Full Text Journal Articles by
Author Margaret Herridge

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Patient and Family Engagement in Critical Illness: Erratum.

Cheryl Misak, Margaret Herridge, E Wesley Ely, Alison Clay, Mark E Mikkelsen,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1195]

Cited: 0 times

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Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.

Jennie Johnstone, Maureen Meade, François Lauzier, John Marshall, Erick Duan, Joanna Dionne, Yaseen M Arabi, Diane Heels-Ansdell, Lehana Thabane, Daphnee Lamarche, Michael Surette, Nicole Zytaruk, Sangeeta Mehta, Peter Dodek, Lauralyn McIntyre, Shane English, Bram Rochwerg, Tim Karachi, William Henderson, Gordon Wood, Daniel Ovakim, Margaret Herridge, John Granton, M Elizabeth Wilcox, Alberto Goffi, Henry T Stelfox, Daniel Niven, John Muscedere, François Lamontagne, Frédérick D'Aragon, Charles St-Arnaud, Ian Ball, Dave Nagpal, Martin Girard, Pierre Aslanian, Emmanuel Charbonney, David Williamson, Wendy Sligl, Jan Friedrich, Neill K Adhikari, François Marquis, Patrick Archambault, Kosar Khwaja, Arnold Kristof, James Kutsogiannis, Ryan Zarychanski, Bojan Paunovic, Brenda Reeve, François Lellouche, Paul Hosek, Jennifer Tsang, Alexandra Binnie, Sébastien Trop, Osama Loubani, Richard Hall, Robert Cirone, Steve Reynolds, Paul Lysecki, Eyal Golan, Rodrigo Cartin-Ceba, Robert Taylor, Deborah Cook, ,

<h4>Importance</h4>Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials in this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported.<h4>Objective</h4>To evaluate the effect of Lactobacillus rhamnosus GG on ... Read more >>

JAMA (JAMA)
[2021, 326(11):1024-1033]

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Patient and Family Engagement in Critical Illness.

Cheryl Misak, Margaret Herridge, E Wesley Ely, Alison Clay, Mark E Mikkelsen,

Crit Care Med (Critical care medicine)
[2021, 49(9):1389-1401]

Cited: 0 times

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Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.

Leah B Kosyakovsky, Federico Angriman, Emma Katz, Neill K Adhikari, Lucas C Godoy, John C Marshall, Bruno L Ferreyro, Douglas S Lee, Robert S Rosenson, Naveed Sattar, Subodh Verma, Augustin Toma, Marina Englesakis, Barry Burstein, Michael E Farkouh, Margaret Herridge, Dennis T Ko, Damon C Scales, Michael E Detsky, Lior Bibas, Patrick R Lawler,

<h4>Purpose</h4>We aimed to determine the association between sepsis and long-term cardiovascular events.<h4>Methods</h4>We conducted a systematic review of observational studies evaluating post-sepsis cardiovascular outcomes in adult sepsis survivors. MEDLINE, Embase, and the Cochrane Controlled Trials Register and Database of Systematic Reviews were searched from inception until April 21st, 2021. Two reviewers ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(9):931-942]

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Recovery after prolonged ICU treatment in patients with COVID-19.

Matteo Parotto, Sheila Nainan Myatra, Daniel Munblit, Alyaa Elhazmi, Otavio T Ranzani, Margaret S Herridge,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(8):812-814]

Cited: 0 times

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Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19.

Luca Carenzo, Alessandro Protti, Francesca Dalla Corte, Romina Aceto, Giacomo Iapichino, Angelo Milani, Alessandro Santini, Chiara Chiurazzi, Michele Ferrari, Enrico Heffler, Claudio Angelini, Alessio Aghemo, Michele Ciccarelli, Arturo Chiti, Theodore J Iwashyna, Margaret S Herridge, Maurizio Cecconi, ,

<h4>Background</h4>Survivors of severe COVID-19 are at risk of impaired health-related quality of life (HRQoL) and persistent physical and psychological disability after ICU and hospital discharge. The subsequent social burden is a major concern. We aimed to assess the short-term HRQoL, physical function and prevalence of post-traumatic stress symptoms of invasively ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):91]

Cited: 1 time

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Caractéristiques et issues des hospitalisations pour les cas de COVID-19 et d’influenza dans la région de Toronto.

Amol A Verma, Tejasvi Hora, Hae Young Jung, Michael Fralick, Sarah L Malecki, Lauren Lapointe-Shaw, Adina Weinerman, Terence Tang, Janice L Kwan, Jessica J Liu, Shail Rawal, Timothy C Y Chan, Angela M Cheung, Laura C Rosella, Marzyeh Ghassemi, Margaret Herridge, Muhammad Mamdani, Fahad Razak,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(23):E859-E869]

Cited: 0 times

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Suicide and self-harm in adult survivors of critical illness: population based cohort study.

