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Author Marco Alloisio

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Subpopulations of Circulating Cells with Morphological Features of Malignancy Are Preoperatively Detected and Have Differential Prognostic Significance in Non-Small Cell Lung Cancer.

Emanuela Fina, Davide Federico, Pierluigi Novellis, Elisa Dieci, Simona Monterisi, Federica Cioffi, Giuseppe Mangiameli, Giovanna Finocchiaro, Marco Alloisio, Giulia Veronesi,

<h4>Background</h4>Non-small cell lung cancer (NSCLC) frequently presents when surgical intervention is no longer feasible. Despite local treatment with curative intent, patients might experience disease recurrence. In this context, accurate non-invasive biomarkers are urgently needed. We report the results of a pilot study on the diagnostic and prognostic role of circulating ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(17):]

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Does morbid obesity influence perioperative outcomes after video-assisted thoracic surgery (VATS) lobectomy for non-small cell lung cancer? Analysis of the Italian VATS group registry.

Francesco Guerrera, Paraskevas Lyberis, Paolo Olivo Lausi, Riccardo Carlo Cristofori, Roberto Giobbe, Massimo Molinatti, Pier Luigi Filosso, Carlo Curcio, Roberto Crisci, Enrico Ruffini, ,

<h4>Objectives</h4>Obesity in Europe, and worldwide, has been an increasing epidemic during the past decades. Moreover, obesity has important implications regarding technical issues and the risks associated with surgical interventions. Nevertheless, there is a lack of evidence assessing the influence of obesity on video-assisted thoracic surgery (VATS) lobectomy results. Our study ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, :]

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Locally advanced primary mediastinal atypical carcinoid successfully resected after neoadjuvant treatment: A case report.

Alberto Testori, Vittorio Perfetti, Camilla De Carlo, Paola Bossi, Marco Alloisio, Giuseppe Mangiameli,

Neuroendocrine tumors (NETs) are epithelial neoplasms with predominant neuroendocrine differentiation that arise in most organs of the body. Mediastinal NETs are very rare, and account for no more than 5% of all mediastinal tumors. R0 surgery represents the milestone of treatment. Here, we describe a case of a locally advanced ... Read more >>

Thorac Cancer (Thoracic cancer)
[2021, 12(17):2415-2419]

Cited: 1 time

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Tracheal polypoid combined small cell lung cancer (C-SCLC): A case report.

Alberto Testori, Giorgio Ferraroli, Camilla De Carlo, Paola Bossi, Marco Alloisio, Giuseppe Mangiameli,

Small cell lung cancer (SCLC) is an aggressive malignancy with a poor prognosis that accounts for 10% of all cases of clinical lung cancer. Due to its high growth fraction and rapid doubling time it is usually diagnosed as extensive local or metastatic disease in 60%-70% of cases. Combined small ... Read more >>

Thorac Cancer (Thoracic cancer)
[2021, 12(13):2035-2038]

Cited: 1 time

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Impact of active cancer on COVID-19 survival: a matched-analysis on 557 consecutive patients at an Academic Hospital in Lombardy, Italy.

Alexia F Bertuzzi, Michele Ciccarelli, Andrea Marrari, Nicolò Gennaro, Andrea Dipasquale, Laura Giordano, Umberto Cariboni, Vittorio Lorenzo Quagliuolo, Marco Alloisio, Armando Santoro,

<h4>Background</h4>The impact of active cancer in COVID-19 patients is poorly defined; however, most studies showed a poorer outcome in cancer patients compared to the general population.<h4>Methods</h4>We analysed clinical data from 557 consecutive COVID-19 patients. Uni-multivariable analysis was performed to identify prognostic factors of COVID-19 survival; propensity score matching was used ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 125(3):358-365]

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Case Report: COVID-19 Pneumonia Following Left Pneumonectomy for Lung Cancer Complicated by Empyema and Bronchopleural Fistula.

