Full Text Journal Articles by
Author Manu L N G Malbrain

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Potentially Detrimental Effects of Hyperosmolality in Patients Treated for Traumatic Brain Injury.

Wojciech Dabrowski, Dorota Siwicka-Gieroba, Chiara Robba, Magdalena Bielacz, Joanna Sołek-Pastuszka, Katarzyna Kotfis, Romuald Bohatyrewicz, Andrzej Jaroszyński, Manu L N G Malbrain, Rafael Badenes,

Hyperosmotic therapy is commonly used to treat intracranial hypertension in traumatic brain injury patients. Unfortunately, hyperosmolality also affects other organs. An increase in plasma osmolality may impair kidney, cardiac, and immune function, and increase blood-brain barrier permeability. These effects are related not only to the type of hyperosmotic agents, but ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(18):]

Cited: 1 time

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Non-Invasive Intra-Abdominal Pressure Measurement by Means of Transient Radar Method: In Vitro Validation of a Novel Radar-Based Sensor.

Salar Tayebi, Ali Pourkazemi, Manu L N G Malbrain, Johan Stiens,

Intra-abdominal hypertension, defined as an intra-abdominal pressure (IAP) equal to or above 12 mmHg is one of the major risk-factors for increased morbidity (organ failure) and mortality in critically ill patients. Therefore, IAP monitoring is highly recommended in intensive care unit (ICU) patients to predict development of abdominal compartment syndrome ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2021, 21(18):]

Cited: 0 times

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Dosing of Extracorporeal Cytokine Removal In Septic Shock (DECRISS): protocol of a prospective, randomised, adaptive, multicentre clinical trial.

Anna Kanjo, Zsolt Molnar, Noémi Zádori, Noémi Gede, Bálint Erőss, Lajos Szakó, Tamás Kiss, Zsolt Márton, Manu L N G Malbrain, Konstanty Szuldrzynski, Jakub Szrama, Krzysztof Kusza, Klaus Kogelmann, Péter Hegyi,

<h4>Introduction</h4>Sepsis and septic shock have mortality rates between 20% and 50%. In sepsis, the immune response becomes dysregulated, which leads to an imbalance between proinflammatory and anti-inflammatory mediators. When standard therapeutic measures fail to improve patients' condition, additional therapeutic alternatives are applied to reduce morbidity and mortality. One of the ... Read more >>

BMJ Open (BMJ open)
[2021, 11(8):e050464]

Cited: 0 times

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Fluid-induced harm in the hospital: look beyond volume and start considering sodium. From physiology towards recommendations for daily practice in hospitalized adults.

Niels Van Regenmortel, Lynn Moers, Thomas Langer, Ella Roelant, Tim De Weerdt, Pietro Caironi, Manu L N G Malbrain, Paul Elbers, Tim Van den Wyngaert, Philippe G Jorens,

<h4>Purpose</h4>Iatrogenic fluid overload is a potential side effect of intravenous fluid therapy in the hospital. Little attention has been paid to sodium administration as a separate cause of harm. With this narrative review, we aim to substantiate the hypothesis that a considerable amount of fluid-induced harm is caused not only ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):79]

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Transpulmonary thermodilution during extracorporeal organ support (ECOS): is it worth it?A brief commentary on the effects of the extracorporeal circuit on TPTD-derived parameters.

Andrea Minini, Matthias Raes, Fabio S Taccone, Manu L N G Malbrain,

J Clin Monit Comput (Journal of clinical monitoring and computing)
[2021, 35(4):681-687]

Cited: 0 times

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Intra-abdominal hypertension and hypoxic respiratory failure together predict adverse outcome - A sub-analysis of a prospective cohort.

Adrian Regli, Annika Reintam Blaser, Bart De Keulenaer, Joel Starkopf, Edward Kimball, Manu L N G Malbrain, Peter Vernon Van Heerden, Wendy A Davis, , Annamaria Palermo, Wojciech Dabrowski, Dorota Siwicka-Gieroba, Malgorzata Barud, Ioana Grigoras, Anca Irina Ristescu, Adina Blejusca, Kadri Tamme, Liivi Maddison, Ülle Kirsimägi, Andrey Litvin, Anastasiya Kazlova, Aliaksandr Filatau, Francisco Pracca, Gustavo Sosa, Maicol Dos Santos, Mikhail Kirov, Alexey Smetkin, Yana Ilyina, Daniel Gilsdorf, Carlos A Ordoñez, Yaset Caicedo, Patrick Greiffenstein, Margaret M Morgan, Zsolt Bodnar, Edit Tidrenczel, Gina Oliveira, Ana Albuquerque, Bruno M Pereira,

