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Author Margaret R Hammerschlag

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Chlamydia pneumoniae immunoglobulin E antibody levels in patients with asthma compared with non-asthma.

Tamar A Smith-Norowitz, Jeffrey Loeffler, Yvonne Huang, Elliot Klein, Yitzchok M Norowitz, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff,

Chlamydia pneumoniae is an obligate intracellular bacterium that causes respiratory infection in adults and children. There is evidence for an association between atypical bacterial pathogens and asthma pathogenesis. We sought to determine whether past C. pneumoniae infection triggers C. pneumoniae- IgE antibodies (Abs) in asthmatics and non-asthmatics, who had detectable IgG titers. ... Read more >>

Heliyon (Heliyon)
[2020, 6(2):e03512]

Cited: 0 times

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Association of Routine Chlamydia trachomatis Screening During Pregnancy and Seroprevalence of Chlamydial Infection in Children, 1991-2015.

Natalie Banniettis, Kimberly Wisecup, Leah Bylard, Izumi Watanabe, Margaret R Hammerschlag, Stephan Kohlhoff,

We performed a seroepidemiologic study of sera from children in Brooklyn, New York, before and after the implementation of prenatal chlamydial screening almost 20% of children aged ≤10 years in the prescreening group had anti-Chlamydia trachomatis immunoglobulin G compared with none in the postscreening group. ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, :]

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Diagnostic Practices for Suspected Community-Acquired Central Nervous System Infection in the Post-Conjugate Vaccine Era.

Natalie Banniettis, Saumya Joshi, Shubhi Kaushik, Stephan Kohlhoff, Margaret R Hammerschlag,

OBJECTIVE:The aim of this study was to evaluate diagnostic practices for suspected community-acquired central nervous system (CNS) infection in an urban pediatric population. METHODS:This is an observational, retrospective single-center review of cerebrospinal fluid (CSF) studies in children, 1 month to 21 years old, evaluated for suspected CNS infection from 2004 ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2019, 35(11):774-776]

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Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections in Children: a Reappraisal of Vancomycin.

Roopali Sharma, Margaret R Hammerschlag,

PURPOSE OF REVIEW:In the last 50 years, vancomycin has been the agent of choice to treat infections due to methicillin-resistant Staphylococcus aureus (MRSA). However, vancomycin treatment failure is not uncommon, even when MRSA strains are fully susceptible to vancomycin. Treatment with vancomycin requires careful monitoring of drug levels as there is ... Read more >>

Curr Infect Dis Rep (Current infectious disease reports)
[2019, 21(10):37]

Cited: 1 time

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In Vitro Activity of Levonadifloxacin (WCK 771) against Chlamydia pneumoniae.

Stephan Kohlhoff, Natalia Huerta, Margaret R Hammerschlag,

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2019, 63(8):]

Cited: 1 time

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Outsourcing Microbiology Services in Medical Centers: Is It Worth It?

Manuel E Penton, Caitlin Otto, Margaret R Hammerschlag,

BACKGROUND:Outsourcing of microbiology laboratory services is a growing trend in US medical centers. Data on the actual impact of outsourcing on patient care, safety, and medical education, including costs, are limited. The objective of this study was to examine the published literature on the potential benefits and harms when medical ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, :]

Cited: 0 times

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In Vitro Activity of Omadacycline against Chlamydia pneumoniae.

Stephan A Kohlhoff, Natalia Huerta, Margaret R Hammerschlag,

The in vitro activities of omadacycline, azithromycin, doxycycline, moxifloxacin, and levofloxacin were tested against 15 isolates of Chlamydia pneumoniae The minimum inhibitory concentration at which 90% of the isolates of C. pneumoniae were inhibited by omadacycline was 0.25 μg/ml (range, 0.03 to 0.5 μg/ml). ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2019, 63(2):]

Cited: 3 times

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Caution Is Required When Using Non-Food and Drug Administration-Cleared Assays to Diagnose Sexually Transmitted Infections in Children.

Amanda D Brownell, Robert A Shapiro, Margaret R Hammerschlag,

Nucleic acid amplification testing is the gold-standard for Chlamydia trachomatis and Neisseria gonorrhoeae testing in adults. We present 3 pediatric cases in which testing resulted in probable false-positive results. Clinicians should avoid tests without clearance from a regulatory agency and should maintain consistent communication with laboratories. ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2019, 206:280-282]

Cited: 0 times

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Cost-Benefit Analysis of a Chlamydia trachomatis Vaccine Program in Adolescent Girls in the United States.

Jared Ditkowsky, Afsana Rahman, Margaret R Hammerschlag, Stephan Kohlhoff, Tamar A Smith-Norowitz,

Background:With >1.4 million cases in the United States reported to the Centers for Disease Control and Prevention in 2012, Chlamydia trachomatis infection is a major public health concern. We examined the impact of a C trachomatis vaccination program using a decision-analysis model to estimate the effects of vaccination on C ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2018, 7(4):296-302]

Cited: 0 times

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Perinatally Acquired Chlamydia trachomatis Infection in Children.

