Full Text Journal Articles by
Author Maneesh Kumar

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False Positivity of rK39 Test in Five Chronic Myeloid Leukemia Cases from Bihar, India: A Possible Challenge to Leishmaniasis Diagnosis.

Roshan Kamal Topno, Major Madhukar, Krishna Pandey, Rishikesh Kumar, Vidya Nand Rabidas, Maneesh Kumar, Kanhaiya Agrawal, Neena Verma, Devendra Prasad Yadav, Sanjeeva Bimal, Niyamat Ali Siddiqui, Pradeep Das,

A rapid and noninvasive rK39 rapid diagnostic test (RDT) is the best and most reliable tool for visceral leishmaniasis (VL) screening in the field. However, splenic and bone marrow aspiration remain two gold standard methods for microscopic identification of <i>Leishmania donovani</i> (LD) bodies and confirmatory diagnosis of VL. Five patients ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2020, 103(6):2257-2259]

Cited: 0 times

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Advanced case of PKDL due to delayed treatment: A rare case report.

Roshan Kamal Topno, Vidya Nand Rabi Das, Maneesh Kumar, Major Madhukar, Krishna Pandey, Neena Verma, Kanhaiya Agrawal, Chandra Shekhar Lal, Niyamat Ali Siddiqui, Sanjiva Bimal, Pradeep Das,

Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Leishmania donovani has been reported and is ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2020, 14(3):e0008052]

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Hydrogen Peroxide Mediates Artemisinin-Derived C-16 Carba-Dimer-Induced Toxicity of Human Cancer Cells.

Amanda L Kalen, Brett A Wagner, Ehab H Sarsour, Maneesh G Kumar, Jessica L Reedy, Garry R Buettner, Nabin C Barua, Prabhat C Goswami,

This study used a nitroaliphatic chemistry approach to synthesize a novel artemisinin-derived carba-dimer (AG-1) and determined its anti-proliferative effects in human normal and cancer cells. AG-1 treatments selectively inhibit proliferation of cancer cells compared to normal human fibroblasts. Compared to artemisinin, AG-1 is more toxic to human breast, prostate, head-neck, ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(2):]

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Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies.

Maneesh Kumar, Roshan Kamal Topno, Manas Ranjan Dikhit, Bhawana, Ganesh Chandra Sahoo, Major Madhukar, Krishna Pandey, Pradeep Das,

The arthropod-transmitted chikungunya virus has emerged as an epidemic menace that causes debilitating polyarthritis. With this life-threatening impact on humans, the possible treatment requires to cure the viral infectivity. But, devoid of any vaccine against the chikungunya virus (CHIKV), there is a need to develop a novel chemotherapeutic strategy to ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2019, 120(10):18298-18308]

Cited: 1 time

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Moisture sorption characteristics of ready-to-eat snack food enriched with purslane leaves.

Niharika Shanker, Mediboyina Maneesh Kumar, Praneeth Juvvi, Sukumar Debnath,

Green leafy vegetables are important part of our regular diet that provides us with essential nutrients necessary to support human life and health. Since these are produced in surplus and have limited shelf-life, preservation of vegetables can help to prevent wastage and increase nutrient availability in the diet during off-season. ... Read more >>

J Food Sci Technol (Journal of food science and technology)
[2019, 56(4):1918-1926]

Cited: 0 times

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Severe Manifestations of Chikungunya Fever in Children, India, 2016.

Pradeep K Sharma, Maneesh Kumar, Girraj K Aggarwal, Virender Kumar, R D Srivastava, Ashish Sahani, Rohit Goyal,

Chikungunya is a relatively benign disease, and a paucity of literature on severe manifestations in children exits. We describe a cohort of pediatric chikungunya fever patients in New Delhi, India, who had severe sepsis and septic shock, which can develop during the acute phase of illness. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2018, 24(9):1737-1739]

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Severe Sepsis and Septic Shock Associated with Chikungunya Fever in an Adolescent.