Alberto Testori, Veronica M Giudici, Marco Alloisio, Ugo Cioffi,

<b>Background:</b> Venous and arterial thromboembolism is commonly reported in critically ill COVID-19 patients, although there are still no definitive statistical data regarding its incidence. <b>Case presentation:</b> we report a case of a patient who fell ill with Covid during hospitalization for a pneumonectomy complicated by empyema and bronchopleural fistula. The ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:679757]

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Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression.

Raoul J P Bonnal, Grazisa Rossetti, Enrico Lugli, Marco De Simone, Paola Gruarin, Jolanda Brummelman, Lorenzo Drufuca, Marco Passaro, Ramona Bason, Federica Gervasoni, Giulia Della Chiara, Claudia D'Oria, Martina Martinovic, Serena Curti, Valeria Ranzani, Chiara Cordiglieri, Giorgia Alvisi, Emilia Maria Cristina Mazza, Stefania Oliveto, Ylenia Silvestri, Elena Carelli, Saveria Mazzara, Roberto Bosotti, Maria Lucia Sarnicola, Chiara Godano, Valeria Bevilacqua, Mariangela Lorenzo, Salvatore Siena, Emanuela Bonoldi, Andrea Sartore-Bianchi, Alessio Amatu, Giulia Veronesi, Pierluigi Novellis, Marco Alloisio, Alessandro Giani, Nicola Zucchini, Enrico Opocher, Andrea Pisani Ceretti, Nicolò Mariani, Stefano Biffo, Daniele Prati, Alberto Bardelli, Jens Geginat, Antonio Lanzavecchia, Sergio Abrignani, Massimiliano Pagani,

Regulatory T (T<sub>reg</sub>) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4<sup>+</sup> T cells infiltrating primary and metastatic colorectal cancer and non-small-cell lung cancer are highly enriched for two subsets of comparable size and suppressor function comprising forkhead box protein ... Read more >>

Nat Immunol (Nature immunology)
[2021, 22(6):735-745]

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Quality of Life, Postoperative Pain, and Lymph Node Dissection in a Robotic Approach Compared to VATS and OPEN for Early Stage Lung Cancer.

Pierluigi Novellis, Patrick Maisonneuve, Elisa Dieci, Emanuele Voulaz, Edoardo Bottoni, Sara Di Stefano, Michela Solinas, Alberto Testori, Umberto Cariboni, Marco Alloisio, Giulia Veronesi,

We compare the perioperative course, postoperative pain, and quality-of-life (QOL) in patients undergoing anatomic resections of early-stage lung cancer by means of robotic surgery (RATS), video-assisted thoracic surgery (VATS), or muscle-sparing thoracotomy (OPEN); 169 consecutive patients with known/suspected lung cancer, candidates to anatomic resection, were enrolled in a single-center prospective ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(8):]

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Bronchoalveolar lavage in suspected COVID-19 cases with a negative nasopharyngeal swab: a retrospective cross-sectional study in a high-impact Northern Italy area.

Caterina Barberi, Elena Castelnuovo, Andrea Dipasquale, Federica Mrakic Sposta, Giulia Vatteroni, Lorenzo Maria Canziani, Marco Alloisio, Michele Ciccarelli, Carlo Selmi, Giorgio Maria Ferraroli,

COVID-19 diagnosis relies on molecular testing for SARS-CoV-2 via nasopharyngeal swab in the presence of suggestive clinical, radiological and laboratory findings. Since bronchoalveolar lavage liquid (BAL) collected during fibrobronchoscopy may increase test sensitivity compared to nasopharyngeal swabs, it was performed during the 2020 pandemic in clinically or radiologically suspected cases. ... Read more >>

Intern Emerg Med (Internal and emergency medicine)
[2021, :]

Cited: 3 times

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Primary signet-ring cell carcinoma of the lung in an HIV-positive patient.