Natalie Banniettis, Margaret R Hammerschlag,

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2018, 37(8):835]

Cited: 0 times

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Management Practices for Methicillin-Resistant Staphylococcus aureus Bacteremia by Adult Infectious Diseases Physicians.

Natalie Banniettis, Susan E Beekmann, Philip M Polgreen, Shubhi Kaushik, Stephan Kohlhoff, David Gilbert, John E Bennett, Margaret R Hammerschlag,

To assess current use of vancomycin for methicillin-resistant Staphylococcus aureus bacteremia, we surveyed adult infectious disease physicians. Most respondents reported personal experience with infections failing to respond to vancomycin despite minimum inhibitory concentration data indicating susceptibility. In a hypothetical case of such an infection, most would change to daptomycin with ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(5):ofy093]

Cited: 1 time

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Chlamydia pneumoniae-induced tumour necrosis factor alpha responses are lower in children with asthma compared with non-asthma.

Tamar Anne Smith-Norowitz, Kobkul Chotikanatis, Diana Weaver, Jared Ditkowsky, Yitzchok Meir Norowitz, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff,

Chlamydia pneumoniae respiratory tract infection has been implicated in the pathogenesis of reactive airway disease and asthma. Innate cytokine responses that are protective of infection with intracellular pathogens may be impaired in patients with asthma. Tumour necrosis factor alpha (TNF-α) is a cytokine related to functions of monocytes and may ... Read more >>

BMJ Open Respir Res (BMJ open respiratory research)
[2018, 5(1):e000239]

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Doxycycline suppresses Chlamydia pneumoniae induced interferon-gamma responses in peripheral blood mononuclear cells in children with allergic asthma.

Tamar A Smith-Norowitz, Diana Weaver, Yitzchok M Norowitz, Margaret R Hammerschlag, Rauno Joks, Helen G Durkin, Stephan Kohlhoff,

Persistent respiratory infections caused by Chlamydia pneumoniae have been implicated in the pathogenesis of chronic diseases (e.g. asthma). Antibiotics are used to treat C. pneumoniae respiratory infections; however, the use of antibiotics as anti-inflammatory agents in treatment of asthma remains controversial. The current study investigated whether ciprofloxacin, azithromycin, or doxycycline can ... Read more >>

J. Infect. Chemother. (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2018, 24(6):470-475]

Cited: 0 times

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New Antimicrobial Agents for the Treatment of Staphylococcal Infections in Children.

Roopali Sharma, Densley Francois, Margaret R Hammerschlag,

Several new antimicrobial agents-daptomycin, ceftaroline, telavancin, dalbavancin, and-tedizolid have been approved for the treatment of staphylococcal infections, including methicillin-resistant Staphylococcus aureus (MRSA), in adults. Ceftaroline and daptomycin have been approved by the US Food and Drug Administration for use in children. Ceftaroline, a beta-lactam antibiotic with activity against MRSA, has ... Read more >>

Pediatr. Clin. North Am. (Pediatric clinics of North America)
[2017, 64(6):1369-1387]

Cited: 6 times

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Seroprevalence of Chlamydia trachomatis in Inner-City Children and Adolescents-Implications for Vaccine Development.

Natalie Banniettis, Sirisha Thumu, Jeremy Weedon, Kobkul Chotikanatis, Aviva Szigeti, Margaret R Hammerschlag, Stephan A Kohlhoff,

Prevention of Chlamydia trachomatis infection is an ideal application for a vaccine program, which should optimally be administered before sexual debut. However, there are limited epidemiologic studies of C. trachomatis infection in an unselected pediatric population since routine screening and treatment of pregnant women was implemented in the United States ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2017, 44(12):717-721]

Cited: 3 times

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Keeping an Eye on Chlamydia and Gonorrhea Conjunctivitis in Infants in the United States, 2010-2015.

Margaret R Hammerschlag, Tamar Smith-Norowitz, Stephan A Kohlhoff,

Sex Transm Dis (Sexually transmitted diseases)
[2017, 44(9):577]

Cited: 0 times

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Cost-benefit analysis of Chlamydia trachomatis screening in pregnant women in a high burden setting in the United States.

Jared Ditkowsky, Khushal H Shah, Margaret R Hammerschlag, Stephan Kohlhoff, Tamar A Smith-Norowitz,

Chlamydia trachomatis is the most common bacterial sexually transmitted infection (STI) in the United States (U.S.) [1] and remains a major public health problem. We determined the cost- benefit of screening all pregnant women aged 15-24 for Chlamydia trachomatis infection compared with no screening.We developed a decision analysis model to ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2017, 17(1):155]

Cited: 3 times

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Evaluation of clinical outcome in children and adolescents receiving vancomycin for invasive infections due to methicillin-resistant Staphylococcus aureus: impact of increasing vancomycin MICs.

