Full Text Journal Articles by
Author Marian Knight

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Mode of birth and risk of infection-related hospitalisation in childhood: A population cohort study of 7.17 million births from 4 high-income countries.

Jessica E Miller, Raphael Goldacre, Hannah C Moore, Justin Zeltzer, Marian Knight, Carole Morris, Sian Nowell, Rachael Wood, Kim W Carter, Parveen Fathima, Nicholas de Klerk, Tobias Strunk, Jiong Li, Natasha Nassar, Lars H Pedersen, David P Burgner,

BACKGROUND:The proportion of births via cesarean section (CS) varies worldwide and in many countries exceeds WHO-recommended rates. Long-term health outcomes for children born by CS are poorly understood, but limited data suggest that CS is associated with increased infection-related hospitalisation. We investigated the relationship between mode of birth and childhood ... Read more >>

PLoS Med (PLoS medicine)
[2020, 17(11):e1003429]

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Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.

Chris Gale, Maria A Quigley, Anna Placzek, Marian Knight, Shamez Ladhani, Elizabeth S Draper, Don Sharkey, Cora Doherty, Helen Mactier, Jennifer J Kurinczuk,

BACKGROUND:Babies differ from older children with regard to their exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data describing the effect of SARS-CoV-2 in this group are scarce, and guidance is variable. We aimed to describe the incidence, characteristics, transmission, and outcomes of SARS-CoV-2 infection in neonates who ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

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Performance of sFlt-1/PlGF ratio ≥85 for ruling in preeclampsia within 4 weeks.

Ana Sofia Cerdeira, Joe O'Sullivan, Eric O Ohuma, Tim James, Aris T Papageorghiou, Marian Knight, Manu Vatish,

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2020, :]

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Management of Gastroschisis: Results From the NETS2G Study, a Joint British, Irish, and Canadian Prospective Cohort Study of 1268 Infants.

Benjamin S R Allin, Charles Opondo, Jennifer J Kurinczuk, Rob Baird, P Puligandla, Erik Skarsgard, Marian Knight, ,

OBJECTIVE:In infants with gastroschisis, outcomes were compared between those where operative reduction and fascial closure were attempted ≤24 hours of age (PC), and those who underwent planned closure of their defect >24 hours of age following reduction with a pre-formed silo (SR). SUMMARY OF BACKGROUND DATA:Inadequate evidence exists to determine how best ... Read more >>

Ann Surg (Annals of surgery)
[2020, :]

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Outcomes at five to eight years of age for children with Hirschsprung's disease.

Benjamin Saul Raywood Allin, Charles Opondo, Timothy John Bradnock, Simon Edward Kenny, Jennifer J Kurinczuk, Gregor M Walker, Marian Knight, ,

OBJECTIVE:This study describes core outcomes of Hirschsprung's disease (HD) in a UK-wide cohort of primary school-aged children. DESIGN:A prospective cohort study conducted from 1 October 2010 to 30 September 2012. Outcomes data were collected from parents and clinicians when children were 5-8 years of age, and combined with data collected ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, :]

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Neonatal admission and mortality in babies born in UK alongside midwifery units: a national population-based case-control study using the UK Midwifery Study System (UKMidSS).

Rachel Rowe, Aung Soe, Marian Knight, Jennifer J Kurinczuk, ,

OBJECTIVES:To determine the incidence of and risk factors for neonatal unit admission, intrapartum stillbirth or neonatal death without admission, and describe outcomes, in babies born in an alongside midwifery unit (AMU). DESIGN:National population-based case-control study. METHOD:We used the UK Midwifery Study System to identify and collect data about 1041 women ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2020, :]

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Lessons learned from the A (H1N1) influenza pandemic

Nicola Vousden, Marian Knight,

Influenza in pregnancy is a common condition that is associated with an increased risk of hospital admission. Women with comorbidities are at a greater risk of severe outcomes. There are substantial gaps in our knowledge of the impact of severe influenza on perinatal outcomes, particularly in low- and middle-income countries, ... Read more >>

Best Pract Res Clin Obstet Gynaecol (Best practice & research. Clinical obstetrics & gynaecology)
[2020, :]

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Lessons learned from the A (H1N1) influenza pandemic.

Nicola Vousden, Marian Knight,

Influenza in pregnancy is a common condition that is associated with an increased risk of hospital admission. Women with comorbidities are at a greater risk of severe outcomes. There are substantial gaps in our knowledge of the impact of severe influenza on perinatal outcomes, particularly in low- and middle-income countries, ... Read more >>

Best Pract Res Clin Obstet Gynaecol (Best practice & research. Clinical obstetrics & gynaecology)
[2020, :]

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The incidence, maternal, fetal and neonatal consequences of single intrauterine fetal death in monochorionic twins: A prospective observational UKOSS study.

