Full Text Journal Articles by
Author Marcel Ruzicka

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Kidney, Cardiac, and Safety Outcomes Associated With α-Blockers in Patients With CKD: A Population-Based Cohort Study.

Gregory L Hundemer, Greg A Knoll, William Petrcich, Swapnil Hiremath, Marcel Ruzicka, Kevin D Burns, Cedric Edwards, Ann Bugeja, Emily Rhodes, Manish M Sood,

<h4>Rationale & objectives</h4>Alpha-blockers (ABs) are commonly prescribed for control of resistant or refractory hypertension in patients with and without chronic kidney disease (CKD). The association between AB use and kidney, cardiac, mortality, and safety-related outcomes in CKD remains unknown.<h4>Study design</h4>Population-based retrospective cohort study.<h4>Settings & participants</h4>Ontario (Canada) residents 66 years and ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2021, 77(2):178-189.e1]

Cited: 1 time

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Impact of uncomplicated controlled hypertension on thermoregulation during exercise-heat stress.

Ashley P Akerman, Sean R Notley, Ronald J Sigal, Pierre Boulay, Marcel Ruzicka, Brian J Friesen, Glen P Kenny,

Exercise is promoted for management of hypertension and as a general healthy behavior, but environmental conditions are seldom considered in these recommendations. Hypertension may affect skin blood flow and sweating, two of the primary mechanisms which prevent continued elevations in core temperature by facilitating whole-body heat loss during exercise-heat stress. ... Read more >>

J Hum Hypertens (Journal of human hypertension)
[2020, :]

Cited: 0 times

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Inter-arm difference in blood pressure in patients referred to tertiary hypertension center: Prevalence, risk factors, and relevance to physicians.

Januvi Jegatheswaran, Swapnil Hiremath, Cedric Edwards, Marcel Ruzicka,

The prevalence of inter-arm BP difference is high in hypertension and is associated with adverse cardiovascular outcomes. We performed a retrospective chart review of prevalent patients in the Ottawa Hospital Hypertension Center to assess for prevalence, risk factors, and whether finding of inter-arm BP difference >10 mmHg leads to investigations of ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2020, 22(8):1513-1517]

Cited: 0 times

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The Prevalence of Non-Adherence in Patients with Resistant Hypertension: a Systematic Review and Meta-Analysis

Gabrielle Bourque, Julius Vladimir Ilin, Marcel Ruzicka, Alexandra Davis, Gregory Hundemer, Swapnil Hiremath,

<h4>ABSTRACT</h4> <h4>Background</h4> Resistant hypertension is quite prevalent and a risk factor for cardiovascular events. Patients with suspected resistant hypertension undergo more screening intensity for secondary hypertension, despite some of them being non-adherent to prescribed pharmacotherapy. The prevalence of non-adherence in this setting varies from about 5 to 80% in the ... Read more >>

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High Anion Gap Metabolic Acidosis on Continuous Renal Replacement Therapy.

Sriram Sriperumbuduri, Edward Clark, Mohan Biyani, Marcel Ruzicka,

Kidney Int Rep (Kidney international reports)
[2020, 5(10):1833-1835]

Cited: 0 times

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Hypertension Canada's 2020 Evidence Review and Guidelines for the Management of Resistant Hypertension.

Swapnil Hiremath, Ruth Sapir-Pichhadze, Meranda Nakhla, Jonathan Y Gabor, Nadia A Khan, Laura M Kuyper, Marcel Ruzicka, Sheldon W Tobe, Karen Tran, Doreen M Rabi, Stella S Daskalopoulou,

We present Hypertension Canada's inaugural evidence-based recommendations for the diagnosis and management of resistant hypertension. Hypertension is present in 21% of the Canadian population, and among those with hypertension, resistant hypertension has an estimated prevalence from 10% to 30%. This subgroup of hypertensive individuals is important, because resistant hypertension portends ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2020, 36(5):625-634]

Cited: 1 time

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Renal infarct in a COVID-19-positive kidney-pancreas transplant recipient.

Jieqing J Xu, Daniel Samaha, Suhas Mondhe, David Massicotte-Azarniouch, Gregory Knoll, Marcel Ruzicka,

The novel coronavirus disease 2019 (COVID-19) is associated with increased risk of thromboembolic events, but the extent and duration of this hypercoagulable state remain unknown. We describe the first case report of renal allograft infarction in a 46-year-old kidney-pancreas transplant recipient with no prior history of thromboembolism, who presented 26 days ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, 20(11):3221-3224]

Cited: 6 times

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Effects of CPAP on Blood Pressure and Sympathetic Activity in Patients With Diabetes Mellitus, Chronic Kidney Disease, and Resistant Hypertension.

