Full Text Journal Articles by
Author Marco Giorgio

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Hematopoietic and non-hematopoietic p66Shc differentially regulates stem cell traffic and vascular response to ischemia in diabetes.

Mattia Albiero, Marianna D'Anna, Benedetta Maria Bonora, Gaia Zuccolotto, Antonio Rosato, Marco Giorgio, Elisabetta Iori, Angelo Avogaro, Gian Paolo Fadini,

<h4>Aims</h4>Peripheral artery disease (PAD) is a severe complication of diabetes, characterized by defective traffic of hematopoietic stem/progenitor cells (HSPCs). We examined the hematopoietic versus non-hematopoietic role of p66Shc in regulating HSPC traffic and blood flow recovery after ischemia in diabetic mice.<h4>Results</h4>Using streptozotocin-induced diabetes, chimeric mice with GFP+ bone marrow (BM), ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

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Comparative Analysis of Histone H3K4me3 Distribution in Mouse Liver in Different Diets Reveals the Epigenetic Efficacy of Cyanidin-3-O-glucoside Dietary Intake.

Giuseppe Persico, Francesca Casciaro, Alessandra Marinelli, Chiara Tonelli, Katia Petroni, Marco Giorgio,

<h4>Background</h4>Different diets result in significantly different phenotypes through metabolic and genomic reprogramming. Epigenetic marks, identified in humans and mouse models through caloric restriction, a high-fat diet or the intake of specific bioactives, suggest that genomic reprogramming drives this metabolic reprogramming and mediates the effect of nutrition on health. Histone modifications ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(12):]

Cited: 0 times

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Time makes histone H3 modifications drift

Roman Hillje, Lucilla Luzi, Stefano Amatori, Mirco Fanelli, Pier Giuseppe Pelicci, Marco Giorgio,

To disclose the epigenetic drift of time passing, we determined the genome-wide distributions of mono- and tri-methylated lysine 4 and acetylated and tri-methylated lysine 27 of histone H3 in the livers of healthy 3, 6 and 12 months old C57BL/6 mice. The comparison of different age profiles of histone H3 ... Read more >>

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In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.

Maurizio D Baroni, Sonia Colombo, Olivier Libens, Rani Pallavi, Marco Giorgio, Enzo Martegani,

Caloric restriction mimetics (CRMs) are promising molecules to prevent age-related diseases as they activate pathways driven by a true caloric restriction. Hydroxycitric acid (HCA) is considered a bona fide CRM since it depletes acetyl-CoA pools by acting as a competitive inhibitor of ATP citrate lyase (ACLY), ultimately repressing protein acetylation ... Read more >>

Apoptosis (Apoptosis : an international journal on programmed cell death)
[2020, 25(9-10):686-696]

Cited: 0 times

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Metabolic Constrains Rule Metastasis Progression.

Niccolo' Roda, Valentina Gambino, Marco Giorgio,

Metastasis formation accounts for the majority of tumor-associated deaths and consists of different steps, each of them being characterized by a distinctive adaptive phenotype of the cancer cells. Metabolic reprogramming represents one of the main adaptive phenotypes exploited by cancer cells during all the main steps of tumor and metastatic ... Read more >>

Cells (Cells)
[2020, 9(9):]

Cited: 2 times

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The Determining Role of Mitochondrial Reactive Oxygen Species Generation and Monoamine Oxidase Activity in Doxorubicin-Induced Cardiotoxicity.

Salvatore Antonucci, Moises Di Sante, Federica Tonolo, Laura Pontarollo, Valeria Scalcon, Petra Alanova, Roberta Menabò, Andrea Carpi, Alberto Bindoli, Maria Pia Rigobello, Marco Giorgio, Nina Kaludercic, Fabio Di Lisa,

<b><i>Aims:</i></b> Doxorubicin cardiomyopathy is a lethal pathology characterized by oxidative stress, mitochondrial dysfunction, and contractile impairment, leading to cell death. Although extensive research has been done to understand the pathophysiology of doxorubicin cardiomyopathy, no effective treatments are available. We investigated whether monoamine oxidases (MAOs) could be involved in doxorubicin-derived oxidative ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, 34(7):531-550]

Cited: 1 time

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Diabetes-Associated Myelopoiesis Drives Stem Cell Mobilopathy Through an OSM-p66Shc Signaling Pathway.

