Full Text Journal Articles by
Author Maria Keller

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Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial.

Anat Yaskolka Meir, Maria Keller, Stephan H Bernhart, Ehud Rinott, Gal Tsaban, Hila Zelicha, Alon Kaplan, Dan Schwarzfuchs, Ilan Shelef, Yftach Gepner, Jun Li, Yifei Lin, Matthias Blüher, Uta Ceglarek, Michael Stumvoll, Peter F Stadler, Meir J Stampfer, Peter Kovacs, Liming Liang, Iris Shai,

<h4>Background</h4>DNA methylation age (mAge), a methylation biomarker for the aging process, might serve as a more accurate predictor of morbidity and aging status than chronological age. We evaluated the role of multiple factors, including fat deposition, cardiometabolic risk factors and lifestyle weight-loss intervention, on the deviation of mAge from chronological ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2021, 13(1):48]

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Kidney Transplant Evaluation and Listing: Development and Preliminary Evaluation of Multimedia Education for Patients.

Liise K Kayler, Beth Dolph, Molly Ranahan, Maria Keller, Renee Cadzow, Thomas H Feeley,

BACKGROUND Patient knowledge gaps about the evaluation and waitlisting process for kidney transplantation lead to delayed and incomplete testing, which compromise transplant access. We aimed to develop and evaluate a novel video education approach to empower patients to proceed with the transplant evaluation and listing process and to increase their ... Read more >>

Ann Transplant (Annals of transplantation)
[2021, 26:e929839]

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DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial.

Maria Keller, Anat Yaskolka Meir, Stephan H Bernhart, Yftach Gepner, Ilan Shelef, Dan Schwarzfuchs, Gal Tsaban, Hila Zelicha, Lydia Hopp, Luise Müller, Kerstin Rohde, Yvonne Böttcher, Peter F Stadler, Michael Stumvoll, Matthias Blüher, Peter Kovacs, Iris Shai,

<h4>Background</h4>One of the major challenges in obesity treatment is to explain the high variability in the individual's response to specific dietary and physical activity interventions. With this study, we tested the hypothesis that specific DNA methylation changes reflect individual responsiveness to lifestyle intervention and may serve as epigenetic predictors for ... Read more >>

Genome Med (Genome medicine)
[2020, 12(1):97]

Cited: 1 time

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Technology access and use among kidney transplant candidates vulnerable to health disparities.

Sophia Smith, Jing Nie, Katia Noyes, Maria Keller, Liise Kayler,

Clin Transplant (Clinical transplantation)
[2020, 34(11):e14012]

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#BlackBreastsMatter: Process Evaluation of Recruitment and Engagement of Pregnant African American Women for a Social Media Intervention Study to Increase Breastfeeding.

Cassy Dauphin, Nikia Clark, Renee Cadzow, Frances Saad-Harfouche, Elisa Rodriguez, Kathryn Glaser, Marc Kiviniemi, Maria Keller, Deborah Erwin,

<h4>Background</h4>In the United States, there are lower rates of breastfeeding among African American mothers, particularly those who are younger women. Recent epidemiological studies have shown a strong association of more aggressive types of breast cancer (estrogen receptor negative) among African American women, with a higher risk in African American women ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2020, 22(8):e16239]

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Genetically programmed changes in transcription of the novel progranulin regulator.

Maria Keller, Claudia Gebhardt, Sandra Huth, Dorit Schleinitz, Henrike Heyne, Markus Scholz, Michael Stumvoll, Yvonne Böttcher, Anke Tönjes, Peter Kovacs,

Progranulin is a glycoprotein marking chronic inflammation in obesity and type 2 diabetes. Previous studies suggested PSRC1 (proline and serine rich coiled-coil 1) to be a target of genetic variants associated with serum progranulin levels. We aimed to identify potentially functional variants and characterize their role in regulation of PSRC1. ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2020, 98(8):1139-1148]

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Is it disgusting or am I just easily disgusted? The relation between situational disgust, dispositional disgust, and colonoscopy intentions.

