Full Text Journal Articles by
Author Maria Westerhoff

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Helicobacter pylori Antigen But Not the Organism Is Occasionally Present Within Germinal Centers: Implications for Patient Management and Biology.

Nya D Nelson, Rashmi Tondon, Danielle Fortuna, Maria Westerhoff, Paul E Swanson, Emma Furth,

Helicobacter pylori infection is present in two thirds of the world's population and induces a myriad of human diseases, ranging from gastritis to gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Detection is critical for treatment and may require immunohistochemical (IHC) staining when organisms are not visible on hematoxylin and eosin. ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(11):1528-1534]

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Interobserver study on histologic features of idiopathic non-cirrhotic portal hypertension.

Michel Kmeid, Chunlai Zuo, Stephen M Lagana, Won-Tak Choi, Jingmei Lin, Zhaohai Yang, Xiuli Liu, Maria Westerhoff, M Isabel Fiel, Kajsa Affolter, Eun-Young K Choi, Hwajeong Lee,

BACKGROUND:Histologic features of idiopathic non-cirrhotic portal hypertension (INCPH) may overlap with those without INCPH. Recently, these features have been recognized as part of the larger spectrum of porto-sinusoidal vascular disease (PSVD). We assessed interobserver agreement on histologic features that are commonly associated with INCPH and studied whether a provision of ... Read more >>

Diagn Pathol (Diagnostic pathology)
[2020, 15(1):129]

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Reproducibility of AJCC Criteria for Classifying Deeply Invasive Colon Cancers Is Suboptimal for Consistent Cancer Staging.

Nicole C Panarelli, Suntrea T G Hammer, Jingmei Lin, Purva Gopal, ILKe Nalbantoglu, Lili Zhao, Jerome Cheng, Adam J Gersten, Jonathan B McHugh, Vinita Parkash, Elena Lucas, Maria Westerhoff,

The eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual attempts to address ambiguity in the pT category assignment for colon cancer from prior editions. Despite modifications, the distinction between the pT3 and pT4a categories continues to be a source of diagnostic confusion. In this study, we ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(10):1381-1388]

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History!

Luke J Nayak, Arjun R Sondhi, Maria Westerhoff,

Gastroenterology (Gastroenterology)
[2020, :]

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Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.

Lei Zhao, Liyan Xu, Amanda Hemmerich, N Lynn Ferguson, Cynthia D Guy, Shannon J McCall, Diana M Cardona, Maria Westerhoff, Rish K Pai, Shu-Yuan Xiao, Beiyu Liu, Cynthia L Green, John Hart, Xuefeng Zhang,

The diagnosis of invasive adenocarcinoma of the gallbladder can sometimes be challenging. The presence of true desmoplastic reaction facilitates the diagnosis of invasion. However, desmoplasia-like changes can be observed in benign gallbladder conditions, and recognition of desmoplasia may be challenging based on morphology. In this study, we tested the expression ... Read more >>

Virchows Arch. (Virchows Archiv : an international journal of pathology)
[2020, :]

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Molecular and Immunohistochemical Analysis of Mucinous Cystic Neoplasm of the Liver.

Benjamin J Van Treeck, Mira Lotfalla, Thomas W Czeczok, Taofic Mounajjed, Roger K Moreira, Daniela S Allende, Michelle D Reid, Bita V Naini, Maria Westerhoff, N Volkan Adsay, Sarah E Kerr, Sumera H Rizvi, Rory L Smoot, Yuanhang Liu, Jaime Davila, Rondell P Graham,

OBJECTIVES:Mucinous cystic neoplasm of the liver is characterized by neoplastic mucinous and/or biliary epithelium surrounded by ovarian-type stroma. Immunohistochemical studies have shown that the ovarian-type stroma expresses estrogen receptor, suggesting potential hormonal responsiveness. The molecular biology of mucinous cystic neoplasm of the liver remains poorly studied. METHODS:Transcriptome sequencing and immunohistochemistry ... Read more >>

Am. J. Clin. Pathol. (American journal of clinical pathology)
[2020, :]

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Optimizing small liver biopsy specimens: a combined cytopathology and surgical pathology perspective.

