Full Text Journal Articles by
Author Marian Kampschulte

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Resonance vibration interventions in the femur: Experimental-numerical modelling approaches.

Alexandre Presas, David Valentin, Joseph Deering, Marian Kampschulte, Bosco Yu, Kathryn Grandfield, Elisa Mele, Christoph Biehl, Gabriele A Krombach, Christian Heiss, Wolfram A Bosbach,

<h4>Motive</h4>External vibration excitation might be key to many novel non-surgical interventions for pathologies in the musculoskeletal system and in other parts of the human organism. Lack of understanding about vibration patterns, their controllability, and reproducibility are three limitations of ongoing research. This study establishes a bovine vibration model and animal ... Read more >>

J Mech Behav Biomed Mater (Journal of the mechanical behavior of biomedical materials)
[2021, 124:104850]

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Bone Status in a Mouse Model of Experimental Autoimmune-Orchitis.

Fabian Hemm, Monika Fijak, Jan Belikan, Marian Kampschulte, Thaqif El Khassawna, Adrian Pilatz, Christian Heiss, Katrin Susanne Lips,

Investigations in male patients with fertility disorders revealed a greater risk of osteoporosis. The rodent model of experimental autoimmune-orchitis (EAO) was established to analyze the underlying mechanisms of male infertility and causes of reduced testosterone concentration. Hence, we investigated the impact of testicular dysfunction in EAO on bone status. Male ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(15):]

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Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.

Markus Rupp, Christoph Biehl, Deeksha Malhan, Fathi Hassan, Sameh Attia, Sebastian Rosch, Annemarie B Schäfer, Erin McMahon, Marian Kampschulte, Christian Heiss, Thaqif El Khassawna,

Osteoporosis is a common metabolic disorder diagnosed by lower bone density and higher risk of fracture. Fragility fractures because of osteoporosis are associated with high mortality rate. Deep understanding of fracture healing in osteoporosis is important for successful treatment. Therefore, the FDA approved the use of small and large animal ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(3):]

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Partial cortico-hippocampectomy in cats, as therapy for refractory temporal epilepsy: A descriptive cadaveric study.

Jessica Zilli, Monika Kressin, Anne Schänzer, Marian Kampschulte, Martin J Schmidt,

Cats, similar to humans, are known to be affected by hippocampal sclerosis (HS), potentially causing antiepileptic drug (AED) resistance. HS can occur as a consequence of chronic seizure activity, trauma, inflammation, or even as a primary disease. In humans, temporal lobe resection is the standardized therapy in patients with refractory ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0244892]

Cited: 1 time

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Galleria mellonella as an alternative in vivo model to study bacterial biofilms on stainless steel and titanium implants

Gopala K Mannala, Markus Rupp, Francisca Alagboso, Maximilian Kerschbaum, Christian Pfeifer, Ursula Sommer, Marian Kampschulte, Eugen Domann, Volker Alt,

The purpose of this study was to establish an infection model of Galleria mellonella larvae as an alternative in vivo model for biofilm-associated infections on stainless steel and titanium implants. First, the model was established with sterile implants to evaluate biocompatibility. Titanium or stainless steel implants were implanted without adverse ... Read more >>

ALTEX (ALTEX)
[2021, 38(2):245-252]

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Rounded Atelectasis After Exposure to Refectory Ceramic Fibres - A Case Report

Ulrike Brückner, Anne Schulze, Marian Kampschulte, Joachim Schneider,

<h4>Background: </h4> Refractory Ceramic fibres (RCF) are man-made mineral fibres used in high performance thermal insulation applications and mostly to line furnaces, kilns and other industrial heaters. Analogous to asbestos fibres, RCF are respirable, show a pleural drift and can persist in human lung tissue for more than 20 years ... Read more >>

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Re-evaluation of Zospeumschaufussi von Frauenfeld, 1862 and Z.suarezi Gittenberger, 1980, including the description of two new Iberian species using Computer Tomography (CT) (Eupulmonata, Ellobioidea, Carychiidae).

Adrienne Jochum, Carlos E Prieto, Marian Kampschulte, Gunhild Martels, Bernhard Ruthensteiner, Marko Vrabec, Dorian D Dörge, Anton J de Winter,

The present study aims to clarify the confused taxonomy of <i>Z.schaufussi</i> von Frauenfeld, 1862 and <i>Zospeumsuarezi</i> Gittenberger, 1980. Revision of Iberian <i>Zospeum</i> micro snails is severely hindered by uncertainties regarding the identity of the oldest Iberian <i>Zospeum</i> species, <i>Z.schaufussi</i> von Frauenfeld, 1862. In this paper, we clarify its taxonomic status ... Read more >>

Zookeys (ZooKeys)
[2019, 835:65-86]

Cited: 1 time

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Unilateral and bilateral agenesis of the upper thyroid horns - A morphometric analysis of the larynx.

