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Early warning signals in psychopathology: what do they tell?

Marieke J Schreuder, Catharina A Hartman, Sandip V George, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Bart P F Rutten, Nele Jacobs, Jim van Os, Johanna T W Wigman, Marieke Wichers,

BACKGROUND:Despite the increasing understanding of factors that might underlie psychiatric disorders, prospectively detecting shifts from a healthy towards a symptomatic state has remained unattainable. A complex systems perspective on psychopathology implies that such symptom shifts may be foreseen by generic indicators of instability, or early warning signals (EWS). EWS include, ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):269]

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Lower emotional complexity as a prospective predictor of psychopathology in adolescents from the general population.

Marieke J Schreuder, Marieke Wichers, Catharina A Hartman, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Bart P F Rutten, Nele Jacobs, Jim van Os, Johanna T W Wigman,

Emotional complexity (EC) involves the ability to distinguish between distinct emotions (differentiation) and the experience of a large range of emotions (diversity). Lower EC has been related to psychopathology in cross-sectional studies. This study aimed to investigate (a) whether EC prospectively predicts psychopathology and (b) whether this effect is contingent ... Read more >>

Emotion (Emotion (Washington, D.C.))
[2020, :]

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Risk of Hospitalized Falls and Hip Fractures in 22,103 Older Adults Receiving Mental Health Care vs 161,603 Controls: A Large Cohort Study.

Brendon Stubbs, Gayan Perara, Ai Koyanagi, Nicola Veronese, Davy Vancampfort, Joseph Firth, Katie Sheehan, Marc De Hert, Robert Stewart, Christoph Mueller,

OBJECTIVES:To investigate the risk of hospitalized fall or hip fracture among older adults using mental health services. DESIGN:Retrospective cohort study. SETTING AND PARTICIPANTS:Residents of a South London catchment aged >60 years receiving specialist mental health care between 2008 and 2016. MEASURES:Falls and/or a hip fracture leading to hospitalization were ascertained from linked ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2020, :]

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Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study.

Konstantinos N Fountoulakis, Elena Dragioti, Antonis T Theofilidis, Tobias Wiklund, Xenofon Atmatzidis, Ioannis Nimatoudis, Erik Thys, Martien Wampers, Luchezar Hranov, Trayana Hristova, Daniil Aptalidis, Roumen Milev, Felicia Iftene, Filip Spaniel, Pavel Knytl, Petra Furstova, Tiina From, Henry Karlsson, Maija Walta, Raimo K R Salokangas, Jean-Michel Azorin, Justine Bouniard, Julie Montant, Georg Juckel, Ida S Haussleiter, Athanasios Douzenis, Ioannis Michopoulos, Panagiotis Ferentinos, Nikolaos Smyrnis, Leonidas Mantonakis, Zsófia Nemes, Xenia Gonda, Dora Vajda, Anita Juhasz, Amresh Shrivastava, John Waddington, Maurizio Pompili, Anna Comparelli, Valentina Corigliano, Elmars Rancans, Alvydas Navickas, Jan Hilbig, Laurynas Bukelskis, Lidija I Stevovic, Sanja Vodopic, Oluyomi Esan, Oluremi Oladele, Christopher Osunbote, Janusz Κ Rybakowski, Pawel Wojciak, Klaudia Domowicz, Maria L Figueira, Ludgero Linhares, Joana Crawford, Anca-Livia Panfil, Daria Smirnova, Olga Izmailova, Dusica Lecic-Tosevski, Henk Temmingh, Fleur Howells, Julio Bobes, Maria P Garcia-Portilla, Leticia García-Alvarez, Gamze Erzin, Hasan Karadağ, Avinash De Sousa, Anuja Bendre, Cyril Hoschl, Cristina Bredicean, Ion Papava, Olivera Vukovic, Bojana Pejuskovic, Vincent Russell, Loukas Athanasiadis, Anastasia Konsta, Dan Stein, Michael Berk, Olivia Dean, Rajiv Tandon, Siegfried Kasper, Marc De Hert,

BACKGROUND.:The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. METHODS.:Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression ... Read more >>

CNS Spectr (CNS spectrums)
[2020, :1-9]

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Measuring resilience prospectively as the speed of affect recovery in daily life: a complex systems perspective on mental health.