Marcel Ruzicka, Greg Knoll, Frans H H Leenen, Judith Leech, Shawn D Aaron, Swapnil Hiremath,

<h4>Background</h4>Patients with obstructive sleep apnea (OSA) have increased sympathetic activity and frequently also have resistant hypertension (HTN). Treatment of OSA with continuous positive airway pressure (CPAP) decreases awake and sleep blood pressure (BP) and sympathetic activity. This study was designed to assess the effect of treatment of OSA with CPAP ... Read more >>

CJC Open (CJC open)
[2020, 2(4):258-264]

Cited: 1 time

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Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children.

Doreen M Rabi, Kerry A McBrien, Ruth Sapir-Pichhadze, Meranda Nakhla, Sofia B Ahmed, Sandra M Dumanski, Sonia Butalia, Alexander A Leung, Kevin C Harris, Lyne Cloutier, Kelly B Zarnke, Marcel Ruzicka, Swapnil Hiremath, Ross D Feldman, Sheldon W Tobe, Tavis S Campbell, Simon L Bacon, Kara A Nerenberg, George K Dresser, Anne Fournier, Ellen Burgess, Patrice Lindsay, Simon W Rabkin, Ally P H Prebtani, Steven Grover, George Honos, Jeffrey E Alfonsi, JoAnne Arcand, François Audibert, Geneviève Benoit, Jesse Bittman, Peter Bolli, Anne-Marie Côté, Janis Dionne, Andrew Don-Wauchope, Cedric Edwards, Tabassum Firoz, Jonathan Y Gabor, Richard E Gilbert, Jean C Grégoire, Steven E Gryn, Milan Gupta, Fady Hannah-Shmouni, Robert A Hegele, Robert J Herman, Michael D Hill, Jonathan G Howlett, Gregory L Hundemer, Charlotte Jones, Janusz Kaczorowski, Nadia A Khan, Laura M Kuyper, Maxime Lamarre-Cliche, Kim L Lavoie, Lawrence A Leiter, Richard Lewanczuk, Alexander G Logan, Laura A Magee, Birinder K Mangat, Philip A McFarlane, Donna McLean, Andre Michaud, Alain Milot, Gordon W Moe, S Brian Penner, Andrew Pipe, Alexandre Y Poppe, Evelyne Rey, Michael Roerecke, Ernesto L Schiffrin, Peter Selby, Mike Sharma, Ashkan Shoamanesh, Praveena Sivapalan, Raymond R Townsend, Karen Tran, Luc Trudeau, Ross T Tsuyuki, Michel Vallée, Vincent Woo, Alan D Bell, Stella S Daskalopoulou,

Hypertension Canada's 2020 guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children provide comprehensive, evidence-based guidance for health care professionals and patients. Hypertension Canada develops the guidelines using rigourous methodology, carefully mitigating the risk of bias in our process. All draft recommendations undergo critical ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2020, 36(5):596-624]

Cited: 9 times

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The Hypertension Canada blood pressure device recommendation listing: Empowering use of clinically validated devices in Canada.

Raj Padwal, Angelique Berg, Mark Gelfer, Karen Tran, Jennifer Ringrose, Marcel Ruzicka, Swapnil Hiremath, ,

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2020, 22(5):933-936]

Cited: 0 times

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Renovascular hypertension from the BCR-ABL tyrosine kinase inhibitor ponatinib.

Syed O Amin, Marcel Ruzicka, Kevin D Burns, Isabelle A Bence-Bruckler, Stephen E Ryan, Adnan Hadziomerovic, Swapnil Hiremath,

Drug-induced hypertension is one of the commonest causes of secondary hypertension. In the last few years, secondary hypertension due to tyrosine kinase inhibitors, from the vascular endothelial growth factor class, has been recognized to be an important cause of hypertension, as well as proteinuria, and occasionally kidney dysfunction in some ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2020, 22(4):678-682]

Cited: 1 time

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Unintended Consequences: Perils of Renal Revascularization for Severe Hypertension.