Pradeep Kumar Sharma, Maneesh Kumar, Neha Bhandari, Anand Kushwaha,

Chikungunya is usually a benign disease, and little is known on the occurrence of severe clinical complications. We describe a 12-year-old boy with rapid onset septic shock and multi-organ failure associated with chikungunya fever. Severe sepsis and septic shock can be associated with chikungunya. ... Read more >>

J Trop Pediatr (Journal of tropical pediatrics)
[2018, 64(6):557-559]

Cited: 1 time

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Noninvasive Sweat-Based Diagnosis of Visceral Leishmaniasis and Post Kala-Azar Dermal Leishmaniasis.

Roshan Kamal Topno, Vikas Shankar, Manas Ranjan Dikhit, Major Madhukar, Krishna Pandey, V N R Das, Maneesh Kumar, Bipin Kumar, Kanhaiya Agrawal, Niyamat Ali Siddiqui, Ganesh Chandra Sahoo, Rishikesh Kumar, Ashish Kumar Singh, Rajeev Kumar, Dharmendra Singh, Pradeep Das,

The diagnosis of visceral leishmaniasis (VL) is one of the foremost barriers in the control of this disease, as demonstration of the parasite by splenic/bone marrow aspiration is relatively difficult and requires expertise and laboratory support. The aim of the present study was to find a noninvasive diagnostic approach using ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2018, 99(5):1162-1164]

Cited: 2 times

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Fluid Overload and Renal Angina Index at Admission Are Associated With Worse Outcomes in Critically Ill Children.

Sidharth K Sethi, Veena Raghunathan, Shilpi Shah, Maninder Dhaliwal, Pranaw Jha, Maneesh Kumar, Sravanthi Paluri, Shyam Bansal, Maroun J Mhanna, Rupesh Raina,

Objectives: We investigated the association of fluid overload and oxygenation in critically sick children, and their correlation with various outcomes (duration of ventilation, ICU stay, and mortality). We also assessed whether renal angina index (RAI) at admission can predict mortality or acute kidney injury (AKI) on day 3 after admission. ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2018, 6:118]

Cited: 2 times

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Severe Hypertriglyceridemia Causing Pancreatitis in a Child with New-onset Type-I Diabetes Mellitus Presenting with Diabetic Ketoacidosis.

Pradeep Kumar Sharma, Maneesh Kumar, Dinesh Kumar Yadav,

The triad of pancreatitis, hypertriglyceridemia, and diabetic ketoacidosis and its treatment has not been extensively discussed in the pediatric literature. We report a 4-year-old child with severe hypertriglyceridemia, pancreatitis, and diabetic ketoacidosis. Hypertriglyceridemia and pancreatitis with diabetic ketoacidosis can be successfully managed with insulin and hydration therapy in children. Early ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2017, 21(3):176-178]

Cited: 4 times

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Ex Utero Intrapartum Treatment (EXIT) for a Large Fetal Neck Mass.

Manisha M Beck, Ekta Rai, Reeta Vijayaselvi, Mary John, Naina Picardo, Sridhar Santhanam, Maneesh Kumar, Benjamin J Ross,

J Obstet Gynaecol India (Journal of obstetrics and gynaecology of India)
[2018, 68(2):142-144]

Cited: 0 times

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Growth and biochemical characteristics of an indigenous freshwater microalga, Scenedesmus obtusus, cultivated in an airlift photobioreactor: effect of reactor hydrodynamics, light intensity, and photoperiod.

T Sarat Chandra, S Aditi, M Maneesh Kumar, S Mukherji, J Modak, V S Chauhan, R Sarada, S N Mudliar,

The freshwater green algae, Scenedesmus obtusus, was cultivated in a 3.4 L airlift photobioreactor. The hydrodynamic parameters were estimated at different inlet gas flow rates (1, 2, 3, and 4 LPM) and their subsequent impact on the growth and biochemical characteristics of microalgae was studied. The biomass concentration and productivity increased ... Read more >>

Bioprocess Biosyst Eng (Bioprocess and biosystems engineering)
[2017, 40(7):1057-1068]

Cited: 2 times

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Homology Modeling of Leishmania donovani Enolase and its Molecular Interaction with Novel Inhibitors.