Anna Kuranova, Sanne H Booij, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Bart P F Rutten, Nele Jacobs, Jim van Os, Johanna T W Wigman, Marieke Wichers,

INTRODUCTION:There is growing evidence that mental disorders behave like complex dynamic systems. Complex dynamic systems theory states that a slower recovery from small perturbations indicates a loss of resilience of a system. This study is the first to test whether the speed of recovery of affect states from small daily ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):36]

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Links between the amount of antipsychotic medication prescribed per population at general practice level, local demographic factors and medication selection

Adrian Hugh Heald, Mike Stedman, Sanam Farman, Chaw Khine, Mark Davies, Marc de Hert, David Taylor,

Abstract BACKGROUND Antipsychotic medications are the first-line pharmacological intervention for severe mental illnesses(SMI) such as schizophrenia and other psychoses, while also being used to relieve distress and treat neuropsychiatric symptoms in dementia. Since 2014 many antipsychotic agents have moved to generic provision. In 2017_18 supplies of certain generic agents were ... Read more >>

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Early warning signals in psychopathology: what do they tell?

Marieke J. Schreuder, Catharina A. Hartman, Sandip V. George, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Bart P. F. Rutten, Nele Jacobs, Jim van Os, Johanna T. W. Wigman, Marieke Wichers,

Background Despite the increasing understanding of factors that might underlie psychiatric disorders, prospectively detecting shifts from a healthy towards a symptomatic state has remained unattainable. A complex systems perspective on psychopathology implies that such symptom shifts may be foreseen by generic indicators of instability, or early warning signals (EWS). EWS ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):]

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TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample.

Lotta-Katrin Pries, Clara Snijders, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Sinan Guloksuz, Jim van Os, Bart P F Rutten,

Meta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are determined by the interplay between genetic and nongenetic factors contributing to the severity of psychopathology. The liability to mental ill health can be psychometrically ... Read more >>

Twin Res Hum Genet (Twin research and human genetics : the official journal of the International Society for Twin Studies)
[2019, 22(6):460-466]

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Reduced interhemispheric and increased intrahemispheric connectivity in schizophrenia brain networks

Jorne Laton, Jeroen Van Schependom, Jeroen Decoster, Tim Moons, Marc De Hert, Guy Nagels, Maarten De Vos,

Abstract Introduction Brain connectivity is disturbed in schizophrenia, both during resting state and during active tasks. Schizophrenia is characterised by a corpus callosum pathology and an inability to suppress overstimulation, both of which relate to this disturbed connectivity. We wanted to verify whether network analysis on EEG sensor level can ... Read more >>

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Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study.

Konstantinos N Fountoulakis, Elena Dragioti, Antonis T Theofilidis, Tobias Wikilund, Xenofon Atmatzidis, Ioannis Nimatoudis, Erik Thys, Martien Wampers, Luchezar Hranov, Trayana Hristova, Daniil Aptalidis, Roumen Milev, Felicia Iftene, Filip Spaniel, Pavel Knytl, Petra Furstova, Tiina From, Henry Karlsson, Maija Walta, Raimo K R Salokangas, Jean-Michel Azorin, Justine Bouniard, Julie Montant, Georg Juckel, Ida S Haussleiter, Athanasios Douzenis, Ioannis Michopoulos, Panagiotis Ferentinos, Nikolaos Smyrnis, Leonidas Mantonakis, Zsófia Nemes, Xenia Gonda, Dora Vajda, Anita Juhasz, Amresh Shrivastava, John Waddington, Maurizio Pompili, Anna Comparelli, Valentina Corigliano, Elmars Rancans, Alvydas Navickas, Jan Hilbig, Laurynas Bukelskis, Lidija Injac Stevovic, Sanja Vodopic, Oluyomi Esan, Oluremi Oladele, Christopher Osunbote, Janusz Κ Rybakowski, Pawel Wojciak, Klaudia Domowicz, Maria Luisa Figueira, Ludgero Linhares, Joana Crawford, Anca-Livia Panfil, Daria Smirnova, Olga Izmailova, Dusica Lecic-Tosevski, Henk Temmingh, Fleur Howells, Julio Bobes, Maria Paz Garcia-Portilla, Leticia García-Alvarez, Gamze Erzin, Hasan Karadağ, Avinash De Sousa, Anuja Bendre, Cyril Hoschl, Cristina Bredicean, Ion Papava, Olivera Vukovic, Bojana Pejuskovic, Vincent Russell, Loukas Athanasiadis, Anastasia Konsta, Dan Stein, Michael Berk, Olivia Dean, Rajiv Tandon, Siegfried Kasper, Marc De Hert,

