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Author Maria Trinidad Herrero

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Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease: focus on sex-specific associations with vascular outcomes and all-cause mortality.

Agne Laucyte-Cibulskiene, Liam J Ward, Thomas Ebert, Giulia Tosti, Claudia Tucci, Leah Hernandez, Alexandra Kautzky-Willer, Maria-Trinidad Herrero, Colleen M Norris, Louise Pilote, Magnus Söderberg, Torkel B Brismar, Jonaz Ripsweden, Peter Stenvinkel, Valeria Raparelli, Karolina Kublickiene, ,

<h4>Background</h4>Sex differences are underappreciated in the current understanding of cardiovascular disease (CVD) in association with chronic kidney disease (CKD). A hallmark of CKD is vascular aging that is characterised, amongst others, by; systemic inflammation, microbiota disbalance, oxidative stress, and vascular calcification-features linked to atherosclerosis/arteriosclerosis development. Thus, it is the necessary ... Read more >>

Biol Sex Differ (Biology of sex differences)
[2021, 12(1):50]

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Determinants of perceived health and unmet healthcare needs in universal healthcare systems with high gender equality.

Christina P Tadiri, Teresa Gisinger, Alexandra Kautzky-Willer, Karolina Kublickiene, Maria Trinidad Herrero, Colleen M Norris, Valeria Raparelli, Louise Pilote, ,

<h4>Background</h4>Patient attitudes about health and healthcare have emerged as important outcomes to assess in clinical studies. Gender is increasingly recognized as an intersectional social construct that may influence health. Our objective was to determine potential sex differences in self-reported overall health and access to healthcare and whether those differences are ... Read more >>

BMC Public Health (BMC public health)
[2021, 21(1):1488]

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Can synthetic data be a proxy for real clinical trial data? A validation study.

Zahra Azizi, Chaoyi Zheng, Lucy Mosquera, Louise Pilote, Khaled El Emam, ,

<h4>Objectives</h4>There are increasing requirements to make research data, especially clinical trial data, more broadly available for secondary analyses. However, data availability remains a challenge due to complex privacy requirements. This challenge can potentially be addressed using synthetic data.<h4>Setting</h4>Replication of a published stage III colon cancer trial secondary analysis using synthetic ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e043497]

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Identification and inclusion of gender factors in retrospective cohort studies: the GOING-FWD framework.

Valeria Raparelli, Colleen M Norris, Uri Bender, Maria Trinidad Herrero, Alexandra Kautzky-Willer, Karolina Kublickiene, Khaled El Emam, Louise Pilote, ,

Gender refers to the socially constructed roles, behaviours, expressions and identities of girls, women, boys, men and gender diverse people. Gender-related factors are seldom assessed as determinants of health outcomes, despite their powerful contribution. The Gender Outcomes INternational Group: to Further Well-being Development (GOING-FWD) project developed a standard five-step methodology ... Read more >>

BMJ Glob Health (BMJ global health)
[2021, 6(4):]

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Sex, Gender, and Cardiovascular Health in Canadian and Austrian Populations.

Zahra Azizi, Teresa Gisinger, Uri Bender, Carola Deischinger, Valeria Raparelli, Colleen M Norris, Karolina Kublickiene, Maria Trinidad Herrero, Khaled El Emam, Alexandra Kautzky-Willer, Louise Pilote, ,

<h4>Background</h4>Evidence differentiating the effect of biological sex from psychosociocultural factors (gender) in different societies and its relation to cardiovascular diseases is scarce. We explored the association between sex, gender, and cardiovascular health (CVH) among Canadian (CAN) and Austrian (AT) populations.<h4>Methods</h4>The Canadian Community Health Survey (CCHS) (n = 63,522; 55% female) and Austrian ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2021, 37(8):1240-1247]

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A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity.