R Katie Morris, Fiona Mackie, Aurelio Tobías Garces, Marian Knight, Mark D Kilby,

OBJECTIVE:Report maternal, fetal and neonatal complications associated with single intrauterine fetal death (sIUFD) in monochorionic twin pregnancies. DESIGN:Prospective observational study. SETTING:UK. POPULATION:81 monochorionic twin pregnancies with sIUFD after 14 weeks gestation, irrespective of cause. METHODS:UKOSS reporters submitted data collection forms using data from hospital records. MAIN OUTCOME MEASURES:Aetiology of sIUFD; ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0239477]

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A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process.

Rachel Harwood, Benjamin Allin, Christine E Jones, Elizabeth Whittaker, Padmanabhan Ramnarayan, Athimalaipet V Ramanan, Musa Kaleem, Robert Tulloh, Mark J Peters, Sarah Almond, Peter J Davis, Michael Levin, Andrew Tometzki, Saul N Faust, Marian Knight, Simon Kenny, ,

Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a novel condition that was first reported in April, 2020. We aimed to develop a national consensus management pathway for the UK to provide guidance for clinicians caring for children with PIMS-TS. A three-phase online Delphi process and virtual consensus ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

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Include pregnant women in research-particularly covid-19 research.

Marian Knight, R Katie Morris, Jenny Furniss, Lucy C Chappell,

BMJ (BMJ (Clinical research ed.))
[2020, 370:m3305]

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Maternal and perinatal Health Research Collaboration, India (MaatHRI): methodology for establishing a hospital-based research platform in a low and middle income country setting

Manisha Nair, Babul Bezbaruah, Amrit Krishna Bora, Krishnaram Bora, Shakuntala Chhabra, Saswati Choudhury, Arup Choudhury, Dipika Deka, Gitanjali Deka, Vijay Anand Ismavel, Swapna Kakoty, Roshine Koshy, Pramod Kumar, Pranabika Mahanta, Robin Medhi, Pranoy Nath, Anjali Rani, Indrani Roy, Usha Sarma, Carolin Solomi V, Ratna Kanta Talukdar, Farzana Zahir, Michael Hill, Nimmi Kansal, Reena Nakra, Colin Baigent, Marian Knight, Jenny Kurinczuk,

Background: Maternal and perinatal Health Research collaboration, India (MaatHRI) is a research platform that aims to improve evidence-based pregnancy care and outcomes for mothers and babies in India, a country with the second highest burden of maternal and perinatal deaths. The objective of this paper is to describe the methods ... Read more >>

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The Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials in Mozambique, Pakistan, and India: an individual participant-level meta-analysis.

Peter von Dadelszen, Zulfiqar A Bhutta, Sumedha Sharma, Jeffrey Bone, Joel Singer, Hubert Wong, Mrutyunjaya B Bellad, Shivaprasad S Goudar, Tang Lee, Jing Li, Ashalata A Mallapur, Khátia Munguambe, Beth A Payne, Rahat N Qureshi, Charfudin Sacoor, Esperança Sevene, Marianne Vidler, Laura A Magee, ,

BACKGROUND:To overcome the three delays in triage, transport and treatment that underlie adverse pregnancy outcomes, we aimed to reduce all-cause adverse outcomes with community-level interventions targeting women with pregnancy hypertension in three low-income countries. METHODS:In this individual participant-level meta-analysis, we de-identified and pooled data from the Community-Level Interventions for Pre-eclampsia ... Read more >>

Lancet (Lancet (London, England))
[2020, 396(10250):553-563]

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One Year Outcomes of Congenital Duodenal Obstruction - A Population Based Study.

George S Bethell, Anna-May Long, Marian Knight, Nigel J Hall, ,

OBJECTIVES:Congenital duodenal obstruction (CDO) occurs in 1.2 per 10,000 live births and is frequently associated with other anomalies, most commonly cardiac. The aim of this study was to report important outcomes to 1 year following surgical repair. METHODS:This was a prospective population-based study using the British Association of Paediatric Surgeons ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2020, :]

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Incidence, risk factors and impact of seasonal influenza in pregnancy: A national cohort study

Nicola Vousden, Kathryn Bunch, Marian Knight, ,

Background Pregnant women are particularly vulnerable to severe infection from influenza resulting in poor neonatal outcomes. The majority of evidence relates to pandemic 2009 A/H1N1 influenza. The objective of this study was to describe the characteristics and outcomes of pregnant women hospitalised with seasonal influenza. Methods This national, ... Read more >>

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A national consensus management pathway for Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS): The results of a national Delphi process

Rachel Harwood, Benjamin Allin, Christine Jones, Elizabeth Whittaker, Padmanabhan Ramnarayan, Athimalaipet Ramanan, Musa Kaleem, Robert Tulloh, Mark Peters, Sarah Almond, Peter Davis, Michael Levin, Saul Faust, Marian Knight, Simon Kenny, ,

Objective: To develop a consensus management pathway for children with Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS). Design: A three-phase online Delphi process and virtual consensus meeting sought consensus over the investigation, management and research priorities from 98 multidisciplinary participants caring for children with PIMS-TS. 46 ... Read more >>

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The impact of the national clinical outcome review programmes in England: a review of the evidence.

