Full Text Journal Articles by
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Household Severe Acute Respiratory Syndrome Coronavirus 2 Transmission and Children: A Network Prospective Study.

Antoni Soriano-Arandes, Anna Gatell, Pepe Serrano, Mireia Biosca, Ferran Campillo, Ramon Capdevila, Anna Fàbrega, Zulema Lobato, Núria López, Ana Mª Moreno, Miriam Poblet, Maria Teresa Riera-Bosch, Neus Rius, Montserrat Ruiz, Almudena Sánchez, Cinta Valldepérez, Mònica Vilà, Valentí Pineda, Uxue Lazcano, Yesika Díaz, Juliana Reyes-Urueña, Pere Soler-Palacín, ,

<h4>Background</h4>The role of children in household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. We describe the epidemiological and clinical characteristics of children with coronavirus disease 2019 (COVID-19) in Catalonia, Spain, and investigate the household transmission dynamics.<h4>Methods</h4>A prospective, observational, multicenter study was performed during summer and school ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 73(6):e1261-e1269]

Cited: 13 times

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The Novel Antitumor Compound HCA Promotes Glioma Cell Death by Inducing Endoplasmic Reticulum Stress and Autophagy.

Roberto Beteta-Göbel, Javier Fernández-Díaz, Laura Arbona-González, Raquel Rodríguez-Lorca, Manuel Torres, Xavier Busquets, Paula Fernández-García, Pablo V Escribá, Victoria Lladó,

Glioblastoma (GBM) is the most common and aggressive type of primary brain tumor in adults, and the median survival of patients with GBM is 14.5 months. Melitherapy is an innovative therapeutic approach to treat different diseases, including cancer, and it is based on the regulation of cell membrane composition and ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(17):]

Cited: 0 times

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Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective study.

Alexy Inciarte, Celia Cardozo, Mariana Chumbita, Pau Alcubilla, Berta Torres, Ana González Cordón, Veronica Rico, Daiana Aguero, Nicole García-Pouton, Marta Hernández-Meneses, Laia Albiach, Fernanda Meira, Lorena De la Mora, Laura Linares, Pedro Puerta-Alcalde, Irene Macaya, Josep Mensa, Montse Laguno, Juan Ambrosioni, Angela Ramos, Laura Morata, Marta Bodro, Estela Moreno-García, Antonio Moreno, Montse Sola, Jhon Rojas, Lorna Leal, Manuel Torres, Carolina Garcia-Vidal, Jose Antonio Martínez, Isam Alobid, Alex Soriano, Felipe Garcia,

<h4>Importance</h4>Identifying undetected clinical signs is imperative in the prevention of SARS-CoV-2.<h4>Objective</h4>To establish the prevalence of clinical gustatory and olfactory dysfunctions in patients with COVID-19 pneumonia. Clinical outcomes and recovery rates associated with gustatory and olfactory dysfunctions were also assessed.<h4>Design</h4>A prospective study was performed in 80 patients admitted to Hospital Clínic ... Read more >>

BMJ Open (BMJ open)
[2021, 11(8):e040775]

Cited: 0 times

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Experience with the use of siltuximab in patients with SARS-CoV-2 infection.

F Meira, L Albiach, C Carbonell, J A Martín-Oterino, M Martín-Ordiales, L Linares, I Macaya, D Agüero, J Ambrosioni, M Bodro, C Cardozo, M Chumbita, M De la Mora, N García-Pouton, C Garcia-Vidal, A González-Cordón, M Hernández-Meneses, A Inciarte, M Laguno, L Leal, L Morata, P Puerta-Alcalde, V Rico, L Letona, A Cózar-Llistó, G Dueñas, M Solá, B Torres, J Rojas, A Moreno, E Moreno-García, M Torres, J A Martínez, A Soriano, F García,

<h4>Objective</h4>The study aims to describe characteristics and clinical outcome of patients with SARS-CoV-2 infection that received siltuximab according to a protocol that aimed to early block the activity of IL-6 to avoid the progression of the inflammatory flare.<h4>Methods</h4>Retrospective review of the first 31 patients with SARS-CoV-2 treated with siltuximab, in ... Read more >>

Rev Esp Quimioter (Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia)
[2021, 34(4):337-341]

Cited: 0 times

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Tocilizumab reduces the risk of ICU admission and mortality in patients with SARS-CoV-2 infection.