<h4>Purpose</h4>To assess whether the combination of intra-abdominal hypertension (IAH, intra-abdominal pressure ≥ 12 mmHg) and hypoxic respiratory failure (HRF, PaO2/FiO2 ratio < 300 mmHg) in patients receiving invasive ventilation is an independent risk factor for 90- and 28-day mortality as well as ICU- and ventilation-free days.<h4>Methods</h4>Mechanically ventilated patients who had ... Read more >>

J Crit Care (Journal of critical care)
[2021, 64:165-172]

Cited: 1 time

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The prone position must accommodate changes in IAP in traumatic brain injury patients.

Wojciech Dabrowski, Dorota Siwicka-Gieroba, Chiara Robba, Rafael Badenes, Manu L N G Malbrain,

Crit Care (Critical care (London, England))
[2021, 25(1):132]

Cited: 0 times

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Future developments in the imaging of the gastrointestinal tract: the role of ultrasound.

Adrian Wong, Gibran Timothy Yusuf, Manu L N G Malbrain,

<h4>Purpose of review</h4>The purpose of this review is to summarize the utilization and most recent developments with regard to the use of ultrasound when imaging the abdomen and gastrointestinal tract.<h4>Recent findings</h4>Although the use of ultrasound to assess the anatomy of the various abdominal organs is well established within radiology and ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2021, 27(2):147-156]

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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 26 times

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Ventilator-associated bacterial pneumonia in coronavirus 2019 disease, a retrospective monocentric cohort study.

Marco Moretti, Johan Van Laethem, Andrea Minini, Denis Pierard, Manu L N G Malbrain,

<h4>Introduction</h4>Severe coronavirus 2019 disease (CoViD-19) may lead to respiratory failure and mechanical ventilation. Therefore, ventilator associated pneumonia (VAP) may complicate the course of the disease. The aim of the current article was to investigate possible predictive factors for bacterial VAP on a retrospective manner, in a cohort of mechanically ventilated ... Read more >>

J Infect Chemother (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2021, 27(6):826-833]

Cited: 6 times

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Human factors and ergonomics to improve performance in intensive care units during the COVID-19 pandemic.

Valentina Della Torre, Flavio Nacul, Peter Rosseel, Heather Baid, Kaushik Bhowmick, Piotr Szawarski, Tapas K Sahoo, Tughan Utku, Adrian Wong, Manu L N G Malbrain,

The COVID-19 pandemic has tested the very elements of human factors and ergonomics (HFE) to their maximum. HFE is an established scientific discipline that studies the interrelationship between humans, equipment, and the work environment. HFE includes situation awareness, decision making, communication, team working, leadership, managing stress, and coping with fatigue, ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(3):265-270]

Cited: 0 times

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Comprehensive assessment of the aortic valve in critically ill patients for the non-cardiologist. Part I: Aortic stenosis of the native valve.

Jeroen Walpot, Guy L Vermeiren, Amar Al Mafragi, Manu L N G Malbrain,

Aortic stenosis (AS) causes left ventricular outflow obstruction. Severe AS has major haemodynamic implications in critically ill patients, in whom increased cardiac output and oxygen delivery are often required. Transthoracic echocardiography (TTE) plays a key role in the AS severity grading. In this review, we will give an overview of how ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(1):37-54]

Cited: 0 times

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Comprehensive assessment of the aortic valve in critically ill patients for the non-cardiologist. Part II: Chronic aortic regurgitation of the native valve.

Jeroen Walpot, Guy L Vermeiren, Amar Al Mafragi, Manu L N G Malbrain,

Inadequate diastolic closure of the aortic valve causes aortic regurgitation (AR). Diastolic regurgitation towards the left ventricle (LV) causes LV volume overload, resulting in eccentric LV remodelling. Transthoracic echocardiography (TTE) is the first line examination in the work-up of AR. TTE allows quantification of left ventricular end-diastolic diameter and volume ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(1):55-68]

Cited: 0 times

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Aiming for zero fluid accumulation: First, do no harm.

