Full Text Journal Articles by
Author Marcos G Lopez

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Ear Plugs, Eye Masks, and Risk of Bias.

Marcos G Lopez, Christina Boncyk,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1180]

Cited: 0 times

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Intraoperative venous congestion and acute kidney injury in cardiac surgery: an observational cohort study.

Marcos G Lopez, Matthew S Shotwell, Jennifer Morse, Yafen Liang, Jonathan P Wanderer, Tarek S Absi, Keki R Balsara, Melissa M Levack, Ashish S Shah, Antonio Hernandez, Frederic T Billings,

<h4>Background</h4>Increased intravascular volume has been associated with protection from acute kidney injury (AKI), but in patients with congestive heart failure, venous congestion is associated with increased AKI. We tested the hypothesis that intraoperative venous congestion is associated with AKI after cardiac surgery.<h4>Methods</h4>In patients enrolled in the Statin AKI Cardiac Surgery ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(3):599-607]

Cited: 0 times

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The incidence, risk, presentation, pathophysiology, treatment, and effects of perioperative acute kidney injury.

Frederic T Billings, Marcos G Lopez, Andrew D Shaw,

<h4>Purpose</h4>Present clinical updates, current research findings, and consensus statements relevant to the care of the acute kidney injury (AKI) patient.<h4>Principal findings</h4>Acute kidney injury is one of the most frequent and debilitating complications of surgery and critical illness. Consensus criteria use serum creatinine and urine output measurements to diagnose AKI and ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, 68(3):409-422]

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Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension.

Anna Dikalova, Vladimir Mayorov, Liang Xiao, Alexander Panov, Venkataraman Amarnath, Irene Zagol-Ikapitte, Aurelia Vergeade, Mingfang Ao, Valery Yermalitsky, Rafal R Nazarewicz, Olivier Boutaud, Marcos G Lopez, Frederic T Billings, Sean Davies, L Jackson Roberts, David G Harrison, Sergey Dikalov,

Hypertension remains a major health problem in Western Societies, and blood pressure is poorly controlled in a third of patients despite use of multiple drugs. Mitochondrial dysfunction contributes to hypertension, and mitochondria-targeted agents can potentially improve treatment of hypertension. We have proposed that mitochondrial oxidative stress produces reactive dicarbonyl lipid ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 76(6):1980-1991]

Cited: 2 times

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Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.

Marcos G Lopez, Christopher G Hughes, Anthony DeMatteo, Jason B O'Neal, J Brennan McNeil, Matthew S Shotwell, Jennifer Morse, Michael R Petracek, Ashish S Shah, Nancy J Brown, Frederic T Billings,

<h4>Background</h4>Mechanisms of postoperative delirium remain poorly understood, limiting development of effective treatments. We tested the hypothesis that intraoperative oxidative damage is associated with delirium and neuronal injury and that disruption of the blood-brain barrier modifies these associations.<h4>Methods</h4>In a prespecified cohort study of 400 cardiac surgery patients enrolled in a clinical ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(3):551-561]

Cited: 5 times

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Perioperative Clinical Trials in AKI.

David R McIlroy, Marcos G Lopez, Frederic T Billings,

To characterize current evidence and current foci of perioperative clinical trials, we systematically reviewed Medline and identified perioperative trials involving 100 or more adult patients undergoing surgery and reporting renal end points that were published in high-impact journals since 2004. We categorized the 101 trials identified based on the nature ... Read more >>

Semin Nephrol (Seminars in nephrology)
[2020, 40(2):173-187]

Cited: 1 time

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Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.

Anna E Dikalova, Arvind Pandey, Liang Xiao, Liaisan Arslanbaeva, Tatiana Sidorova, Marcos G Lopez, Frederic T Billings, Eric Verdin, Johan Auwerx, David G Harrison, Sergey I Dikalov,

<h4>Rationale</h4>Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to hypertension, but specific mechanisms are unclear. The mitochondrial deacetylase Sirt3 (Sirtuin 3) is critical in the regulation of metabolic and antioxidant functions which are associated with ... Read more >>

Circ Res (Circulation research)
[2020, 126(4):439-452]

Cited: 25 times

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Serratus anterior plane block for minimally invasive valve surgery thoracotomy pain.

Michael R Kazior, Adam B King, Marcos G Lopez, Frederic T Billings, William T Costello,

J Clin Anesth (Journal of clinical anesthesia)
[2019, 56:48-49]

Cited: 0 times

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Intraoperative prediction of cardiac surgery-associated acute kidney injury using urinary biomarkers of cell cycle arrest.

Jared J Cummings, Andrew D Shaw, Jing Shi, Marcos G Lopez, Jason B O'Neal, Frederic T Billings,

<h4>Objective</h4>Tissue inhibitor of metalloproteinases 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are postoperative urinary biomarkers of renal stress and acute kidney injury (AKI). We conducted this study to test the hypothesis that intraoperative concentrations of urinary [TIMP-2]·[IGFBP7] are associated with postoperative AKI.<h4>Methods</h4>We measured urinary [TIMP-2]·[IGFBP7] at 8 perioperative ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2019, 157(4):1545-1553.e5]

Cited: 10 times

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Not All Calcium Formulations Are Alike.