INTRODUCTION:A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method. METHODS:Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, ... Read more >>

Int J Neuropsychopharmacol (The international journal of neuropsychopharmacology)
[2019, 22(11):681-697]

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Interaction between polygenic liability for schizophrenia and childhood adversity influences daily-life emotional dysregulation and psychosis proneness

Lotta-Katrin Pries, Boris Klingenberg, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Ozan Cinar, Bochao Lin, Jurjen Luykx, Bart Rutten, Jim van Os, Sinan Guloksuz,

Abstract Background The earliest stages of the pluripotent psychopathology on the pathway to psychotic disorders is represented by emotional dysregulation and subtle psychosis expression, which can be measured using the Ecological Momentary Assessment (EMA). However, it is not clear to what degree common genetic and environmental risk factors for psychosis ... Read more >>

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Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study.

Alex J Mitchell, Davy Vancampfort, Peter Manu, Christoph U Correll, Martien Wampers, Ruud van Winkel, Weiping Yu, Marc De Hert,

OBJECTIVE:We aimed to investigate which clinical and metabolic tests offer optimal accuracy and acceptability to help diagnose diabetes among a large sample of people with serious mental illness in receipt of antipsychotic medication. METHODS:A prospective observational study design of biochemical and clinical factors was used. Biochemical measures were fasting glucose, ... Read more >>

PLoS One (PloS one)
[2019, 14(9):e0210674]

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Test-retest reliability, concurrent validity and correlates of the two-minute walk test in outpatients with psychosis.

Davy Vancampfort, Samuel Kimbowa, David Basangwa, Lee Smith, Brendon Stubbs, Tine Van Damme, Marc De Hert, James Mugisha,

The aim of this study was to investigate the test-retest reliability of the 2-minute walk test (2MWT) and the concurrent validity with the 6-minute walk test (6MWT) in outpatients with psychosis. We also explored whether there was a practice effect, determined minimal detectable changes (MDC) and assessed which factors are ... Read more >>

Psychiatry Res (Psychiatry research)
[2019, 282:112619]

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The sublingual use of atropine in the treatment of clozapine-induced sialorrhea: A systematic review.

Thomas Van der Poorten, Marc De Hert,

Clozapine is considered the golden standard in the treatment of therapy-resistant schizophrenia; however, it associated with bothersome side effects such as sialorrhea. Current evidence suggests that the sublingual use of atropine seems to be safe and effective and could be considered as a first-line treatment of clozapine-induced sialorrhea. ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(11):2108-2113]

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Barriers, attitudes, confidence, and knowledge of nurses regarding metabolic health screening and intervention in people with mental illness: a pilot study from Uganda.

Davy Vancampfort, Andrew Watkins, Philip B Ward, Michel Probst, Marc De Hert, Tine Van Damme, James Mugisha,

Background:People with mental illness are at an increased risk for developing cardio-metabolic disorders. Routine screening following pharmacotherapy is however unacceptably low in sub-Saharan African countries with less than 1% adequately screened. It is unknown whether this is due to a lack of adequate competences. Objectives:The aim of this pilot study ... Read more >>

Afr Health Sci (African health sciences)
[2019, 19(3):2546-2554]

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Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms.

