Mårten Segelmark, Jean-Yves Cesbron, Chantal Dumestre-Pérard,

Detection of circulating anti-GBM antibodies has a key role for the diagnosis of Goodpasture syndrome but immunoassays using purified or recombinant alpha3(IV)NC1 as antigen do not recognize all anti-GBM antibodies. We show that anti-GBM antibodies directed against epitopes in their native conformation or cryptic epitopes are detected by indirect immunofluorescence. ... Read more >>

Eur. J. Immunol. (European journal of immunology)
[2018, 48(6):1082-1084]

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Eculizumab reversed severe distal ischemic syndrome and glomerulonephritis with isolated C3 deposits associated with anti-factor H autoantibodies: a case report.

Samuel Deshayes, Nicolas Martin Silva, Valérie Chatelet, Sylvain Chantepie, Moglie Le Quintrec, François Comoz, Frank Bridoux, Marie-Agnès Dragon-Durey, Achille Aouba,

B-cell clones can produce a monoclonal immunoglobulin, which may be responsible for visceral involvements. Kidney involvement is frequent, affecting 20 to 50% of patients with multiple myeloma. One mechanism underlying this involvement is a dysregulation of the complement alternative pathway, leading to C3 glomerulopathies. We report a patient who had ... Read more >>

Clin. Rheumatol. (Clinical rheumatology)
[2018, 37(4):1119-1122]

Cited: 0 times

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Testing anti-neutrophil cytoplasmic antibodies (ANCA): analysis of the European EASI survey on the daily practice of the French laboratories.

Marie-Agnès Dragon-Durey, Nicole Fabien, Georges Chyderiotis, Lucile Musset, Bach-Nga Pham, Niels Olsson,

Anti-neutrophil cytoplasmic antibodies (ANCA) are mainly searched for the diagnosis of autoimmune vasculitis. They may be found also in other conditions with chronic inflammation. Testing ANCA is based on two main technics: indirect immunofluorescence (IFI) and immunochemical technics to identify the antigenic specificity of the autoantibodies. There is heterogeneity among ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2017, 75(5):531-541]

Cited: 2 times

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C5 nephritic factors drive the biological phenotype of C3 glomerulopathies.

Maria-Chiara Marinozzi, Sophie Chauvet, Moglie Le Quintrec, Morgane Mignotet, Florent Petitprez, Christophe Legendre, Mathilde Cailliez, Georges Deschenes, Michel Fischbach, Alexandre Karras, Francois Nobili, Christine Pietrement, Marie-Agnes Dragon-Durey, Fadi Fakhouri, Lubka T Roumenina, Veronique Fremeaux-Bacchi,

C3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis, are associated with genetic and acquired dysregulation of the C3 convertase alternative pathway of complement. The potential role of the activation of the C5 convertase has not been studied extensively. Here we analyzed IgG samples from patients with C3 Glomerulopathies ... Read more >>

Kidney Int. (Kidney international)
[2017, 92(5):1232-1241]

Cited: 19 times

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A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

Shambhuprasad K Togarsimalemath, Sidharth K Sethi, Rajan Duggal, Moglie Le Quintrec, Pranaw Jha, Régis Daniel, Florence Gonnet, Shyam Bansal, Lubka T Roumenina, Veronique Fremeaux-Bacchi, Vijay Kher, Marie-Agnes Dragon-Durey,

The intrinsic similarity shared between the members of the complement factor H family, which comprises complement factor H and five complement factor H-related (CFHR) genes, leads to various recombination events. In turn these events lead to deletions of some genes or abnormal proteins, which are found in patients with atypical ... Read more >>

Kidney Int. (Kidney international)
[2017, 92(4):876-887]

Cited: 11 times

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Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.

Timothy H J Goodship, H Terence Cook, Fadi Fakhouri, Fernando C Fervenza, Véronique Frémeaux-Bacchi, David Kavanagh, Carla M Nester, Marina Noris, Matthew C Pickering, Santiago Rodríguez de Córdoba, Lubka T Roumenina, Sanjeev Sethi, Richard J H Smith, ,

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global ... Read more >>

Kidney Int. (Kidney international)
[2017, 91(3):539-551]

Cited: 90 times

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Auto-immunité et gestion des toxicités des traitements par anti-check point inhibiteurs.

Marie Senant, Delphine Giusti, Laurence Weiss, Marie-Agnès Dragon-Durey,

AUTOIMMUNITY AND MANAGEMENT OF THE IMMUNE-RELATED ADVERSE EFFECTS OF THE IMMUNE CHECKPOINT INHIBITORS: The immune checkpoint molecules such as CTLA-4 and PD-1 are involved in the tolerance mechanisms preventing the immune system to react against the self-antigens. When these receptors expressed on the lymphocyte membrane, bind to their ligands, they ... Read more >>

Bull Cancer (Bulletin du cancer)
[2016, 103 Suppl 1:S175-S185]

Cited: 0 times

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Anti-complement-factor H-associated glomerulopathies.

