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Author Marcello Ceccaroni

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Author's reply to: Comments on the utilization of Mann-Whitney U test and Kaplan-Meier method.

Marcello Ceccaroni, Giovanni Roviglione, Simone Garzon, Francesco Bruni, Stefano Uccella,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e54]

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Comorbidities and Quality of Life in Women Undergoing First Surgery for Endometriosis: Differences Between Chinese and Italian Population.

Huixi Chen, Silvia Vannuccini, Tommaso Capezzuoli, Marcello Ceccaroni, Liu Mubiao, Huang Shuting, Yanting Wu, Hefeng Huang, Felice Petraglia,

An observational cross-sectional study was conducted in a group (n = 371) of fertile age women with endometriosis, by administering a structured questionnaire, in order to evaluate the incidence of gynecological and systemic comorbidities and the impact on quality of life (QoL) in two different groups of Italian and Chinese patients ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2021, :]

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Correction to: Minimally invasive treatment of diaphragmatic endometriosis: a 15-year single referral center's experience on 215 patients.

Marcello Ceccaroni, Giovanni Roviglione, Antonino Farulla, Pietro Bertoglio, Roberto Clarizia, Andrea Viti, Daniele Mautone, Matteo Ceccarello, Anna Stepniewska, Alberto Claudio Terzi,

Surg Endosc (Surgical endoscopy)
[2021, :]

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Laparoscopic colorectal resection for deep infiltrating endometriosis: can we reliably predict anastomotic leakage and major postoperative complications in the early postoperative period?

Elisa Bertocchi, Giuliano Barugola, Marcello Ceccaroni, Massimo Guerriero, Roberto Rossini, Irene Gentile, Giacomo Ruffo,

<h4>Background</h4>Anastomotic leakage (AL) and major complications after colorectal resection for deep infiltrating endometriosis (DIE) have a remarkable impact on patient outcomes. The aim of this study is to assess the predictive value of C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBCs) and the Dutch Leakage Score (DLS) as ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, :]

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Minimally invasive treatment of diaphragmatic endometriosis: a 15-year single referral center's experience on 215 patients.

Marcello Ceccaroni, Giovanni Roviglione, Antonino Farulla, Pietro Bertoglio, Roberto Clarizia, Andrea Viti, Daniele Mautone, Matteo Ceccarello, Anna Stepniewska, Alberto Claudio Terzi,

<h4>Background</h4>Diaphragmatic endometriosis (DE) is a rare and often misdiagnosed condition. Most of the times it is asymptomatic and due to the low accuracy of diagnostic tests, it is almost always detected during surgery for pelvic endometriosis. Its management is challenging and, until now, there are not guidelines about its treatment.<h4>Methods</h4>We ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, :]

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A Fascial Reinterpretation of the Classical Female Pelvic Surgical Anatomy: Seeing Things from a Different Angle.

Stefano Cosma, Domenico Ferraioli, Andrea Carosso, Marcello Ceccaroni, Chiara Benedetto,

<h4>Study objective</h4>The classical surgical anatomy of the female pelvis was born with radical hysterectomy [1] and focused on the pivotal role of the lateral parametrium, a conceptually complex structure, an artifact of surgical anatomy [2] without which the whole classical model would collapse. Here, using natural planes, we tried to ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2020, :]

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Total laparoscopic vs. conventional open abdominal nerve-sparing radical hysterectomy: clinical, surgical, oncological and functional outcomes in 301 patients with cervical cancer.

Marcello Ceccaroni, Giovanni Roviglione, Mario Malzoni, Francesco Cosentino, Emanuela Spagnolo, Roberto Clarizia, Paolo Casadio, Renato Seracchioli, Fabio Ghezzi, Daniele Mautone, Francesco Bruni, Stefano Uccella,

<h4>Objective</h4>Total laparoscopic nerve-sparing radical hysterectomy (TL-NSRH) has been considered a promising approach, however, surgical, clinical, oncological and functional outcomes have not been systematically addressed. We present a large retrospective multi-center experience comparing TL-NSRH vs. open abdominal NSRH (OA-NSRH) for early and locally-advanced cervical cancer, with particular emphasis on post-surgical pelvic ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(1):e10]

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Nerve-sparing laparoscopic disc excision of deep endometriosis involving the bowel: a single-center experience on 371 consecutives cases.