E Moreno-García, E Rico, L Albiach, D Agüero, J Ambrosioni, M Bodro, C Cardozo, M Chumbita, M De la Mora, N García-Pouton, C Garcia-Vidal, A González-Cordón, M Hernández-Meneses, A Inciarte, M Laguno, L Leal, L Linares, I Macay, F Meira, J Mensa, A Moreno, L Morata, P Puerta-Alcalde, J Rojas, M Solá, B Torres, M Torres, A Tomé, M Tuset, P Castro, S Fernández, J M Nicolás, A Almuedo-Riera, J Muñoz, M Fernandez-Pittol, M A Marcos, D Soy, J A Martínez, F García, A Soriano,

<h4>Objective</h4>In some patients the immune response triggered by SARS-CoV-2 is unbalanced, presenting an acute respiratory distress syndrome which in many cases requires intensive care unit (ICU) admission. The limitation of ICU beds has been one of the major burdens in the management around the world; therefore, clinical strategies to avoid ... Read more >>

Rev Esp Quimioter (Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia)
[2021, 34(3):238-244]

Cited: 2 times

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Double-blind, randomized, controlled, trial to assess the efficacy of allogenic mesenchymal stromal cells in patients with acute respiratory distress syndrome due to COVID-19 (COVID-AT): A structured summary of a study protocol for a randomised controlled trial.

Concepción Payares-Herrera, María E Martínez-Muñoz, Inés Lipperheide Vallhonrat, Rosa Malo de Molina, Manuel Pérez Torres, Andrea Trisan, Isabel Salcedo de Diego, Rosalía Alonso, Rocío Zafra, Trinidad Donaire, Rocío Sánchez, Juan José Rubio, Rafael F Duarte Palomino, Cristina Avendaño Solá,

<h4>Objectives</h4>1. To assess the efficacy of Mesenchymal Stromal Cells (MSC) versus a control arm as described in the primary endpoint. 2. To evaluate the effects of MSC on the secondary efficacy endpoints. 3. To evaluate the safety and tolerability profiles of MSC. 4. To study soluble and cellular biomarkers that ... Read more >>

Trials (Trials)
[2021, 22(1):9]

Cited: 2 times

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Faradaic electrochemical impedance spectroscopy for enhanced analyte detection in diagnostics.

Madison E Strong, Jeffrey R Richards, Manuel Torres, Connor M Beck, Jeffrey T La Belle,

Electrochemical impedance spectroscopy (EIS) is a widely implementable technique that can be applied to many fields, ranging from disease detection to environmental monitoring. EIS as a biosensing tool allows detection of a broad range of target analytes in point-of-care (POC) and continuous applications. The technique is highly suitable for multimarker ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2021, 177:112949]

Cited: 3 times

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Impact of low serum calcium at hospital admission on SARS-CoV-2 infection outcome.

Berta Torres, Pau Alcubilla, Ana González-Cordón, Alexy Inciarte, Mariana Chumbita, Celia Cardozo, Fernanda Meira, Marga Giménez, Ana de Hollanda, Alex Soriano, ,

<h4>Background</h4>Calcium is an essential ion for pathogen survival and virulence and is involved in the regulation of the inflammatory response. Hypocalcemia is a common laboratory finding in critically ill patients. Data regarding levels of calcium in SARS-CoV-2 infection is scarce. Patients with SARS-CoV-2 infection who present with hypocalcemia could have ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, 104:164-168]

Cited: 3 times

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Analysis of standards of quality for outcomes in acute heart failure patients directly discharged home from emergency departments and their relationship with the emergency department direct discharge rate.

Òscar Miró, María Pilar López-Díez, Xavier Rossello, Víctor Gil, Pablo Herrero, Javier Jacob, Pere Llorens, Rosa Escoda, Sira Aguiló, Aitor Alquézar, Josep Tost, Amparo Valero, Cristina Gil, José Manuel Garrido, Héctor Alonso, Francisco Javier Lucas-Invernón, José Torres-Murillo, Raquel-Torres-Gárate, Ana B Mecina, Lissette Traveria, Carmen Agüera, Koji Takagi, Martin Möckel, Peter S Pang, Sean P Collins, Christian E Mueller, Francisco Javier Martín-Sánchez, ,

<h4>Objective</h4>Experts recommended that direct discharge without hospitalization (DDWH) for emergency departments (EDs) able to observe acute heart failure (AHF) patients should be >40%, and these discharged patients should fulfil the following outcome standards: 30-day all-cause mortality <2% (outcome A); 7-day ED revisit due to AHF < 10% (outcome B); and 30-day ED ... Read more >>

