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Author Manabu Fujita

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Determinant Factors on Differences in Survival for Gastric Cancer Between the United States and Japan Using Nationwide Databases.

Yuri Ito, Isao Miyashiro, Takashi Ishikawa, Kohei Akazawa, Keisuke Fukui, Hitoshi Katai, Souya Nunobe, Ichiro Oda, Yoh Isobe, Shunichi Tsujitani, Hiroyuki Ono, Satoshi Tanabe, Takeo Fukagawa, Satoshi Suzuki, Yoshihiro Kakeji, Mitsuru Sasako, Anton Bilchik, Manabu Fujita,

<h4>Background</h4>Although the incidence and mortality have decreased, gastric cancer (GC) is still a public health issue globally. An international study reported higher survival in Korea and Japan than other countries, including the United States. We examined the determinant factors of the high survival in Japan compared with the United States.<h4>Methods</h4>We ... Read more >>

J Epidemiol (Journal of epidemiology)
[2021, 31(4):241-248]

Cited: 0 times

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Regional Node Basin Recurrence in Melanoma Patients: More Common After Node Dissection for Macroscopic Rather than Clinically Occult Nodal Disease.

Abhineet Uppal, Stacey Stern, John F Thompson, Leland Foshag, Nicola Mizzollo, Omgo E Nieweg, Harald J Hoekstra, Daniel F Roses, Vernon K Sondak, Mohammed Kashani-Sabet, Brendon J Coventry, Alistair J Cochran, Manabu Fujita, Myung Sim-Shin, David Elashoff, Robert M Elashoff, Mark B Faries,

<h4>Background</h4>Recommended treatment for patients with sentinel lymph node (SLN)-positive melanoma has recently changed. Randomized trials demonstrated equivalent survival with close observation versus completion lymph node dissection (CLND), but increased regional node recurrence. We evaluated factors related to in-basin nodal recurrence after lymphadenectomy (LND) for SLN-positive or macroscopic nodal metastases.<h4>Methods</h4>An institutional ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2020, 27(6):1970-1977]

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The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury).

Keitaro Yamagami, Ryota Kurogi, Ai Kurogi, Kunihiro Nishimura, Daisuke Onozuka, Nice Ren, Akiko Kada, Ataru Nishimura, Koichi Arimura, Keisuke Ido, Masahiro Mizoguchi, Tetsuya Sakamoto, Takamasa Kayama, Michiyasu Suzuki, Hajime Arai, Akihito Hagihara, Koji Iihara, ,

<h4>Background</h4>The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging societies. We assessed the influence of age on outcomes of patients with TBI and sought to identify prognostic factors for in-hospital mortality of TBI among elderly patients.<h4>Methods</h4>Using ... Read more >>

World Neurosurg (World neurosurgery)
[2019, 130:e26-e46]

Cited: 3 times

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Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin.

Ryota Kurogi, Kunihiro Nishimura, Michikazu Nakai, Akiko Kada, Satoru Kamitani, Jyoji Nakagawara, Kazunori Toyoda, Kuniaki Ogasawara, Junichi Ono, Yoshiaki Shiokawa, Toru Aruga, Shigeru Miyachi, Izumi Nagata, Shinya Matsuda, Shinichi Yoshimura, Kazuo Okuchi, Akifumi Suzuki, Fumiaki Nakamura, Daisuke Onozuka, Keisuke Ido, Ai Kurogi, Nobutaka Mukae, Ataru Nishimura, Koichi Arimura, Takanari Kitazono, Akihito Hagihara, Koji Iihara, ,

OBJECTIVES:This cross-sectional survey explored the characteristics and outcomes of direct oral anticoagulant (DOAC)-associated nontraumatic intracerebral hemorrhages (ICHs) by analyzing a large nationwide Japanese discharge database. METHODS:We analyzed data from 2,245 patients who experienced ICHs while taking anticoagulants (DOAC: 227; warfarin: 2,018) and were urgently hospitalized at 621 institutions in Japan ... Read more >>

Neurology (Neurology)
[2018, 90(13):e1143-e1149]

Cited: 5 times

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Survival Analysis with Extended Lymphadenectomy for Gastric Cancer: Removing Stage Migration from the Equation.

