Full Text Journal Articles by
Author Margit Fisch

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Cystatin C predicts renal function impairment after partial or radical tumor nephrectomy.

Mike Wenzel, Hang Yu, Annemarie Uhlig, Christoph Würnschimmel, Manuel Wallbach, Andreas Becker, Margit Fisch, Felix K H Chun, Christian P Meyer, Marianne Leitsmann,

<h4>Purpose</h4>To test the value of preoperative and postoperative cystatin C (CysC) as a predictor on kidney function after partial (PN) or radical nephrectomy (RN) in renal cell carcinoma (RCC) patients with normal preoperative renal function.<h4>Methods</h4>From 01/2011 to 12/2014, 195 consecutive RCC patients with a preoperative estimated glomerular filtration rate (eGFR) > 60 ml/min/1.73m<sup>2</sup> ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2021, :]

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Contemporary Outcomes after Transurethral Procedures for Bladder Neck Contracture Following Endoscopic Treatment of Benign Prostatic Hyperplasia.

Clemens M Rosenbaum, Malte W Vetterlein, Margit Fisch, Philipp Reiss, Thomas Stefan Worst, Jennifer Kranz, Joachim Steffens, Luis A Kluth, Daniel Pfalzgraf, On Behalf Of The Trauma And Reconstructive Urology Working Party Of The European Association Of Urology Eau Young Academic Urologists Yau,

<h4>Objectives</h4>Bladder neck contracture (BNC) is a bothersome complication following endoscopic treatment for benign prostatic hyperplasia (BPH). The objective of our study was to give a more realistic insight into contemporary endoscopic BNC treatment and to evaluate and identify risk factors associated with inferior outcome.<h4>Material and methods</h4>We identified patients who underwent ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(13):]

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Update on the management of penile and meatal strictures.

Malte W Vetterlein, Margit Fisch, Valentin Zumstein, ,

<h4>Purpose of review</h4>Treatment of penile and distal urethral strictures including the fossa navicularis and the meatus remains challenging due to their adverse etiology and lack of ventral tissue support. In this contemporary review, we summarize the available evidence and recent advancements in reconstructive techniques.<h4>Recent findings</h4>Over the last years, several refinements ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, :]

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[Contemporary management of urethral strictures in women].

Lennart Kühnke, Margit Fisch, Malte W Vetterlein,

Urethral strictures in women are rare and patients may present with varying symptoms. Hence, clinical guidelines regarding diagnostic algorithms and treatment approaches are scarce. Several small case series have presented results for several operative techniques, but patient cohorts are generally heterogeneous and relatively small, which hampers reliable comparability across institutions. ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2021, 52(3):260-267]

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Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer.

Katharina Möller, Christoph Fraune, Niclas C Blessin, Maximilian Lennartz, Martina Kluth, Claudia Hube-Magg, Linnea Lindhorst, Roland Dahlem, Margit Fisch, Till Eichenauer, Silke Riechardt, Ronald Simon, Guido Sauter, Franziska Büscheck, Wolfgang Höppner, Cord Matthies, Ousman Doh, Till Krech, Andreas H Marx, Henrik Zecha, Michael Rink, Stefan Steurer, Till S Clauditz,

<h4>Background</h4>PD-L1 expression predicts response to immune checkpoint inhibitors in renal cell carcinomas (RCC), but has also been suggested to be linked to poor patient outcome.<h4>Methods</h4>We analyzed PD-L1 in > 1400 RCC in a tissue microarray format by immunohistochemistry. Results were compared with histological tumor type, parameters of cancer aggressiveness, and intratumoral CD8<sup>+</sup> cytotoxic ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2021, :]

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Exploring the intersection of functional recurrence, patient-reported sexual function, and treatment satisfaction after anterior buccal mucosal graft urethroplasty.

Malte W Vetterlein, Almut Gödde, Valentin Zumstein, Philipp Gild, Phillip Marks, Armin Soave, Christian P Meyer, Silke Riechardt, Roland Dahlem, Margit Fisch, Luis A Kluth, ,

<h4>Purpose</h4>To evaluate the interplay of stricture recurrence, sexual function, and treatment satisfaction after substitution urethroplasty.<h4>Methods</h4>Observational study of men undergoing 1-stage buccal mucosal graft urethroplasty for anterior urethral stricture between 2009 and 2016. Patients were dichotomized by self-reported treatment satisfaction. Sexual function was assessed by validated and non-validated patient-reported outcome measures. ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Predictive value of De Ritis ratio in metastatic renal cell carcinoma treated with tyrosine-kinase inhibitors.