Madelyn Lew, Erika M Hissong, Maria A Westerhoff, Laura W Lamps,

Both fine-needle aspiration (FNA) and core needle biopsy (CNB) are widely used to obtain liver biopsy specimens, particularly from mass lesions. However, the advantages and disadvantages of FNA versus CNB in terms of appropriate use, diagnostic yield, complications, and whether or not specimens should be handled by cytopathologists, surgical pathologists, ... Read more >>

J Am Soc Cytopathol (Journal of the American Society of Cytopathology)
[2020, 9(5):405-421]

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The complicated clinical course in a case of atypical lipodystrophy after development of neutralizing antibody to metreleptin: treatment with setmelanotide.

Baris Akinci, Rasimcan Meral, Diana Rus, Rita Hench, Adam H Neidert, Frank DiPaola, Maria Westerhoff, Simeon I Taylor, Elif A Oral,

Summary:A patient with atypical partial lipodystrophy who had a transient initial response to metreleptin experienced acute worsening of her metabolic state when neutralizing antibodies against metreleptin appeared. Because her metabolic status continued to deteriorate, a therapeutic trial with melanocortin-4 receptor agonist setmelanotide, that is believed to function downstream from leptin ... Read more >>

(Endocrinology, diabetes & metabolism case reports)
[2020, 2020:]

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Effect of immediate cold formalin fixation on phosphoprotein IHC tumor biomarker signal in liver tumors using a cold transport device.

Melissa L Lerch, Heidi L Kenerson, David Chafin, Maria Westerhoff, Abbey Theiss, Michael Otter, Raymond S Yeung, Geoffrey S Baird,

Phosphoproteins are the key indicators of signaling network pathway activation. Many disease treatment therapies are designed to inhibit these pathways and effective diagnostics are required to evaluate the efficacy of these treatments. Phosphoprotein IHC have been impractical for diagnostics due to inconsistent results occurring from technical limitations. We have designed ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2147]

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Two-stage biologically interpretable neural-network models for liver cancer prognosis prediction using histopathology and transcriptomic data

Lana Garmire, Zhucheng Zhan, Zheng Jing, Bing He, Noshad Hossenei, Maria Westerhoff, Eun-Young Choi,

Purpose: Pathological images are easily accessible data with the potential as prognostic biomarkers. Moreover, integration of heterogeneous data types from multi-modality, such as pathological image and gene expression data, is invaluable to help predicting cancer patient survival. However, the analytical challenges are significant. Experimental Design: Here we take the ... Read more >>

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Clinicopathologic features of Buschke-Löwenstein tumor: a multi-institutional analysis of 38 cases.

Dongwei Zhang, Raul S Gonzalez, Michael Feely, Kavita Umrau, Hwajeong Lee, Daniela S Allende, Dipti M Karamchandani, Michael Zaleski, Jingmei Lin, Maria Westerhoff, Xuchen Zhang, Lindsay Alpert, Xiaoyan Liao, Jinping Lai, Xiuli Liu,

Buschke-Löwenstein tumor (BLT) is a rare sexually transmitted disease, mostly described in clinical literature as case reports or small series. Here, we investigated the clinicopathologic features of BLT in a total of 38 cases retrieved from multiple academic institutions. The average age was 47.6 ± 12.8 (mean ± SD) years ... Read more >>

Virchows Arch. (Virchows Archiv : an international journal of pathology)
[2020, 476(4):543-550]

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Rapid tissue processing using a temperature-controlled collection device to preserve tumor biomarkers.