J Cardiol (Journal of cardiology)
[2021, 77(3):245-253]

Cited: 0 times

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Tocilizumab is associated with reduced risk of ICU admission and mortality in patients with SARS-CoV-2 infection

Estela Moreno-García, Verónica Rico, Laia Albiach, Daiana Agüero, Juan Ambrosioni, Marta Bodro, Celia Cardozo, Mariana Chumbita, Lorena De la Mora, Nicole García-Pouton, Carolina Garcia-Vidal, Ana González-Cordón, Marta Hernández-Meneses, Alexy Inciarte, Montse Laguno, Lorna Leal, Laura Linares, Irene Macaya, Fernanda Meira, Josep Mensa, Antonio Moreno, Laura Morata, Pedro Puerta-Alcalde, Jhon Rojas, Montse Solá, Berta Torres, Manuel Torres, Adrià Tomé, Pedro Castro, Sara Fernández, Josep Maria Nicolás, Alex Almuedo-Riera, Jose Muñoz, Mariana Jose Fernandez-Pittol, Maria Angeles Marcos, Dolors Soy, José Antonio Martínez, Felipe García, Alex Soriano,

<h4>Background</h4> In some patients the immune response triggered by SARS-CoV-2 is unbalanced, presenting an acute respiratory distress syndrome which in many cases requires intensive care unit (ICU) admission. The limitation of ICU beds has been one of the major burdens in the management worldwide; therefore, clinical strategies to avoid ICU ... Read more >>

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Cited: 2 times

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Coronary artery aneurysms, insights from the international coronary artery aneurysm registry (CAAR).

Iván J Núñez-Gil, Enrico Cerrato, Mario Bollati, Luis Nombela-Franco, Belén Terol, Emilio Alfonso-Rodríguez, Santiago J Camacho Freire, Pedro A Villablanca, Ignacio J Amat Santos, José M de la Torre Hernández, Isaac Pascual, Christoph Liebetrau, Benjamín Camacho, Marco Pavani, Juan Albistur, Roberto Adriano Latini, Ferdinando Varbella, Víctor Alfonso Jiménez-Díaz, Davide Piraino, Massimo Mancone, Fernando Alfonso, José Antonio Linares, Ramón Rodríguez-Olivares, Jesús M Jiménez Mazuecos, Jorge Palazuelos Molinero, Alejandro Sánchez-Grande Flecha, Joan Antoni Gomez-Hospital, Alfonso Ielasi, Íñigo Lozano, Pierluigi Omedè, Rodrigo Bagur, Fabrizio Ugo, Massimo Medda, Boshra F Louka, Petr Kala, Javier Escaned, Daniel Bautista, Gisela Feltes, Pablo Salinas, Mohamad Alkhouli, Carlos Macaya, Antonio Fernández-Ortiz, ,

<h4>Background</h4>Coronary Aneurysms are a focal dilatation of an artery segment >1.5-fold the normal size of adjacent segments. Although some series have suggested a prevalence of 0.3-12%, data are lacking. In addition, they are not mentioned in practice guidelines. Our aim was investigate its prevalence, management and long-term outcomes.<h4>Methods and results</h4>The ... Read more >>

Int J Cardiol (International journal of cardiology)
[2020, 299:49-55]

Cited: 9 times

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Coping After Involuntary Pregnancy Loss: Perspectives of Spanish European Women.

Sara Fernández-Basanta, Paulina Van, Carmen Coronado, Manuel Torres, María-Jesús Movilla-Fernández,

The purpose of this qualitative study was to discover the coping strategies used by Spanish (European) women to cope with a pregnancy loss. Sixteen women with miscarriages and stillbirths were interviewed. All of the women were Spanish European. The mean age of the women was 35 years, and most were ... Read more >>

Omega (Westport) (Omega)
[2021, 83(2):310-324]

Cited: 1 time

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The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt.

Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J López, Silvia Terés, María Alonso-Sande, Mónica Higuera, Manuel Torres, Xavier Busquets, Pablo V Escribá,

The plasma membrane is an attractive target for new anticancer drugs, not least because regulating its lipid structure can control multiple signaling pathways involved in cancer cell proliferation, differentiation and survival. Accordingly, the novel anticancer drug hydroxytriolein (HTO) was designed to interact with and regulate the composition and structure of ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(26):2486-2507]

Cited: 2 times

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The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer's disease, improving behavioral motor function and survival.