Florian Janisch, Thomas Klotzbücher, Phillip Marks, Christina Kienapfel, Christian P Meyer, Hang Yu, Constantin Fühner, Tobias Hillemacher, Keiichiro Mori, Hadi Mostafei, Shahrokh F Shariat, Margit Fisch, Roland Dahlem, Michael Rink,

<h4>Background</h4>Predictive markers can help tailor treatment to the individual in metastatic renal cell carcinoma (mRCC). De Ritis ratio (DRR) is associated with oncologic outcomes in various solid tumors.<h4>Objective</h4>To assess the value of DRR in prognosticating survival in mRCC patients treated with tyrosine-kinase inhibitors (TKI).<h4>Methods</h4>Overall, 220 mRCC patients treated with TKI ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Mismatch repair deficiency occurs very rarely in seminomas.

David Dum, Stefan Steurer, Ronald Simon, Pia Victoria Zimmermann, Eike Burandt, Till Sebastian Clauditz, Margit Fisch, Michael Rink, Roland Dahlem, Wolfgang Höppner, Henrik Zecha, Ousman Doh, Cord Matthies, Waldemar Wilczak, Guido Sauter, Christoph Fraune,

<h4>Background</h4>Dense tumor-associated lymphocyte infiltration is linked to mismatch repair (MMR) deficiency in colorectal and endometrial cancer. MMR deficiency is of high clinical importance as MMR deficient cancers tend to react favorably to treatment with immune checkpoint inhibitors. Strong lymphocytic infiltration is a morphological hallmark of seminomas. We thus asked whether ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(3):1048-1055]

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Y-chromosome loss is frequent in male renal tumors.

Franziska Büscheck, Christoph Fraune, Seyedehmina Garmestani, Ronald Simon, Martina Kluth, Claudia Hube-Magg, Kathrin Ketterer, Christian Eichelberg, Doris Höflmayer, Frank Jacobsen, Corinna Wittmer, Waldemar Wilczak, Guido Sauter, Margit Fisch, Till Eichenauer, Michael Rink,

<h4>Background</h4>Loss of the Y-chromosome is a common event in different tumor types but its prevalence and clinical relevance in renal cell tumors is still not understood.<h4>Methods</h4>It was the aim of this study to estimate the frequency and clinical relevance of Y-loss in kidney neoplasms. A cohort of 1,252 male renal ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(3):209]

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Assessing the Outcome of Holmium Laser Enucleation of the Prostate by Age, Prostate Volume, and a History of Blood Thinning Agents: Report from a Single-Center Series of >1800 Consecutive Cases.

Philipp Gild, Lukas Lenke, Raisa S Pompe, Malte W Vetterlein, Tim A Ludwig, Armin Soave, Felix K-H Chun, Sascha Ahyai, Roland Dahlem, Margit Fisch, Michael Rink, Christian P Meyer, Andreas Becker,

<b><i>Purpose:</i></b> To assess perioperative outcomes of holmium laser enucleation of the prostate (HoLEP) in a real-world scenario and with a focus on demanding patient factors, such as large prostate size, advanced patient age, and anticoagulation therapy (AT). <b><i>Materials and Methods:</i></b> We retrospectively analyzed HoLEP procedures at our institution between 2010 ... Read more >>

J Endourol (Journal of endourology)
[2021, 35(5):639-646]

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p63 expression in human tumors and normal tissues: a tissue microarray study on 10,200 tumors.

Stefan Steurer, Claudia Riemann, Franziska Büscheck, Andreas M Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Anne Menz, Margit Fisch, Michael Rink, Christian Bernreuther, Patrick Lebok, Till S Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, David Dum, Ronald Simon, Sarah Minner, Eike Burandt, Rainer Krech, Till Krech, Andreas H Marx,

<h4>Background</h4>Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classification but published data on its expression in cancer is conflicting.<h4>Methods</h4>To comprehensively catalogue p63 expression, tissue microarrays (TMAs) containing 12,620 tissue ... Read more >>

Biomark Res (Biomarker research)
[2021, 9(1):7]

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Continence and Complication Rates of Artificial Urinary Sphincter Devices (AMS 800) for Parkinson and Stroke Patients with Incontinence after Prostate Surgery: Retrospective Analysis of a Prospective Database.

Valentin Maurer, Justus Stahlberg, Insa Schiffmann, Phillip Marks, Clemens M Rosenbaum, Armin Soave, Malte W Vetterlein, Christian P Meyer, Silke Riechardt, Margit Fisch, Tim A Ludwig, Roland Dahlem,

<h4>Objectives</h4>The artificial urinary sphincter (AUS) is the gold standard treatment for severe stress urinary incontinence (SUI). According to the literature, patients suffering from Parkinson's disease (PD) or stroke (ST) show adverse continence outcomes after prostate surgery and, therefore, constitute a challenging cohort for continence surgery. However, little is known with ... Read more >>

Urol Int (Urologia internationalis)
[2021, 105(3-4):225-231]

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Is Standardization Transferable? Initial Experience of Urethral Surgery at the University Hospital Frankfurt.