Mattia Albiero, Stefano Ciciliot, Serena Tedesco, Lisa Menegazzo, Marianna D'Anna, Valentina Scattolini, Roberta Cappellari, Gaia Zuccolotto, Antonio Rosato, Andrea Cignarella, Marco Giorgio, Angelo Avogaro, Gian Paolo Fadini,

Diabetes impairs the mobilization of hematopoietic stem/progenitor cells (HSPCs) from the bone marrow (BM), which can worsen the outcomes of HSPC transplantation and of diabetic complications. In this study, we examined the oncostatin M (OSM)-p66Shc pathway as a mechanistic link between HSPC mobilopathy and excessive myelopoiesis. We found that streptozotocin-induced ... Read more >>

Diabetes (Diabetes)
[2019, 68(6):1303-1314]

Cited: 19 times

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Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.

Sarah Costantino, Francesco Paneni, Agostino Virdis, Shafaat Hussain, Shafeeq Ahmed Mohammed, Giuliana Capretti, Alexander Akhmedov, Kevin Dalgaard, Sergio Chiandotto, J Andrew Pospisilik, Thomas Jenuwein, Marco Giorgio, Massimo Volpe, Stefano Taddei, Thomas F Lüscher, Francesco Cosentino,

Aims:Accumulation of reactive oxygen species (ROS) promotes vascular disease in obesity, but the underlying molecular mechanisms remain poorly understood. The adaptor p66Shc is emerging as a key molecule responsible for ROS generation and vascular damage. This study investigates whether epigenetic regulation of p66Shc contributes to obesity-related vascular disease. Methods and ... Read more >>

Eur Heart J (European heart journal)
[2019, 40(4):383-391]

Cited: 15 times

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Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology.

Stefano Amatori, Giuseppe Persico, Claudio Paolicelli, Roman Hillje, Nora Sahnane, Francesco Corini, Daniela Furlan, Lucilla Luzi, Saverio Minucci, Marco Giorgio, Pier Giuseppe Pelicci, Mirco Fanelli,

<h4>Background</h4>The introduction of pathology tissue-chromatin immunoprecipitation (PAT-ChIP), a technique allowing chromatin immunoprecipitation (ChIP) from formalin-fixed paraffin-embedded (FFPE) tissues, has extended the application of chromatin studies to clinical patient samples. However, extensive crosslinking introduced during routine tissue fixation of clinical specimens may hamper the application of PAT-ChIP to genome-wide studies (PAT-ChIP-Seq) ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2018, 10(1):143]

Cited: 3 times

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Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma.

Micol Ravà, Aleco D'Andrea, Paola Nicoli, Ilaria Gritti, Giulio Donati, Mirko Doni, Marco Giorgio, Daniela Olivero, Bruno Amati,

High-grade B cell lymphomas with concurrent activation of the <i>MYC</i> and <i>BCL2</i> oncogenes, also known as double-hit lymphomas (DHL), show dismal prognosis with current therapies. <i>MYC</i> activation sensitizes cells to inhibition of mitochondrial translation by the antibiotic tigecycline, and treatment with this compound provides a therapeutic window in a mouse ... Read more >>

Sci Transl Med (Science translational medicine)
[2018, 10(426):]

Cited: 14 times

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Erratum. Deletion of p66Shc Longevity Gene Protects Against Experimental Diabetic Glomerulopathy by Preventing Diabetes-Induced Oxidative Stress. Diabetes 2006;55:1642-1650.

Stefano Menini, Lorena Amadio, Giovanna Oddi, Carlo Ricci, Carlo Pesce, Francesco Pugliese, Marco Giorgio, Enrica Migliaccio, PierGiuseppe Pelicci, Carla Iacobini, Giuseppe Pugliese,

Diabetes (Diabetes)
[2018, 67(1):165]

Cited: 1 time

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Glucose and Lactate Miniaturized Biosensors for SECM-Based High-Spatial Resolution Analysis: A Comparative Study.

Alice Soldà, Giovanni Valenti, Massimo Marcaccio, Marco Giorgio, Pier Giuseppe Pelicci, Francesco Paolucci, Stefania Rapino,

With the aim of developing miniaturized enzymatic biosensors suitable for in vitro diagnostic applications, such as monitoring of metabolites at single cell level, glucose and lactate biosensors were fabricated by immobilizing enzymes (glucose oxidase and lactate oxidase, respectively) on 10 μm Pt ultramicroelectrodes. These electrodes are meant to be employed ... Read more >>

ACS Sens (ACS sensors)
[2017, 2(9):1310-1318]

Cited: 8 times

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Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction.