Alberto Testori, Gianluca Perroni, Camilla De Carlo, Alessandro Crepaldi, Marco Alloisio, Ugo Cioffi,

Primary lung signet-ring cell carcinomas are a rare entity and only a few cases of pure signet-ring cell carcinomas of the lung are reported in the English literature. They usually have an aggressive behavior and a poor prognosis because in most cases they are identified at an advanced stage. We ... Read more >>

Thorac Cancer (Thoracic cancer)
[2021, 12(7):1122-1125]

Cited: 1 time

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Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database.

Stefano Bongiolatti, Alessandro Gonfiotti, Sara Borgianni, Roberto Crisci, Carlo Curcio, Luca Voltolini, ,

<h4>Background</h4>Thoracoscopic lobectomy (VATS-L) for non-small-cell lung cancer (NSCLC) is a well-established option for early stage NSCLC, but the evidences are limited for octogenarians.<h4>Objective</h4>The objectives of this multi-institutional study were to evaluate the post-operative outcomes of VATS-L in octogenarians and to estimate the post-operative quality of life (QoL) using a validated ... Read more >>

Surg Oncol (Surgical oncology)
[2021, 37:101530]

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A risk stratification scheme for synchronous oligometastatic non-small cell lung cancer developed by a multicentre analysis.

Lorenzo Spaggiari, Luca Bertolaccini, Francesco Facciolo, Filippo Tommaso Gallina, Federico Rea, Marco Schiavon, Stefano Margaritora, Maria Teresa Congedo, Marco Lucchi, Ilaria Ceccarelli, Marco Alloisio, Edoardo Bottoni, Giampiero Negri, Angelo Carretta, Giuseppe Cardillo, Sara Ricciardi, Enrico Ruffini, Lorena Costardi, Giovanni Muriana, Domenico Viggiano, Michele Rusca, Luigi Ventura, Giuseppe Marulli, Angela De Palma, Lorenzo Rosso, Paolo Mendogni, Roberto Crisci, Andrea De Vico, Pio Maniscalco, Nicola Tamburini, Francesco Puma, Silvia Ceccarelli, Luca Voltolini, Stefano Bongiolatti, Angelo Morelli, Francesco Londero,

<h4>Backgrounds</h4>Oligometastatic Non-Small Cell Lung Cancer (NSCLC) patients represent a category without a standard therapeutic approach. However, in selected oligometastatic NSCLC, radical surgery seems to offer a good prognosis. This retrospective study aimed to analyse the long-term outcomes of synchronous oligometastatic patients treated with curative intent and identify the factors associated ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2021, 154:29-35]

Cited: 1 time

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Perioperative Outcome of Robotic Approach Versus Manual Videothoracoscopic Major Resection in Patients Affected by Early Lung Cancer: Results of a Randomized Multicentric Study (ROMAN Study)

Giulia Veronesi, Abbas El-Sayed Abbas, Piergiorgio Muriana, Rosalba Lembo, Edoardo Bottoni, Gianluca Perroni, Alberto Testori, Elisa Dieci, Charles T. Bakhos, Shamus Car, Luca Luzzi, Marco Alloisio, Pierluigi Novellis,

<h4>Introduction</h4> We report the results of the first prospective international randomized control trial to compare the perioperative outcome and surgical radicality of the robotic approach with those of traditional video-assisted surgery in the treatment of early-stage lung cancer. <h4>Methods</h4> Patients with clinical stage T1–T2, N0–N1 non-small cell lung cancer (NSCLC) ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:]

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Voluminous schwannoma type 'ancient' of the cervicothoracic district removed through a cervicotomic approach.

Alberto Testori, Marco Alloisio, Umberto Cariboni, Francesco Costa, Emanuele Voulaz, Edoardo Bottoni, Matilde De Simone, Daoud Rahal, Ugo Cioffi,

Schwannomas are generally benign tumors, well delimited, resulting from nerve sheaths that are frequently found in the thorax, mainly in the posterior mediastinum. We report a 58-year-old patient who carried out investigations following the appearance of a large right supraclavicular cervical mass associated with anisocoria and eyelid ptosis, histologically diagnosed ... Read more >>

J Surg Case Rep (Journal of surgical case reports)
[2020, 2020(9):rjaa402]

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Surgery at the frontline at the time of the COVID-19 outbreak.

