Full Text Journal Articles by
Author Maria Arafah

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Carcinomas of the Uterine Cervix: Comprehensive Review With An Update on Pathogenesis, Nomenclature of Precursor and Invasive Lesions, and Differential Diagnostic Considerations.

Maria Arafah, Sameera Rashid, Asma Tulbah, Mohammed Akhtar,

Most cervical carcinomas and their related lesions are attributed to an infection by human papillomavirus (HPV). The infection usually starts in the basal cells at the squamocolumnar junction. It causes cell proliferation and maturation abnormalities along with nuclear abnormalities resulting in low-grade squamous intraepithelial lesions. An overwhelming majority of these ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):150-170]

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A Giant Leiomyoma with Massive Cystic Hydropic Degeneration Mimicking an Aggressive Neoplasm: A Challenging Case with a Literature Review.

Khalid Akkour, Mais Alhulwah, Nayef Alqahtani, Maria A Arafah,

BACKGROUND Leiomyomas are the most frequent benign tumors of the uterus. They often exhibit degenerative changes (hyaline, myxoid, hemorrhagic, hydropic, and cystic), which lead to varying and sometimes challenging clinical, radiological, and histopathological features. We present this case to highlight the importance of recognizing these variants and their differential diagnosis ... Read more >>

Am J Case Rep (The American journal of case reports)
[2021, 22:e929085]

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Prognostic significance of estrogen, progesterone and HER2 receptors' status conversion following neoadjuvant chemotherapy in patients with locally advanced breast cancer: Results from a tertiary Cancer Center in Saudi Arabia.

Khalid Al-Saleh, Tareq Salah, Maria Arafah, Sufia Husain, Ammar Al-Rikabi, Nashwa Abd El-Aziz,

<h4>Background</h4>The prognostic impact of neoadjuvant chemotherapy (NAC) on the receptor expression status in patients with locally advanced breast cancer (LABC) is still not fully understood. We aimed to evaluate the changes in hormone (estrogen and progesterone) receptor (HR) and human epidermal growth factor receptor 2 (HER2) status post-NAC and their ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0247802]

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Massive Retinal Gliosis in an Infant Microphthalmic Globe: A Case Report.

Rakan S Al-Essa, Hind Manaa Alkatan, Maria A Arafah, Yasser H Al-Faky,

BACKGROUND Massive retinal gliosis (MRG) is a rare benign intraocular tumor that results from the proliferation of well-differentiated glial cells in response to long-standing pathological processes, including glaucoma, trauma, chronic inflammation, vascular disorders, and congenital anomalies. This lesion is considered to be nonneoplastic and occurs ≥10 years after the predisposing ... Read more >>

Am J Case Rep (The American journal of case reports)
[2021, 22:e929363]

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Schinus terebinthifolius fruits intake ameliorates metabolic disorders, inflammation, oxidative stress, and related vascular dysfunction, in atherogenic diet-induced obese rats. Insight of their chemical characterization using HPLC-ESI-QTOF-MS/MS.

Anouar Feriani, Meriam Tir, Maria Arafah, Ana María Gómez-Caravaca, María Del Mar Contreras, Saber Nahdi, Amani Taamalli, Mohamed Salah Allagui, Saleh Alwasel, Antonio Segura-Carretero, Abdel Halim Harrath, Nizar Tlili,

<h4>Ethnopharmacology relevance</h4>Schinus terebinthifolius is traditionally used for its anti inflammatory capacity, and indicated as a cardioprotective agent, whereas, its preventive effect against atherogenic diet fed (AD) induced metabolic disorders and the underlying mechanisms has not yet been explored.<h4>Aim of the study</h4>This study was undertaken to investigate the ameliorative role of ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2021, 269:113701]

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Creating a Multisite Perinatal Psychiatry Databank: Purpose and Development.

Wid Kattan, Laura Avigan, Barbara Hayton, Jennifer L Barkin, Martin St-André, Tuong-Vi Nguyen, Hannah Schwartz, Marie-Josée Poulin, Irena Stikarovska, Rahel Wolde-Giorghis, Maria Arafah, Phyllis Zelkowitz,

Mental health issues during the perinatal period are common; up to 29% of pregnant and 15% of postpartum women meet psychiatric diagnostic criteria. Despite its ubiquity, little is known about the longitudinal trajectories of perinatal psychiatric illness. This paper describes a collaboration among six perinatal mental health services in Quebec, ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(24):]

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Prognostic Significance of HER2 Expression Changes Following Neoadjuvant Chemotherapy in Saudi Patients With Locally Advanced Breast Cancer.