Jay Prakash Mahato, Sindhuprava Rana, Maneesh Kumar, Surendra Sarsaiya,

<h4>Introduction</h4>The treatment of Indian tropical disease such as kala-azar is likely to be troublesome to the clinicians as AmpB- and miltefosine-resistant <i>Leishmania donovani</i> has been reported. The rationale behind designed a novel inhibitors of model of <i>L. donovani</i> enolase and performing a binding study with its inhibitors to gain details ... Read more >>

J Pharm Bioallied Sci (Journal of pharmacy & bioallied sciences)
[2017, 9(2):99-105]

Cited: 0 times

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Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish.

Brian P Grone, Maria Marchese, Kyla R Hamling, Maneesh G Kumar, Christopher S Krasniak, Federico Sicca, Filippo M Santorelli, Manisha Patel, Scott C Baraban,

Mutations in the synaptic machinery gene syntaxin-binding protein 1, STXBP1 (also known as MUNC18-1), are linked to childhood epilepsies and other neurodevelopmental disorders. Zebrafish STXBP1 homologs (stxbp1a and stxbp1b) have highly conserved sequence and are prominently expressed in the larval zebrafish brain. To understand the functions of stxbp1a and stxbp1b, ... Read more >>

PLoS One (PloS one)
[2016, 11(3):e0151148]

Cited: 24 times

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Evaluation of indigenous fresh water microalga Scenedesmus obtusus for feed and fuel applications: Effect of carbon dioxide, light and nutrient sources on growth and biochemical characteristics.

T Sarat Chandra, R S Deepak, M Maneesh Kumar, S Mukherji, V S Chauhan, R Sarada, S N Mudliar,

Scenedesmus obtusus, a freshwater microalga, was evaluated for its growth and biochemical characteristics under various culture conditions. S. obtusus was tolerant at all tested CO2 concentrations up to 20%. Among the different nitrogen sources, urea showed enhanced biomass productivities up to 2-fold compared to control, where the nitrogen source was ... Read more >>

Bioresour Technol (Bioresource technology)
[2016, 207:430-439]

Cited: 11 times

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Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome.

Maneesh G Kumar, Shane Rowley, Ruth Fulton, Matthew T Dinday, Scott C Baraban, Manisha Patel,

Altered metabolism is an important feature of many epileptic syndromes but has not been reported in Dravet syndrome (DS), a catastrophic childhood epilepsy associated with mutations in a voltage-activated sodium channel, Nav1.1 (SCN1A). To address this, we developed novel methodology to assess real-time changes in bioenergetics in zebrafish larvae between ... Read more >>

eNeuro (eNeuro)
[2016, 3(2):]

Cited: 13 times

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Acute kidney injury in children after cardiopulmonary bypass: risk factors and outcome.

Sidharth Kumar Sethi, Maneesh Kumar, Rajesh Sharma, Subeeta Bazaz, Vijay Kher,

<h4>Objective</h4>To determine the incidence, risk factors and outcomes of acute kidney injury in children undergoing cardiac surgery for congenital heart disease.<h4>Methods</h4>We enrolled 208 patients undergoing cardiac surgery for congenital heart disease during January 2012 to March 2013. Acute kidney injury was defined as per Acute Kidney Injury Network criteria.<h4>Results</h4>Twenty patients ... Read more >>

Indian Pediatr (Indian pediatrics)
[2015, 52(3):223-226]

Cited: 7 times

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Guillain-barré syndrome: a clinical study of twenty children.

Maneesh Kumar, Shrikiran Aroor, Suneel Mundkur, Sandeep Kumar,

<h4>Background</h4>Guillain-Barre Syndrome (GBS) is an acute monophasic demyelinating neuropathy characterized by progressive motor weakness of limbs with areflexia.<h4>Aim</h4>To study the clinical pattern and outcome of children with Guillain-Barre syndrome.<h4>Materials and methods</h4>It was a cross-sectional study conducted in a pediatric unit of tertiary care hospital over a period of 18 months. ... Read more >>

J Clin Diagn Res (Journal of clinical and diagnostic research : JCDR)
[2015, 9(1):SC09-12]

Cited: 4 times

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Vasoactive Inotrope Score as a tool for clinical care in children post cardiac surgery.