Shannon M Fernando, Danial Qureshi, Manish M Sood, Michael Pugliese, Robert Talarico, Daniel T Myran, Margaret S Herridge, Dale M Needham, Bram Rochwerg, Deborah J Cook, Hannah Wunsch, Robert A Fowler, Damon C Scales, O Joseph Bienvenu, Kathryn M Rowan, Magdalena Kisilewicz, Laura H Thompson, Peter Tanuseputro, Kwadwo Kyeremanteng,

<h4>Objective</h4>To analyse the association between survival from critical illness and suicide or self-harm after hospital discharge.<h4>Design</h4>Population based cohort study using linked and validated provincial databases.<h4>Setting</h4>Ontario, Canada between January 2009 and December 2017 (inclusive).<h4>Participants</h4>Consecutive adult intensive care unit (ICU) survivors (≥18 years) were included. Linked administrative databases were used to compare ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2021, 373:n973]

Cited: 1 time

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Research priorities for Long Covid: refined through an international multi-stakeholder forum.

Gail Carson, ,

BMC Med (BMC medicine)
[2021, 19(1):84]

Cited: 5 times

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Rétablissement à la suite d’un séjour prolongé à l’unité des soins intensifs.

Matteo Parotto, Margaret S Herridge,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(7):E260]

Cited: 0 times

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Characteristics and outcomes of hospital admissions for COVID-19 and influenza in the Toronto area.

Amol A Verma, Tejasvi Hora, Hae Young Jung, Michael Fralick, Sarah L Malecki, Lauren Lapointe-Shaw, Adina Weinerman, Terence Tang, Janice L Kwan, Jessica J Liu, Shail Rawal, Timothy C Y Chan, Angela M Cheung, Laura C Rosella, Marzyeh Ghassemi, Margaret Herridge, Muhammad Mamdani, Fahad Razak,

<h4>Background</h4>Patient characteristics, clinical care, resource use and outcomes associated with admission to hospital for coronavirus disease 2019 (COVID-19) in Canada are not well described.<h4>Methods</h4>We described all adults with COVID-19 or influenza discharged from inpatient medical services and medical-surgical intensive care units (ICUs) between Nov. 1, 2019, and June 30, 2020, ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(12):E410-E418]

Cited: 4 times

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COVID-19: a heavy toll on health-care workers.

Sangeeta Mehta, Flavia Machado, Arthur Kwizera, Laurent Papazian, Marc Moss, Élie Azoulay, Margaret Herridge,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(3):226-228]

Cited: 34 times

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Leaving a mark: pressure injury research in the intensive care unit.

Craig M Dale, Jake Tran, Margaret S Herridge,

Intensive Care Med (Intensive care medicine)
[2021, 47(2):222-224]

Cited: 0 times

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Recovery after prolonged treatment in the intensive care unit.

Matteo Parotto, Margaret S Herridge,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(48):E1637]

Cited: 1 time

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Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition.

Heta Lad, Tyler M Saumur, Margaret S Herridge, Claudia C Dos Santos, Sunita Mathur, Jane Batt, Penney M Gilbert,

Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from the critical illness itself, and results in sustained disability long after the ICU stay. Weakness can be attributed to muscle wasting, impaired contractility, neuropathy, and major pathways associated with muscle protein degradation such as the ubiquitin proteasome system ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(21):]

Cited: 5 times

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Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.

, , , , , , Sean M Bagshaw, Ron Wald, Neill K J Adhikari, Rinaldo Bellomo, Bruno R da Costa, Didier Dreyfuss, Bin Du, Martin P Gallagher, Stéphane Gaudry, Eric A Hoste, François Lamontagne, Michael Joannidis, Giovanni Landoni, Kathleen D Liu, Daniel F McAuley, Shay P McGuinness, Javier A Neyra, Alistair D Nichol, Marlies Ostermann, Paul M Palevsky, Ville Pettilä, Jean-Pierre Quenot, Haibo Qiu, Bram Rochwerg, Antoine G Schneider, Orla M Smith, Fernando Thomé, Kevin E Thorpe, Suvi Vaara, Matthew Weir, Amanda Y Wang, Paul Young, Alexander Zarbock,

<h4>Background</h4>Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for the initiation of such therapy remains uncertain.<h4>Methods</h4>We conducted a multinational, randomized, controlled trial involving critically ill patients with severe acute kidney injury. Patients were randomly assigned to receive an ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(3):240-251]

Cited: 40 times

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Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol.

Vincent Issac Lau, Deborah J Cook, Robert Fowler, Bram Rochwerg, Jennie Johnstone, François Lauzier, John C Marshall, John Basmaji, Diane Heels-Ansdell, Lehana Thabane, Feng Xie, ,

<h4>Introduction</h4>Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in the intensive care unit (ICU). Probiotics are defined as live microorganisms that may confer health benefits when ingested. Prior randomised trials suggest that probiotics may prevent infections such as VAP and <i>Clostridioides difficile</i>-associated diarrhoea (CDAD). PROSPECT (Probiotics to Prevent Severe Pneumonia ... Read more >>

BMJ Open (BMJ open)
[2020, 10(6):e036047]

Cited: 0 times

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The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database.