Marcello Ceccaroni, Matteo Ceccarello, Roberto Clarizia, Enrico Fusco, Giovanni Roviglione, Daniele Mautone, Camilla Cavallero, Simone Orlandi, Roberto Rossini, Giuliano Barugola, Giacomo Ruffo,

<h4>Background</h4>Bowel endometriosis is the most common pattern of Deep Endometriosis (DE). Arising from the posterior portion of the cervix and spreading to the recto-vaginal septum, utero-sacral and parametrial ligaments could lead to a distortion of normal pelvic anatomy, causing pain and infertility. Hormonal therapy is the first-line treatment in non-symptomatic patient. Conversely, laparoscopic ... Read more >>

Surg Endosc (Surgical endoscopy)
[2020, :]

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Management and 1-year outcomes of anastomotic leakage after elective colorectal surgery.

, Felice Borghi, Marco Migliore, Desirée Cianflocca, Giacomo Ruffo, Alberto Patriti, Paolo Delrio, Marco Scatizzi, Stefano Mancini, Gianluca Garulli, Andrea Lucchi, Alessandro Carrara, Felice Pirozzi, Stefano Scabini, Andrea Liverani, Gianluca Baiocchi, Roberto Campagnacci, Andrea Muratore, Graziano Longo, Marco Caricato, Raffaele Macarone Palmieri, Nereo Vettoretto, Paolo Ciano, Michele Benedetti, Elisa Bertocchi, Marcello Ceccaroni, Ugo Pace, Lorenzo Pandolfini, Andrea Sagnotta, Basilio Pirrera, Vincenzo Alagna, Giacomo Martorelli, Giuseppe Tirone, Michele Motter, Antonio Sciuto, Antonio Martino, Andrea Scarinci, Sarah Molfino, Angela Maurizi, Patrizia Marsanic, Federico Tomassini, Simone Santoni, Gabriella Teresa Capolupo, Pietro Amodio, Elisa Arici, Simone Cicconi, Irene Marziali, Gianluca Guercioni, Marco Catarci,

<h4>Purpose</h4>To analyze different types of management and one-year outcomes of anastomotic leakage (AL) after elective colorectal resection.<h4>Methods</h4>All patients with anastomotic leakage after elective colorectal surgery with anastomosis (76/1,546; 4.9%), with the exclusion of cases with proximal diverting stoma, were followed-up for at least one year. Primary endpoints were as follows: ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2021, 36(5):929-939]

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Sphingosine 1-phosphate receptors are dysregulated in endometriosis: possible implication in transforming growth factor β-induced fibrosis.

Caterina Bernacchioni, Tommaso Capezzuoli, Valentina Vannuzzi, Francesca Malentacchi, Francesca Castiglione, Francesca Cencetti, Marcello Ceccaroni, Chiara Donati, Paola Bruni, Felice Petraglia,

<h4>Objective</h4>To study the molecular mechanisms involved in the appearance of the fibrotic trait in endometriosis by investigating whether the signaling pathway of the bioactive sphingolipid sphingosine 1-phosphate (S1P) was altered in endometriotic lesions.<h4>Design</h4>Case-control laboratory study.<h4>Setting</h4>University research institute and university hospital.<h4>Patient(s)</h4>A total of 75 women, with and without endometriosis, were included ... Read more >>

Fertil Steril (Fertility and sterility)
[2021, 115(2):501-511]

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Primary site disease and recurrence location in ovarian cancer patients undergoing primary debulking surgery vs. interval debulking surgery.

Capozzi Vito Andrea, Stefano Uccella, Giulio Sozzi, Marcello Ceccaroni, Daniele Mautone, Giulia Armano, Massimo Franchi, Vito Chiantera, Roberto Berretta,

<h4>Introduction</h4>The natural history and patterns of ovarian cancer (OC) relapse are still unclear. Recurrent disease can be peritoneal, parenchymal, or nodal. This study aims to analyze the location and pattern of OC recurrence according to the primary site of disease and to the type of surgical approach used.<h4>Material and methods</h4>All ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2020, :]

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Long-term hormonal treatment reduces repetitive surgery for endometriosis recurrence.

Tommaso Capezzuoli, Silvia Vannuccini, Daniele Mautone, Flavia Sorbi, Huixi Chen, Fernando M Reis, Marcello Ceccaroni, Felice Petraglia,

<h4>Research question</h4>How effective is medical hormonal treatment in preventing endometriosis recurrence and in improving women's clinical symptoms and quality of life?<h4>Design</h4>This observational cross-sectional study evaluated the effects of hormonal medical treatment (progestins, gonadotrophin-releasing hormone analogues or continuous oral contraceptives) on endometriosis recurrence, current clinical symptoms and quality of life in ... Read more >>

Reprod Biomed Online (Reproductive biomedicine online)
[2021, 42(2):451-456]

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Intraoperative Ultrasound for Bowel Deep Infiltrating Endometriosis: A Preliminary Report.

