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Author Maribel Casas

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Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project.

Karine Audouze, Denis Sarigiannis, Paloma Alonso-Magdalena, Celine Brochot, Maribel Casas, Martine Vrijheid, Patrick J Babin, Spyros Karakitsios, Xavier Coumoul, Robert Barouki,

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union (EU) to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(8):]

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Time Trends and Sociodemographic Factors Associated With Overweight and Obesity in Children and Adolescents in Spain.

Jeroen de Bont, Yesika Díaz, Maribel Casas, Maria García-Gil, Martine Vrijheid, Talita Duarte-Salles,

Importance:Time-trend studies of overweight and obesity in childhood by sociodemographic factors are important for prioritizing public health initiatives. However, little is known about these trends in Spain, where high levels of obesity are found and where important demographic changes have occurred during the last 2 decades. Objective:To examine how time ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201171]

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Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children.

Nikos Stratakis, David V Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F Farzan, Serena Fossati, Juan R Gonzalez, Regina Grazuleviciene, Barbara Heude, Lea Maitre, Rosemary R C McEachan, Ioannis Theologidis, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Rob McConnell, Anne-Lise Brantsaeter, Helle-Margrete Meltzer, Martine Vrijheid, Leda Chatzi,

Importance:The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. Objective:To assess the associations of fish intake and mercury exposure during pregnancy with metabolic syndrome in children and alterations in biomarkers of inflammation in children. Design, Setting, ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201007]

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Early life tobacco exposure and children's telomere length: The HELIX project.

Citlalli Osorio-Yáñez, Diana B P Clemente, Lea Maitre, Martha Vives-Usano, Mariona Bustamante, David Martinez, Maribel Casas, Jan Alexander, Cathrine Thomsen, Leda Chatzi, Kristine B Gützkow, Regina Grazuleviciene, Dries S Martens, Michelle Plusquin, Remy Slama, Rosemary C McEachan, John Wright, Tiffany C Yang, Jose Urquiza, Ibon Tamayo, Jordi Sunyer, Marina Vafeiadi, Tim S Nawrot, Martine Vrijheid,

Telomere length and mitochondrial DNA content are considered biomarkers of cellular aging, oxidative stress, and inflammation, but there is almost no information on their association with tobacco smoke exposure in fetal and early life. The aim of this study was to assess whether prenatal and childhood tobacco exposure were associated ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 711:135028]

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Air pollution exposure and interstitial lung diseases: have we identified all the harmful environmental exposures?

Maribel Casas,

Thorax (Thorax)
[2019, 74(11):1013-1014]

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Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries.

Eleni Papadopoulou, Line Småstuen Haug, Amrit Kaur Sakhi, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Sílvia Fernández-Barrés, Regina Grazuleviciene, Helle Katrine Knutsen, Lea Maitre, Helle Margrete Meltzer, Rosemary R C McEachan, Theano Roumeliotaki, Remy Slama, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen, Leda Chatzi,

BACKGROUND:Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. OBJECTIVES:Our objective was to study the association between diet and measured blood and urinary levels of environmental contaminants in mother-child pairs from six European birth ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2019, 127(10):107005]

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Early-Life Environmental Exposures and Blood Pressure in Children.

Charline Warembourg, Léa Maitre, Ibon Tamayo-Uria, Serena Fossati, Theano Roumeliotaki, Gunn Marit Aasvang, Sandra Andrusaityte, Maribel Casas, Enrique Cequier, Lida Chatzi, Audrius Dedele, Juan-Ramon Gonzalez, Regina Gražulevičienė, Line Smastuen Haug, Carles Hernandez-Ferrer, Barbara Heude, Marianna Karachaliou, Norun Hjertager Krog, Rosemary McEachan, Mark Nieuwenhuijsen, Inga Petraviciene, Joane Quentin, Oliver Robinson, Amrit Kaur Sakhi, Rémy Slama, Cathrine Thomsen, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Martine Vrijheid, Xavier Basagaña,

BACKGROUND:Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. OBJECTIVES:This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(10):1317-1328]

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Prenatal exposure to organochlorine compounds and lung function during childhood.

Alicia Abellan, Jordi Sunyer, Raquel Garcia-Esteban, Mikel Basterrechea, Talita Duarte-Salles, Amparo Ferrero, Judith Garcia-Aymerich, Mireia Gascon, Joan O Grimalt, Maria-Jose Lopez-Espinosa, Carlos Zabaleta, Martine Vrijheid, Maribel Casas,

INTRODUCTION:Prenatal exposure to organochlorine compounds (OCs) can increase the risk of reported respiratory symptoms in children. It remains unclear whether these compounds can also impact on lung function. We assessed the association between prenatal exposure to OCs and lung function during childhood. METHODS:We included 1308 mother-child pairs enrolled in a ... Read more >>

Environ Int (Environment international)
[2019, 131:105049]

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Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study.