Florentina M E Pinckaers, Iris L M Rotee, C Vicky Nwosu, Pauline Krolinski, Antonius P W Smeets, Sinan Gülöksüz, Lea de Jong, Thomas S J Vaessen, Thomas Damen, Aniek Uittenboogaard, Annika T Schäfer, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Bart P F Rutten, Jim van Os, Marjan Drukker,

PURPOSE:Whilst childhood trauma (CT) is a known risk factor across the spectrum of psychosis expression, little is known about possible interplay with genetic liability. METHODS:The TwinssCan Study collected data in general population twins, focussing on expression of psychosis at the level of subthreshold psychotic experiences. A multilevel mixed-effects linear regression ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2019, 54(9):1045-1054]

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A quantitative assessment of the views of mental health professionals on exercise for people with mental illness: perspectives from a low-resource setting.

Davy Vancampfort, Robert Stanton, Michel Probst, Marc De Hert, Ruud van Winkel, Inez Myin-Germeys, Eugene Kinyanda, James Mugisha,

Background:Exercise is nowadays considered as an evidence-based treatment modality in people with mental illness. Nurses and occupational therapists working in low-resourced mental health settings are well-placed to provide exercise advice for people with mental illness. Objectives:We examined the current exercise prescription practices employed by Ugandan health care professionals when working ... Read more >>

Afr Health Sci (African health sciences)
[2019, 19(2):2172-2182]

Cited: 2 times

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Meta-analysis of the Efficacy and Safety of Adjunctive Rosuvastatin for Dyslipidemia in Patients with Schizophrenia.

Wei Zheng, Wei Yang, Qing-E Zhang, Xin-Hu Yang, Dong-Bin Cai, Jin-Qing Hu, Gabor S Ungvari, Chee H Ng, Marc De Hert, Yu-Ping Ning, Yu-Tao Xiang,

Background:Metabolic syndrome in patients with schizophrenia is a major health concern. The efficacy and safety of adjunctive rosuvastatin in treating dyslipidemia were controversial. Aims:To assess the efficacy and safety of adjunctive rosuvastatin for dyslipidemia in patients with schizophrenia. Methods:We systematically searched for relevant controlled clinical trials from the following databases: ... Read more >>

(Shanghai archives of psychiatry)
[2018, 30(1):4-11]

Cited: 1 time

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Associations of the Built Environment With Physical Activity and Sedentary Time in Ugandan Outpatients With Mental Health Problems.

Davy Vancampfort, Brendon Stubbs, James F Sallis, Justine Nabanoba, David Basangwa, Adewale L Oyeyemi, Sandra S Kasoma, Marc De Hert, Inez Myin-Germeys, James Mugisha,

BACKGROUND:This study investigated whether reported neighborhood variables explained variance in time spent walking, exercising, and being sedentary, in addition to mental health and demographic variables among Ugandan outpatients with mental illness. METHODS:Ninety-nine outpatients (78 men; 31.1 [8.6] y) of the Butabika National Referral Hospital in Uganda completed the Neighborhood Environment Walkability ... Read more >>

J Phys Act Health (Journal of physical activity & health)
[2019, 16(4):243-250]

Cited: 2 times

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7.3 POLYGENIC RISK FOR SCHIZOPHRENIA MODERATES THE INFLUENCE OF CHILDHOOD ADVERSITY ON DAILY-LIFE EMOTIONAL DYSREGULATION AND PSYCHOSIS PRONENESS.

Lotta-Katrin Pries, Boris Klingenberg, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Ozan Cinar, Bochao Lin, Jurjen Luykx, Bart Rutten, Jim van Os, Sinan Guloksuz,

AbstractBackgroundEmotional dysregulation and subtle psychosis expression mark the earliest manifestation of psychopathology. Furthermore, using Ecological Momentary Assessment (EMA), studies indicate that emotional and psychotic reactivity to daily-life stressors are associated with psychosis expression in individuals at varying clinical stages (e.g. service users, clinical high-risk, or first episode psychosis). The question ... Read more >>

(Schizophrenia bulletin)
[2019, 45(Suppl 2):S98-S98]

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The impact of pharmacological and non-pharmacological interventions to improve physical health outcomes in people with schizophrenia: a meta-review of meta-analyses of randomized controlled trials.