Can-Felix Winzek, Luisa C M Hartrampf, Marian Kampschulte, Jörn Pons-Kühnemann, Christoph G Birngruber, Reinhard Dettmeyer, Klaus-Steffen Saternus,

The agenesis of one or both upper thyroid horns (UTH) cannot be considered rare with an incidence ranging between 0.8-9.4%. Studies so far have mostly described frequencies, yet surveys on its morphology and traumatology are missing. It is unknown to what extent this anatomical variant impacts the overall symmetry of ... Read more >>

Forensic Sci Int (Forensic science international)
[2019, 301:225-230]

Cited: 1 time

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Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.

Cho-Ming Chao, Alena Moiseenko, Djuro Kosanovic, Stefano Rivetti, Elie El Agha, Jochen Wilhelm, Marian Kampschulte, Faady Yahya, Harald Ehrhardt, Klaus-Peter Zimmer, Guillermo Barreto, Albert A Rizvanov, Ralph T Schermuly, Irwin Reiss, Rory E Morty, Robbert J Rottier, Saverio Bellusci, Jin-San Zhang,

Bronchopulmonary dysplasia (BPD), characterized by alveoli simplification and dysmorphic pulmonary microvasculature, is a chronic lung disease affecting prematurely born infants. Pulmonary hypertension (PH) is an important BPD feature associated with morbidity and mortality. In human BPD, inflammation leads to decreased fibroblast growth factor 10 (FGF10) expression but the impact on ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2019, 28(9):1429-1444]

Cited: 6 times

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Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography.

Baktybek Kojonazarov, Alexander Belenkov, Shohei Shinomiya, Jochen Wilchelm, Marian Kampschulte, Shiro Mizuno, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Norbert Weissmann, Werner Seeger, Ralph Theo Schermuly,

<h4>Background</h4>The use of microscopic computed tomography to assess the key functional parameters of systolic emptying or diastolic filling in small animals has not been previously reported. The aim of the study was to test whether microscopic computed tomography can assess the dynamics of both left ventricle and right ventricle (RV) ... Read more >>

Circ Cardiovasc Imaging (Circulation. Cardiovascular imaging)
[2018, 11(12):e007653]

Cited: 5 times

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Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure.

Lisa Baumann, Vivien Kauschke, Anna Vikman, Lutz Dürselen, Gabriela Krasteva-Christ, Marian Kampschulte, Christian Heiss, Kathleen T Yee, Douglas E Vetter, Katrin Susanne Lips,

Alterations in bone strength and structure were found in knockout (KO) mouse strains with deletion of several acetylcholine receptors. Interestingly, the expression of the nicotinic acetylcholine receptors (nAChR) subunit α10 was down-regulated in osteogenic differentiated mesenchymal stem cells of patients with osteoporosis whereas the expression of subunit α9 was not ... Read more >>

Bone (Bone)
[2019, 120:285-296]

Cited: 4 times

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Fulfilling the taxonomic consequence after DNA Barcoding: Carychiumpanamaense sp. n. (Eupulmonata, Ellobioidea, Carychiidae) from Panama is described using computed tomographic (CT) imaging.

Adrienne Jochum, Bernhard Ruthensteiner, Marian Kampschulte, Gunhild Martels, Jeannette Kneubühler, Adrien Favre,

Five years ago, the Panamanian evolutionary lineage (EL) C12 was uncovered along with four other ELs in an integrative phylogenetic investigation of worldwide Carychiidae. Since EL C12 lacked shell material post-molecular analysis to serve as a museum voucher, it remained undescribed. Now, after recent collection efforts of C12 and the ... Read more >>

Zookeys (ZooKeys)
[2018, (795):1-12]

Cited: 0 times

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Low testosterone in ApoE/LDL receptor double-knockout mice is associated with rarefied testicular capillaries together with fewer and smaller Leydig cells.

Kai Steinfeld, Daniela Beyer, Christian Mühlfeld, Andrea Mietens, Gerrit Eichner, Bora Altinkilic, Marian Kampschulte, Qingkui Jiang, Gabriele A Krombach, Thomas Linn, Wolfgang Weidner, Ralf Middendorff,

The testis as a site for atherosclerotic changes has so far attracted little attention. We used the apolipoprotein E (ApoE)/low density lipoprotein (LDL) receptor deficient mouse model (KO) for atherosclerosis (20, 40, 60 and 87-week-old) to investigate whether Leydig cells or the capillary network are responsible for reduced serum testosterone ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):5424]

Cited: 4 times

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Quantitative computed tomography applied to interstitial lung diseases.

