Full Text Journal Articles by
Author Marco Moschini

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Impact of the preoperative modified glasgow prognostic score on disease outcome after radical cystectomy for urothelial carcinoma of the bladder.

Victor M Schuettfort, Kilian Gust, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Mohammad Abufaraj, Pierre I Karakiewicz, Stefano Luzzago, Morgan Rouprêt, Dmitry Enikeev, Kristin Zimmermann, Marina Deuker, Marco Moschini, Reza Sari Motlagh, Nico C Grossmann, Satoshi Katayama, Benjamin Pradere, Shahrokh F Shariat,

<h4>Background</h4>To investigate the predictive and prognostic value of the preoperative modified Glasgow Prognostic Score (mGPS) in patients with urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC).<h4>Methods</h4>We conducted a retrospective analysis of an established multicenter database consisting of 4,335 patients who were treated with RC +/- adjuvant chemotherapy ... Read more >>

Minerva Urol Nephrol (Minerva urology and nephrology)
[2021, :]

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Adverse events of the second-line treatment for patients with locally advanced or metastatic urothelial carcinoma of the bladder: network meta-analysis.

Ekaterina Laukhtina, Keiichiro Mori, Hadi Mostafaei, Axel S Merseburger, Peter Nyirady, Marco Moschini, Fahad Quhal, Victor M Schuettfort, Benjamin Pradere, Reza Sari Motlagh, Dmitry Enikeev, Shahrokh F Shariat, European Association Of Urology-Young Academic Urologists Eau-Yau Urothelial Carcinoma Working Group,

<b>Aim:</b> We aimed to compare the mortality rates related to adverse events (AEs) and discontinuation of treatment due to toxicity as well as all AEs of currently used regimens of second-line treatment strategies for advanced or metastatic urothelial carcinoma of the bladder. <b>Methods:</b> The MEDLINE and EMBASE databases were searched ... Read more >>

Immunotherapy (Immunotherapy)
[2021, :]

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Current application of the enhanced recovery after surgery protocol for patients undergoing radical cystectomy: lessons learned from European excellence centers.

Simone Albisinni, Marco Moschini, Ettore Di Trapani, Francesco Soria, Andrea Mari, Atiqullah Aziz, Jeremy Teoh, Ekaterina Laukhtina, Keiichiro Mori, David D'Andrea, Diego M Carrion, Wojciech Krajewski, Mohammad Abufaraj, Alessia Cimadamore, Wei Shen Tan, Ronan Flippot, Jonathan Khalifa, Kimberly Gonsette, Benjamin Pradere, ,

<h4>Purpose</h4>There is no consensus on which items of Enhanced Recovery After Surgery (ERAS) should and should not be implemented in radical cystectomy (RC). The aim of this study is to report current practices across European high-volume RC centers involved in ERAS.<h4>Methods</h4>Based on the recommendations of the ERAS society, we developed ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Differential Prognosis and Response of Denovo vs. Secondary Muscle-Invasive Bladder Cancer: An Updated Systematic Review and Meta-Analysis.

Mario Pones, David D'Andrea, Keiichiro Mori, Mohammad Abufraj, Marco Moschini, Eva Comperat, Shahrokh F Shariat,

To evaluate oncological outcomes of primary versus secondary muscle-invasive bladder cancer treated with radical cystectomy. Medline, Embase, Scopus and Cochrane Library were searched for eligible studies. Hazard ratios for overall survival (OS), cancer specific survival (CSS) and progression free survival (PFS) were calculated using survival data extracted from Kaplan-Meier curves. ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(10):]

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Accuracy and Clinical Utility of a Tumor Grade- and Stage-based Predictive Model in Localized Upper Tract Urothelial Carcinoma.