Melissa Lerch, Heidi Kenerson, Abbey Theiss, David Chafin, Maria Westerhoff, Michael Otter, Raymond Yeung, Geoffrey Baird,

Precision tissue diagnostics rely on high quality input specimens so that assay results are not affected by artifact, but advances in collection and processing of tissue specimens have lagged behind innovations in diagnostic assay development. Therefore, we have designed and evaluated a novel surgical tissue collection device that maintains and ... Read more >>

Cell Tissue Bank (Cell and tissue banking)
[2020, 21(1):89-97]

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Contributions From University of Michigan 2018 New Frontiers in Pathology Conference.

Lauren B Smith, Maria Westerhoff, David R Lucas,

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2019, 143(11):1302-1303]

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Varying practices in tumor regression grading of gastrointestinal carcinomas after neoadjuvant therapy: results of an international survey.

Maria Westerhoff, Marek Osecky, Rupert Langer,

Tumor regression grading is routinely performed on neoadjuvantly treated gastrointestinal cancer resections. Challenges in tumor regression grading include grossing standards, multiple grading systems, and difficulty interpreting therapy-induced changes. We surveyed gastrointestinal pathologists around the world for their practices in handling neoadjuvantly treated gastrointestinal cancer specimens and reporting tumor regression using ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(4):676-689]

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Increased Frequency of Heterozygous Alpha-1-Antitrypsin Deficiency in Liver Explants From Nonalcoholic Steatohepatitis Patients.

Gregory Cheeney, Lincoln J Pac, Purva Gopal, Charles S Landis, Eric Q Konnick, Paul E Swanson, Dina N Greene, Christina M Lockwood, Maria Westerhoff,

Cirrhotic explanted livers occasionally have unexpected periodic acid-Schiff-diastase (PASD)-positive globules within the hepatocyte cytoplasm. It is often unclear whether this finding is a nonspecific consequence of cirrhosis or is indicative of an underlying alpha-1-antitrypsin deficiency (A1ATD) contributing to the cirrhosis. In this study, explanted livers were retrospectively evaluated for histopathology ... Read more >>

Liver Transpl. (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2020, 26(1):17-24]

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Utility of glutamine synthetase immunohistochemistry in identifying features of regressed cirrhosis.

Rouba Hadi, Kseniya Shin, Nicholas Reder, Lindsay Alpert, Lisa Koch, Won-Tak Choi, Paul E Swanson, John Hart, Maria Westerhoff,

The prevailing view that cirrhosis is irreversible has been challenged. It has been proposed that varying degrees of fibrosis regression can be achieved if the injurious agent is removed. In the normal liver, glutamine synthetase immunostaining is present around central veins. In regressed cirrhosis, although fibrous bands between portal tracts ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(3):448-455]

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Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma.

Lei Zhao, Maria Westerhoff, Jason L Hornick, Thomas Krausz, Tatjana Antic, Shu-Yuan Xiao, John Hart,

MFAP5, a 25-kD microfibril-associated glycoprotein that is involved in elastic microfibril assembly, has been demonstrated to be significantly downregulated in tumor stroma by previous gene expression study. The aim of this study was to confirm the reduced expression of MFAP5 in colonic tumor stroma using immunohistochemistry and to explore the ... Read more >>

Virchows Arch. (Virchows Archiv : an international journal of pathology)
[2020, 476(3):383-390]

Cited: 1 time

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Challenges with colorectal cancer staging: results of an international study.

Dipti M Karamchandani, Runjan Chetty, Tonya S King, Xiuli Liu, Maria Westerhoff, Zhaohai Yang, Rhonda K Yantiss, David K Driman,

Challenges exist with standardized colorectal cancer reporting despite adoption of the American Joint Committee on Cancer-Staging Manual 8th edition. We performed this study to gauge current practice patterns among a diverse group of surgical pathologists. A web-based questionnaire depicting problematic issues and images related to colorectal carcinoma staging was circulated ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(1):153-163]

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Vanishing bile duct syndrome arising in a patient with HIV infection sequentially treated with trimethoprim/sulfamethoxazole and dapsone.