Sriram Sriperumbuduri, George Hajjar, Prasad Jetty, Swapnil Hiremath, Marcel Ruzicka,

Revascularization of atherosclerotic renal artery stenosis may cure hypertension, but paradoxically, improvement in systemic blood pressure in response to successful revascularization may precipitate ischemia in other organs affected by previously silent atherosclerotic disease. We describe bowel ischemia secondary to preexisting celiac artery stenosis after revascularisation. Prior knowledge of multivessel disease ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2020, 36(6):967.e9-967.e11]

Cited: 0 times

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The Prevalence of Nonadherence in Patients With Resistant Hypertension: A Systematic Review Protocol.

Gabrielle Bourque, Julius Vladimir Ilin, Marcel Ruzicka, Alexandra Sascha Davis, Swapnil Hiremath,

Background:Resistant hypertension, usually defined as blood pressure remaining above goal despite the concurrent use of 3 or more antihypertensive agents of different classes, is common (about 10% prevalence) and known to be a risk factor for cardiovascular events. These patients also undergo more screening intensity for secondary hypertension. However, not ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2019, 6:2054358119897196]

Cited: 0 times

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Use of Directly Observed Therapy to Assess Treatment Adherence in Patients With Apparent Treatment-Resistant Hypertension.

Marcel Ruzicka, Frans H H Leenen, Tim Ramsay, Ann Bugeja, Cedric Edwards, Brendan McCormick, Swapnil Hiremath,

JAMA Intern Med (JAMA internal medicine)
[2019, :]

Cited: 1 time

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Alpha-Blocker Use and the Risk of Hypotension and Hypotension-Related Clinical Events in Women of Advanced Age.

Swapnil Hiremath, Marcel Ruzicka, William Petrcich, Megan K McCallum, Gregory L Hundemer, Peter Tanuseputro, Douglas Manuel, Kevin Burns, Cedric Edwards, Ann Bugeja, Peter Magner, Brendan McCormick, Amit X Garg, Emily Rhodes, Manish M Sood,

Alpha-blockers (ABs) are commonly prescribed as part of a multidrug regimen in the management of hypertension. We set out to assess the risk of hypotension and related adverse events with AB use compared with other blood pressure (BP) lowering drugs using a population-based, retrospective cohort study of women (≥66 years) ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2019, 74(3):645-651]

Cited: 3 times

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Cause, Consequence or confounding? The kidney in hypertension.

Marcel Ruzicka, Swapnil Hiremath,

J Hum Hypertens (Journal of human hypertension)
[2019, 33(9):639-640]

Cited: 0 times

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Behind the Mask.

Marcel Ruzicka, Swapnil Hiremath,

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2018, 72(4):841-842]

Cited: 0 times

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Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children.

Kara A Nerenberg, Kelly B Zarnke, Alexander A Leung, Kaberi Dasgupta, Sonia Butalia, Kerry McBrien, Kevin C Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Raj S Padwal, Karen C Tran, Steven Grover, Simon W Rabkin, Gordon W Moe, Jonathan G Howlett, Patrice Lindsay, Michael D Hill, Mike Sharma, Thalia Field, Theodore H Wein, Ashkan Shoamanesh, George K Dresser, Pavel Hamet, Robert J Herman, Ellen Burgess, Steven E Gryn, Jean C Grégoire, Richard Lewanczuk, Luc Poirier, Tavis S Campbell, Ross D Feldman, Kim L Lavoie, Ross T Tsuyuki, George Honos, Ally P H Prebtani, Gregory Kline, Ernesto L Schiffrin, Andrew Don-Wauchope, Sheldon W Tobe, Richard E Gilbert, Lawrence A Leiter, Charlotte Jones, Vincent Woo, Robert A Hegele, Peter Selby, Andrew Pipe, Philip A McFarlane, Paul Oh, Milan Gupta, Simon L Bacon, Janusz Kaczorowski, Luc Trudeau, Norman R C Campbell, Swapnil Hiremath, Michael Roerecke, Joanne Arcand, Marcel Ruzicka, G V Ramesh Prasad, Michel Vallée, Cedric Edwards, Praveena Sivapalan, S Brian Penner, Anne Fournier, Geneviève Benoit, Janusz Feber, Janis Dionne, Laura A Magee, Alexander G Logan, Anne-Marie Côté, Evelyne Rey, Tabassum Firoz, Laura M Kuyper, Jonathan Y Gabor, Raymond R Townsend, Doreen M Rabi, Stella S Daskalopoulou, ,

Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis, assessment, prevention, and treatment of hypertension in adults and children. This year, the adult and pediatric guidelines are combined in one document. The new 2018 pregnancy-specific hypertension guidelines are published separately. For 2018, 5 new guidelines are introduced, and 1 ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2018, 34(5):506-525]

Cited: 108 times

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Thiazide diuretic-caused hyponatremia in the elderly hypertensive: will a bottle of Nepro a day keep hyponatremia and the doctor away? Study protocol for a proof-of-concept feasibility trial.