Orlando R Perez Nieto, Adrian Wong, Jorge Lopez Fermin, Eder I Zamarron Lopez, Jose A Meade Aguilar, Ernesto Deloya Tomas, Jorge D Carrion Moya, Gabriela Castillo Gutierrez, Maria G Olvera Ramos, Xiomara García Montes, Manuel Alberto Guerrero Gutiérrez, Fernando George Aguilar, Jesús Salvador Sánchez Díaz, Raúl Soriano Orozco, Eduardo Ríos Argaiz, Thierry Hernandez-Gilsoul, Roberto Secchi Del Rio, Silvio Antonio Ñamendys-Silva, Manu L N G Malbrain,

Critically ill patients are often presumed to be in a state of "constant dehydration" or in need of fluid, thereby justifying a continuous infusion with some form of intravenous (IV) fluid, despite their clinical data suggesting otherwise. Overzealous fluid administration and subsequent fluid accumulation and overload are associated with poorer outcomes. Fluids ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(2):162-178]

Cited: 1 time

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Reproducibility of fluid status measured by bioelectrical impedance analysis in healthy volunteers: a key requirement to monitor fluid status in the intensive care unit.

Matthias Gijsen, Eline Simons, Pieter De Cock, Manu L N G Malbrain, Joost Wauters, Isabel Spriet,

<h4>Introduction</h4>Little is known about the use of bioelectrical impedance analysis (BIA) in critically ill patients. The objective of this study was to evaluate the reproducibility of BIA measurements by comparing non-dominant versus dominant body-side measurements at 2 separate time points in healthy volunteers in order to extrapolate key elements that ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(3):193-199]

Cited: 0 times

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Prognostic value of bioelectrical impedance analysis for assessment of fluid overload in ICU patients: a pilot study.

Robbert Cleymaet, Thomas Scheinok, Hanne Maes, Amber Stas, Luca Malbrain, Inneke De Laet, Karen Schoonheydt, Hilde Dits, Niels van Regenmortel, Michaël Mekeirele, Andrea Minini, Paolo Severgnini, Adrian Wong, Manu L N G Malbrain,

<h4>Introduction</h4>The non-invasive analysis of body fluid composition with bio-electrical impedance analysis (BIA) provides additional information allowing for more persona-lised therapy to improve outcomes. The aim of this study is to assess the prognostic value of fluid overload (FO) in the first week of intensive care unit (ICU) stay.<h4>Material and methods</h4>A retrospective, ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(1):10-17]

Cited: 2 times

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A porcine model of endothelial glycocalyx damage by enzymatic digestion: A pilot study.

David Astapenko, Alena Ticha, Radomir Hyspler, Adela Tomasova, Pavel Navratil, Ondrej Maly, Renata Cerna Parizkova, Dana Cizkova, Shin Chua Huey, Christian Lehmann, Manu L N G Malbrain, Vladimir Cerny,

<h4>Background</h4>The endothelial glycocalyx (EG) plays a vital role in the physiology and pathophysiology of human microcirculation. Having relevant EG damage model would be important tool for testing new interventions aiming at EG protection and recovery. We describe the first in vivo EG damage model in pig.<h4>Objective</h4>To investigate the course of ... Read more >>

Clin Hemorheol Microcirc (Clinical hemorheology and microcirculation)
[2021, 78(3):325-338]

Cited: 0 times

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Intra-abdominal hypertension, fluid balance, and adverse outcomes after orthotopic liver transplantation.

Marlon S Freitas, Flavio E Nacul, Manu L N G Malbrain, Rita C M A Silva, Francisco R M Lobo, Neymar E Oliveira, Renato F da Silva, Suzana M Lobo,

<h4>Background</h4>Intra-abdominal hypertension (IAH) is frequently encountered in critically ill surgical patients. We aimed to evaluate the incidence of IAH after orthotopic liver transplant (OLT) and its impact on organ function, hospital length-of-stay (LOS), and death.<h4>Methods</h4>This prospective, observational, cohort study evaluated consecutive adult patients admitted in the ICU after undergoing OLT. ... Read more >>

J Crit Care (Journal of critical care)
[2021, 62:271-275]

Cited: 0 times

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Modeling intra-abdominal volume and respiratory driving pressure during pneumoperitoneum insufflation-a patient-level data meta-analysis.