Robert E Freundlich, Marcos G Lopez, Adam J Kingeter,

Anesth Analg (Anesthesia and analgesia)
[2018, 126(2):728]

Cited: 1 time

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The Risk of Oxygen during Cardiac Surgery (ROCS) trial: study protocol for a randomized clinical trial.

Marcos G Lopez, Mias Pretorius, Matthew S Shotwell, Robert Deegan, Susan S Eagle, Jeremy M Bennett, Bantayehu Sileshi, Yafen Liang, Brian J Gelfand, Adam J Kingeter, Kara K Siegrist, Frederick W Lombard, Tiffany M Richburg, Dane A Fornero, Andrew D Shaw, Antonio Hernandez, Frederic T Billings,

<h4>Background</h4>Anesthesiologists administer excess supplemental oxygen (hyper-oxygenation) to patients during surgery to avoid hypoxia. Hyper-oxygenation, however, may increase the generation of reactive oxygen species and cause oxidative damage. In cardiac surgery, increased oxidative damage has been associated with postoperative kidney and brain injury. We hypothesize that maintenance of normoxia during cardiac ... Read more >>

Trials (Trials)
[2017, 18(1):295]

Cited: 4 times

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Delayed Recall and Working Memory MMSE Domains Predict Delirium following Cardiac Surgery.

Catherine C Price, Cynthia Garvan, Loren P Hizel, Marcos G Lopez, Frederic T Billings,

<h4>Background</h4>Reduced preoperative cognition is a risk factor for postoperative delirium. The significance for type of preoperative cognitive deficit, however, has yet to be explored and could provide important insights into mechanisms and prediction of delirium.<h4>Objective</h4>Our goal was to determine if certain cognitive domains from the general cognitive screener, the Mini-Mental ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2017, 59(3):1027-1035]

Cited: 7 times

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Intraoperative cerebral oxygenation, oxidative injury, and delirium following cardiac surgery.

Marcos G Lopez, Pratik Pandharipande, Jennifer Morse, Matthew S Shotwell, Ginger L Milne, Mias Pretorius, Andrew D Shaw, L Jackson Roberts, Frederic T Billings,

<h4>Background</h4>Delirium affects 20-30% of patients after cardiac surgery and is associated with increased mortality and persistent cognitive decline. Hyperoxic reperfusion of ischemic tissues increases oxidative injury, but oxygen administration remains high during cardiac surgery. We tested the hypothesis that intraoperative hyperoxic cerebral reperfusion is associated with increased postoperative delirium and ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2017, 103:192-198]

Cited: 19 times

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Anesthesiologist staffing considerations consequent to the temporal distribution of hypoxemic episodes in the postanesthesia care unit.

Richard H Epstein, Franklin Dexter, Marcos G Lopez, Jesse M Ehrenfeld,

<h4>Background</h4>Hypoxemia, as measured by pulse oximetry (SpO2), is common in postanesthesia care unit (PACU) patients. The temporal distribution of desaturation has managerial implications because treatment may necessitate the presence of an anesthesiologist.<h4>Methods</h4>We retrieved SpO2 values recorded electronically every 30 to 60 seconds from 137,757 PACU patients over n = 80 ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2014, 119(6):1322-1333]

Cited: 14 times

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Roles of nitric oxide and prostaglandins in the hyperemic response to a maximal metabolic stimulus: redundancy prevails.

Marcos G Lopez, Bruno M Silva, Michael J Joyner, Darren P Casey,

Vasodilatory mechanisms controlling post-exercise or post-ischemic hyperemia are thought to be under redundant control and remain incompletely understood. A maximal metabolic stimulus evoked by ischemic exercise (IE) might limit redundancy by full activation of multiple pathways. We tested whether nitric oxide (NO) and/or prostaglandins contribute to the hyperemic response to ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2013, 113(6):1449-1456]

Cited: 6 times

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Ischemic exercise hyperemia in the human forearm: reproducibility and roles of adenosine and nitric oxide.

Marcos G Lopez, Bruno M Silva, Michael J Joyner, Darren P Casey,

The roles of local metabolites in reactive and exercise hyperemia remain incompletely understood. A maximum metabolic stimulus caused by ischemic exercise (IE) could potentially fully activate all vasodilator pathways and limit potential redundancy amongst vasoactive substances. We tested the hypotheses that IE elicits a reproducible hyperemic response in the forearm ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2012, 112(6):2065-2072]

Cited: 6 times

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Altered microvascular control of exercising skeletal muscle blood flow: the unfortunate male?

Emma C Hart, Marcos G Lopez, Darren P Casey,

J Physiol (The Journal of physiology)
[2010, 588(Pt 20):3851-3852]

Cited: 0 times

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