Full Text Journal Articles by
Author Maria Jose da Silva Fernandes

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Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy.

Daniele Suzete Persike, Rebeca Padrão Amorim Puccinelli, Maria José da Silva Fernandes,

We aimed to characterize the mechanisms involved in neuroprotection by R-PIA administered before pilocarpine-induced seizures. Caspase-1 and caspase-3 activities were assayed using fluorimetry, and cathepsin D, HSP-70, and AKT expression levels were assayed using Western Blot of hippocampal samples. R-PIA was injected before pilocarpine (PILO), and four groups were studied ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2021, 14(4):]

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Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson's Disease.

Valeria C Gonçalves, Lorena Cuenca-Bermejo, Emiliano Fernandez-Villalba, Sebastian Martin-Balbuena, Maria Jose da Silva Fernandes, Carla A Scorza, Maria-Trinidad Herrero,

It has been more than 200 years since James Parkinson made the first descriptions of the disease that bears his name. Since then, knowledge about Parkinson's disease has been improved, and its pathophysiology, diagnosis, and treatments are well described in the scientific and medical literature. However, there is no way ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421990000]

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Enriched environment and exercise effects on parvalbumin expression and distribution in the hippocampal formation of developing rats.

Fernando Tadeu Serra, Bruno Henrique Silva Araujo, Eduardo Varejão Díaz Placencia, Jessica Salles Henrique, Flávia Dona, Laila Brito Torres, Maria José da Silva Fernandes, Ricardo Mario Arida, Sérgio Gomes da Silva,

Several models of environmental enrichment and physical exercise have been used to explore the experience effects on brain functions and plasticity, mainly in adult animals. In order to examine the early influence of these stimuli on developing brain, the present study used calcium-binding protein parvalbumin as neuroplastic marker in the ... Read more >>

Brain Res Bull (Brain research bulletin)
[2020, 160:85-90]

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Using RNA Interference for Purinoceptor Knockdown In Vivo.

Rebeca Padrão Amorim, Iscia Teresinha Lopes Cendes, Maria Jose da Silva Fernandes,

RNA interference (RNAi) is a powerful post-transcriptional gene silencing (PTGS) induced by small double-stranded RNA (dsRNA). The method allows silencing of genes of interest by translation inhibition or by mRNA degradation. In this chapter, we provide a brief overview of the mechanisms involved in each step of gene silencing. A ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2020, 2041:77-86]

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Altered Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy.

Daniele Suzete Persike, Jose Eduardo Marques-Carneiro, Mariana Leão de Lima Stein, Elza Marcia Targas Yacubian, Ricardo Centeno, Mauro Canzian, Maria José da Silva Fernandes,

Mesial temporal lobe epilepsy (MTLE) is usually associated with drug-resistant seizures and cognitive deficits. Efforts have been made to improve the understanding of the pathophysiology of MTLE for new therapies. In this study, we used proteomics to determine the differential expression of proteins in the hippocampus of patients with MTLE ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2018, 11(4):]

Cited: 8 times

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Bone marrow-derived mesenchymal stem cells versus adipose-derived mesenchymal stem cells for peripheral nerve regeneration.

Marcela Fernandes, Sandra Gomes Valente, Rodrigo Guerra Sabongi, João Baptista Gomes Dos Santos, Vilnei Mattioli Leite, Henning Ulrich, Arthur Andrade Nery, Maria José da Silva Fernandes,

Studies have confirmed that bone marrow-derived mesenchymal stem cells (MSCs) can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs (BMSCs) is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem ... Read more >>

Neural Regen Res (Neural regeneration research)
[2018, 13(1):100-104]

Cited: 8 times

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Neurochemical Changes and c-Fos Mapping in the Brain after Carisbamate Treatment of Rats Subjected to Lithium-Pilocarpine-Induced Status Epilepticus.

José Eduardo Marques-Carneiro, Astrid Nehlig, Jean-Christophe Cassel, Eduardo Ferreira Castro-Neto, Julia Julie Litzahn, Anne Pereira de Vasconcelos, Maria da Graça Naffah-Mazacoratti, Maria José da Silva Fernandes,

The administration of lithium-pilocarpine (LiPilo) in adult rats is a validated model reproducing the main clinical and neuropathological features of temporal lobe epilepsy (TLE). Previous studies have shown that carisbamate (CRS) has the property of modifying epileptogenesis in this model. When treated with CRS, about 50% of rats undergoing LiPilo ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2017, 10(4):]

Cited: 1 time

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Hippocampal Proteome of Rats Subjected to the Li-Pilocarpine Epilepsy Model and the Effect of Carisbamate Treatment.