Khalid Al-Saleh, Abdurrahman Aldiab, Tareq Salah, Maria Arafah, Sufia Husain, Ammar Al-Rikabi, Nashwa Abd El-Aziz,

<h4>Background</h4>Progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) significantly influence disease prognosis and therapeutic response in patients with breast cancer. Neoadjuvant chemotherapy (NACT) can change the receptor status, affecting the disease characteristics.<h4>Patients and methods</h4>A retrospective chart review was carried out at a single tertiary ... Read more >>

Clin Breast Cancer (Clinical breast cancer)
[2020, :]

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Endometriosis: A Comprehensive Review.

Maria Arafah, Sameera Rashid, Mohammed Akhtar,

Endometriosis is a relatively common condition in which endometrial tissue is established in locations outside the uterus where, like the eutopic endometrium, it responds to hormonal stimuli and develops internal bleeding, inflammation, and fibrosis. These changes are associated with chronic and often debilitating cyclic pain and infertility. The pathogenesis of ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):30-43]

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A comparative study between a single-dose and 24-hour multiple-dose antibiotic prophylaxis for elective hysterectomy.

Khalid Mohammed Akkour, Maria Abdulrahim Arafah, Mais Mohammed Alhulwah, Rana Saeed Badaghish, Hani Abdulmohsen Alhalal, Nada Mohammed Alayed, Sarah Batel Alqahtani, Shazia Shahzad Ahmad Iqbal,

<h4>Introduction</h4>Surgical site infections (SSIs) are a major health issue in surgical specialties in terms of health care costs and patients' clinical outcomes. At the level of the patient, prolonged hospital stays or readmissions for SSIs, can affect the patient's quality of life. At the level of the health care system, ... Read more >>

J Infect Dev Ctries (Journal of infection in developing countries)
[2020, 14(11):1306-1313]

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Mucormycosis: An 8-year experience of a tertiary care centre in Saudi Arabia.

Fatehi Elzein, Ahmed Albarrag, Kiran Kalam, Maria Arafah, Abeer Al-Baadani, Nazik Eltayeb, Fadel Aloteibi, Abdulrahman Alrashed, Rashid Al Abdullah, Shuaa Alasiri,

Mucormycosis is a rare fungal infection with an extremely high morbidity and mortality. Data on the burden of the disease in the Arab world is lacking. The aim of this study is to highlight the incidence and outcome of this infection in a tertiary care center in the Kingdom of ... Read more >>

J Infect Public Health (Journal of infection and public health)
[2020, 13(11):1774-1779]

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Laparoscopic resection of retroperitoneal intra-psoas muscle schwannoma: A case report and extensive literature review.

Awadh AlQahtani, Mohammed N AlAli, Safaa Allehiani, Sulaiman AlShammari, Hussein Al-Sakkaf, Maria A Arafah,

<h4>Introduction</h4>Soft tissue tumors of Schwann cells in either the peripheral or cranial nerves are known as schwannomas or also as neurilemmomas. Limited data exists regarding psoas muscle schwannoma in the literature. Therefore, we have done an extensive literature review and found a total number of 46 cases of intra-psoas schwannoma ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2020, 74:1-9]

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Good Outcome of Early-Stage Rectal Cancer Diagnosed During Pregnancy.

Waleed H Alkhamis, Tammam Naama, Maria A Arafah, Sahar H Abdulghani,

BACKGROUND Colorectal cancer (CRC) in pregnancy is very rare. It is often associated with poor prognosis which is contributed to delayed diagnosis due to the overlapping symptoms of CRC and pregnancy. The purpose of this case report is to highlight the importance of early diagnosis and treatment of CRC in ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e925673]

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Tocilizumab potentiates cisplatin cytotoxicity and targets cancer stem cells in triple-negative breast cancer.