Pauline Heslop, Elena Baker-Glenn, Peter Fleming, Marian Knight, Marisa Mason, Pauline Turnbull, Clare Wade,

BACKGROUND:There is a lack of evidence about the effectiveness of the national clinical outcome review programmes in England. METHODS:We undertook a scoping review of the published literature for evidence of the impact of any of the current programmes or their predecessors, and asked programme leads to share examples of the ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(4):e52-e58]

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National active surveillance to understand and inform neonatal care in COVID-19.

Chris Gale, Marian Knight, Shamez Ladhani, Elizabeth S Draper, Don Sharkey, Cora Doherty, Helen Mactier, Jennifer J Kurinczuk, ,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(4):346-347]

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Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study.

Marian Knight, Kathryn Bunch, Nicola Vousden, Edward Morris, Nigel Simpson, Chris Gale, Patrick O'Brien, Maria Quigley, Peter Brocklehurst, Jennifer J Kurinczuk, ,

OBJECTIVES:To describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants. DESIGN:Prospective national population based cohort study using the UK Obstetric Surveillance ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2020, 369:m2107]

Cited: 26 times

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Epidemiological analysis of peripartum hysterectomy across nine European countries.

Athanasios F Kallianidis, Alice Maraschini, Jakub Danis, Lotte B Colmorn, Catherine Deneux-Tharaux, Serena Donati, Mika Gissler, Maija Jakobsson, Marian Knight, Alexandra Kristufkova, Pelle G Lindqvist, Griet Vandenberghe, Thomas Van Den Akker, ,

INTRODUCTION:Peripartum hysterectomy is a surgical procedure performed for severe obstetric complications such as major obstetric hemorrhage. The prevalence of peripartum hysterectomy in high-resource settings is relatively low. Hence, international comparisons and studying indications and associations with mode of birth rely on the use of national obstetric survey data. Objectives were ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(10):1364-1373]

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The UK hibernated pandemic influenza research portfolio: triggered for COVID-19.

Colin R Simpson, Benjamin D Thomas, Kirsty Challen, Daniela De Angelis, Ellen Fragaszy, Steve Goodacre, Andrew Hayward, Wei Shen Lim, G James Rubin, Malcolm G Semple, Marian Knight, ,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(7):767-769]

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Early evaluation of the 'STOP SEPSIS!' WHO Global Maternal Sepsis Awareness Campaign implemented for healthcare providers in 46 low, middle and high-income countries.

Vanessa Brizuela, Mercedes Bonet, Carla Lionela Trigo Romero, Edgardo Abalos, Adama Baguiya, Bukola Fawole, Marian Knight, Pisake Lumbiganon, Meilė Minkauskienė, Ashraf Nabhan, Nafissa Bique Osman, Zahida P Qureshi, João Paulo Souza, ,

OBJECTIVE:To evaluate changes in awareness of maternal sepsis among healthcare providers resulting from the WHO Global Maternal Sepsis Study (GLOSS) awareness campaign. DESIGN:Independent sample precampaign/postcampaign through online and paper-based surveys available for over 30 days before campaign roll-out (pre) and after study data collection (post). Descriptive statistics were used for ... Read more >>

BMJ Open (BMJ open)
[2020, 10(5):e036338]

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Characteristics and outcomes of pregnant women hospitalised with confirmed SARS-CoV-2 infection in the UK: a national cohort study using the UK Obstetric Surveillance System (UKOSS)

Marian Knight, Kathryn Bunch, Nicola Vousden, Edward Morris, Nigel Simpson, Christopher Gale, Patrick O'Brien, Maria Quigley, Peter Brocklehurst, Jennifer Kurinczuk,

Objective: To describe a national cohort of pregnant women hospitalised with SARS-CoV-2 infection in the UK, identify factors associated with infection and describe outcomes, including transmission of infection, for mother and infant. Design: Prospective national population-based cohort study using the UK Obstetric Surveillance System (UKOSS). Setting: All 194 obstetric units ... Read more >>

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Severe maternal morbidity and maternal mortality: A need for consensus on concepts and prevention efforts.

Marian Knight, K S Joseph,

Paediatr Perinat Epidemiol (Paediatric and perinatal epidemiology)
[2020, 34(4):377-378]

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Frequency and management of maternal infection in health facilities in 52 countries (GLOSS): a 1-week inception cohort study.

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BACKGROUND:Maternal infections are an important cause of maternal mortality and severe maternal morbidity. We report the main findings of the WHO Global Maternal Sepsis Study, which aimed to assess the frequency of maternal infections in health facilities, according to maternal characteristics and outcomes, and coverage of core practices for early ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2020, 8(5):e661-e671]

Cited: 2 times

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