Alberto Testori, Ugo Cioffi, Michele M Ciulla, Edoardo Bottoni, Umberto Cariboni, Gianluca Perroni, Marco Alloisio,

Thorac Cancer (Thoracic cancer)
[2020, 11(11):3057-3059]

Cited: 2 times

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Pulmonary Lobectomy After COVID-19.

Alberto Testori, Gianluca Perroni, Emanuele Voulaz, Alessandro Crepaldi, Marco Alloisio,

Concomitant coronavirus disease 19 (COVID-19) is a major risk factor for complications in any type of surgical procedure, especially in thoracic surgery, were the primary organ involved, the lung, is manipulated to perform parenchymal resection. However, it is not clear whether previous infection from severe acute respiratory syndrome coronavirus 2 ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 111(3):e181-e182]

Cited: 1 time

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Distinguishing multiple lung primaries from intra-pulmonary metastases and treatment implications.

Emanuele Voulaz, Pierluigi Novellis, Francesca Rossetti, Michela Solinas, Sabrina Rossi, Marco Alloisio, Giuseppe Pelosi, Giulia Veronesi,

<h4>Introduction</h4>The distinction between multiple primary lung cancers and intra-pulmonary metastases has been extensively investigated because of its important clinical and therapeutic implications.<h4>Areas covered</h4>Rapidly improving imaging technology and genomic analysis has led to a finer discrimination between multiple primary lung tumors and pulmonary metastases. However, over the past few decades, standardized ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2020, 20(11):985-995]

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Endoscopic Lipofilling for the Treatment of Bronchopleural Fistulas After Anatomic Lung Resection.

Edoardo Bottoni, Barbara Paola Banzatti, Pierluigi Novellis, Giorgio Maria Ferraroli, Marco Alloisio,

A bronchopleural fistula is a potentially fatal complication of anatomic lung resection surgery. Bronchoscopy has been described in the treatment of small-caliber fistulas. An endoscopic procedure based on instillation of mesenchymal stem cells for the treatment of bronchopleural fistula has recently been successful. Fat tissue is rich in mesenchymal stem ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 111(2):e143-e145]

Cited: 2 times

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Correction to: Predictors of nodal upstaging in patients with cT1-3N0 non-small cell lung cancer (NSCLC): results from the Italian VATS Group Registry.

Giuseppe Marulli, Eleonora Faccioli, Marco Mammana, Samuele Nicotra, Giovanni Comacchio, Enrico Verderi, Angela De Palma, Carlo Curcio, Federico Rea, ,

In the original publication, Carlo Curcio was not included in the author list. The correct author list is included in this Correction. ... Read more >>

Surg Today (Surgery today)
[2020, 50(7):719-720]

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Extraordinary emergency measures set up by a Breast Unit to prevent COVID-19: Report of our experience.

Alberto Testori, Marco Alloisio, Valentina Errico, Gianluca Perroni, Wolfgang Gatzemeier, Corrado Tinterri,

Breast J (The breast journal)
[2020, 26(8):1611-1612]

Cited: 1 time

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IRF4 instructs effector Treg differentiation and immune suppression in human cancer.