Raheem J Mohaibes, María A Fiol-deRoque, Manuel Torres, Margarita Ordinas, David J López, José A Castro, Pablo V Escribá, Xavier Busquets,

We have compared the effect of the commonly used ω-3 fatty acid, docosahexaenoic acid ethyl ester (DHA-EE), and of its 2-hydroxylated DHA form (DHA-H), on brain lipid composition, behavior and lifespan in a new human transgenic Drosophila melanogaster model of Alzheimer's disease (AD). The transgenic flies expressed human Aβ42 and ... Read more >>

Biochim Biophys Acta Biomembr (Biochimica et biophysica acta. Biomembranes)
[2017, 1859(9 Pt B):1596-1603]

Cited: 6 times

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Validation of a Spanish Version of the Mental Health Continuum-Short Form Questionnaire.

Guadalupe Echeverría, Manuel Torres, Nuria Pedrals, Oslando Padilla, Attilio Rigotti, Marcela Bitran,

<h4>Background</h4>The Mental Health Continuum-Short Form (MHC-SF) is a multidimensional measure of well-being designed to assess emotional, psychological and social well-being.  It has been translated into different languages; however, there is no validated Spanish version.  Our aim was to provide the Spanish-speaking community with a validated version of the MHC-SF.<h4>Method</h4>We translated ... Read more >>

Psicothema (Psicothema)
[2017, 29(1):96-102]

Cited: 4 times

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Tubularized Gastric Conduit is More Desirable in Pediatric Patients Treated with Minimally Invasive Esophagectomy and Gastric Pull-Up.

Shannon L Castle, Mubina Isani, Manuel B Torres, Dean M Anselmo, Nam X Nguyen,

<h4>Introduction</h4>Conditions requiring an esophagectomy and esophageal replacement are rare in children. The preferred method and ideal replacement organ continue to be debated. We present long-term outcomes in children treated with esophagectomy and gastric pull-up.<h4>Methods</h4>We conducted a retrospective review of all the patients who underwent a esophagectomy and gastric pull-up at ... Read more >>

J Laparoendosc Adv Surg Tech A (Journal of laparoendoscopic & advanced surgical techniques. Part A)
[2017, 27(4):427-429]

Cited: 1 time

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A Phase 2 Randomized Study Investigating the Efficacy and Safety of Myostatin Antibody LY2495655 versus Placebo in Patients Undergoing Elective Total Hip Arthroplasty.

L Woodhouse, R Gandhi, S J Warden, S Poiraudeau, S L Myers, C T Benson, L Hu, Q I Ahmad, P Linnemeier, E V Gomez, O Benichou, ,

<h4>Background</h4>Total hip arthroplasty relieves joint pain in patients with end stage osteoarthritis. However, postoperative muscle atrophy often results in suboptimal lower limb function. There is a need to improve functional recovery after total hip arthroplasty.<h4>Objectives</h4>To assess safety and efficacy of LY2495655, a humanized monoclonal antibody targeting myostatin, in patients undergoing ... Read more >>

J Frailty Aging (The Journal of frailty & aging)
[2016, 5(1):62-70]

Cited: 23 times

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Acute respiratory distress syndrome after convalescent plasma use: treatment of a patient with Ebola virus disease contracted in Madrid, Spain.

Marta Mora-Rillo, Marta Arsuaga, Germán Ramírez-Olivencia, Fernando de la Calle, Alberto M Borobia, Paz Sánchez-Seco, Mar Lago, Juan C Figueira, Belén Fernández-Puntero, Aurora Viejo, Anabel Negredo, Concepción Nuñez, Eva Flores, Antonio J Carcas, Victor Jiménez-Yuste, Fátima Lasala, Abelardo García-de-Lorenzo, Francisco Arnalich, Jose R Arribas, ,

<h4>Background</h4>In the current epidemic of Ebola virus disease, health-care workers have been transferred to Europe and the USA for optimised supportive care and experimental treatments. We describe the clinical course of the first case of Ebola virus disease contracted outside of Africa, in Madrid, Spain.<h4>Methods</h4>Herein we report clinical, laboratory, and ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2015, 3(7):554-562]

Cited: 57 times

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The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer's disease.

Manuel Torres, Amaia Marcilla-Etxenike, Maria A Fiol-deRoque, Pablo V Escribá, Xavier Busquets,

The unfolded protein response (UPR) and autophagy are two cellular processes involved in the clearing of intracellular misfolded proteins. Both pathways are targets for molecules that may serve as treatments for several diseases, including neurodegenerative disorders like Alzheimer's disease (AD). In the present work, we show that 2-hydroxy-DHA (HDHA), a ... Read more >>

Apoptosis (Apoptosis : an international journal on programmed cell death)
[2015, 20(5):712-724]

Cited: 8 times

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Disruption of amyloid plaques integrity affects the soluble oligomers content from Alzheimer disease brains.

