Full Text Journal Articles by
Author Manish Jain

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Multiscale modelling reveals higher charge transport efficiencies of DNA relative to RNA independent of mechanism.

Abhishek Aggarwal, Saientan Bag, Ravindra Venkatramani, Manish Jain, Prabal K Maiti,

In this study, we compare the charge transport properties of multiple double-stranded (ds)RNA sequences with corresponding dsDNA sequences. Recent studies have presented a contradictory picture of relative charge transport efficiencies in A-form DNA : RNA hybrids and dsDNA. Using a multiscale modelling framework, we compute conductance of dsDNA and dsRNA using Landauer ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(36):18750-18760]

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Evolution of high-frequency Raman modes and their doping dependence in twisted bilayer MoS2.

Rahul Debnath, Indrajit Maity, Rabindra Biswas, Varun Raghunathan, Manish Jain, Arindam Ghosh,

Twisted van der Waals heterostructures provide a new platform for studying strongly correlated quantum phases. The interlayer coupling in these heterostructures is sensitive to the twist angle (θ) and key to controllably tuning several interesting properties. Here, we demonstrate the systematic evolution of the interlayer coupling strength with twist angle ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(33):17272-17280]

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Comments on: Monocyte to high-density lipoprotein ratio in central serous chorioretinopathy: A biomarker of inflammation or epiphenomenon.

Manish Jain, Fady Gerges,

Indian J Ophthalmol (Indian journal of ophthalmology)
[2021, 69(2):471]

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Tuberculin sensitivity test in uveitis: Immunological perspectives.

Manish Jain, Yashik Bansal,

Indian J Ophthalmol (Indian journal of ophthalmology)
[2021, 69(1):180-181]

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22(R)-hydroxycholesterol for dopaminergic neuronal specification of MSCs and amelioration of Parkinsonian symptoms in rats.

Manisha Singh, Manish Jain, Samrat Bose, Ashutosh Halder, Tapas Chandra Nag, Amit Kumar Dinda, Sujata Mohanty,

Oxysterols play vital roles in the human body, ranging from cell cycle regulation and progression to dopaminergic neurogenesis. While naïve human mesenchymal stem cells (hMSCs) have been explored to have neurogenic effect, there is still a grey area to explore their regenerative potential after in vitro differentiation. Hence, in the ... Read more >>

Cell Death Discov (Cell death discovery)
[2021, 7(1):13]

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Cellular fibronectin promotes deep vein thrombosis in diet-induced obese mice.

Nirav Dhanesha, Manish Jain, Prakash Doddapattar, Anetta Undas, Anil K Chauhan,

<h4>Background</h4>Overweight and obesity are significant risk factors for deep vein thrombosis (DVT). Cellular fibronectin containing extra domain A (Fn-EDA), an endogenous ligand for toll-like-receptor 4 (TLR4), contributes to thrombo-inflammation. The role of Fn-EDA in the modulation of DVT is not elucidated yet.<h4>Objective</h4>To determine whether Fn-EDA promotes DVT in the context ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2020, :]

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Misorientation-Controlled Cross-Plane Thermoelectricity in Twisted Bilayer Graphene.

Phanibhusan S Mahapatra, Bhaskar Ghawri, Manjari Garg, Shinjan Mandal, K Watanabe, T Taniguchi, Manish Jain, Subroto Mukerjee, Arindam Ghosh,

The introduction of "twist" or relative rotation between two atomically thin van der Waals membranes gives rise to periodic moiré potential, leading to a substantial alteration of the band structure of the planar assembly. While most of the recent experiments primarily focus on the electronic-band hybridization by probing in-plane transport ... Read more >>

Phys Rev Lett (Physical review letters)
[2020, 125(22):226802]

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Metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis.

Manasa K Nayak, Madankumar Ghatge, Gagan D Flora, Nirav Dhanesha, Manish Jain, Kathleen R Markan, Matthew J Potthoff, Steven R Lentz, Anil K Chauhan,

Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic reprogramming. Herein, we report that limiting PKM2 dimer formation, using a small molecule inhibitor ... Read more >>

Blood (Blood)
[2020, :]

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Intra-individual Genomic Variation Analysis in Tissues (Blood vs. Testis) Through SNP Microarray: A Case Report of Two Patients with Idiopathic Sertoli Cell Only Syndrome (SCOS).

Aiyush Sharma, Ashutosh Halder, Seema Kaushal, Manish Jain,

<h4>Background</h4>Sertoli cell only syndrome (SCOS) or germ cell aplasia is characterized by the existence of only sertoli cells in the seminiferous tubule without any germ cells. SCOS is a multifactorial disorder but genetic factors play a major role in pathogenesis of idiopathic SCOS.<h4>Case presentation</h4>Two cases of idiopathic SCOS had been ... Read more >>

J Reprod Infertil (Journal of reproduction & infertility)
[2020, 21(4):298-307]

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An unusual headache: CSF negative APML relapse in the brain.