Marcel Ruzicka, Brendan McCormick, Peter Magner, Tim Ramsay, Cedric Edwards, Ann Bugeja, Swapnil Hiremath,

Background:Hypertension is the most common modifiable risk factor for cardiovascular disease, with an increasing prevalence with age, but with easily available medications to control it. Adverse effects of these medications do limit their use, in particular hyponatremia due to thiazide and thiazide-like diuretics. This is more common in the elderly ... Read more >>

Pilot Feasibility Stud (Pilot and feasibility studies)
[2018, 4:71]

Cited: 2 times

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Spironolactone is effective in treating hypokalemia among peritoneal dialysis patients.

Amit Langote, Swapnil Hiremath, Marcel Ruzicka, Brendan B McCormick,

<h4>Background</h4>Hypokalemia is common in peritoneal dialysis (PD) patients and is associated with increased cardiovascular and all-cause mortality. The management approach for such patients routinely includes spironolactone at our centre. We undertook this study to assess the efficacy of spironolactone for the treatment of hypokalemia in PD patients.<h4>Methods</h4>Retrospective chart review of ... Read more >>

PLoS One (PloS one)
[2017, 12(11):e0187269]

Cited: 1 time

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Longitudinal Blood Pressure in Late-Stage Chronic Kidney Disease and the Risk of End-Stage Kidney Disease or Mortality (Best Blood Pressure in Chronic Kidney Disease Study).

Manish M Sood, Ayub Akbari, Douglas G Manuel, Marcel Ruzicka, Swapnil Hiremath, Deborah Zimmerman, Brendan McCormick, Monica Taljaard,

Whether different methods of quantitating blood pressure (BP) in late chronic kidney disease better mimic pathophysiological processes and clinical outcomes remains unclear. In a retrospective study, we determined the association of BP with end-stage kidney disease (ESKD) and all-cause mortality with BP modeled at baseline versus longitudinally with time-varying Cox ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(6):1210-1218]

Cited: 3 times

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Thus Far and No Further: Should Diastolic Hypotension Limit Intensive Blood Pressure Lowering?

Marcel Ruzicka, Cedric Edwards, Brendan McCormick, Swapnil Hiremath,

<h4>Opinion statement</h4>Intensive blood pressure lowering to systolic blood pressure thresholds of less than 120 mmHg is making a slow comeback with the publication of trials supporting its benefit, especially in lowering stroke and congestive heart failure. At the same time, there is an increasing awareness of the prevalence and risk of ... Read more >>

Curr Treat Options Cardiovasc Med (Current treatment options in cardiovascular medicine)
[2017, 19(10):80]

Cited: 1 time

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Accuracy-Limiting Factor of Home Blood Pressure Monitors?

Marcel Ruzicka, Swapnil Hiremath,

Am J Hypertens (American journal of hypertension)
[2017, 30(7):661-664]

Cited: 2 times

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Precision Medicine for Hypertension Management in Chronic Kidney Disease: Relevance of SPRINT for Therapeutic Targets in Nondiabetic Renal Disease.

Marcel Ruzicka, Kevin D Burns, Swapnil Hiremath,

In this review we evaluate the literature to determine if lower blood pressure (BP) targets are beneficial for patients with nondiabetic chronic kidney disease (CKD). Modification of Diet in Renal Disease (MDRD), African American Study of Kidney Disease and Hypertension (AASK), and Ramipril Efficacy in Nephropathy-2 (REIN-2), designed to assess ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2017, 33(5):611-618]

Cited: 4 times

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Balancing Overscreening and Underdiagnosis in Secondary Hypertension: The Case of Fibromuscular Dysplasia.

Marcel Ruzicka, Sarah E Kucharski, Swapnil Hiremath,

Knowledge about fibromuscular dysplasia (FMD) has broadened over the last several decades. It is no longer considered a rare and benign entity limited to renal arteries and causing just hypertension. It affects other parts of the arterial tree nearly as frequently as the renal arteries. Complications of undiagnosed and untreated ... Read more >>

Cardiol Clin (Cardiology clinics)
[2017, 35(2):247-254]

Cited: 1 time

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