Lorena Cuenca-Bermejo, Elisa Pizzichini, Valeria C Gonçalves, María Guillén-Díaz, Elena Aguilar-Moñino, Consuelo Sánchez-Rodrigo, Ana-María González-Cuello, Emiliano Fernández-Villalba, María Trinidad Herrero,

The diurnal rodent <i>Octodon degus</i> (<i>O. degus</i>) is considered an attractive natural model for Alzheimer's disease and other human age-related features. However, it has not been explored so far if the <i>O. degus</i> could be used as a model to study Parkinson's disease. To test this idea, 10 adult male ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(9):]

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Cardiac Tyrosine Hydroxylase Activation and Mb-Comt in Dyskinetic Monkeys

Lorena Cuenca-Bermejo, Pilar Almela, Pablo Gallo-Soljancic, José Yuste, Vicente de Pablos, Victor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

The impact of age-associated disorders is increasing as the life expectancy of the population increments. Cardiovascular diseases and neurodegenerative disorders, such as Parkinson’s disease, have the highest social and economic burden and increasing evidence show interrelations between them. Particularly, dysfunction of the cardiovascular nervous system is part of the dysautonomic ... Read more >>

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Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson's Disease?

Javier Navarro-Zaragoza, Lorena Cuenca-Bermejo, Pilar Almela, María-Luisa Laorden, María-Trinidad Herrero,

Small heat shock proteins (HSPs), such as HSP27, are ubiquitously expressed molecular chaperones and are essential for cellular homeostasis. The major functions of HSP27 include chaperoning misfolded or unfolded polypeptides and protecting cells from toxic stress. Dysregulation of stress proteins is associated with many human diseases including neurodegenerative diseases, such ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

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Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson’s Disease?

Javier Navarro-Zaragoza, Lorena Cuenca-Bermejo, Pilar Almela, María-Luisa Laorden, María-Trinidad Herrero,

Small heat shock proteins (HSPs), such as HSP27, are ubiquitously expressed molecular chaperones and are essential for cellular homeostasis. The major functions of HSP27 include chaperoning misfolded or unfolded polypeptides and protecting cells from toxic stress. Dysregulation of stress proteins is associated with many human diseases including neurodegenerative diseases, such ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

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Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson's Disease.

Valeria C Gonçalves, Lorena Cuenca-Bermejo, Emiliano Fernandez-Villalba, Sebastian Martin-Balbuena, Maria Jose da Silva Fernandes, Carla A Scorza, Maria-Trinidad Herrero,

It has been more than 200 years since James Parkinson made the first descriptions of the disease that bears his name. Since then, knowledge about Parkinson's disease has been improved, and its pathophysiology, diagnosis, and treatments are well described in the scientific and medical literature. However, there is no way ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421990000]

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A Causal Role for the Right Dorsolateral Prefrontal Cortex in Avoidance of Risky Choices and Making Advantageous Selections.

Ignacio Obeso, Maria-Trinidad Herrero, Romain Ligneul, John C Rothwell, Marjan Jahanshahi,

In everyday life, risky decision-making relies on multiple cognitive processes including sensitivity to reinforcers, exploration, learning, and forgetting. Neuroimaging evidence suggests that the dorsolateral prefrontal cortex (DLPFC) is involved in exploration and risky decision-making, but the nature of its computations and its causal role remain uncertain. We provide evidence for ... Read more >>

Neuroscience (Neuroscience)
[2021, 458:166-179]

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Octodon degus: a natural model of multimorbidity for ageing research.

Lorena Cuenca-Bermejo, Elisa Pizzichini, Ana Maria Gonzalez-Cuello, Maria Egle De Stefano, Emiliano Fernandez-Villalba, María-Trinidad Herrero,

Integrating the multifactorial processes co-occurring in both physiological and pathological human conditions still remains one of the main challenges in translational investigation. Moreover, the impact of age-associated disorders has increased, which underlines the urgent need to find a feasible model that could help in the development of successful therapies. In ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2020, 64:101204]

Cited: 1 time

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Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy.