Lynne B Klasko-Foster, Maria M Keller, Marc T Kiviniemi,

<h4>Objective</h4>While early detection is an effective way to reduce mortality from colorectal cancer, screening rates are low. An underlying factor in screening completion failure may be experiences of disgust when learning about screening and/or dispositional disgust.<h4>Method</h4>Participants recruited via Amazon MTurk (N = 296) read information about colonoscopy and completed an online survey ... Read more >>

Eur J Cancer Care (Engl) (European journal of cancer care)
[2020, 29(5):e13244]

Cited: 0 times

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Educational Animations to Inform Transplant Candidates About Deceased Donor Kidney Options: An Efficacy Randomized Trial.

Liise K Kayler, Beth A Dolph, Chelsea N Cleveland, Maria M Keller, Thomas H Feeley,

<h4>Background</h4>Transplant candidates struggle making decisions about accepting kidneys with variable kidney donor profile index (KDPI) and increased risk donor (IRD) status.<h4>Methods</h4>This single site, pilot randomized controlled trial evaluated the efficacy of 2 animations to improve KDPI/IRD knowledge, decisional self-efficacy, and willingness. Kidney candidates were randomly assigned to animation viewing plus ... Read more >>

Transplant Direct (Transplantation direct)
[2020, 6(7):e575]

Cited: 1 time

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Development of the living donation and kidney transplantation information made easy (KidneyTIME) educational animations.

Liise K Kayler, Beth Dolph, Rachel Seibert, Maria Keller, Renee Cadzow, Thomas H Feeley,

BACKGROUND:Current web-based educational approaches about living kidney donation (LKD) are complex, lengthy, and/or text-laden, which may impair accurate interpretation of information, thereby limiting kidney transplant access. PURPOSE:This paper describes the process of developing animation-based LKD education designed to be suitable for and acceptable to kidney transplant candidates and their support ... Read more >>

Clin Transplant (Clinical transplantation)
[2020, 34(4):e13830]

Cited: 2 times

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Role of the DNA repair genes H2AX and HMGB1 in human fat distribution and lipid profiles.

Kerstin Rohde, Torunn Rønningen, Lars la Cour Poulsen, Maria Keller, Matthias Blüher, Yvonne Böttcher,

<h4>Introduction</h4>Regional fat distribution strongly relates to metabolic comorbidities. We identified the DNA repair genes <i>H2AX</i> and <i>HMGB1</i> to be differentially expressed between human subcutaneous (SAT) and omental visceral adipose tissue (OVAT) depots. As increased DNA damage is linked to metabolic disease, we here sought to analyze whether depot-specific <i>H2AX</i> and ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

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Development and preliminary evaluation of ilearnKAS: An animated video about kidney allocation to support transplant decision-making.

Liise K Kayler, Maria M Keller, Natalia Crenesse-Cozien, Beth Dolph, Renee Cadzow, Thomas H Feeley,

<h4>Background</h4>We aimed to develop and feasibility test an educational video culturally targeted to African American (AA) patients regarding kidney allocation.<h4>Methods</h4>We iteratively refined an animated video for AAs with multiple stakeholder input and conducted a one-group, pre-post study with 50 kidney transplant candidates to assess video feasibility and acceptability. A mixed ... Read more >>

Clin Transplant (Clinical transplantation)
[2019, 33(8):e13638]

Cited: 0 times

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(Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution.

Kerstin Rohde, Maria Keller, Lars la Cour Poulsen, Torunn Rønningen, Michael Stumvoll, Anke Tönjes, Peter Kovacs, Annette Horstmann, Arno Villringer, Matthias Blüher, Yvonne Böttcher,

<h4>Background</h4>In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding and chromatin structure, implying epigenetic regulation of CRTC1. We sought to understand the relevance of CRTC1 SNPs, DNA ... Read more >>

EBioMedicine (EBioMedicine)
[2019, 44:476-488]

Cited: 2 times

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Treatment with the long-acting insulin analog degludec during pregnancy in women with type 1 diabetes: An observational study of 22 cases.

Maria Fredsgaard Keller, Marianne Vestgaard, Peter Damm, Elisabeth Reinhardt Mathiesen, Lene Ringholm,

<h4>Aim</h4>To report glycemic control and pregnancy outcome in pregnant women with type 1 diabetes on insulin degludec.<h4>Methods</h4>Twenty-two women with type 1 diabetes on degludec from conception to delivery between 2014 and 2018 were compared with 51 pregnant women with type 1 diabetes on glargine.<h4>Results</h4>Baseline characteristics were comparable, however HbA1c was ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2019, 152:58-64]

Cited: 0 times

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Genetics and epigenetics in obesity.