Sebastian Jimenez, Victoria Navarro, Javier Moyano, María Sanchez-Mico, Manuel Torres, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of soluble extracellular Abeta species, such as monomeric and/or oligomeric Abeta, seems to correlate with the clinico-pathological dysfunction observed in AD patients. However, the nature (monomeric, dimeric or other oligomers), the relative ... Read more >>

PLoS One (PloS one)
[2014, 9(12):e114041]

Cited: 12 times

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Factors associated with depression and severe depression in patients with COPD.

Marc Miravitlles, Jesús Molina, José Antonio Quintano, Anna Campuzano, Joselín Pérez, Carlos Roncero, ,

<h4>Background</h4>Depression is very prevalent in COPD and may be associated with poor clinical outcomes.<h4>Method</h4>This was a multicenter, cross-sectional study aimed at evaluating the prevalence of depression and moderate to severe depression in COPD. Depressive symptoms were evaluated with the Beck's Depression Inventory. The COPD assessment test (CAT) and the EuroQoL-5 ... Read more >>

Respir Med (Respiratory medicine)
[2014, 108(11):1615-1625]

Cited: 23 times

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Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment.

Maria A Fiol-deRoque, Raquel Gutierrez-Lanza, Silvia Terés, Manuel Torres, Pere Barceló, Rubén V Rial, Alexei Verkhratsky, Pablo V Escribá, Xavier Busquets, José J Rodríguez,

Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly. In the last years, abnormalities of lipid metabolism and in particular of docosahexaenoic acid (DHA) have been recently linked with the development of the disease. According to the recent studies showing how hydroxylation of fatty acids enhances their ... Read more >>

Biogerontology (Biogerontology)
[2013, 14(6):763-775]

Cited: 17 times

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Pharmacokinetics, metabolism, and in vivo efficacy of the antimalarial natural product bromophycolide A.

Margaret E Teasdale, Jacques Prudhomme, Manuel Torres, Matthew Braley, Serena Cervantes, Shanti C Bhatia, James J La Clair, Karine Le Roch, Julia Kubanek,

A suite of pharmacokinetic and pharmacological studies show that bromophycolide A (<b>1</b>), an inhibitor of drug-sensitive and drug-resistant <i>Plasmodium falciparum</i>, displays a typical small molecule profile with low toxicity and good bioavailability. Despite susceptibility to liver metabolism and a short <i>in vivo</i> half-life, <b>1</b> significantly decreased parasitemia in a malaria ... Read more >>

ACS Med Chem Lett (ACS medicinal chemistry letters)
[2013, 4(10):989-993]

Cited: 1 time

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Laparoscopic versus open treatment of congenital duodenal obstruction: multicenter short-term outcomes analysis.

Aaron R Jensen, Scott S Short, Dean M Anselmo, Manuel B Torres, Philip K Frykman, Cathy E Shin, Kasper Wang, Nam X Nguyen,

<h4>Background</h4>Laparoscopic repair of congenital duodenal obstruction has become popularized over the past decade. Comparative data on outcomes, however, are sparse. We hypothesized that laparoscopic repair of congenital duodenal obstruction could be performed with similar outcomes to traditional open repair.<h4>Patients and methods</h4>Medical records for all cases of congenital duodenal obstruction from ... Read more >>

J Laparoendosc Adv Surg Tech A (Journal of laparoendoscopic & advanced surgical techniques. Part A)
[2013, 23(10):876-880]

Cited: 13 times

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Alleles conferring improved fiber quality from EMS mutagenesis of elite cotton genotypes.

Jinesh D Patel, Robert J Wright, Dick Auld, Rahul Chandnani, Valorie H Goff, Jennifer Ingles, Gary J Pierce, Manuel J Torres, Andrew H Paterson,

<h4>Key message</h4>Genetic improvements for many fiber traits are obtained by mutagenesis of elite cottons, mitigating genetic uniformity in this inbred polyploid by contributing novel alleles important to ongoing crop improvement. The elite gene pool of cotton (Gossypium spp.) has less diversity than those of most other major crops, making identification ... Read more >>

Theor Appl Genet (TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik)
[2014, 127(4):821-830]

Cited: 2 times

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