Aparna Arun, Siddharth Swamy, Kathleen Jacob, Roopali Sharma, Stephan A Kohlhoff, Margaret R Hammerschlag,

BACKGROUND:Vancomycin is the preferred drug for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in children. In adults, treatment failure with vancomycin has been associated with an area under the curve/24 hrs /MIC (AUC24/MIC) ratio of ≤400 and high minimum inhibitory concentrations (MIC ≥1.0 mg/L). Vancomycin dosing information to ensure ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2018, 70(3):207-211]

Cited: 1 time

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Cost-effectiveness analysis of Chlamydia trachomatis screening in Dutch pregnant women.

G I J G Rours, Tamar Anne Smith-Norowitz, Jared Ditkowsky, Margaret R Hammerschlag, R P Verkooyen, R de Groot, H A Verbrugh, M J Postma,

Chlamydia trachomatis infections during pregnancy may have serious consequences for women and their offspring. Chlamydial infections are largely asymptomatic. Hence, prevention is based on screening. The objective of this study was to estimate the cost-effectiveness of C. trachomatis screening during pregnancy. We used a health-economic decision analysis model, which included ... Read more >>

Pathog Glob Health (Pathogens and global health)
[2016, 110(7-8):292-302]

Cited: 2 times

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Epigallocatechin gallate suppresses Chlamydia pneumoniae mediated IgE responses in peripheral blood mononuclear cells: a pilot study.

Tamar A Smith-Norowitz, Kobkul Chotikanatis, Elizabeth Tam, Yitzchok M Norowitz, Rauno Joks, Helen G Durkin, Margaret R Hammerschlag, Stephan Kohlhoff,

Chlamydia pneumoniae (C. pneumoniae) causes respiratory infection in children and adults and is associated with asthma and induction of immunoglobulin E (IgE) responses. Previous studies in our laboratory reported that green tea extract (GTE) and its catechin, epigallocatechin gallate (EGCG) have immunoregulatory effects on IgE responses. Whereas tea polyphenols have ... Read more >>

Minerva Med. (Minerva medica)
[2016, 107(6):363-369]

Cited: 1 time

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IgE anti-Haemophilus influenzae type b (Hib) antibodies detected in serum of Hib-vaccinated asthmatic and non-asthmatic pediatric patients.

Tamar A Smith-Norowitz, Tehila A Saadia, Natalie Banniettis, Yitzchok M Norowitz, Rauno Joks, Margaret R Hammerschlag, Helen G Durkin, Stephan Kohlhoff,

Haemophilus influenzae type b (Hib) bacterium causes severe illness in infants and children, but has largely been eliminated by introducing a universal Hib conjugate vaccine. While effects of certain vaccinations on atopic disease have been studied, little is known about the relationship between Hib vaccination and diseases of altered immunoglobulin ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2018, 70(2):111-116]

Cited: 0 times

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Chlamydia pneumoniae enhances the Th2 profile of stimulated peripheral blood mononuclear cells from asthmatic patients.

Tamar A Smith-Norowitz, Kobkul Chotikanatis, David P Erstein, Jason Perlman, Yitzchok M Norowitz, Rauno Joks, Helen G Durkin, Margaret R Hammerschlag, Stephan Kohlhoff,

Chlamydia pneumoniae is a cause of respiratory infection in adults and children. There is evidence for an association between atypical bacterial respiratory pathogens and the pathogenesis of asthma. We compared T helper (Th) responses in C. pneumoniae - infected peripheral blood mononuclear cells (PBMC) in patients with or without asthma. ... Read more >>

Hum. Immunol. (Human immunology)
[2016, 77(5):382-388]

Cited: 2 times

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Steady-state pharmacokinetics of oral linezolid suspension in a premature infant with osteomyelitis.

Natalie Banniettis, Roopali Sharma, Ivan Hand, Charles A Peloquin, Stephan Kohlhoff, Margaret R Hammerschlag,

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2016, 71(6):1738]

Cited: 0 times

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Sexual Assault and Sexually Transmitted Infections in Adults, Adolescents, and Children.

Arlene C Seña, Katherine K Hsu, Nancy Kellogg, Rebecca Girardet, Cindy W Christian, Judith Linden, William Griffith, Anne Marchant, Carole Jenny, Margaret R Hammerschlag,

Survivors of sexual assault are at risk for acquiring sexually transmitted infections (STIs). We conducted literature reviews and invited experts to assist in updating the sexual assault section for the 2015 Centers for Disease Control and Prevention sexually transmitted diseases (STD) treatment guidelines. New recommendations for STI management among adult ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2015, 61 Suppl 8:S856-64]

Cited: 6 times

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Treatment of Chlamydial infections: 2014 update.

Stephan A Kohlhoff, Margaret R Hammerschlag,

INTRODUCTION: Chlamydiae are obligate intracellular bacterial pathogens whose entry into mucosal epithelial cells is required for intracellular survival and subsequent growth. The life cycle of Chlamydia spp. and the ability to cause persistent, often subclinical infection, has major ramifications for diagnosis and treatment of Chlamydia trachomatis and C. pneumoniae infections ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2015, 16(2):205-212]

Cited: 26 times

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