Cyntia B Manzano-Salgado, Berit Granum, Maria-Jose Lopez-Espinosa, Ferran Ballester, Carmen Iñiguez, Mireia Gascón, David Martínez, Mònica Guxens, Mikel Basterretxea, Carlos Zabaleta, Thomas Schettgen, Jordi Sunyer, Martine Vrijheid, Maribel Casas,

BACKGROUND:Prenatal exposure to perfluoroalkyl substances (PFASs) has been associated with impaired immune and respiratory health during childhood but the evidence is inconsistent and limited for lung function. We studied the association between prenatal PFASs exposure and immune and respiratory health, including lung function, up to age 7 years in the ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2019, 222(6):945-954]

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Prediction of maternal and foetal exposures to perfluoroalkyl compounds in a Spanish birth cohort using toxicokinetic modelling.

Céline Brochot, Maribel Casas, Cyntia Manzano-Salgado, Florence A Zeman, Thomas Schettgen, Martine Vrijheid, Frédéric Y Bois,

Prenatal exposures to perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) have been associated with child health outcomes, but many of these associations remain poorly characterized. The aim of this work was to provide new indicators of foetal exposure for the Spanish INMA birth cohort. First, a pregnancy and lactation physiologically ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2019, 379:114640]

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First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy.

Olga Costa, Carmen Iñiguez, Cyntia B Manzano-Salgado, Pilar Amiano, Mario Murcia, Maribel Casas, Amaia Irizar, Mikel Basterrechea, Andrea Beneito, Thomas Schettgen, Jordi Sunyer, Martine Vrijheid, Ferran Ballester, Maria-Jose Lopez-Espinosa,

BACKGROUND:Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied the possible association between PFASs and fetal biometry. METHODS:In 1230 mother-child pairs of three cohorts from the Spanish INMA-Project, we analyzed perfluorohexanesulfonic acid (PFHxS), ... Read more >>

Environ Int (Environment international)
[2019, 130:104830]

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Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain.

Antonio J Signes-Pastor, Jesús Vioque, Eva M Navarrete-Muñoz, Manus Carey, Miguel García-Villarino, Ana Fernández-Somoano, Adonina Tardón, Loreto Santa-Marina, Amaia Irizar, Maribel Casas, Mònica Guxens, Sabrina Llop, Raquel Soler-Blasco, Manoli García-de-la-Hera, Margaret R Karagas, Andrew A Meharg,

Early-life exposure to inorganic arsenic (iAs) may adversely impact health later in life. To date, evidence of iAs adverse effects on children's neurodevelopment comes mainly from populations highly exposed to contaminated water with conflicting results. Little is known about those effects among populations with low iAs exposure from food intake. ... Read more >>

Environ. Res. (Environmental research)
[2019, 174:135-142]

Cited: 3 times

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Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts.

Parisa Montazeri, Cathrine Thomsen, Maribel Casas, Jeroen de Bont, Line S Haug, Léa Maitre, Eleni Papadopoulou, Amrit K Sakhi, Rémy Slama, Pierre Jean Saulnier, Jose Urquiza, Regina Grazuleviciene, Sandra Andrusaityte, Rosie McEachan, John Wright, Leda Chatzi, Xavier Basagaña, Martine Vrijheid,

BACKGROUND:Human exposure to environmental chemical contaminants at critical periods of development can lead to lifelong health consequences. Traditionally, socioeconomically disadvantaged groups are thought to experience higher contaminant exposures; however, this relationship may not hold for all contaminants. METHODS:Using data from six European birth cohorts (1301 mother-child pairs), we determined biomarkers ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2019, 222(5):864-872]

Cited: 1 time

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Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort.

Vicente Mustieles, Maribel Casas, Patricia Ferrando-Marco, Olga Ocón-Hernández, Iris Reina-Pérez, Andrea Rodríguez-Carrillo, Fernando Vela-Soria, Rocío Pérez-Lobato, Eva María Navarrete-Muñoz, Carmen Freire, Nicolás Olea, Mariana F Fernández,

INTRODUCTION:Childhood obesity is one of the most serious public health challenges of our times. Although an important body of experimental evidence highlights the obesogenic potential of endocrine disruptors such as bisphenol A (BPA), the epidemiological evidence remains inconclusive and limited. OBJECTIVE:To assess associations between urinary BPA concentrations and several adiposity ... Read more >>

Environ. Res. (Environmental research)
[2019, 173:443-451]

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Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration.