José Eduardo Marques-Carneiro, Daniele Suzete Persike, Julia Julie Litzahn, Jean-Christophe Cassel, Astrid Nehlig, Maria José da Silva Fernandes,

In adult rats, the administration of lithium-pilocarpine (LiPilo) reproduces most clinical and neuropathological features of human temporal lobe epilepsy (TLE). Carisbamate (CRS) possesses the property of modifying epileptogenesis in this model. Indeed, about 50% of rats subjected to LiPilo status epilepticus (SE) develop non-convulsive seizures (NCS) instead of motor seizures ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2017, 10(3):]

Cited: 6 times

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Silencing of P2X7R by RNA interference in the hippocampus can attenuate morphological and behavioral impact of pilocarpine-induced epilepsy.

Rebeca Padrão Amorim, Michelle Gasparetti Leão Araújo, Jorge Valero, Iscia Lopes-Cendes, Vinicius Davila Bitencourt Pascoal, João Oliveira Malva, Maria José da Silva Fernandes,

Cell signaling mediated by P2X7 receptors (P2X7R) has been suggested to be involved in epileptogenesis, via modulation of intracellular calcium levels, excitotoxicity, activation of inflammatory cascades, and cell death, among other mechanisms. These processes have been described to be involved in pilocarpine-induced status epilepticus (SE) and contribute to hyperexcitability, resulting ... Read more >>

Purinergic Signal (Purinergic signalling)
[2017, 13(4):467-478]

Cited: 5 times

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Maternal seizures can affect the brain developing of offspring.

Ana Carolina Cossa, Daiana Correia Lima, Tiago Gurgel do Vale, Anna Karynna Alves de Alencar Rocha, Maria da Graça Naffah-Mazzacoratti, Maria José da Silva Fernandes, Debora Amado,

To elucidate the impact of maternal seizures in the developing rat brain, pregnant Wistar rats were subjected to the pilocarpine-induced seizures and pups from different litters were studied at different ages. In the first 24 h of life, blood glucose and blood gases were analyzed. (14)C-leucine [(14)C-Leu] incorporation was used to ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2016, 31(4):891-900]

Cited: 1 time

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Variations of ATP and its metabolites in the hippocampus of rats subjected to pilocarpine-induced temporal lobe epilepsy.

Flávia Doná, Isaltino Marcelo Conceição, Henning Ulrich, Eliane Beraldi Ribeiro, Thalma Ariani Freitas, Ana Leonor Abrahao Nencioni, Maria José da Silva Fernandes,

Although purinergic receptor activity has lately been associated with epilepsy, little is known about the exact role of purines in epileptogenesis. We have used a rat model of temporal lobe epilepsy induced by pilocarpine to study the dynamics of purine metabolism in the hippocampus during different times of status epilepticus ... Read more >>

Purinergic Signal (Purinergic signalling)
[2016, 12(2):295-302]

Cited: 10 times

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Neuroprotective agents and modulation of temporal lobe epilepsy.

Maria Jose da Silva Fernandes, Jose Eduardo Marques Carneiro, Rebeca Padrão Amorim, Michelle Gasparetti Leão Araujo, Astrid Nehlig,

Temporal Lobe Epilepsy (TLE) is a chronic condition characterized by epileptic seizures originating mainly in temporal lobe areas. Epileptogenesis is a process in which a central nervous system injury can lead surviving neuronal populations to generate abnormal, synchronous and recurrent epileptiform discharges producing focal or generalized seizures. Hipocampal sclerosis, a ... Read more >>

Front Biosci (Elite Ed) (Frontiers in bioscience (Elite edition))
[2015, 7:79-93]

Cited: 9 times

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Neuroprotective effects of peroxisome proliferator-activated receptor alpha and gamma agonists in model of parkinsonism induced by intranigral 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine.

Janaína K Barbiero, Ronise M Santiago, Daniele Suzete Persike, Maria José da Silva Fernandes, Fernanda S Tonin, Claudio da Cunha, Suelen Lucio Boschen, Marcelo M S Lima, Maria A B F Vital,

A large body of evidence suggests that peroxisome proliferator-activated receptor (PPAR) agonists may improve some of the pathological features of Parkinson's disease (PD). In the present study, we evaluated the effects of the PPAR-α agonist fenofibrate (100mg/kg) and PPAR-γ agonist pioglitazone (30mg/kg) in a rat model of parkinsonism induced by ... Read more >>

Behav Brain Res (Behavioural brain research)
[2014, 274:390-399]

Cited: 32 times

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Consequences of pilocarpine-induced status epilepticus in immunodeficient mice.