Thomas Quinn, Manish Jain, Ming-Te Lee,

Acute Promyelocytic Leukaemia (APML) is a subtype of Acute Myeloid Leukaemia (AML), responsible for around 10% of cases of the disease in adults. Extra medullary disease (EMD) occurs infrequently in APML, but where EMD does occur, the central nervous system is one of the most commonly infiltrated sites. Our case ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2020, 2020(9):omaa075]

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An unusual headache: CSF negative APML relapse in the brain

Thomas Quinn, Manish Jain, Ming-Te Lee,

ABSTRACT Acute Promyelocytic Leukaemia (APML) is a subtype of Acute Myeloid Leukaemia (AML), responsible for around 10% of cases of the disease in adults. Extra medullary disease (EMD) occurs infrequently in APML, but where EMD does occur, the central nervous system is one of the most commonly infiltrated sites. Our ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2020, 2020(9):]

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Development of a hub and spoke model for quality improvement in rural and urban healthcare settings in India: a pilot study.

Sushil Srivastava, Vikram Datta, Rahul Garde, Mahtab Singh, Ankur Sooden, Harish Pemde, Manish Jain, Poonam Shivkumar, Akash Bang, Prabha Kumari, Sonia Makhija, Tarun Ravi, Sumita Mehta, Bishan Singh Garg, Rajesh Mehta,

<h4>Objective</h4>Hub and spoke model has been used across industries to augment peripheral services by centralising key resources. This exercise evaluated the feasibility of whether such a model can be developed and implemented for quality improvement across rural and urban settings in India with support from a network for quality improvement.<h4>Methods</h4>This ... Read more >>

BMJ Open Qual (BMJ open quality)
[2020, 9(3):]

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Surgical Management of Right Atrial Mass Associated with a Vascular Access Catheter.

David Ferreira, Anthony Le, John Khoo, Paul Nguyen, Manish Jain, Timothy Spicer, Craig Juergens,

Atrial masses are an uncommon but serious clinical problem. The authors report a case of an atrial mass associated with a tunnelled vascular access catheter in an immunosuppressed haemodialysis patient. In the setting of immunosuppression with fevers, a broad differential for the atrial mass was considered. Multidisciplinary team review was ... Read more >>

Case Rep Cardiol (Case reports in cardiology)
[2020, 2020:4590147]

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Electronic and thermoelectric properties of Zn and Se double substituted tetrahedrite.

Sahil Tippireddy, Raju Chetty, Krushna Kumari Raut, Mit H Naik, Prashanta K Mukharjee, Manish Jain, R Nath, Krzysztof Wojciechowski, Ramesh Chandra Mallik,

The influence of Zn and Se double substitution on the electronic and thermoelectric properties of tetrahedrite was investigated in this study. The samples Cu11Zn1Sb4S13-xSex (x = 0.25, 0.5, 0.75, 1, and 2) were prepared via solid state synthesis followed by field assisted sintering. The density functional theory (DFT) results showed ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2018, 20(45):28667-28677]

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Differential Roles of Endothelial Cell-Derived and Smooth Muscle Cell-Derived Fibronectin Containing Extra Domain A in Early and Late Atherosclerosis.

Prakash Doddapattar, Rishabh Dev, Manish Jain, Nirav Dhanesha, Anil K Chauhan,

<h4>Objective</h4>The extracellular matrix of atherosclerotic arteries contains abundant deposits of cellular Fn-EDA (fibronectin containing extra domain A), suggesting a functional role in the pathophysiology of atherosclerosis. Fn-EDA is synthesized by several cell types, including endothelial cells (ECs) and smooth muscle cells (SMCs), which are known to contribute to different stages ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2020, 40(7):1738-1747]

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Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation.

Nirav Dhanesha, Manish Jain, Amit K Tripathi, Prakash Doddapattar, Mehul Chorawala, Girish Bathla, Manasa K Nayak, Madankumar Ghatge, Steven R Lentz, Shigeyuki Kon, Anil K Chauhan,

RATIONALE:Currently, there is no effective intervention available that can reduce brain damage following reperfusion. Clinical studies suggest a positive correlation between the increased influx of neutrophils and severity of brain injury following reperfusion. Integrin α9β1 is highly expressed on activated neutrophils and contributes to stable adhesion, but its role in ... Read more >>

Circ Res (Circulation research)
[2020, 126(12):1779-1794]

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Evaluation of spatial and temporal heterogeneity of black carbon aerosol mass concentration over India using three year measurements from IMD BC observation network.

Ravi Ranjan Kumar, Vijay Kumar Soni, Manish Kumar Jain,

Extensive measurements of equivalent black carbon (EBC) aerosol mass concentration at fifteen stations of India Meteorological Department (IMD) BC observation network during the period 2016-2018 are used to study the spatial and temporal heterogeneity over India. The sampling sites represent different geographical region of India. Spatial distribution shows higher values ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 723:138060]

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Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice.