Martin Obert, Marian Kampschulte, Rebekka Limburg, Stefan Barańczuk, Gabriele A Krombach,

<h4>Objectives</h4>To evaluate a new image marker that retrieves information from computed tomography (CT) density histograms, with respect to classification properties between different lung parenchyma groups. Furthermore, to conduct a comparison of the new image marker with conventional markers.<h4>Materials and methods</h4>Density histograms from 220 different subjects (normal = 71; emphysema = 73; fibrotic = 76) were used ... Read more >>

Eur J Radiol (European journal of radiology)
[2018, 100:99-107]

Cited: 5 times

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Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing.

Seemun Ray, Ulrich Thormann, Marlen Eichelroth, Matthäus Budak, Christoph Biehl, Markus Rupp, Ursula Sommer, Thaqif El Khassawna, Francisca I Alagboso, Marian Kampschulte, Marcus Rohnke, Anja Henß, Klaus Peppler, Vanessa Linke, Peter Quadbeck, Axel Voigt, Florian Stenger, Daniel Karl, Reinhard Schnettler, Christian Heiss, Katrin S Lips, Volker Alt,

The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariectomy ... Read more >>

Biomaterials (Biomaterials)
[2018, 157:1-16]

Cited: 6 times

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Strontium-modification of porous scaffolds from mineralized collagen for potential use in bone defect therapy.

Mandy Quade, Matthias Schumacher, Anne Bernhardt, Anja Lode, Marian Kampschulte, Andrea Voß, Paul Simon, Ortrud Uckermann, Matthias Kirsch, Michael Gelinsky,

The present study describes the development and characterization of strontium(II)-modified biomimetic scaffolds based on mineralized collagen type I as potential biomaterial for the local treatment of defects in systemically impaired (e.g. osteoporotic) bone. In contrast to already described collagen/hydroxyapatite nanocomposites calcium was substituted with strontium to the extent of 25, ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2018, 84:159-167]

Cited: 12 times

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Three new species of Carychium O.F. Müller, 1773 from the Southeastern USA, Belize and Panama are described using computer tomography (CT) (Eupulmonata, Ellobioidea, Carychiidae).

Adrienne Jochum, Alexander M Weigand, Estee Bochud, Thomas Inäbnit, Dorian D Dörge, Bernhard Ruthensteiner, Adrien Favre, Gunhild Martels, Marian Kampschulte,

Three new species of the genus <i>Carychium</i> O.F. Müller, 1773, <i>Carychium hardiei</i> Jochum & Weigand, <b>sp. n.</b>, <i>Carychium belizeense</i> Jochum & Weigand, <b>sp. n.</b> and <i>Carychium zarzaae</i> Jochum & Weigand, <b>sp. n.</b> are described from the Southeastern United States, Belize and Panama, respectively. In two consecutive molecular phylogenetic studies of ... Read more >>

Zookeys (ZooKeys)
[2017, (675):97-127]

Cited: 1 time

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Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice.

Philipp Stieger, Jan-Marcus Daniel, Christiane Thölen, Jochen Dutzmann, Kai Knöpp, Dursun Gündüz, Muhammad Aslam, Marian Kampschulte, Alexander Langheinrich, Silvia Fischer, Hector Cabrera-Fuentes, Yong Wang, Kai C Wollert, Johann Bauersachs, Rüdiger Braun-Dullaeus, Klaus T Preissner, Daniel G Sedding,

<h4>Background</h4>Following myocardial infarction (MI), peri-infarct myocardial edema formation further impairs cardiac function. Extracellular RNA (eRNA) released from injured cells strongly increases vascular permeability. This study aimed to assess the role of eRNA in MI-induced cardiac edema formation, infarct size, cardiac function, and survival after acute MI and to evaluate the ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(6):]

Cited: 9 times

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The Auditory System of the Dipteran Parasitoid Emblemasoma auditrix (Sarcophagidae).

Nanina Tron, Heiko Stölting, Marian Kampschulte, Gunhild Martels, Andreas Stumpner, Reinhard Lakes-Harlan,

Several taxa of insects evolved a tympanate ear at different body positions, whereby the ear is composed of common parts: a scolopidial sense organ, a tracheal air space, and a tympanal membrane. Here, we analyzed the anatomy and physiology of the ear at the ventral prothorax of the sarcophagid fly, ... Read more >>

J Insect Sci (Journal of insect science (Online))
[2016, 16(1):]

Cited: 1 time

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Sonothrombolysis with BR38 Microbubbles Improves Microvascular Patency in a Rat Model of Stroke.