Thiago Vignoli, Astrid Nehlig, Silvia Gomes Massironi, Rita de Cássia Sinigaglia Coimbra, Maria da Graça Naffah Mazzacoratti, Iara Ribeiro Silva, Eduardo Ferreira de Castro Neto, Daniele Suzete Persike, Maria José da Silva Fernandes,

Systemic injection of pilocarpine in rodents induces status epilepticus (SE) and reproduces the main characteristics of temporal lobe epilepsy (TLE). Different mechanisms are activated by SE contributing to cell death and immune system activation. We used BALB/c nude mice, a mutant that is severely immunocompromised, to characterize seizure pattern, neurochemical ... Read more >>

Brain Res (Brain research)
[2012, 1450:125-137]

Cited: 2 times

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Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.

Fernanda Elisa Rosim, Daniele Suzete Persike, Astrid Nehlig, Rebeca Padrão Amorim, Daniela Mara de Oliveira, Maria José da Silva Fernandes,

Aiming at a better understanding of the role of A(2A) in temporal lobe epilepsy (TLE), we characterized the effects of the A(2A) antagonist SCH58261 (7-(2-phenylethyl)-5-amino-2(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine) on seizures and neuroprotection in the pilocarpine model. The effects of SCH58261 were further analyzed in combination with the A(1) agonist R-Pia (R(-)-N(6)-(2)-phenylisopropyl adenosine). Eight ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2011, 22(2):207-213]

Cited: 20 times

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Neuroglobin is up-regulated in the cerebellum of pups exposed to maternal epileptic seizures.

Daiana Correia Lima, Ana Carolina Cossa, Sandra Regina Perosa, Elaine Menezes de Oliveira, José Antonio da Silva, Maria José da Silva Fernandes, Iara Ribeiro da Silva, Elisa Mieko Suemitsu Higa, Maria da Graça Naffah-Mazzacoratti, Esper Abrão Cavalheiro, Débora Amado,

To evaluate a potential insult in the cerebellum of pups exposed to maternal epileptic seizures during intrauterine life, female rats were subjected to pilocarpine-induced epilepsy. Pups from different litters were sacrificed at 1, 3, 7 and 14 post-natal days (PN) and neuroglobin (Ngb) and gliosis were analyzed in the cerebellum ... Read more >>

Int J Dev Neurosci (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience)
[2011, 29(8):891-897]

Cited: 8 times

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The A1 receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: could this mechanism be involved with neuroprotection?

Iara Ribeiro Silva, Astrid Nehlig, Fernanda Elisa Rosim, Thiago Vignoli, Daniele Suzete Persike, Arielle Ferrandon, Rita Sinigaglia-Coimbra, Maria José da Silva Fernandes,

It is well known that the uncoupling between local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF), i.e. decrease in LCBF rates with high LCGU, is frequently associated with seizure-induced neuronal damage. This study was performed to assess if the neuroprotective effect of the adenosinergic A(1) receptor agonist ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2011, 41(1):169-176]

Cited: 6 times

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Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats.

Mônica Sílvia Rodrigues de Oliveira, Maria José da Silva Fernandes, Fulvio Alexandre Scorza, Danielle Suzete Persike, Carla Alessandra Scorza, Jaqueline Botelho da Ponte, Marly de Albuquerque, Esper Abrão Cavalheiro, Ricardo Mario Arida, Ricardo Mario Arida,

Exercise stimulates the release of beta-endorphin and other endogenous opioid peptides that are believed to be responsible for changes in mood, perception of pain and also performance. Although the vast majority of literature data support the role of physical exercise in increasing beta-endorphin levels, indirect measures such as increased endorphin ... Read more >>

Brain Res Bull (Brain research bulletin)
[2010, 83(5):278-283]

Cited: 25 times

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Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression.

Sérgio Gomes da Silva, Flávia Doná, Maria José da Silva Fernandes, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Ricardo Mario Arida, Ricardo Mario Arida,

In order to investigate whether physical exercise during development would promote changes the calcium-binding protein parvalbumin (PV) expression in the hippocampal formation, we performed an immunostaining study after an aerobic exercise program in rats during adolescent period of life. Wistar rats were submitted to daily exercise program in a treadmill ... Read more >>

Brain Dev (Brain & development)
[2010, 32(2):137-142]

Cited: 26 times

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Bone marrow cells are able to increase vessels number during repair of sciatic nerve lesion.