Marie-Agnes Dragon Durey, Aditi Sinha, Shambhuprasad Kotresh Togarsimalemath, Arvind Bagga,

Atypical haemolytic uraemic syndrome (aHUS), an important cause of acute kidney injury, is characterized by dysregulation of the complement pathway, frequent need for dialysis, and progression to end-stage renal disease. Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement system, account ... Read more >>

Nat Rev Nephrol (Nature reviews. Nephrology)
[2016, 12(9):563-578]

Cited: 23 times

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Application of Deamidated Gliadin Antibodies in the Follow-Up of Treated Celiac Disease.

Luc de Chaisemartin, Tchao Meatchi, Georgia Malamut, Fahima Fernani-Oukil, Frédérique Hosking, Dorothée Rault, Fabienne Bellery, Christophe Cellier, Marie-Agnès Dragon-Durey,

The role of serological tests such as IgA anti-transglutaminase autoantibodies has become increasingly important in celiac disease (CD) diagnosis. However, the efficiency of these tests for patient follow-up is controversial. We investigated the correlation of 12 different serological tests, including recent deamidated gliadin and actin IgA tests, with villous atrophy ... Read more >>

PLoS ONE (PloS one)
[2015, 10(8):e0136745]

Cited: 8 times

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Functional Characterization of Autoantibodies against Complement Component C3 in Patients with Lupus Nephritis.

Vasil V Vasilev, Remi Noe, Marie-Agnes Dragon-Durey, Sophie Chauvet, Valentin J Lazarov, Boriana P Deliyska, Veronique Fremeaux-Bacchi, Jordan D Dimitrov, Lubka T Roumenina,

Lupus nephritis (LN) is a complication of the autoimmune disease systemic lupus erythematosus. Because the complement system plays a critical role in orchestrating inflammatory and immune responses as well as in the clearance of immune complexes, autoreactivity to complement components may have considerable pathological consequences. Autoantibodies against the central complement ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2015, 290(42):25343-25355]

Cited: 11 times

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Anti-factor H autoantibodies in C3 glomerulopathies and in atypical hemolytic uremic syndrome: one target, two diseases.

Caroline Blanc, Shambhuprasad Kotresh Togarsimalemath, Sophie Chauvet, Moglie Le Quintrec, Bruno Moulin, Matthias Buchler, T Sakari Jokiranta, Lubka T Roumenina, Véronique Fremeaux-Bacchi, Marie-Agnès Dragon-Durey,

Autoantibodies targeting factor H (FH), which is a main alternative complement pathway regulatory protein, have been well characterized in atypical hemolytic uremic syndrome (aHUS) but have been less well described in association with alternative pathway-mediated glomerulopathies (GP). In this study, we studied 17 patients presenting with GP who were positive ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2015, 194(11):5129-5138]

Cited: 33 times

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A case of C3 glomerulonephritis successfully treated with eculizumab.

Alexis Payette, Natalie Patey, Marie-Agnès Dragon-Durey, Véronique Frémeaux-Bacchi, Françoise Le Deist, Anne-Laure Lapeyraque,

C3 glomerulonephritis (C3GN) is a rare form of glomerulopathy that is characterized by predominant C3 deposits. Eculizumab, a humanized monoclonal C5 antibody, has recently emerged as a treatment option for C3GN. We report a C3GN patient successfully treated with eculizumab.A 5-year-old boy who presented with proteinuria, hematuria, high ASO titers, ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2015, 30(6):1033-1037]

Cited: 16 times

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Atypical aHUS: State of the art.

Carla M Nester, Thomas Barbour, Santiago Rodriquez de Cordoba, Marie Agnes Dragon-Durey, Veronique Fremeaux-Bacchi, Tim H J Goodship, David Kavanagh, Marina Noris, Matthew Pickering, Pilar Sanchez-Corral, Christine Skerka, Peter Zipfel, Richard J H Smith,

Tremendous advances in our understanding of the thrombotic microangiopathies (TMAs) have revealed distinct disease mechanisms within this heterogeneous group of diseases. As a direct result of this knowledge, both children and adults with complement-mediated TMA now enjoy higher expectations for long-term health. In this update on atypical hemolytic uremic syndrome, ... Read more >>

Mol. Immunol. (Molecular immunology)
[2015, 67(1):31-42]

Cited: 85 times

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