Alvar Agusti, Rosa Faner, Gavin Donaldson, Elise Heuvelin, Robab Breyer-Kohansal, Erik Melén, Anke H Maitland-van der Zee, Jørgen Vestbo, James P Allinson, Lowie E G W Vanfleteren, Maarten van den Berge, Ian M Adcock, Lies Lahousse, Guy Brusselle, Jadwiga A Wedzicha, , ,

Eur. Respir. J. (The European respiratory journal)
[2019, 53(3):]

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Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort.

Lydiane Agier, Xavier Basagaña, Lea Maitre, Berit Granum, Philippa K Bird, Maribel Casas, Bente Oftedal, John Wright, Sandra Andrusaityte, Montserrat de Castro, Enrique Cequier, Leda Chatzi, David Donaire-Gonzalez, Regina Grazuleviciene, Line S Haug, Amrit K Sakhi, Vasiliki Leventakou, Rosemary McEachan, Mark Nieuwenhuijsen, Inga Petraviciene, Oliver Robinson, Theano Roumeliotaki, Jordi Sunyer, Ibon Tamayo-Uria, Cathrine Thomsen, Jose Urquiza, Antonia Valentin, Rémy Slama, Martine Vrijheid, Valérie Siroux,

BACKGROUND:Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children. METHODS:In this analysis, we used data ... Read more >>

Lancet Planet Health (The Lancet. Planetary health)
[2019, 3(2):e81-e92]

Cited: 1 time

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Placental metal concentrations and birth outcomes: The Environment and Childhood (INMA) project.

Carmen Freire, Esperanza Amaya, Fernando Gil, Mario Murcia, Sabrina LLop, Maribel Casas, Martine Vrijheid, Aitana Lertxundi, Amaia Irizar, Guillermo Fernández-Tardón, Rafael Vicente Castro-Delgado, Nicolás Olea, Mariana F Fernández, ,

OBJECTIVE:To examine the association of placental levels of arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb), manganese (Mn), and chromium (Cr) with birth outcomes (birth weight, length, and head circumference, low birth weight [LBW], gestational age, preterm delivery, and small for gestational age [SGA]) in mother-child pairs from the Environment ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2019, 222(3):468-478]

Cited: 1 time

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Exposure to phthalate metabolites, phenols and organophosphate pesticide metabolites and blood pressure during pregnancy.

Charline Warembourg, Xavier Basagaña, Chiara Seminati, Jeroen de Bont, Berit Granum, Sarah Lyon-Caen, Cyntia B Manzano-Salgado, Isabelle Pin, Amrit K Sakhi, Valérie Siroux, Rémy Slama, Jose Urquiza, Martine Vrijheid, Cathrine Thomsen, Maribel Casas,

INTRODUCTION:Hypertensive disorders during pregnancy are one of the leading causes of maternal and offspring mortality and morbidity. Exposure to environmental chemicals is suspected to increase blood pressure (BP) but few studies have investigated the impact of non-persistent chemicals, in particular among pregnant women. METHODS:Women included in the study were 152 ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2019, 222(3):446-454]

Cited: 1 time

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ERS International Congress 2018: highlights from best-abstract awardees.

Olivier Burgy, Jesse Armitage, Louise Wain, Maribel Casas, Leandro Cruz Mantoani, Elsa Bodier-Montagutelli, Cristina Boccabella, Jana De Brandt,

A summary of the ERS International Congress 2018 from the best-abstract awardees for each ERS Assembly and their views on the evolving field of research of their respective Assemblies http://ow.ly/c0eq30ntKuw. ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2018, 14(4):e137-e142]

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The early-life exposome: Description and patterns in six European countries.

Ibon Tamayo-Uria, Léa Maitre, Cathrine Thomsen, Mark J Nieuwenhuijsen, Leda Chatzi, Valérie Siroux, Gunn Marit Aasvang, Lydiane Agier, Sandra Andrusaityte, Maribel Casas, Montserrat de Castro, Audrius Dedele, Line S Haug, Barbara Heude, Regina Grazuleviciene, Kristine B Gutzkow, Norun H Krog, Dan Mason, Rosemary R C McEachan, Helle M Meltzer, Inga Petraviciene, Oliver Robinson, Theano Roumeliotaki, Amrit K Sakhi, Jose Urquiza, Marina Vafeiadi, Dagmar Waiblinger, Charline Warembourg, John Wright, Rémy Slama, Martine Vrijheid, Xavier Basagaña,

Characterization of the "exposome", the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases. Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, ... Read more >>

Environ Int (Environment international)
[2019, 123:189-200]

Cited: 0 times

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Determinants of the urinary and serum metabolome in children from six European populations.