Marcela Fernandes, Sandra Gomes Valente, Maria José da Silva Fernandes, Evandro Penteado Villar Félix, Maria da Graça Naffah Mazzacoratti, Débora Amado Scerni, João Baptista Gomes dos Santos, Vilnei Mattioli Leite, Flávio Faloppa,

The aim of this study was to compare the outcomes of nerve autografts (GRF) and venous grafts containing mononuclear bone marrow cells (BMCs) in sciatic nerve-lesioned rats. Control animals underwent sham operations (SHAM), received empty venous grafts (EPV), or received venous grafts containing BMC vehicle (AGR). Outcome was evaluated through ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2008, 170(1):16-24]

Cited: 19 times

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Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus.

Daniele Suzete Persike, Rodrigo Luiz Oliveira Rodrigues Cunha, Luiz Juliano, Iara Ribeiro Silva, Fernanda Elisa Rosim, Thiago Vignoli, Flavia Dona, Esper Abrão Cavalheiro, Maria José da Silva Fernandes,

Temporal lobe epilepsy is the most common form of epilepsy in humans. Caspase activation is a mechanism of cell death induced by seizures. Tellurium (IV) compounds present antitumoral, immunomodulatory and neuroprotective effects due to their ability to inhibit cysteine proteases. We studied the activity of caspase-1, -3 and -8 in ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2008, 31(1):120-126]

Cited: 20 times

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The Na+/K+ATPase activity is increased in the hippocampus after multiple status epilepticus induced by pilocarpine in developing rats.

Erika Reime Kinjo, Ricardo Mario Arida, Ricardo Mario Arida, Daniela Mara de Oliveira, Maria José da Silva Fernandes,

The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat. Na(+)/K(+)ATPase is a membrane-bound enzyme responsible for the active transport of sodium and potassium ions through the membrane. It is necessary to maintain neuronal excitability. The malfunction of this enzyme has been ... Read more >>

Brain Res (Brain research)
[2007, 1138:203-207]

Cited: 9 times

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Pro-epileptic effect of alfentanil in rats subjected to pilocarpine-induced chronic epilepsy.

Emilio Rafael Garrido Sanabria, Isabella D'Andrea Vieira, Maria Fernanda da Silveira Pereira, Leonardo Coutinho Faria, André César da Silva, Esper Abrão Cavalheiro, Maria José da Silva Fernandes,

Pharmacological induction of epileptiform activity is a complementary method to study the epileptogenic area in drug-resistant epileptic patients. Among the different activation methods, fentanyl derivatives (e.g. alfentanil) provide one of the most efficient tools in triggering epileptiform abnormalities in surgical candidates. In this study, we tested the pro-epileptic effect of ... Read more >>

Brain Res Bull (Brain research bulletin)
[2006, 69(5):535-545]

Cited: 4 times

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Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.

Eduardo Paulo Morowsky Vianna, Alice Teixeira Ferreira, Flávia Doná, Esper Abrão Cavalheiro, Maria José da Silva Fernandes,

<h4>Purpose</h4>Adenosine is a major negative neuromodulator of synaptic activity in the central nervous system and can exert anticonvulsant and neuroprotective effects in many experimental models of epilepsy. Extracellular adenosine can be formed by a membrane-anchored enzyme ecto-5'-nucleotidase. The purposes of this study were to characterize the role of adenosine receptors ... Read more >>

Epilepsia (Epilepsia)
[2005, 46 Suppl 5:166-173]

Cited: 27 times

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Physical training does not influence interictal LCMRglu in pilocarpine-treated rats with epilepsy.

Ricardo Mario Arida, Ricardo Mario Arida, Maria José da Silva Fernandes, Fulvio Alexandre Scorza, Silvio César Preti, Esper Abrão Cavalheiro,

This study evaluated, using local cerebral metabolic rates for glucose (LCMRglu) in 39 brain regions, whether physical training modifies the functional activity in rats with epilepsy. Most animals present seizures at rest rather than during exercise and LCMRglu was measured during the interictal phase of the chronic period of a ... Read more >>

Physiol Behav (Physiology & behavior)
[2003, 79(4-5):789-794]

Cited: 20 times

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