Nadine Schleicher, Amelia J Tomkins, Marian Kampschulte, Jean-Marc Hyvelin, Catherine Botteron, Martin Juenemann, Mesut Yeniguen, Gabriele A Krombach, Manfred Kaps, Neil J Spratt, Tibo Gerriets, Max Nedelmann,

<h4>Background</h4>Early recanalization of large cerebral vessels in ischemic stroke is associated with improved clinical outcome, however persisting hypoperfusion leads to poor clinical recovery despite large vessel recanalization. Limited experimental sonothrombolysis studies have shown that addition of microbubbles during treatment can improve microvascular patency. We aimed to determine the effect of ... Read more >>

PLoS One (PloS one)
[2016, 11(4):e0152898]

Cited: 10 times

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Neovascularization of osteoporotic metaphyseal bone defects: A morphometric micro-CT study.

Marian Kampschulte, Gabriele A Krombach, Dana C Richards, Jonas Sender, Katrin S Lips, Ulrich Thormann, Thaqif El Khassawna, Seemun Ray, Volker Alt, Alexander C Langheinrich,

<h4>Purpose</h4>Neovascularization is essential for bone regeneration in fractures. This study aimed to investigate the microvascular morphology and distribution in the non-injured femur and the neovascularization of the metaphyseal critical size defect in a small animal model of osteoporosis.<h4>Materials and methods</h4>Female rats (n=7) were ovariectomized (OVX) and received a multideficiency diet. ... Read more >>

Microvasc Res (Microvascular research)
[2016, 105:7-14]

Cited: 4 times

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Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats.

Thaqif El Khassawna, Wolfgang Böcker, Katharina Brodsky, David Weisweiler, Parameswari Govindarajan, Marian Kampschulte, Ulrich Thormann, Anja Henss, Marcus Rohnke, Natali Bauer, Robert Müller, Andreas Deutsch, Anita Ignatius, Lutz Dürselen, Alexander Langheinrich, Katrin S Lips, Reinhard Schnettler, Christian Heiss,

Bone loss is a symptom related to disease and age, which reflects on bone cells and ECM. Discrepant regulation affects cell proliferation and ECM localization. Rat model of osteoporosis (OVX) was investigated against control rats (Sham) at young and old ages. Biophysical, histological and molecular techniques were implemented to examine ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2015, 144(5):491-507]

Cited: 10 times

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Bone status of acetylcholinesterase-knockout mice.

Vivien Kauschke, Mathias Kneffel, Wolfgang Floel, Sonja Hartmann, Marian Kampschulte, Lutz Dürselen, Anita Ignatius, Reinhard Schnettler, Christian Heiss, Katrin Susanne Lips,

Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh) to acetate and choline and thereby terminates nerve impulse transmission. ACh is also expressed in bone tissue and enhances here proliferation and differentiation of osteoblasts, which makes it interesting to investigate effects of AChE deficiency on bone. To our knowledge, this is the first study ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2015, 29(1):222-230]

Cited: 7 times

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Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer.

Anja Schmall, Hamza M Al-Tamari, Susanne Herold, Marian Kampschulte, Andreas Weigert, Astrid Wietelmann, Natasha Vipotnik, Friedrich Grimminger, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai,

<h4>Rationale</h4>Recent studies indicate that tumor-associated macrophages (MΦ) with an M2 phenotype can influence cancer progression and metastasis, but the regulatory pathways remain poorly characterized.<h4>Objectives</h4>This study investigated the role of tumor-associated MΦ in lung cancer.<h4>Methods</h4>Coculturing of MΦ with mouse Lewis lung carcinoma (LLC1) and 10 different human lung cancer cell lines ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2015, 191(4):437-447]

Cited: 71 times

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Bone status of adult female butyrylcholinesterase gene-deficient mice.

Malte Haupt, Vivien Kauschke, Jonas Sender, Marian Kampschulte, Anna Kovtun, Lutz Dürselen, Christian Heiss, Katrin Susanne Lips,

Butyrylcholinesterase (BChE) degrades acetylcholine in addition to acetylcholinesterase (AChE) which is involved in embryonic development of limbs. Since BChE is expressed by osteoblast-like cells we asked whether it is functional in adult bone remodeling. We addressed this issue by analyzing BChE gene-deficient mice (BChE-KO). Bones were extracted from 16-week old ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2015, 29(1):208-214]

Cited: 2 times

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