Fillipe M de Araújo, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Silvia L Costa, Victor Diogenes A Silva, Maria Trinidad Herrero,

Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the Substantia Nigra pars compacta (SNpc) and deficit of dopamine in the basal ganglia. These motor symptoms can be preceded by pre-motor symptoms ... Read more >>

Cell Mol Neurobiol (Cellular and molecular neurobiology)
[2021, :]

Cited: 6 times

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Cardiac Tyrosine Hydroxylase Activation and MB-COMT in Dyskinetic Monkeys 

Lorena Cuenca-Bermejo, Pilar Almela, Pablo Gallo-Soljancic, Jose Yuste, Vicente de Pablos, Víctor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

<h4>Background: </h4> The impact of age-associated disorders is increasing as the life expectancy of the population increments. Cardiovascular diseases and neurodegenerative disorders, such as Parkinson’s disease, have the highest social and economic burden and increasing evidence show interrelations between them. Particularly, dysfunction of the cardiovascular nervous system is part of ... Read more >>

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The influence of sex and gender domains on COVID-19 cases and mortality.

Christina P Tadiri, Teresa Gisinger, Alexandra Kautzy-Willer, Karolina Kublickiene, Maria Trinidad Herrero, Valeria Raparelli, Louise Pilote, Colleen M Norris, ,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(36):E1041-E1045]

Cited: 12 times

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Methods for prospectively incorporating gender into health sciences research.

Christina P Tadiri, Valeria Raparelli, Michal Abrahamowicz, Alexandra Kautzy-Willer, Karolina Kublickiene, Maria-Trinidad Herrero, Colleen M Norris, Louise Pilote, ,

Numerous studies have demonstrated that sex (a biological variable) and gender (a psychosocial construct) impact health and have discussed the mechanisms that may explain these relationships. Funding agencies have called for all health researchers to incorporate sex and gender into their studies; however, the way forward has been unclear to ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2021, 129:191-197]

Cited: 2 times

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Study of the Link Between Neuronal Death, Glial Response, and MAPK Pathway in Old Parkinsonian Mice.

Ana Luisa Gil-Martinez, Lorena Cuenca-Bermejo, Pablo Gallo-Soljancic, Consuelo Sanchez-Rodrigo, Virginia Izura, Harry W M Steinbusch, Emiliano Fernandez-Villalba, Maria Trinidad Herrero,

<b>Background</b>: Parkinson's disease (PD) is described as an age-related neurodegenerative disorder. However, the vast majority of research is carried out using experimental models of young animals lacking the implications of the decline processes associated with aging. It has been suggested that several molecular pathways are involved in the perpetuation of ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:214]

Cited: 1 time

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Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates.

Marie-Laure Arotcarena, Sandra Dovero, Alice Prigent, Mathieu Bourdenx, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Maddalena Tasselli, Philippe Aubert, Niels Kruse, Brit Mollenhauer, Ines Trigo Damas, Cristina Estrada, Nuria Garcia-Carrillo, Nishant N Vaikath, Omar M A El-Agnaf, Maria Trinidad Herrero, Miquel Vila, Jose A Obeso, Pascal Derkinderen, Benjamin Dehay, Erwan Bezard,

In Parkinson's disease, synucleinopathy is hypothesized to spread from the enteric nervous system, via the vagus nerve, to the CNS. Here, we compare, in baboon monkeys, the pathological consequences of either intrastriatal or enteric injection of α-synuclein-containing Lewy body extracts from patients with Parkinson's disease. This study shows that patient-derived ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(5):1462-1475]

Cited: 19 times

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The Gender Outcomes International Group: to Further Well-being Development (Going-fwd) Methodology on Identification and Inclusion of Gender Factors in Retrospective Cohort Studies

Valeria Raparelli Raparelli, Colleen Norris, Uri Bender, Maria Trinidad Herrero, Alexandra Kautzky-Willer, Karolina Kublickiene, Khaled El Emam, Louise Pilote,

<h4>Background: </h4> Gender refers to the socially constructed roles, behaviors, expressions, and identities of girls, women, boys, men, and gender diverse people. It influences self-perception, individual’s actions and interactions, as well as the distribution of power and resources in society. Gender-related factors are seldom assessed as determinants of health outcomes, ... Read more >>

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Cardiac Noradrenaline Turnover and Heat Shock Protein 27 Phosphorylation in Dyskinetic Monkeys.