Chung-Ho E Lau, Alexandros P Siskos, Léa Maitre, Oliver Robinson, Toby J Athersuch, Elizabeth J Want, Jose Urquiza, Maribel Casas, Marina Vafeiadi, Theano Roumeliotaki, Rosemary R C McEachan, Rafaq Azad, Line S Haug, Helle M Meltzer, Sandra Andrusaityte, Inga Petraviciene, Regina Grazuleviciene, Cathrine Thomsen, John Wright, Remy Slama, Leda Chatzi, Martine Vrijheid, Hector C Keun, Muireann Coen,

BACKGROUND:Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environment-health interactions. However, large-scale metabolome studies in children combining analyses of these biological fluids are lacking. Here, we sought to characterise the ... Read more >>

BMC Med (BMC medicine)
[2018, 16(1):202]

Cited: 6 times

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Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children.

Maribel Casas, Xavier Basagaña, Amrit K Sakhi, Line S Haug, Claire Philippat, Berit Granum, Cyntia B Manzano-Salgado, Céline Brochot, Florence Zeman, Jeroen de Bont, Sandra Andrusaityte, Leda Chatzi, David Donaire-Gonzalez, Lise Giorgis-Allemand, Juan R Gonzalez, Esther Gracia-Lavedan, Regina Grazuleviciene, Mariza Kampouri, Sarah Lyon-Caen, Pau Pañella, Inga Petraviciene, Oliver Robinson, Jose Urquiza, Marina Vafeiadi, Céline Vernet, Dagmar Waiblinger, John Wright, Cathrine Thomsen, Rémy Slama, Martine Vrijheid,

BACKGROUND:Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. OBJECTIVES:We evaluated the variability of urinary concentrations of 24 non-persistent chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide metabolites, and cotinine, between weeks from different pregnancy trimesters in pregnant ... Read more >>

Environ Int (Environment international)
[2018, 121(Pt 1):561-573]

Cited: 5 times

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In-utero and childhood chemical exposome in six European mother-child cohorts.

Line Småstuen Haug, Amrit Kaur Sakhi, Enrique Cequier, Maribel Casas, Léa Maitre, Xavier Basagana, Sandra Andrusaityte, Georgia Chalkiadaki, Leda Chatzi, Muireann Coen, Jeroen de Bont, Audrius Dedele, Joane Ferrand, Regina Grazuleviciene, Juan Ramon Gonzalez, Kristine Bjerve Gutzkow, Hector Keun, Rosie McEachan, Helle Margrete Meltzer, Inga Petraviciene, Oliver Robinson, Pierre-Jean Saulnier, Rémy Slama, Jordi Sunyer, José Urquiza, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen,

BACKGROUND:Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. OBJECTIVES:To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their children, based on chemical analysis of biological samples from mother-child pairs. METHODS:We relied ... Read more >>

Environ Int (Environment international)
[2018, 121(Pt 1):751-763]

Cited: 2 times

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The effect of early growth patterns and lung function on the development of childhood asthma: a population based study.

Maribel Casas, Herman T den Dekker, Claudia J Kruithof, Irwin K Reiss, Martine Vrijheid, Jordi Sunyer, Johan C de Jongste, Vincent W V Jaddoe, Liesbeth Duijts,

BACKGROUND:Infant weight gain is associated with lower lung function and a higher risk of childhood asthma. Detailed individual childhood growth patterns might be better predictors of childhood respiratory morbidity than the difference between two weight and height measurements. We assessed the associations of early childhood growth patterns with lung function ... Read more >>

Thorax (Thorax)
[2018, 73(12):1137-1145]

Cited: 1 time

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WHO Environmental Noise Guidelines for the European Region: A Systematic Review on Environmental Noise and Cardiovascular and Metabolic Effects: A Summary.

Elise van Kempen, Maribel Casas, Göran Pershagen, Maria Foraster,

To update the current state of evidence and assess its quality, we conducted a systematic review on the effects of environmental noise exposure on the cardio-metabolic systems as input for the new WHO environmental noise guidelines for the European Region. We identified 600 references relating to studies on effects of ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2018, 15(2):]

Cited: 16 times

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