Nirav Dhanesha, Manasa K Nayak, Prakash Doddapattar, Manish Jain, Gagan D Flora, Shigeyuki Kon, Anil K Chauhan,

Evidence suggests that neutrophils contribute to thrombosis via several mechanisms, including neutrophil extracellular traps (NETs) formation. Integrin α9β1 is highly expressed on neutrophils when compared with monocytes. It undergoes affinity upregulation on neutrophil activation, and stabilizes adhesion to the activated endothelium. The role of integrin α9 in arterial thrombosis remains ... Read more >>

Blood (Blood)
[2020, 135(11):857-861]

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Pollution evaluation, spatial distribution, and source apportionment of trace metals around coal mines soil: the case study of eastern India.

Azeem Uddin Siddiqui, Manish Kumar Jain, Reginald Ebhin Masto,

The degradation of land by trace metals contamination around coal mining areas is a serious environmental issue, and therefore, it is necessary to have detailed information about the pollution caused by them and their sources. The objective of the work was to study the impact of trace metals (e.g., Cd, ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(10):10822-10834]

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Immunoadsorption in ABO-incompatible kidney transplantation in adult and pediatric patients with follow-up on graft and patient survival: First series from India.

Aseem Kumar Tiwari, Geet Aggarwal, Dinesh Arora, Gunjan Bhardwaj, Manish Jain, Shyam Bihari Bansal, Sidharth K Sethi,

<h4>Background</h4>There are no published reports on desensitization protocol for ABO-incompatible kidney transplants using Immuno-Adsorption (IA) plasmapheresis from India. IA offers certain advantages including processing of larger plasma volumes, quicker reduction of isoagglutinin titers and no requirement of replacement fluids.<h4>Aims and objectives</h4>Authors' center evaluated success of desensitization protocol, and graft/patient outcomes ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2020, 14(1):13-18]

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Cellular mesenchymal epithelial transition (C-MET) gene copy number variation in gastric adenocarcinoma: A pilot search for new marker for targeted therapy in HER-2/neu resistance.

Pragya Jain, Neelam Wadhwa, Mohit K Joshi, Manish Jain, Ashutosh Halder, Kiran Mishra,

Increasing HER-2/neu resistance in gastric carcinoma has encouraged search for new biomarkers for targeted therapy. Cellular mesenchymal epithelial transition (C-MET) is one such tyrosine kinase inhibitor proposed for personalized salvage treatment. We determined frequency of C-MET gene copy number variation (CNV) by Fluorescent in-situ hybridization (FISH) in gastric adenocarcinoma (GAC) ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2020, 63(1):86-89]

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Evaluation of change in biochar properties derived from different feedstock and pyrolysis temperature for environmental and agricultural application.

Priya Pariyar, Kanchan Kumari, Manish Kumar Jain, Pradip S Jadhao,

In recent years, the application of biochar has increased significantly for sustainable and efficient carbon sequestration, improving soil quality and enhancement of plant growth. The biochar is mostly made from agricultural residues and waste materials. The objective of this study was to assess the changes in physicochemical, surface morphology, and ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 713:136433]

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Smooth muscle cell-specific fibronectin-EDA mediates phenotypic switching and neointimal hyperplasia.

Manish Jain, Nirav Dhanesha, Prakash Doddapattar, Mehul R Chorawala, Manasa K Nayak, Anne Cornelissen, Liang Guo, Aloke V Finn, Steven R Lentz, Anil K Chauhan,

Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. The role of SMC-derived Fn-EDA in SMC phenotypic switching or its implication in neointimal hyperplasia remains unclear. Herein, using human coronary artery sections with a bare metal stent, we demonstrate the expression of ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(1):295-314]

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Real-world evaluation of the clinical safety and efficacy of fluticasone/formoterol FDC via the Revolizer® in patients with persistent asthma in India.

Aloke Ghoshal, Pradyut Waghray, George Dsouza, Mahip Saluja, Mayank Agarwal, Ashish Goyal, Sneha Limaye, Akash Balki, Sudhir Bhatnagar, Manish Jain, Sharad Tikkiwal, Abhijit Vaidya, Meena Lopez, Rashmi Hegde, Jaideep Gogtay,

The combination of inhaled corticosteroids (ICS) and long-acting beta<sub>2</sub>-agonists (LABAs) is widely used for the management of asthma. This prospective, open-label, non-comparative, observational, 24-week multicentre study is the first real-world study from India to compare the efficacy and safety of fixed-dose combination of fluticasone/formoterol (Maxiflo® 100/6 mcg or 250/6 mcg) ... Read more >>

Pulm Pharmacol Ther (Pulmonary pharmacology & therapeutics)
[2020, 60:101869]

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Total Gluteal Reconstruction with "IGA-based V-Y Myocutaneous Advancement Flap".

Madhubari Vathulya, Amborish Nath, Manish Jain, Rajkumar Kottayasamy Seenivasagam,

Introduction  A 44-year-old man was presented with chronic discharging multiple perianal fistula and squamous cell carcinoma of the left buttock. Report  The patient was subjected to wide local excision of the entire left gluteal and adjacent sacral regions and reconstruction with extended island inferior gluteal artery based V-Y myocutaneous advancement ... Read more >>

Indian J Plast Surg (Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India)
[2019, 52(3):355-357]

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