Giancarlo Marenzi, Nicola Cosentino, Jasper Boeddinghaus, Mirella Trinei, Marco Giorgio, Valentina Milazzo, Marco Moltrasio, Daniela Cardinale, Maria Teresa Sandri, Fabrizio Veglia, Alice Bonomi, Max Kaech, Raphael Twerenbold, Thomas Nestelberger, Tobias Reichlin, Karin Wildi, Samyut Shrestha, Nikola Kohzuharov, Zaid Sabti, Carlo M Cipolla, Christian Mueller, Antonio L Bartorelli,

<h4>Rationale</h4>In contrast to cardiomyocyte necrosis, which can be quantified by cardiac troponin, functional cardiomyocyte impairment, including mitochondrial dysfunction, has escaped clinical recognition in acute myocardial infarction (AMI) patients.<h4>Objective</h4>To investigate the diagnostic accuracy for AMI and prognostic prediction of in-hospital mortality of cytochrome c.<h4>Methods and results</h4>We prospectively assessed cytochrome c serum ... Read more >>

Circ Res (Circulation research)
[2016, 119(12):1339-1346]

Cited: 6 times

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The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas.

Aleco D'Andrea, Ilaria Gritti, Paola Nicoli, Marco Giorgio, Mirko Doni, Annalisa Conti, Valerio Bianchi, Lucia Casoli, Arianna Sabò, Alexandre Mironov, Galina V Beznoussenko, Bruno Amati,

The oncogenic transcription factor Myc is required for the progression and maintenance of diverse tumors. This has led to the concept that Myc itself, Myc-activated gene products, or associated biological processes might constitute prime targets for cancer therapy. Here, we present an in vivo reverse-genetic screen targeting a set of ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(45):72415-72430]

Cited: 18 times

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Maternal Care Determinant of Longevity?

Marco Giorgio, Chiara Renzi, Serena Oliveri, Gabriella Pravettoni,

Maternal care is an essential early environment in mammals that ensures emotional regulation and adaptive fitness of progeny. Longevity and healthy aging are associated with favorable environmental factors including fitting social and behavioral features. In the present review, we discuss the findings that link rearing conditions and early maternal care ... Read more >>

Arch Ital Biol (Archives italiennes de biologie)
[2016, 154(1):14-25]

Cited: 1 time

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New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases.

Fabio Di Lisa, Marco Giorgio, Peter Ferdinandy, Rainer Schulz,

Although reactive oxygen species (ROS) act as crucial factors in the onset and progression of a wide array of diseases, they are also involved in numerous signalling pathways related to cell metabolism, growth and survival. ROS are produced at various cellular sites, and it is generally agreed that mitochondria generate ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2017, 174(12):1690-1703]

Cited: 27 times

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P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.

Marco Giorgio, Massimo Stendardo, Enrica Migliaccio, Pier Giuseppe Pelicci,

Oxidative stress and telomere attrition are considered the driving factors of aging. As oxidative damage to telomeric DNA favors the erosion of chromosome ends and, in turn, telomere shortening increases the sensitivity to pro-oxidants, these two factors may trigger a detrimental vicious cycle. To check whether limiting oxidative stress slows ... Read more >>

Aging Cell (Aging cell)
[2016, 15(3):446-454]

Cited: 6 times

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Erratum to: The p66Shc redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

Annalisa Natalicchio, Federica Tortosa, Rossella Labarbuta, Giuseppina Biondi, Nicola Marrano, Emanuele Carchia, Anna Leonardini, Angelo Cignarelli, Marco Bugliani, Piero Marchetti, Gian Paolo Fadini, Marco Giorgio, Angelo Avogaro, Sebastio Perrini, Luigi Laviola, Francesco Giorgino,

Diabetologia (Diabetologia)
[2015, 58(11):2682]

Cited: 1 time

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Oxidative stress and the unfulfilled promises of antioxidant agents.

Marco Giorgio,

It is well known that aging and its associated diseases, including cancer, are triggered by oxidative damage to biological macromolecules. However, antioxidant compounds are still disappointingly distant from any clinical application, so that Jim Watson has declared that antioxidant supplementation may have caused more cancers than it has prevented Watson ... Read more >>

Ecancermedicalscience (Ecancermedicalscience)
[2015, 9:556]

Cited: 8 times

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p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans.