Davy Vancampfort, Joseph Firth, Christoph U Correll, Marco Solmi, Dan Siskind, Marc De Hert, Rebekah Carney, Ai Koyanagi, André F Carvalho, Fiona Gaughran, Brendon Stubbs,

We summarized and compared meta-analyses of pharmacological and non-pharmacological interventions targeting physical health outcomes among people with schizophrenia spectrum disorders. Major databases were searched until June 1, 2018. Of 3,709 search engine hits, 27 meta-analyses were included, representing 128 meta-analyzed trials and 47,231 study participants. While meta-analyses were generally of ... Read more >>

(World psychiatry : official journal of the World Psychiatric Association (WPA))
[2019, 18(1):53-66]

Cited: 10 times

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Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder.

Carolin Hoffmann, Jo Stevens, Shenghua Zong, Daan van Kruining, Abhishek Saxena, Cem İsmail Küçükali, Erdem Tüzün, Nazlı Yalçınkaya, Marc De Hert, Emiliano González-Vioque, Celso Arango, Jon Lindstrom, Marc H De Baets, Bart P F Rutten, Jim van Os, Peter Molenaar, Mario Losen, Pilar Martinez-Martinez,

The α7 acetylcholine receptor (AChR) has been linked with the onset of psychotic symptoms and we hypothesized therefore that it might also be an autoimmune target. Here, we describe a new radioimmunoassay (RIA) using iodine 125-labelled α-bungarotoxin and membrane extract from transfected HEK293 cells expressing human α7 AChR. This RIA ... Read more >>

PLoS One (PloS one)
[2018, 13(12):e0208412]

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EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH).

Brendon Stubbs, Davy Vancampfort, Mats Hallgren, Joseph Firth, Nicola Veronese, Marco Solmi, Serge Brand, Joachim Cordes, Berend Malchow, Markus Gerber, Andrea Schmitt, Christoph U Correll, Marc De Hert, Fiona Gaughran, Frank Schneider, Florence Kinnafick, Peter Falkai, Hans-Jürgen Möller, Kai G Kahl,

Physical activity (PA) may be therapeutic for people with severe mental illness (SMI) who generally have low PA and experience numerous life style-related medical complications. We conducted a meta-review of PA interventions and their impact on health outcomes for people with SMI, including schizophrenia-spectrum disorders, major depressive disorder (MDD) and ... Read more >>

Eur. Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2018, 54:124-144]

Cited: 23 times

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The Urgent Need for Optimal Monitoring of Metabolic Adverse Effects in Children and Youngsters Who Take On-label or Off-label Antipsychotic Medication.

Marc De Hert, Johan Detraux,

JAMA Psychiatry (JAMA psychiatry)
[2018, 75(8):771-772]

Cited: 1 time

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Sensitivity to Peer Evaluation and Its Genetic and Environmental Determinants: Findings from a Population-Based Twin Study.

Annelie Klippel, Ulrich Reininghaus, Wolfgang Viechtbauer, Jeroen Decoster, Philippe Delespaul, Cathérine Derom, Marc de Hert, Nele Jacobs, Claudia Menne-Lothmann, Bart Rutten, Evert Thiery, Jim van Os, Ruud van Winkel, Inez Myin-Germeys, Marieke Wichers,

Adolescents and young adults are highly focused on peer evaluation, but little is known about sources of their differential sensitivity. We examined to what extent sensitivity to peer evaluation is influenced by interacting environmental and genetic factors. A sample of 354 healthy adolescent twin pairs (n = 708) took part in a ... Read more >>

Child Psychiatry Hum Dev (Child psychiatry and human development)
[2018, 49(5):766-778]

Cited: 1 time

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