Jean-Louis Vincent, Andrew Ferguson, Peter Pickkers, Stephan M Jakob, Ulrich Jaschinski, Ghaleb A Almekhlafi, Marc Leone, Majid Mokhtari, Luis E Fontes, Philippe R Bauer, Yasser Sakr, ,

<h4>Background</h4>Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):171]

Cited: 2 times

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Gender Differences in Authorship of Critical Care Literature.

Kelly C Vranas, David Ouyang, Amber L Lin, Christopher G Slatore, Donald R Sullivan, Meeta Prasad Kerlin, Kathleen D Liu, Rebecca M Baron, Carolyn S Calfee, Lorraine B Ware, Scott D Halpern, Michael A Matthay, Margaret S Herridge, Sangeeta Mehta, Angela J Rogers,

<b>Rationale:</b> Gender gaps exist in academic leadership positions in critical care. Peer-reviewed publications are crucial to career advancement, and yet little is known regarding gender differences in authorship of critical care research.<b>Objectives:</b> To evaluate gender differences in authorship of critical care literature.<b>Methods:</b> We used a validated database of author gender ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 201(7):840-847]

Cited: 5 times

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Support needs and health-related quality of life of family caregivers of patients requiring prolonged mechanical ventilation and admission to a specialised weaning centre: A qualitative longitudinal interview study.

Craig M Dale, Sarah Carbone, Laura Istanboulian, Ian Fraser, Jill I Cameron, Margaret S Herridge, Louise Rose,

OBJECTIVES:Family caregivers of patients requiring prolonged mechanical ventilation may experience physical and psychological morbidity associated with a protracted intensive care unit experience. Our aim was to explore potentially modifiable support needs and care processes of importance to family caregivers of patients requiring prolonged mechanical ventilation and transition from the intensive ... Read more >>

Intensive Crit Care Nurs (Intensive & critical care nursing)
[2020, 58:102808]

Cited: 1 time

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Focus on the frail and elderly: who should have a trial of ICU treatment?

Otavio T Ranzani, Bruno A M P Besen, Margaret S Herridge,

Intensive Care Med (Intensive care medicine)
[2020, 46(5):1030-1032]

Cited: 8 times

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Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults.

Michael C Sklar, Martin Dres, Eddy Fan, Gordon D Rubenfeld, Damon C Scales, Margaret S Herridge, Nuttapol Rittayamai, Michael O Harhay, W Darlene Reid, George Tomlinson, Dmitry Rozenberg, William McClelland, Stephen Riegler, Arthur S Slutsky, Laurent Brochard, Niall D Ferguson, Ewan C Goligher,

Importance:Low diaphragm muscle mass at the outset of mechanical ventilation may predispose critically ill patients to poor clinical outcomes. Objective:To determine whether lower baseline diaphragm thickness (Tdi) is associated with delayed liberation from mechanical ventilation and complications of acute respiratory failure (reintubation, tracheostomy, prolonged ventilation >14 days, or death in ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(2):e1921520]

Cited: 5 times

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Canadian Critical Care Society clinical practice guideline: The use of vasopressin and vasopressin analogues in critically ill adults with distributive shock.

Kimia Honarmand, Kevin John Um, Emilie P Belley-Côté, Waleed Alhazzani, Chris Farley, Shannon M Fernando, Kirsten Fiest, Donna Grey, Edita Hajdini, Margaret Herridge, Carmen Hrymak, Morten Hylander Møller, Salmaan Kanji, François Lamontagne, François Lauzier, Sangeeta Mehta, Bojan Paunovic, Rohit Singal, Jennifer Ly Tsang, Christine Wynne, Bram Rochwerg,

<h4>Purpose</h4>Hemodynamic management of adults with distributive shock often includes the use of catecholamine-based vasoconstricting medications. It is unclear whether adding vasopressin or vasopressin analogues to catecholamine therapy is beneficial in the management of patients with distributive shock. The purpose of this guideline was to develop an evidence-based recommendation regarding the ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2020, 67(3):369-376]

Cited: 2 times

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Correction to: Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial.

Devin S McCaskell, Alexander J Molloy, Laura Childerhose, F Aileen Costigan, Julie C Reid, Magda McCaughan, France Clarke, Deborah J Cook, Jill C Rudkowski, Christopher Farley, Tim Karachi, Bram Rochwerg, Anastasia Newman, Alison Fox-Robichaud, Margaret S Herridge, Vincent Lo, Deanna Feltracco, Karen E A Burns, Rebecca Porteous, Andrew J E Seely, Ian M Ball, Amy Seczek, Michelle E Kho,

Following publication of the original article [1], we have been notified that one of the authors' names is spelled incorrectly. In this Correction the incorrect and correct author name are shown. ... Read more >>

Trials (Trials)
[2019, 20(1):606]

Cited: 0 times

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Fostering community hospital research.

Paige Gehrke, Alexandra Binnie, Stephanie P T Chan, Deborah J Cook, Karen E A Burns, Oleksa G Rewa, Margaret Herridge, Jennifer L Y Tsang,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2019, 191(35):E962-E966]

Cited: 2 times

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