Noura N Alraouji, Falah H Al-Mohanna, Hazem Ghebeh, Maria Arafah, Rafa Almeer, Taher Al-Tweigeri, Abdelilah Aboussekhra,

Triple-negative breast cancer (TNBC) is a very aggressive subtype with high recurrence rate and no molecular targets for therapies. This subtype is characterized by high expression/secretion of the proinvasive/metastatic interleukin-6 (IL-6) cytokine. In the present study, we have shown that tocilizumab inhibits the IL-6/STAT3 signaling and suppresses the cancer/inflammatory epigenetic ... Read more >>

Mol Carcinog (Molecular carcinogenesis)
[2020, 59(9):1041-1051]

Cited: 2 times

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Clinical and functional significance of tumor/stromal ATR expression in breast cancer patients.

Mysoon M Al-Ansari, Maher Al-Saif, Maria Arafah, Abdelmonneim M Eldali, Asma Tulbah, Taher Al-Tweigeri, Abdelhabib Semlali, Khalid S Khabar, Abdelilah Aboussekhra,

BACKGROUND:Most breast cancer-associated fibroblasts (CAFs) are active and important cancer-promoting cells, with significant impact on patient prognosis. Therefore, we investigated here the role of the protein kinase ATR in breast stromal fibroblasts in the prognosis of locally advanced breast cancer patients. METHODS:We have used immunohistochemistry to assess the level of ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2020, 22(1):49]

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Immunohistochemistry of mammary Paget's disease. Cytokeratin 7, GATA3, and HER2 are sensitive markers.

Shoukat A Arain, Maria Arafah, Emad M Said Raddaoui, Asma Tulba, Fatimah H Alkhawaja, Ahlam Al Shedoukhy,

<h4>Objectives</h4>To investigate the expression of various immunohistochemical markers in Mammary Paget's disease (MPD) and MPD-associated breast carcinoma and to evaluate their value in establishing the diagnosis.<h4>Methods</h4>This retrospective descriptive study was carried out at King Faisal Specialist Hospital and Research Center and King Khalid University Hospital, Riyadh, Saudi Arabia. All MPD ... Read more >>

Saudi Med J (Saudi medical journal)
[2020, 41(3):232-237]

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Papillon-Lefèvre Syndrome and Basal Cell Carcinoma: A Case Study.

Fahad M Alsaif, Maria A Arafah, Rasha T Alenazi, Ghadah F Alotaibi,

Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder characterized by palmoplantar keratoderma and early-onset periodontitis. It was first described by Papillon and Lefèvre in 1924. PLS is caused by mutations in the cathepsin-C (CTSC) gene. The development of malignant skin neoplasms in PLS patients is extremely rare. To date, ... Read more >>

Case Rep Oncol (Case reports in oncology)
[2019, 12(2):411-417]

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Molecular subtyping of mammary Paget's disease using immunohistochemistry.

Maria Arafah, Shoukat A Arain, Emad M Said Raddaoui, Asma Tulba, Fatimah H Alkhawaja, Ahlam Al Shedoukhy,

<h4>Objective</h4>To evaluate the molecular subtypes of Mammary Paget's disease (MPD) and the associated breast carcinomas.<h4>Methods</h4>This retrospective study was carried out at King Khalid University Hospital and King Faisal Specialist Hospital, Riyadh, Saudi Arabia. Data from MPD patient cases from January 2010 to June 2016 were reviewed. The molecular subtypes were ... Read more >>

Saudi Med J (Saudi medical journal)
[2019, 40(5):440-446]

Cited: 3 times

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A malignant placental site trophoblastic tumor of the uterus with multiple metastases: A case report of a rare tumor showing an aggressive behavior.

Amany Abdulgader Fathaddin, Maria Abdulrahim Arafah,

One of the very rare forms of gestational neoplastic diseases is the malignant placental site trophoblastic tumor. Due to its rarity, the data regarding its diagnosis and management are limited. The prognosis of this tumor is unpredictable with potential malignant behavior and metastasis. We report a case of malignant placental ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2019, 62(1):142-145]

Cited: 1 time

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Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects.