Mike Wenzel, Marieke J Krimphove, Benedikt Lauer, Benedikt Hoeh, Matthias J Müller, Philipp Mandel, Andreas Becker, Malte W Vetterlein, Stefan C Mueller, Roland Dahlem, Margit Fisch, Felix K-H Chun, Luis A Kluth,

<b>Background:</b> Since January 2018 performance of urethroplasties is done on regular basis at the University Hospital Frankfurt (UKF). We aimed to implement and transfer an institutional standardized perioperative algorithm for urethral surgery (established at the University Hospital Hamburg-Eppendorf-UKE) using a validated Urethral Stricture Surgery Patient-Reported Outcome Measure (USS-PROM) in patients ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:600090]

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Copy number variations in primary tumor, serum and lymph node metastasis of bladder cancer patients treated with radical cystectomy.

Armin Soave, Lan Kluwe, Hang Yu, Michael Rink, Philipp Gild, Malte W Vetterlein, Philipp Marks, Guido Sauter, Margit Fisch, Christian P Meyer, Tim Ludwig, Roland Dahlem, Sarah Minner, Klaus Pantel, Bettina Steinbach, Heidi Schwarzenbach,

The aim of the present study was to analyze copy number variations (CNV) of multiple oncogenes and tumor suppressor genes in genomic DNA from primary tumor tissue, lymph node metastasis and cell-free DNA (cfDNA) from serum of 72 urothelial carcinoma of bladder (UCB) patients treated with radical cystectomy (RC), using ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21562]

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Contemporary Management of Vesico-Urethral Anastomotic Stenosis After Radical Prostatectomy.

Clemens M Rosenbaum, Margit Fisch, Malte W Vetterlein,

Vesico-urethral anastomotic stenosis is a well-known sequela after radical prostatectomy for prostate cancer and has significant impact on quality of life. This review aims to summarize contemporary therapeutical approaches and to give an overview of the available evidence regarding endoscopic interventions and open reconstruction. Initial treatment may include dilation, incision ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:587271]

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Long-Term Effects of Mental Training on Manual and Cognitive Skills in Surgical Education - A Prospective Study.

Julia C Kaulfuss, Luis A Kluth, Phillip Marks, Philippe Grange, Margit Fisch, Felix K H Chun, Christian P Meyer,

<h4>Objectives</h4>Limited training opportunities and expanding requirements are challenging surgical education, calling for alternative training methods like simulation or mental training. The aim of this study is to evaluate short- and long-term effects of a structured mental training on surgical performance.<h4>Design</h4>Medical students without laparoscopic experience were randomly assigned to 3 groups: ... Read more >>

J Surg Educ (Journal of surgical education)
[2021, 78(4):1216-1226]

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Learning benefits of live surgery and semi-live surgery in urology-informing the debate with results from the International Meeting of Reconstructive Urology (IMORU) VIII.

Victor M Schuettfort, Tim A Ludwig, Phillip Marks, Malte W Vetterlein, Valentin Maurer, Constantin Fuehner, Florian Janisch, Armin Soave, Michael Rink, Silke Riechardt, Oliver Engel, Margit Fisch, Roland Dahlem, Christian P Meyer,

<h4>Purpose</h4>To analyze the perceived learning opportunities of participants of the International Meeting on Reconstructive Urology (IMORU) VIII for both live surgery demonstrations (LSD) and semi-live surgery demonstrations (SLSD). Safety and educational efficacy of LSD and SLSD at live surgery events (LSE) have been debated extensively, however, objective data comparing learning ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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The Impact of Circulating Tumor Cells on Venous Thromboembolism and Cardiovascular Events in Bladder Cancer Patients Treated with Radical Cystectomy.

Michael Rink, Sabine Riethdorf, Hang Yu, Mara Kölker, Malte W Vetterlein, Roland Dahlem, Margit Fisch, Klaus Pantel, Armin Soave,

<h4>Background</h4>Cancer is a relevant risk factor for venous thromboembolism (VTE). Circulating tumor cells (CTC) are associated with an increased risk of VTE in breast cancer. In addition, circulating cell-free nucleic acids have been associated with cardiovascular events (CVE).<h4>Objective</h4>To investigate the association of CTC status and the risk of VTE as ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

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Nomenclature and treatment of secondary urethral strictures following primary hypospadias repair: weighing up academic principles and clinical pragmatism.

Malte W Vetterlein, Valentin Zumstein, Luis A Kluth, Silke Riechardt, Roland Dahlem, Margit Fisch,

World J Urol (World journal of urology)
[2020, :]

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The Impact of a New Interleukin-2-Based Immunotherapy Candidate on Urothelial Cells to Support Use for Intravesical Drug Delivery.