Satoshi Katayama, Keiichiro Mori, Victor M Schuettfort, Benjamin Pradere, Hadi Mostafaei, Fahad Quhal, Pawel Rajwa, Reza Sari Motlagh, Ekaterina Laukhtina, Marco Moschini, Nico C Grossmann, Motoo Araki, Jeremy Yuen-Chun Teoh, Morgan Rouprêt, Vitaly Margulis, Dmitry Enikeev, Pierre I Karakiewicz, Mohammad Abufaraj, Eva Compérat, Yasutomo Nasu, Shahrokh F Shariat,

<h4>Background</h4>Among various clinicopathologic factors used to identify low-risk upper tract urothelial carcinoma (UTUC), tumor grade and stage are of utmost importance. The clinical value added by inclusion of other risk factors remains unproven.<h4>Objective</h4>To assess the performance of a tumor grade- and stage-based (GS) model to identify patients with UTUC for ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Re: Paolo Dell'Oglio, Elio Mazzone, Edward Lambert, et al. The Effect of Surgical Experience on Perioperative and Oncological Outcomes After Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion: Evidence from a Referral Centre with Extensive Experience in Robotic Surgery. Eur Urol Focus 2021;7:352-8.

Francesco Montorsi, Giorgio Gandaglia, Federico Dehò, Andrea Gallina, Marco Moschini, Andrea Salonia, Alberto Briganti,

Eur Urol Focus (European urology focus)
[2021, :]

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Editorial Comment.

Chiara Lonati, Claudio Simeone, Marco Moschini,

J Urol (The Journal of urology)
[2021, :101097JU000000000000171501]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Impact of preoperative plasma levels of interleukin 6 and interleukin 6 soluble receptor on disease outcomes after radical cystectomy for bladder cancer.

Victor M Schuettfort, Benjamin Pradere, Quoc-Dien Trinh, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Michael Rink, Pierre I Karakiewicz, Piotr Chlosta, Jeremy Yuen-Chun Teoh, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Marco Moschini, Shahrokh F Shariat,

<h4>Background</h4>Preoperative plasma levels of Interleukin 6 (IL6) and its soluble receptor (IL6sR) have previously been associated with oncologic outcomes in urothelial carcinoma of the bladder (UCB); however, external validation in patients treated with radical cystectomy (RC) for UCB is missing.<h4>Patients/methods</h4>We prospectively collected preoperative plasma from 1,036 consecutive patients at two ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2021, :]

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Single staff cystectomy in a low-volume center: Oncological outcomes and complications.

Philipp Baumeister, Davide Galioto, Marco Moschini, Chiara Lonati, Stefania Zamboni, Luca Afferi, Patrick Stucki, Hansjörg Danuser, Dirk Lehnick, Livio Mordasini, Agostino Mattei,

<h4>Introduction</h4>Radical cystectomy (RC) with bilateral pelvic lymph node dissection (PLND) is a complex surgical procedure, associated with substantial perioperative complications. Previous studies suggested reserving it to high-volume centers in order to improve oncological and perioperative outcomes. However, only limited data exist regarding low-volume centers with highly experienced surgeons. We aimed ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, :]

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First-line immune-checkpoint inhibitor combination therapy for chemotherapy-eligible patients with metastatic urothelial carcinoma: A systematic review and meta-analysis.

Keiichiro Mori, Benjamin Pradere, Marco Moschini, Hadi Mostafaei, Ekaterina Laukhtina, Victor M Schuettfort, Reza Sari Motlagh, Francesco Soria, Jeremy Y C Teoh, Shin Egawa, Thomas Powles, Shahrokh F Shariat, ,

<h4>Introduction</h4>Platinum-based combination chemotherapy is the standard treatment for patients with chemotherapy-eligible metastatic urothelial carcinoma (mUC). Immune-checkpoint inhibitors (ICIs) are currently assessed in this setting. This review aimed to assess the role of ICIs alone or in combination as first-line treatment in chemotherapy-eligible patients with mUC.<h4>Methods</h4>Multiple databases were searched for articles ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 151:35-48]

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Long-term Outcomes of Focal Cryotherapy for Low- to Intermediate-risk Prostate Cancer: Results and Matched Pair Analysis with Active Surveillance.

Giancarlo Marra, Timo Soeterik, Davide Oreggia, Rafael Tourinho-Barbosa, Marco Moschini, Claudia Filippini, Harm H E van Melick, Roderick C N van den Bergh, Paolo Gontero, Nathalie Cathala, Petr Macek, Rafael Sanchez-Salas, Xavier Cathelineau,

<h4>Background</h4>To date, only one trial compared focal therapy and active surveillance (AS) for low-risk prostate cancer (PCa). In addition, long-term outcomes of focal cryotherapy (FC) are lacking.<h4>Objective</h4>Our aim was to evaluate long-term outcomes of FC and compare them with AS.<h4>Design, setting, and participants</h4>We included two prospective series of 121 (FC) ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Oncological outcomes of laparoscopic versus open nephroureterectomy for the treatment of upper tract urothelial carcinoma: an updated meta-analysis.