Kerstin Rohde, Maria Keller, Lars la Cour Poulsen, Matthias Blüher, Peter Kovacs, Yvonne Böttcher,

Obesity is among the most threatening health burdens worldwide and its prevalence has markedly increased over the last decades. Obesity maybe considered a heritable trait. Identifications of rare cases of monogenic obesity unveiled that hypothalamic circuits and the brain-adipose axis play an important role in the regulation of energy homeostasis, ... Read more >>

Metabolism (Metabolism: clinical and experimental)
[2019, 92:37-50]

Cited: 22 times

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DNA methylation of SSPN is linked to adipose tissue distribution and glucose metabolism.

Maria Keller, Matthias Klös, Kerstin Rohde, Jacqueline Krüger, Tabea Kurze, Arne Dietrich, Michael R Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Michael Stumvoll, Matthias Blüher, Peter Kovacs, Yvonne Böttcher,

DNA methylation is a crucial epigenetic mechanism in obesity and fat distribution. We explored the Sarcospan ( SSPN) gene locus by using genome-wide data sets comprising methylation and expression data, pyrosequencing analysis in the promoter region, and genetic analysis of an SNP variant rs718314, which was previously reported to associate ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2018, :fj201800528R]

Cited: 2 times

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The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden: the GLACIER Study.

Yan Chen, Angela C Estampador, Maria Keller, Alaitz Poveda, Jonathan Dalla-Riva, Ingegerd Johansson, Frida Renström, Azra Kurbasic, Paul W Franks, Tibor V Varga,

BACKGROUND:Recent analyses in Greenlandic Inuit identified six genetic polymorphisms (rs74771917, rs3168072, rs12577276, rs7115739, rs174602 and rs174570) in the fatty acid desaturase gene cluster (FADS1-FADS2-FADS3) that are associated with multiple metabolic and anthropometric traits. Our objectives were to systematically assess whether dietary polyunsaturated fatty acid (PUFA) intake modifies the associations between ... Read more >>

Int J Obes (Lond) (International journal of obesity (2005))
[2019, 43(4):808-820]

Cited: 2 times

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IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits.

Kerstin Rohde, Matthias Klös, Lydia Hopp, Xuanshi Liu, Maria Keller, Michael Stumvoll, Arne Dietrich, Michael R Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Peter Kovacs, Hans Binder, Matthias Blüher, Yvonne Böttcher,

The SNP variant rs2943650 near IRS1 gene locus was previously associated with decreased body fat and IRS1 gene expression as well as an adverse metabolic profile in humans. Here, we hypothesize that these effects may be mediated by an interplay with epigenetic alterations. We measured IRS1 promoter DNA methylation and ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):12369]

Cited: 3 times

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Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity.

Maria Keller, Lydia Hopp, Xuanshi Liu, Tobias Wohland, Kerstin Rohde, Raffaella Cancello, Matthias Klös, Karl Bacos, Matthias Kern, Fabian Eichelmann, Arne Dietrich, Michael R Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Michael Stumvoll, Peter Kovacs, Anna-Maria DiBlasio, Charlotte Ling, Hans Binder, Matthias Blüher, Yvonne Böttcher,

<h4>Objective/methods</h4>DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter methylation along with mRNA profiles in paired samples of human subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) from non-obese <i>vs.</i> obese individuals.<h4>Results</h4>We identified negatively correlated methylation and expression of several ... Read more >>

Mol Metab (Molecular metabolism)
[2017, 6(1):86-100]

Cited: 33 times

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DNA 5-hydroxymethylation in human adipose tissue differs between subcutaneous and visceral adipose tissue depots.

Kerstin Rohde, Maria Keller, Michael Stumvoll, Arne Dietrich, Matthias Blüher, Yvonne Böttcher,

<h4>Background</h4>A stable intermediate during DNA demethylation, 5-hydroxymethylcytosine (5-hmC), raises questions about its function and distribution. Therefore, we tested whether 5-hmC exists in human adipose tissue depots and correlates with clinical variables.<h4>Materials & methods</h4>We measured the % 5-hmC content in both subcutaneous adipose tissue and visceral adipose tissue (VAT) from 81 ... Read more >>

Epigenomics (Epigenomics)
[2015, 7(6):911-920]

Cited: 2 times

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Genetic variants in AKR1B10 associate with human eating behavior.