Pradeep Reddy Kathi, Maher Tama, Murray Ehrinpreis, Milton Mutchnick, Maria Westerhoff, Jonathan Mowers, Robert John Fontana,

Trimethoprim/sulfamethoxazole is well known to cause intra-hepatic cholestasis which in rare instances can be prolonged and lead to vanishing bile duct syndrome. The risk regarding the potential for cross-reactivity between structurally related molecules such as dapsone and trimethoprim/sulfamethoxazole in causing hepatotoxicity is scarce. Herein, we report a case of vanishing ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2020, 13(2):276-280]

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Natural history of ROHHAD syndrome: development of severe insulin resistance and fatty liver disease over time.

Abdel Wahab Jalal Eldin, Dilara Tombayoglu, Laura Butz, Alison Affinati, Rasimcan Meral, Mehmet Selman Ontan, Kelly Walkovich, Maria Westerhoff, Jeffrey W Innis, Neehar D Parikh, Elif A Oral,

Background:Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare syndrome with unknown etiology. Metabolic abnormalities are not known to be part of the syndrome. We present one of the oldest cases reported in the literature, who developed severe metabolic abnormalities and hepatic disease suggesting that these features may ... Read more >>

(Clinical diabetes and endocrinology)
[2019, 5:9]

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A Rare Complication of a Rare Disease.

Luke J Nayak, Arjun R Sondhi, Maria Westerhoff,

Gastroenterology (Gastroenterology)
[2019, 157(3):616-618]

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The Clinical Significance of Crohn Disease Activity at Resection Margins.

Sasan Setoodeh, Li Liu, Sarag A Boukhar, Amit G Singal, Maria Westerhoff, Akbar K Waljee, Tasneem Ahmed, Purva Gopal,

CONTEXT.—:Conflicting data about the clinical significance of microscopic Crohn disease (CD) activity at resection margins have led to varying practice patterns for routine reporting by pathologists. OBJECTIVE.—:To characterize the association between active disease at resection margins with postoperative CD recurrence and time-to-recurrence in the era of anti-tumor necrosis factor therapy. ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2019, 143(4):505-509]

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Implications of Epigenetic Drift in Colorectal Neoplasia.

Georg E Luebeck, William D Hazelton, Kit Curtius, Sean K Maden, Ming Yu, Kelly T Carter, Wynn Burke, Paul D Lampe, Christopher I Li, Cornelia M Ulrich, Polly A Newcomb, Maria Westerhoff, Andrew M Kaz, Yanxin Luo, John M Inadomi, William M Grady,

Many normal tissues undergo age-related drift in DNA methylation, providing a quantitative measure of tissue age. Here, we identify and validate 781 CpG islands (CGI) that undergo significant methylomic drift in 232 normal colorectal tissues and show that these CGI continue to drift in neoplasia while retaining significant correlations across ... Read more >>

Cancer Res (Cancer research)
[2019, 79(3):495-504]

Cited: 5 times

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Contributions From University of Michigan 2017 New Frontiers in Pathology Conference.

Lauren B Smith, Maria Westerhoff, David R Lucas,

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2018, 142(10):1157-1158]

Cited: 0 times

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Refractory inflammatory bowel disease: is there a role for Epstein-Barr virus? A case-controlled study using highly sensitive Epstein-Barr virus-encoded small RNA1 in situ hybridization.

Maryam Kherad Pezhouh, James Adam Miller, Rajni Sharma, David Borzik, Ogechukwu Eze, Kevin Waters, Maria A Westerhoff, Alyssa M Parian, Mark G Lazarev, Lysandra Voltaggio,

A potential role for viral infections has been implicated in inflammatory bowel disease (IBD) unresponsive to medical treatment. It is well known that Epstein-Barr virus (EBV) infection can elicit a brisk mononuclear response in the gastrointestinal tract. The aim of this study was to further evaluate the role of EBV ... Read more >>

Hum. Pathol. (Human pathology)
[2018, 82:187-192]

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