Pilar Almela, Lorena Cuenca-Bermejo, José E Yuste, Cristina Estrada, Vicente de Pablos, Víctor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

<h4>Background</h4>Autonomic dysfunction is a well-known dominant symptom in the advanced stages of Parkinson's disease. However, the role of cardiac sympathetic nerves still needs to be elucidated.<h4>Objectives</h4>To evaluate cardiac sympathetic response in Parkinsonian and dyskinetic monkeys.<h4>Methods</h4>Adult male monkeys were divided into 1 of the following 3 groups: controls, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys, and ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(4):698-703]

Cited: 1 time

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A role for DJ-1 against oxidative stress in the mammalian retina.

José Martín-Nieto, Mary Luz Uribe, Julián Esteve-Rudd, María Trinidad Herrero, Laura Campello,

We have previously reported the expression of Parkinson disease-associated genes encoding α-synuclein, parkin and UCH-L1 in the retina across mammals. DJ-1, or parkinsonism-associated deglycase, is a redox-sensitive protein with putative roles in cellular protection against oxidative stress, among a variety of functions, acting through distinct pathways and mechanisms in a ... Read more >>

Neurosci Lett (Neuroscience letters)
[2019, 708:134361]

Cited: 4 times

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Voluntary exercise reduces plasma cortisol levels and improves transitory memory impairment in young and aged Octodon degus.

Cristina Estrada, Lorena Cuenca, Lorena Cano-Fernandez, Ana Luisa Gil-Martinez, Consuelo Sanchez-Rodrigo, Ana Maria González-Cuello, Emiliano Fernandez-Villalba, Maria Trinidad Herrero,

Sleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer's disease (AD). SD emulates many aging-related modifications, including important memory dysfunctions possibly caused by triggers of stress such ... Read more >>

Behav Brain Res (Behavioural brain research)
[2019, 373:112066]

Cited: 1 time

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Local Gastrointestinal Injury Exacerbates Inflammation and Dopaminergic Cell Death in Parkinsonian Mice.

Ana-Luisa Gil-Martínez, Cristina Estrada, Lorena Cuenca, Juan-Antonio Cano, Manuel Valiente, Carlos-Manuel Martínez-Cáceres, Emiliano Fernández-Villalba, María-Trinidad Herrero,

The cause of progressive degeneration in Parkinson's disease is not clear, although, in the last years, different studies have suggested that both brain and peripheral inflammation could play a key role in the progression of this disorder. In our study, we aimed to analyze the effect of an acute inflammation ... Read more >>

Neurotox Res (Neurotoxicity research)
[2019, 35(4):918-930]

Cited: 3 times

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Unexpected Exacerbation of Neuroinflammatory Response After a Combined Therapy in Old Parkinsonian Mice.

Ana Luisa Gil-Martínez, Lorena Cuenca, Cristina Estrada, Consuelo Sánchez-Rodrigo, Emiliano Fernández-Villalba, María Trinidad Herrero,

The design of therapeutic strategies that focus on the repositioning of anti-inflammatory and antioxidant drugs are a great bet to slow down the progression of neurodegenerative disorders. Despite the fact that Parkinson's disease (PD) is an age-related pathology, almost all experimental studies are carried out in young animals. Here, we ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2018, 12:451]

Cited: 4 times

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Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential?

Ana-Luisa Gil-Martínez, Lorena Cuenca, Consuelo Sánchez, Cristina Estrada, Emiliano Fernández-Villalba, María Trinidad Herrero,

<h4>Background</h4>Neuroprotective strategies are becoming relevant to slow down dopaminergic cell death and inflammatory processes related to the progressive neurodegeneration in Parkinson's disease (PD). Interestingly, among others, physical activity (PA) or anti-oxidant agents (such as N-acetyl-L-cysteine, NAC) are common therapeutic strategies. Therefore, this study aims to analyze if there is a ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2018, 15(1):328]

Cited: 7 times

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