Andrea Puppo, Elena Olearo, Andrea Gattolin, Roberto Rimonda, Antonia Novelli, Marcello Ceccaroni,

The decision to perform either conservative surgery or segmental bowel resection for bowel deep infiltrating endometriosis (DIE) is made intraoperatively, after a preoperative assessment, based on the nodule's features. We introduce a technique to evaluate DIE bowel nodules using laparoscopic intraoperative ultrasound (US) during laparoscopic radical treatment of 9 cases ... Read more >>

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2020, :]

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A simplified fascial model of pelvic anatomical surgery: going beyond parametrium-centered surgical anatomy.

Stefano Cosma, Domenico Ferraioli, Marco Mitidieri, Marcello Ceccaroni, Paolo Zola, Leonardo Micheletti, Chiara Benedetto,

The classical surgical anatomy of the female pelvis is limited by its gynecological oncological focus on the parametrium and burdened by its modeling based on personal techniques of different surgeons. However, surgical treatment of pelvic diseases, spreading beyond the anatomical area of origin, requires extra-regional procedures and a thorough pelvic ... Read more >>

Anat Sci Int (Anatomical science international)
[2021, 96(1):20-29]

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Bowel resection for intestinal endometriosis.

Simone Ferrero, Cesare Stabilini, Fabio Barra, Roberto Clarizia, Giovanni Roviglione, Marcello Ceccaroni,

Over the last twenty years, segmental resection (SR) has been the technique most frequently used to treat bowel endometriosis. Nowadays, it is most commonly performed by laparoscopy; however, there is evidence that it can be safely performed by robotic-assisted laparoscopic surgery. Rectovaginal fistula and anastomotic leakage are the two major ... Read more >>

Best Pract Res Clin Obstet Gynaecol (Best practice & research. Clinical obstetrics & gynaecology)
[2021, 71:114-128]

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Inflammation calls for more: Severe pelvic inflammatory disease with or without endometriosis. Outcomes on 311 laparoscopically treated women.

Roberto Clarizia, Tommaso Capezzuoli, Matteo Ceccarello, Carlotta Zorzi, Anna Stepniewska, Giovanni Roviglione, Daniele Mautone, Felice Petraglia, Marcello Ceccaroni,

<h4>Objective</h4>To study possible associations between endometriosis and pelvic inflammatory disease (PID).<h4>Design</h4>Retrospective cohort analysis over 14 consecutive years, based on medical records and insurance coding in a tertiary care endometriosis reference center.<h4>Setting</h4>Tertiary care reference center for endometriosis.<h4>Patients</h4>Retrospective analysis on all women submitted to laparoscopy in our Unit MAIN OUTCOME MEASURES: Intra-operative ... Read more >>

J Gynecol Obstet Hum Reprod (Journal of gynecology obstetrics and human reproduction)
[2021, 50(3):101811]

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Risk factors for adverse events after elective colorectal surgery: beware of blood transfusions.

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Purpose of the present study is to analyze risk factors for adverse events after elective colorectal resection. A wide range of adverse events after elective colorectal surgery was reported, anastomotic leakage (AL) and related morbidity and mortality being the most feared ones. Clear definition of risk factors is crucial to ... Read more >>

Updates Surg (Updates in surgery)
[2020, 72(3):811-819]

Cited: 1 time

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Endometriosis Involving the Diaphragm: A Patient-Tailored Minimally Invasive Surgical Treatment.

Andrea Viti, Pietro Bertoglio, Giovanni Roviglione, Roberto Clarizia, Giacomo Ruffo, Marcello Ceccaroni, Alberto C Terzi,

<h4>Background</h4>Diaphragmatic endometriosis is a rare presentation of endometriosis and no standardized technique for surgical treatment is available so far. We aim to verify and describe feasibility, safety and post-operative outcomes of patients affected by diaphragmatic endometriosis treated with a minimally invasive video-assisted thoracic approach.<h4>Methods</h4>We prospectively collected data of all patients ... Read more >>

World J Surg (World journal of surgery)
[2020, 44(4):1099-1104]

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Ectopic Pregnancy Caused by a Stenosing Tubal Localization of Deep Endometriosis.

Marcello Ceccaroni, Angelo Finelli, Maria Manzone, Anna Katarzyna Stepniewska, Roberto Clarizia,

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2021, 28(1):7-8]

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A core outcome set for future endometriosis research: an international consensus development study.