Giorgia Alvisi, Jolanda Brummelman, Simone Puccio, Emilia Mc Mazza, Elisa Paoluzzi Tomada, Agnese Losurdo, Veronica Zanon, Clelia Peano, Federico S Colombo, Alice Scarpa, Marco Alloisio, Ajithkumar Vasanthakumar, Rahul Roychoudhuri, Marinos Kallikourdis, Massimiliano Pagani, Egesta Lopci, Pierluigi Novellis, Jonas Blume, Axel Kallies, Giulia Veronesi, Enrico Lugli,

The molecular mechanisms responsible for the high immunosuppressive capacity of CD4+ Tregs in tumors are not well known. High-dimensional single-cell profiling of T cells from chemotherapy-naive individuals with non-small-cell lung cancer identified the transcription factor IRF4 as specifically expressed by a subset of intratumoral CD4+ effector Tregs with superior suppressive ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(6):3137-3150]

Cited: 21 times

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Favorable incremental cost-effectiveness ratio for lung cancer screening in Italy.

Giulia Veronesi, Niccolò Navone, Pierluigi Novellis, Elisa Dieci, Luca Toschi, Laura Velutti, Michela Solinas, Elena Vanni, Marco Alloisio, Simone Ghislandi,

<h4>Objectives</h4>Lung cancer detection by low-dose computed tomographic screening reduces mortality. However, it is essential to assess cost-effectiveness. We present a cost-effectiveness analysis of screening in Italians at high risk of lung cancer, from the point of view of the Italian tax-payer.<h4>Materials and methods</h4>We used a decision model to estimate the ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2020, 143:73-79]

Cited: 2 times

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Biological Characteristics and Long-term Outcomes in Node-negative Breast Cancer.

Elisa Agostinetto, Laura Giordano, Rosalba Torrisi, Rita De Sanctis, Giovanna Masci, Agnese Losurdo, Monica Zuradelli, Corrado Tinterri, Wolfgang Gatzemeier, Alberto Testori, Marco Alloisio, Fiorenza De Rose, Bethania Fernandes, Armando Santoro,

<h4>Background</h4>Because the risk of relapse of node-negative breast cancer (BC) is varying, we evaluated the prognosis of patients with this disease and the factors associated with increased risk of relapse.<h4>Patients and methods</h4>The clinical charts of patients with BC with evidence of negative nodes and with a potential ≥ 5-year follow-up were ... Read more >>

Clin Breast Cancer (Clinical breast cancer)
[2020, 20(4):e481-e489]

Cited: 1 time

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Correction to: Risk factors and impact of conversion from VATS to open lobectomy: analysis from a national database.

Stefano Bongiolatti, Alessandro Gonfiotti, Domenico Viggiano, Sara Borgianni, Leonardo Politi, Roberto Crisci, Carlo Curcio, Luca Voltolini, ,

In the "Results" section of the Abstract, the sentence: "The mortality rate was similar, but the percentage of patients who suffered from any complication (41.7% vs 24.4%, p < 0.01), the complication rate (65% vs 32.2%, p < 0.01), chest tube duration (p < 0.01) and the hospitalisation rate (p < 0.01) were higher for patients converted." should ... Read more >>

Surg Endosc (Surgical endoscopy)
[2019, 33(12):3963]

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What counts more: the patient, the surgical technique, or the hospital? A multivariable analysis of factors affecting perioperative complications of pulmonary lobectomy by video-assisted thoracoscopic surgery from a large nationwide registry.

Maurizio V Infante, Cristiano Benato, Ronaldo Silva, Gaetano Rocco, Alessandro Bertani, Luca Bertolaccini, Alessandro Gonfiotti, Riccardo Giovannetti, Cinzia Bonadiman, Alessandro Lonardoni, Barbara Canneto, Giovanni Falezza, Paola Gandini, Carlo Curcio, Roberto Crisci, ,

<h4>Objectives</h4>Inherent technical aspects of pulmonary lobectomy by video-assisted thoracoscopic surgery (VATS) may limit surgeons' ability to deal with factors predisposing to complications. We analysed complication rates after VATS lobectomy in a prospectively maintained nationwide registry.<h4>Methods</h4>The registry was queried for all consecutive VATS lobectomy procedures from 49 Italian Thoracic Units. Baseline ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2019, 56(6):1097-1103]

Cited: 1 time

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