Lisa Schmitz, Belinda Berdien, Edith Huland, Petra Dase, Karin Beutel, Margit Fisch, Oliver Engel,

(1) Background: The intravesical instillation of interleukin-2 (IL-2) has been shown to be very well tolerated and promising in patients with bladder malignancies. This study aims to confirm the use of a new IL-2 containing immunotherapy candidate as safe for intravesical application. IL-2, produced in mammalian cells, is glycosylated, because ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2020, 10(10):]

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Longitudinal Evaluation of Perineogenital Pain and Postoperative Complications After One-stage Buccal Mucosal Graft Urethroplasty: A Secondary Analysis of a Randomized Controlled Trial.

Constantin Fuehner, Malte W Vetterlein, Judith Lesske, Michael Rink, Silke Riechardt, Frederik König, Philipp Gild, Hans O Pinnschmidt, Christian P Meyer, Tim A Ludwig, Oliver Engel, Margit Fisch, Roland Dahlem, Armin Soave,

<h4>Background</h4>Little is known about patient-reported intensity and quality of pain at the receiver site as well as postoperative complications following one-stage buccal mucosal graft urethroplasty (BMGU).<h4>Objective</h4>To evaluate perineogenital pain intensity and quality as well as short-term complications after BMGU, and to describe the impact of pain and complications on stricture ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

Cited: 1 time

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[Feminizing Genital Gender-affirmative Surgery in Centralized and Decentralized Health Care Settings - The Hamburg TransCare study].

Andreas Köhler, Bernhard Strauß, Peer Briken, Silke Riechardt, Margit Fisch, Timo O Nieder,

<h4>Background</h4>Gender Dysphoria (GD, formerly known as transsexualism) describes distress and impairment in an individual caused by the incongruence between the experienced gender and the sex assigned at birth (Gender Incongruence: GI). Transgender health care focusses on gender-affirmative treatments (e. g., hormone therapy) and associated needs (e. g., psychotherapy). Moreover, genital surgery is ... Read more >>

Psychother Psychosom Med Psychol (Psychotherapie, Psychosomatik, medizinische Psychologie)
[2021, 71(3-04):132-140]

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Impact of Cardiovascular and Metabolic Risk Factors on Stricture Recurrence After Anterior One-stage Buccal Mucosal Graft Urethroplasty.

Christian P Meyer, Jule Lamp, Malte W Vetterlein, Armin Soave, Oliver Engel, Roland Dahlem, Margit Fisch, Luis A Kluth,

<h4>Objectives</h4>To evaluate the impact of cardiovascular, metabolic and smoking related risk factors on recurrence in patients with buccal mucosal graft urethroplasty for anterior urethral strictures.<h4>Patients and methods</h4>Retrospective single-center analysis between 2009 and 2016. Covariates included American Society of Anesthesiology (ASA) score, body mass index, and smoking status (never vs ever), ... Read more >>

Urology (Urology)
[2020, 146:253-259]

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Incidence and outcome of salvage cystectomy after bladder sparing therapy for muscle invasive bladder cancer: a systematic review and meta-analysis.

Victor M Schuettfort, Benjamin Pradere, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Margit Fisch, David D'Andrea, Michael Rink, Paolo Gontero, Francesco Soria, Shahrokh F Shariat,

<h4>Objective</h4>We conducted a systematic review and meta-analysis to assess the available literature regarding the surgical and oncologic outcomes of patients undergoing salvage radical cystectomy (SV-RC) for recurrence or failure of bladder sparing therapy (BST) for muscle-invasive bladder cancer (MIBC).<h4>Methods</h4>We searched MEDLINE (PubMed), EMBASE and Google Scholar databases in May 2020. ... Read more >>

World J Urol (World journal of urology)
[2021, 39(6):1757-1768]

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Retrograde ejaculation after holmium laser enucleation of the prostate (HoLEP)-Impact on sexual function and evaluation of patient bother using validated questionnaires.

Philipp Gild, Roland Dahlem, Raisa S Pompe, Armin Soave, Malte W Vetterlein, Tim A Ludwig, Valentin Maurer, Phillip Marks, Sascha A Ahyai, Felix K-H Chun, Lukas Lenke, Tabea Ernst, Margit Fisch, Michael Rink, Christian P Meyer, Andreas Becker,

<h4>Background</h4>A vast body of literature has focused on erectile function after Holmium Laser Enucleation of the Prostate (HoLEP). Interestingly, retrograde ejaculation (RE), despite its frequency has sparsely been investigated.<h4>Objectives</h4>To study patient perception and impact of RE on sexuality following HoLEP.<h4>Materials and methods</h4>We retrospectively analyzed 2,131 patients undergoing HoLEP 2006-2015 at ... Read more >>

Andrology (Andrology)
[2020, 8(6):1779-1786]

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