Stefano Ciciliot, Mattia Albiero, Lisa Menegazzo, Nicol Poncina, Valentina Scattolini, Andrea Danesi, Elisa Pagnin, Manuela Marabita, Bert Blaauw, Marco Giorgio, Mirella Trinei, Mirto Foletto, Luca Prevedello, Donato Nitti, Angelo Avogaro, Gian Paolo Fadini,

<h4>Aims/hypothesis</h4>Oxygen radicals generated by p66Shc drive adipogenesis, but contradictory data exist on the role of p66Shc in the development of obesity and the metabolic syndrome. We herein explored the relationships among p66Shc, adipose tissue remodelling and glucose metabolism using mouse models and human adipose tissue samples.<h4>Methods</h4>In wild-type (WT), leptin-deficient (ob/ob), ... Read more >>

Diabetologia (Diabetologia)
[2015, 58(10):2352-2360]

Cited: 13 times

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The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

Annalisa Natalicchio, Federica Tortosa, Rossella Labarbuta, Giuseppina Biondi, Nicola Marrano, Emanuele Carchia, Anna Leonardini, Angelo Cignarelli, Marco Bugliani, Piero Marchetti, Gian Paolo Fadini, Marco Giorgio, Angelo Avogaro, Sebastio Perrini, Luigi Laviola, Francesco Giorgino,

<h4>Aims/hypothesis</h4>The role of the redox adaptor protein p66(Shc) as a potential mediator of saturated fatty acid (FA)-induced beta cell death was investigated.<h4>Methods</h4>The effects of the FA palmitate on p66(Shc) expression were evaluated in human and murine islets and in rat insulin-secreting INS-1E cells. p66(Shc) expression was also measured in islets ... Read more >>

Diabetologia (Diabetologia)
[2015, 58(6):1260-1271]

Cited: 21 times

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Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri.

Chiara Priami, Giulia De Michele, Franco Cotelli, Alessandro Cellerino, Marco Giorgio, Pier Giuseppe Pelicci, Enrica Migliaccio,

Oxidative stress induced by reactive oxygen species (ROS) increases during lifespan and is involved in aging processes. The p66Shc adaptor protein is a master regulator of oxidative stress response in mammals. Ablation of p66Shc enhances oxidative stress resistance both in vitro and in vivo. Most importantly, it has been demonstrated ... Read more >>

Aging Dis (Aging and disease)
[2015, 6(2):95-108]

Cited: 10 times

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The p66ShcA adaptor protein regulates healing after myocardial infarction.

Anton Baysa, Julia Sagave, Andrea Carpi, Tania Zaglia, Marika Campesan, Christen P Dahl, Dusan Bilbija, Maria Troitskaya, Lars Gullestad, Marco Giorgio, Marco Mongillo, Fabio Di Lisa, Jarle I Vaage, Guro Valen,

Heart rupture and heart failure are deleterious complications of myocardial infarction. The ShcA gene encodes for three protein isoforms, p46-, p52- and p66ShcA. p66ShcA induces oxidative stress. We studied the role of p66ShcA post-infarction. Expression of p66ShcA was analyzed in myocardium of patients with stable angina (n = 11), in explanted hearts ... Read more >>

Basic Res Cardiol (Basic research in cardiology)
[2015, 110(2):13]

Cited: 7 times

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The cellular prion protein counteracts cardiac oxidative stress.

Filippo Zanetti, Andrea Carpi, Roberta Menabò, Marco Giorgio, Rainer Schulz, Guro Valen, Anton Baysa, Maria Lina Massimino, Maria Catia Sorgato, Alessandro Bertoli, Fabio Di Lisa,

<h4>Aims</h4>The cellular prion protein, PrP(C), whose aberrant isoforms are related to prion diseases of humans and animals, has a still obscure physiological function. Having observed an increased expression of PrP(C) in two in vivo paradigms of heart remodelling, we focused on isolated mouse hearts to ascertain the capacity of PrP(C) ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2014, 104(1):93-102]

Cited: 14 times

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Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66(Shc-/-) mouse.

Veronica Bellisario, Alessandra Berry, Sara Capoccia, Carla Raggi, Pamela Panetta, Igor Branchi, Giovanni Piccaro, Marco Giorgio, Pier G Pelicci, Francesca Cirulli,

Metabolic stressful challenges during susceptible time windows, such as fetal life, can have important implications for health throughout life. Deletion of the p66(Shc) gene in mice leads to reduced oxidative stress (OS), resulting in a healthy and lean phenotype characterized by increased metabolic rate, resistance to high-fat diet (HFD)-induced obesity ... Read more >>

Front Behav Neurosci (Frontiers in behavioral neuroscience)
[2014, 8:285]

Cited: 17 times

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