Guido Mazzinari, Oscar Diaz-Cambronero, Ary Serpa Neto, Antonio Cañada Martínez, Lucas Rovira, María Pilar Argente Navarro, Manu L N G Malbrain, Paolo Pelosi, Marcelo Gama de Abreu, Markus W Hollmann, Marcus J Schultz,

During pneumoperitoneum, intra-abdominal pressure (IAP) is usually kept at 12-14 mmHg. There is no clinical benefit in IAP increments if they do not increase intra-abdominal volume IAV. We aimed to estimate IAV (ΔIAV) and respiratory driving pressure changes (Δ<i>P</i><sub>RS</sub>) in relation to changes in IAP (ΔIAP). We carried out a ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2021, 130(3):721-728]

Cited: 1 time

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Hypophosphatemia in critically ill adults and children - A systematic review.

Annika Reintam Blaser, Jan Gunst, Carole Ichai, Michael P Casaer, Carina Benstoem, Guillaume Besch, Stéphane Dauger, Sonja M Fruhwald, Michael Hiesmayr, Olivier Joannes-Boyau, Manu L N G Malbrain, Maria-Helena Perez, Stefan J Schaller, Angelique de Man, Joel Starkopf, Kadri Tamme, Jan Wernerman, Mette M Berger,

<h4>Background & aims</h4>Phosphate is the main intracellular anion essential for numerous biological processes. Symptoms of hypophosphatemia are non-specific, yet potentially life-threatening. This systematic review process was initiated to gain a global insight into hypophosphatemia, associated morbidity and treatments.<h4>Methods</h4>A systematic review was conducted (PROSPERO CRD42020163191). Nine clinically relevant questions were generated, ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2021, 40(4):1744-1754]

Cited: 1 time

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Sublingual Sufentanil Tablet System Versus Continuous Morphine Infusion for Postoperative Analgesia in Cardiac Surgery Patients.

Vincent Van Tittelboom, Ruben Poelaert, Manu L N G Malbrain, Mark La Meir, Kurt Staessens, Jan Poelaert,

<h4>Objective(s)</h4>To assess the effectiveness and side effects of a patient-controlled sublingual sufentanil tablet system for postoperative analgesia after cardiac surgery and to compare it to a nurse-controlled continuous morphine infusion.<h4>Design</h4>Prospective, open-label, randomized controlled trial.<h4>Setting</h4>Single university academic center.<h4>Participants</h4>Adult patients undergoing cardiac surgery, which included a sternotomy.<h4>Interventions</h4>Sublingual sufentanil tablet system versus nurse-controlled ... Read more >>

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, 35(4):1125-1133]

Cited: 0 times

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Intra-abdominal pressure as an ignored parameter in the pathophysiology of preeclampsia.

Wilfried Gyselaers, M James Lozada, Luis D Pacheco, Salar Tayebi, Manu L N G Malbrain,

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(8):963-965]

Cited: 1 time

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A concise overview of non-invasive intra-abdominal pressure measurement techniques: from bench to bedside.

Salar Tayebi, Adrian Gutierrez, Ikram Mohout, Evelien Smets, Robert Wise, Johan Stiens, Manu L N G Malbrain,

This review presents an overview of previously reported non-invasive intra-abdominal pressure (IAP) measurement techniques. Each section covers the basic physical principles and methodology of the various measurement techniques, the experimental results, and the advantages and disadvantages of each method. The most promising non-invasive methods for IAP measurement are microwave reflectometry ... Read more >>

J Clin Monit Comput (Journal of clinical monitoring and computing)
[2021, 35(1):51-70]

Cited: 3 times

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Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA).

Manu L N G Malbrain, Thomas Langer, Djillali Annane, Luciano Gattinoni, Paul Elbers, Robert G Hahn, Inneke De Laet, Andrea Minini, Adrian Wong, Can Ince, David Muckart, Monty Mythen, Pietro Caironi, Niels Van Regenmortel,

Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid administration as drug diluent or to preserve catheter patency, i.e., fluid creep, should also be considered. As for antibiotics, intravenous fluid administration should follow the ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):64]

Cited: 18 times

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Predicting fluid responsiveness with the passive leg raising test: don't be fooled by intra-abdominal hypertension!

Andrea Minini, Paul Abraham, Manu L N G Malbrain,

Ann Transl Med (Annals of translational medicine)
[2020, 8(12):799]

Cited: 2 times

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