Radosław Piszczek, Łukasz Nowak, Wojciech Krajewski, Joanna Chorbińska, Sławomir Poletajew, Marco Moschini, Krzysztof Kaliszewski, Romuald Zdrojowy,

<h4>Background</h4>During the past two decades, laparoscopic radical nephroureterectomy (LRNU) has been proposed as an alternative technique to open radical nephroureterectomy (ORNU) and has become increasingly accepted for the treatment of patients with upper tract urothelial carcinoma (UTUC). Nevertheless, the oncologic efficacy of LRNU remains controversial, especially for the treatment of ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2021, 19(1):129]

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Available evidence on HIFU for focal treatment of prostate cancer: a systematic review.

Arnas Bakavicius, Giancarlo Marra, Petr Macek, Cary Robertson, Andre L Abreu, Arvin K George, Bernard Malavaud, Patrick Coloby, Pascal Rischmann, Marco Moschini, Ardeshir R Rastinehad, Abhinav Sidana, Armando Stabile, Rafael Tourinho-Barbosa, Jean de la Rosette, Hashim Ahmed, Thomas Polascik, Xavier Cathelineau, Rafael Sanchez-Salas,

<h4>Purpose</h4>Prostate cancer (PCa) is the second most common oncologic disease among men. Radical treatment with curative intent provides good oncological results for PCa survivors, although definitive therapy is associated with significant number of serious side-effects. In modern-era of medicine tissue-sparing techniques, such as focal HIFU, have been proposed for PCa ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2021, 47:]

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Association Between Lesion Location and Oncological Outcomes after Focal Therapy for Localized Prostate Cancer Using Either High Intensity Focused Ultrasound or Cryotherapy.

Armando Stabile, Rafael Sanchez-Salas, Rafael Tourinho-Barbosa, Petr Macek, Francesco Pellegrino, Giorgio Gandaglia, Marco Moschini, Nathalie Cathala, Annick Mombet, Francesco Montorsi, Alberto Briganti, Xavier Cathelineau,

<h4>Purpose</h4>To assess whether PCa location might affect oncological outcomes after focal therapy (FT) for prostate cancer (PCa).<h4>Materials and methods</h4>We identified 274 men receiving FT for prostate cancer (PCa) using either HIFU or cryotherapy at a high volume centre between 2009 to 2018. Survival analyses using Kaplan Meier method were used ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001787]

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Editorial Comment from Dr Lonati and Dr Moschini to Impact of preoperative sarcopenia and myosteatosis on prognosis after radical cystectomy in patients with bladder cancer.

Chiara Lonati, Marco Moschini,

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy.

Chiara Lonati, Philipp Baumeister, Paola Irene Ornaghi, Ettore Di Trapani, Ottavio De Cobelli, Michael Rink, Robert Jeffrey Karnes, Cédric Poyet, Giuseppe Simone, Luca Afferi, Andrea Necchi, Alberto Briganti, Francesco Montorsi, Wojciech Krajewski, Alessandro Antonelli, Maria Angela Cerruto, Stefania Zamboni, Claudio Simeone, Livio Mordasini, Agostino Mattei, Marco Moschini, ,

<h4>Background</h4>Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.<h4>Objective</h4>To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.<h4>Design, setting, and participants</h4>We retrospectively analyzed 1881 BCa patients who underwent TURB and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Prognostic blood-based biomarkers in patients treated with neoadjuvant chemotherapy for urothelial carcinoma of the bladder: A systematic review.

Ekaterina Laukhtina, Benjamin Pradere, Keiichiro Mori, Victor M Schuettfort, Fahad Quhal, Hadi Mostafaei, Reza Sari Motlagh, Abdulmajeed Aydh, Marco Moschini, Dmitry Enikeev, Pierre I Karakiewicz, Mohammad Abufaraj, Shahrokh F Shariat, ,

<h4>Purpose</h4>The present systematic review aimed to identify prognostic values of blood-based biomarkers in patients treated with neoadjuvant chemotherapy (NAC) for urothelial carcinoma of the bladder (UCB).<h4>Material and methods</h4>The PubMed, Web of Science, and Scopus databases were searched in August 2020 according to the PRISMA statement. Studies were deemed eligible if ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Editorial Comment.