Huda H Al-Khalaf, Bothaina Al-Harbi, Adher Al-Sayed, Maria Arafah, Asma Tulbah, Abdulaziz Jarman, Falah Al-Mohanna, Abdelilah Aboussekhra,

Increasing evidence supports the critical role of active stromal adipocytes in breast cancer development and spread. However, the mediators and the mechanisms of action are still elusive. We show here that cancer-associated adipocytes (CAAs) isolated from 10 invasive breast carcinomas are proinflammatory and exhibit active phenotypes, including higher proliferative, invasive, ... Read more >>

Mol Cell Biol (Molecular and cellular biology)
[2019, 39(2):]

Cited: 7 times

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Endobronchial biopsy in the final diagnosis of chronic obstructive pulmonary disease and asthma: a clinicopathological study.

Maria Abdulrahim Arafah, Emad Raddaoui, Faisal Al Kassimi, Esam H Alhamad, Ahmed Amer Alboukai, Ahlam Abdullah Alshedoukhy, Abderrahman Ouban,

BACKGROUND:Asthma and chronic obstructive pulmonary disease (COPD) are chronic conditions with an increasing prevalence in developing countries. The evaluation of endobronchial biopsies has emerged as a tool to differentiate between both conditions via the measurement of the reticular basement membrane (RBM) thickness with various conclusions drawn from different studies. OBJECTIVES:Compare ... Read more >>

Ann Saudi Med (Annals of Saudi medicine)
[2018, 38(2):118-124]

Cited: 4 times

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Malignant Mixed Germ Cell Tumor Overgrowing a Gonadoblastoma in a Female With a 46, XX Karyotype: A Case Report.

Maria A Arafah, Leen E Raddaoui,

Gonadoblastoma is an uncommon ovarian tumor arising primarily in females with gonadal dysgenesis and a 46, XY karyotype. Germ cell tumors arising within and/or overgrowing a gonadoblastoma have been reported. We report a rare case of a malignant mixed germ cell tumor (yolk sac tumor and choriocarcinoma) arising in a ... Read more >>

Int J Surg Pathol (International journal of surgical pathology)
[2018, 26(3):287-292]

Cited: 2 times

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Radiological tests versus pathological diagnostics: Complimentary or antagonistic relationship? The experience of a tertiary hospital.

Maria A Arafah, Hala M Kfoury,

<h4>Introduction</h4>Early detection of breast cancer plays a pivotal role in the outcome of the disease. Diagnostic modalities encompass radiological and pathological findings. The aim of this study is to evaluate the correlation between the results of these two modalities in a tertiary hospital.<h4>Materials and methods</h4>From a total of 180 patients, ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2017, 60(3):365-370]

Cited: 1 time

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The pathological spectrum associated with the ultrastructural finding of thin glomerular basement membrane: A tertiary medical city experience and review of the literature.

Hala Kfoury, Maria Arafah,

<h4>Background</h4>Thin glomerular basement membrane (GBM) has been noted in several glomerular diseases including IgA nephropathy, focal segmental glomerulosclerosis (FSGS), Fabry's disease, and Alport's syndrome. We conducted this study to investigate the pathological ultrastructural spectrum of thin GBMs, to identify associated diseases, and to measure the GBM thickness in thin GBMs ... Read more >>

Ultrastruct Pathol (Ultrastructural pathology)
[2017, 41(1):51-54]

Cited: 2 times

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Subareolar Sclerosing Ductal Hyperplasia.

Esther Cheng, Timothy M D'Alfonso, Maria Arafah, Rebecca Marrero Rolon, Paula S Ginter, Syed A Hoda,

Subareolar sclerosing duct hyperplasia (SSDH) remains to be fully characterized nearly 20 years after initial description. Thirty-five SSDH cases diagnosed over a 16-year period (January 2000 to December 2015) were reviewed. All patients were female (mean age = 59 years, range = 18-80) who had presented with a unilateral solitary ... Read more >>

Int J Surg Pathol (International journal of surgical pathology)
[2017, 25(1):4-11]

Cited: 0 times

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Squamous Cell Carcinoma In Situ of the Breast: Report of a Case.

Maria Arafah, Paula S Ginter, David C Taylor, Syed A Hoda,

We present the case of a 73-year-old woman with pure squamous cell carcinoma in situ of the left breast. This non-invasive malignancy exhibited pure squamous type of architectural and cytologic features without any evidence of glandular differentiation either in the initial needle core biopsy or in the subsequently performed excisional ... Read more >>

Breast J (The breast journal)
[2016, 22(5):573-577]

Cited: 1 time

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