Kerstin Rohde, Martin Federbusch, Annette Horstmann, Maria Keller, Arno Villringer, Michael Stumvoll, Anke Tönjes, Peter Kovacs, Yvonne Böttcher,

<h4>Background</h4>The human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to the family of aldoketoreductases and may be involved in detoxification of nutrients during digestion. Further, AKR1B10 mRNA (messenger ribonucleic acid) expression was diminished in brain regions potentially involved in the regulation of eating behavior in rats which ... Read more >>

BMC Genet (BMC genetics)
[2015, 16:31]

Cited: 5 times

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Role of genetic variants in ADIPOQ in human eating behavior.

Kerstin Rohde, Maria Keller, Annette Horstmann, Xuanshi Liu, Fabian Eichelmann, Michael Stumvoll, Arno Villringer, Peter Kovacs, Anke Tönjes, Yvonne Böttcher,

The beneficial effects of adiponectin and its negative correlation with BMI are well described. Adiponectin serum levels are altered in eating disorders such as anorexia nervosa, bulimia nervosa or binge eating. Here, we tested the hypothesis that (1) adiponectin serum levels correlate with human eating behavior factors and (2) that ... Read more >>

Genes Nutr (Genes & nutrition)
[2015, 10(1):449]

Cited: 9 times

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Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis.

Maria Keller, Susan Kralisch, Kerstin Rohde, Dorit Schleinitz, Arne Dietrich, Michael R Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Anke Tönjes, Michael Stumvoll, Peter Kovacs, Mathias Fasshauer, Matthias Blüher, Yvonne Böttcher,

<h4>Aims/hypothesis</h4>Epigenetic alterations may influence the metabolic pathways involved in human obesity. We hypothesised that global DNA methylation levels in adipose tissue might be associated with obesity and related phenotypes.<h4>Methods</h4>We measured global DNA methylation levels in paired samples of subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) from 51 ... Read more >>

Diabetologia (Diabetologia)
[2014, 57(11):2374-2383]

Cited: 19 times

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Adipose tissue depot specific promoter methylation of TMEM18.

Kerstin Rohde, Maria Keller, Matthias Klös, Dorit Schleinitz, Arne Dietrich, Michael R Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Michael Stumvoll, Peter Kovacs, Matthias Blüher, Yvonne Böttcher,

<h4>Unlabelled</h4>Epigenetic processes such as dynamic promoter methylation may play a role in obesity, fat distribution and its accompanied metabolic alterations. TMEM18 is a candidate gene for body mass index (BMI) comprising the second largest effect size among all loci identified so far via GWAS. We hypothesized that differential TMEM18 gene ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2014, 92(8):881-888]

Cited: 7 times

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TAS2R38 and its influence on smoking behavior and glucose homeostasis in the German Sorbs.

Maria Keller, Xuanshi Liu, Tobias Wohland, Kerstin Rohde, Marie-Therese Gast, Michael Stumvoll, Peter Kovacs, Anke Tönjes, Yvonne Böttcher,

<h4>Background</h4>Genetic variants within the bitter taste receptor gene TAS2R38 are associated with sensitivity to bitter taste and are related to eating behavior in the Amish population. Sensitivity to bitter taste is further related to anthropometric traits in an genetically isolated Italian population. We tested whether the TAS2R38 variants (rs713598; rs1726866 ... Read more >>

PLoS One (PloS one)
[2013, 8(12):e80512]

Cited: 26 times

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The role of rs2237781 within GRM8 in eating behavior.

Marie-Therese Gast, Anke Tönjes, Maria Keller, Annette Horstmann, Nanette Steinle, Markus Scholz, Ines Müller, Arno Villringer, Michael Stumvoll, Peter Kovacs, Yvonne Böttcher,

The glutamate receptor, metabotropic 8 gene (GRM8) encodes a G-protein-coupled glutamate receptor and has been associated with smoking behavior and liability to alcoholism implying a role in addiction vulnerability. Data from animal studies suggest that GRM8 may be involved in the regulation of the neuropeptide Y and melanocortin pathways and ... Read more >>

Brain Behav (Brain and behavior)
[2013, 3(5):495-502]

Cited: 7 times

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