Chiara Lonati, Marco Moschini,

J Urol (The Journal of urology)
[2021, 206(1):21]

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Postoperative peripheral neuropathies associated with patient positioning during robot-assisted laparoscopic radical prostatectomy (RARP): A systematic review of the literature.

Julian Cornelius, Jonas Mudlagk, Luca Afferi, Philipp Baumeister, Agostino Mattei, Marco Moschini, Christophe Iselin, Livio Mordasini,

<h4>Objective</h4>To perform a systematic review of the literature concerning postoperative peripheral neuropathies associated with patient positioning during robot-assisted laparoscopic radical prostatectomy (RARP).<h4>Patients and methods</h4>A systematic review on articles published from January 1, 1990 to March 15, 2020 was performed in accordance with the PRISMA declaration (Preferred Reporting Items for Systematic ... Read more >>

Prostate (The Prostate)
[2021, 81(7):361-367]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Intravesical Therapy in Patients with Intermediate-risk Non-muscle-invasive Bladder Cancer: A Systematic Review and Network Meta-analysis of Disease Recurrence.

Ekaterina Laukhtina, Mohammad Abufaraj, Abdallah Al-Ani, Mustafa Rami Ali, Keiichiro Mori, Marco Moschini, Fahad Quhal, Reza Sari Motlagh, Benjamin Pradere, Victor M Schuettfort, Hadi Mostafaei, Satoshi Katayama, Nico C Grossmann, Harun Fajkovic, Francesco Soria, Dmitry Enikeev, Shahrokh F Shariat, ,

<h4>Context</h4>Patients with intermediate-risk non-muscle-invasive bladder cancer (NMIBC) may pose a clinical dilemma without an agreed evidence-based decision tree for personalized treatment.<h4>Objective</h4>To perform a systematic review and network meta-analysis (NMA) to summarize available evidence on the oncologic outcomes of intravesical therapy in patients with intermediate-risk NMIBC.<h4>Evidence acquisition</h4>The MEDLINE, EMBASE, and ClinicalTrials.gov ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Detection of Urothelial Bladder Cancer Based on Urine and Tissue Telomerase Activity Measured by Novel RT-TRAP-2PCR Method.

Alexander Glukhov, Natalya Potoldykova, Mark Taratkin, Sergey Gordeev, Konstantin Polyakovsky, Ekaterina Laukhtina, Marco Moschini, Mohammad Abufaraj, Shahrokh F Shariat, Marina Sekacheva, Dmitry Enikeev, Petr Glybochko,

<h4>Purpose</h4>To assess the diagnostic performance of urine telomerase activity (TA) in detecting bladder cancer (BCa) using the modified Telomeric Repeat Amplification Protocol (TRAP) and the Real Time Telomeric Repeat Amplification Protocol with double Polymerase Chain Reaction (RT-TRAP-2PCR).<h4>Methods</h4>In this case-control study, matching urine (in the pre- and post-surgical period) and tissue ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(5):]

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A panel of systemic inflammatory response biomarkers for outcome prediction in patients treated with radical cystectomy for urothelial carcinoma.

Victor M Schuettfort, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Frederik König, Michael Rink, Mohammad Abufaraj, Pierre I Karakiewicz, Stefano Luzzago, Morgan Rouprêt, Dmitry Enikeev, Kristin Zimmermann, Marina Deuker, Marco Moschini, Reza Sari Motlagh, Nico C Grossmann, Satoshi Katayama, Benjamin Pradere, Shahrokh F Shariat,

<h4>Objectives</h4>To determine the predictive and prognostic value of a panel of systemic inflammatory response (SIR) biomarkers relative to established clinicopathological variables in order to improve patient selection and facilitate more efficient delivery of peri-operative systemic therapy.<h4>Materials and methods</h4>The preoperative serum levels of a panel of SIR biomarkers, including albumin-globulin ratio, ... Read more >>

BJU Int (BJU international)
[2021, :]

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