Maneesh Kumar, Rajesh Sharma, Sidharth Kumar Sethi, Subeeta Bazaz, Prerna Sharma, Anil Bhan, Vijay Kher,

BACKGROUND:Neonates and infants undergoing heart surgery on cardiopulmonary bypass (CPB) are at high risk for significant post-operative morbidity and mortality. Hence, there is a need to identify and quantify clinical factors during the early post-operative period that are indicative of short-term as well as long-term outcomes. Multiple inotrope scores have ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2014, 18(10):653-658]

Cited: 10 times

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Migratory skin lesions in a renal transplant recipient.

Sanjay Panda, Maneesh Vijay Kumar, Soumita Bagchi, Geetika Singh, S K Agarwal, Amit Dinda,

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2014, 19(10):661-662]

Cited: 0 times

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Hemolytic uremic syndrome associated with Dengue fever in an adolescent girl.

Shrikiran Aroor, Sandeep Kumar, Suneel Mundkur, Maneesh Kumar,

Indian J Pediatr (Indian journal of pediatrics)
[2014, 81(12):1397-1398]

Cited: 4 times

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Merosin-deficient congenital muscular dystrophy with cerebral white matter changes: a clue to its diagnosis beyond infancy.

Sandeep Kumar, Shrikiran Aroor, Suneel Mundkur, Maneesh Kumar,

A 6-year-old boy born by a third-degree consanguineous marriage presented with progressive muscle weakness and delayed motor milestones noticed in early infancy with preserved language and social milestones. Examination revealed generalised hypotonia and hyporeflexia. Baseline haematological and biochemical investigations were normal except for mildly elevated creatine kinase. Provisional diagnosis of ... Read more >>

BMJ Case Rep (BMJ case reports)
[2014, 2014:]

Cited: 1 time

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Engineered reversal of drug resistance in cancer cells--metastases suppressor factors as change agents.

Vinod Kumar Yadav, Akinchan Kumar, Anita Mann, Suruchi Aggarwal, Maneesh Kumar, Sumitabho Deb Roy, Subrata Kumar Pore, Rajkumar Banerjee, Jerald Mahesh Kumar, Ram Krishna Thakur, Shantanu Chowdhury,

Building molecular correlates of drug resistance in cancer and exploiting them for therapeutic intervention remains a pressing clinical need. To identify factors that impact drug resistance herein we built a model that couples inherent cell-based response toward drugs with transcriptomes of resistant/sensitive cells. To test this model, we focused on ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2014, 42(2):764-773]

Cited: 20 times

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Operational performance and critical success factors of lean manufacturing in European food processing SMEs

Manoj Dora, Adrienn Molnar, Dirk Van Goubergen, Maneesh Kumar, Xavier Gellynck,

This study analyzes the application of lean manufacturing, its impact on operational performance and critical success factors in the food processing SMEs. The review of current literature was complemented with a survey of food processing companies in three European countries in order to gain a deeper understanding of lean manufacturing ... Read more >>

(Trends in food science & technology.)
[2013, 31(2):156-164]

Cited: 1 time

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Reactive oxygen species mediate microRNA-302 regulation of AT-rich interacting domain 4a and C-C motif ligand 5 expression during transitions between quiescence and proliferation.

Maneesh G Kumar, Neil M Patel, Adam M Nicholson, Amanda L Kalen, Ehab H Sarsour, Prabhat C Goswami,

Normal cell growth consists of two distinct phases, quiescence and proliferation. Quiescence, or G(0), is a reversible growth arrest in which cells retain the ability to reenter the proliferative cycle (G(1), S, G(2), and M). Although not actively dividing, quiescent cells are metabolically active and quiescence is actively maintained. Our ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2012, 53(4):974-982]

Cited: 7 times

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