Jmn Duffy, M Hirsch, M Vercoe, J Abbott, C Barker, B Collura, R Drake, Jlh Evers, M Hickey, A W Horne, M L Hull, S Kolekar, S Lensen, N P Johnson, V Mahajan, B W Mol, A-S Otter, L Puscasiu, M B Rodriguez, L Rombauts, A Vail, R Wang, C M Farquhar, ,

<h4>Objective</h4>To develop a core outcome set for endometriosis.<h4>Design</h4>Consensus development study.<h4>Setting</h4>International.<h4>Population</h4>One hundred and sixteen healthcare professionals, 31 researchers and 206 patient representatives.<h4>Methods</h4>Modified Delphi method and modified nominal group technique.<h4>Results</h4>The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall ... Read more >>

BJOG (BJOG : an international journal of obstetrics and gynaecology)
[2020, 127(8):967-974]

Cited: 2 times

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Comparison of Virtual Ultrasonographic Hysteroscopy with Conventional Hysteroscopy in the Workup of Patients Who Are Infertile.

Anna Katarzyna Stepniewska, Paolo Verrazzo, Luca Savelli, Giamberto Trivella, Chiara Signori, Roberto Clarizia, Massimo Guerriero, Antonio Mollo, Giuseppe De Placido, Marcello Ceccaroni,

<h4>Study objective</h4>To compare the tolerability and diagnostic accuracy of virtual ultrasonographic hysteroscopy (VUH) with that of conventional diagnostic outpatient hysteroscopy in the workup of patients who are infertile.<h4>Design</h4>A single-center, retrospective cohort study.<h4>Setting</h4>Department of Obstetrics and Gynecology, Gynecologic Oncology, and Minimally Invasive Pelvic Surgery Unit of Sacred Heart Hospital Don Calabria ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2021, 28(1):63-74]

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Total laparoscopic bladder resection in the management of deep endometriosis: "take it or leave it." Radicality versus persistence.

Marcello Ceccaroni, Roberto Clarizia, Matteo Ceccarello, Paola De Mitri, Giovanni Roviglione, Daniele Mautone, Giuseppe Caleffi, Alberto Molinari, Giacomo Ruffo, Stefano Cavalleri,

<h4>Background</h4>Bladder endometriosis (BE) is the most common external site of deep-infiltrating endometriosis (DIE) affecting the urinary tract. Frequently associated with other DIE lesions, it can be strongly related to a ventral spread of adenomyosis. Possible symptoms are urinary frequency, tenesmus and hematuria, and they are frequently related to DIE of ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2020, 31(8):1683-1690]

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Recurrent endometriosis: a battle against an unknown enemy.

Marcello Ceccaroni, Valentina Elisabetta Bounous, Roberto Clarizia, Daniele Mautone, Mohamed Mabrouk,

Recurrence of endometriosis after conservative surgery is not an uncommon finding. There is no uniformity, however, on what the term 'recurrence' means. Recurrence is variously defined in the literature as the relapse of pain, clinical or instrumental detection of an endometriotic lesion, repeat rise in CA 125 levels, or evidence ... Read more >>

Eur J Contracept Reprod Health Care (The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception)
[2019, 24(6):464-474]

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Nerve-sparing Surgery for Deep Infiltrating Endometriosis: Laparoscopic Eradication of Deep Infiltrating Endometriosis with Rectal and Parametrial Resection According to the Negrar Method.

Marcello Ceccaroni, Roberto Clarizia, Giovanni Roviglione,

<h4>Objective</h4>To show technical highlights of a nerve-sparing laparoscopic eradication of deep infiltrating endometriosis with rectal and parametrial resection according to the Negrar method.<h4>Design</h4>Stepwise demonstration of the technique with narrated video footage.<h4>Setting</h4>Tertiary care endometriosis unit. Bowel endometriosis accounts for about 12% of the total cases of endometriosis. Most frequently, rectal infiltration ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2020, 27(2):263-264]

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Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green.

Manuel Maria Ianieri, Andrea Puppo, Antonia Novelli, Federica Campolo, Tommaso Staniscia, Giuseppe Di Martino, Elisa Piovano, Francesco Bruni, Giovanni Roviglione, Daniele Mautone, Marcello Ceccaroni,

<h4>Background</h4>The sentinel lymph node (SLN) mapping for endometrial cancer staging is gaining wide diffusion, but there is no definitive evidence on the factors associated with the failure of mapping.<h4>Objectives</h4>To analyze the factors associated with the possible failure of bilateral SLN mapping with indocyanine green (ICG).<h4>Methods</h4>A prospective observational study without control ... Read more >>

Gynecol Obstet Invest (Gynecologic and obstetric investigation)
[2019, 84(4):383-389]

Cited: 1 time

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