Brooke Vuong, Amanda N Graff-Baker, Ahmed Dehal, Stacey Stern, Manabu Fujita, Melanie Goldfarb, Anton J Bilchik,

The survival benefit of an extended versus standard lymphadenectomy for gastric cancer (GC) is often attributed to upstaging when more lymph nodes (LNs) are removed, i.e., stage migration. An extended lymphadenectomy is defined as 30 or more LNs examined, a surrogate for a D2 dissection. The aim of this study ... Read more >>

Am Surg (The American surgeon)
[2017, 83(10):1074-1079]

Cited: 2 times

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A new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model.

Tomohiko Sekioka, Michiaki Kadode, Noriko Osakada, Manabu Fujita, Naoya Matsumura, Yoshiyuki Yamaura, Shinji Nakade, Takeshi Nabe, Kazuhito Kawabata,

Although the effectiveness of CysLT<sub>1</sub> receptor antagonists on asthma has been clinically established, the effects of CysLT<sub>2</sub> receptor antagonists are still unclear. The purpose of this study was to develop a new CysLT<sub>1</sub> and CysLT<sub>2</sub> receptors-mediated anaphylaxis guinea pig model using S-hexyl GSH, a γ-glutamyl transpeptidase (GTP) inhibitor, to suppress ... Read more >>

Prostaglandins Leukot Essent Fatty Acids (Prostaglandins, leukotrienes, and essential fatty acids)
[2017, 119:18-24]

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CysLT2 receptor activation is involved in LTC4-induced lung air-trapping in guinea pigs.

Tomohiko Sekioka, Michiaki Kadode, Yasuo Yonetomi, Akihiro Kamiya, Manabu Fujita, Takeshi Nabe, Kazuhito Kawabata,

CysLT<sub>1</sub> receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT<sub>2</sub> receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT<sub>2</sub> receptor-mediated LTC<sub>4</sub>-induced lung air-trapping in guinea pigs and use this model ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2017, 794:147-153]

Cited: 3 times

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Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma.

Yasuo Yonetomi, Tomohiko Sekioka, Michiaki Kadode, Tetsuya Kitamine, Akihiro Kamiya, Atsuto inoue, Takafumi Nakao, Hiroaki Nomura, Masayuki Murata, Shintaro Nakao, Fumio Nambu, Manabu Fujita, Shinji Nakade, Kazuhito Kawabata,

We assessed in this study the anti-asthmatic effects of ONO-6950, a novel cysteinyl leukotriene 1 (CysLT1) and 2 (CysLT2) receptors dual antagonist, in normal and S-hexyl glutathione (S-hexyl GSH)-treated guinea pigs, and compared these effects to those of montelukast, a CysLT1 selective receptor antagonist. Treatment with S-hexyl GSH reduced animals ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2015, 765:242-248]

Cited: 5 times

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Overall Survival Is Impacted by Birthplace and Not Extent of Surgery in Asian Americans with Resectable Gastric Cancer.

Daniel D Kirchoff, Gary B Deutsch, Manabu Fujita, David Y Lee, Myung Shin Sim, Ji Hey Lee, Anton J Bilchik,

Survival from gastric cancer in the USA still lags behind Asia. Genetic, environmental, and tumor biology differences, along with extent of surgery have been implicated. Our aim was to evaluate survival outcomes in Asian-American gastric cancer patients undergoing surgical resection by comparing place of birth and clinicopathologic characteristics (including evaluation ... Read more >>

J Gastrointest Surg (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2015, 19(11):1966-1973]

Cited: 6 times

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Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma.

Satoshi Itadani, Kentaro Yashiro, Yoshiyuki Aratani, Tetsuya Sekiguchi, Atsushi Kinoshita, Hideki Moriguchi, Nobukazu Ohta, Shinya Takahashi, Akiharu Ishida, Yohei Tajima, Katsuya Hisaichi, Masaki Ima, Junya Ueda, Hiromu Egashira, Tomohiko Sekioka, Michiaki Kadode, Yasuo Yonetomi, Takafumi Nakao, Atsuto Inoue, Hiroaki Nomura, Tetsuya Kitamine, Manabu Fujita, Takeshi Nabe, Yoshiyuki Yamaura, Naoya Matsumura, Akira Imagawa, Yoshisuke Nakayama, Jun Takeuchi, Kazuyuki Ohmoto,

An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and dicarboxylic acid moieties is described. Gemilukast (ONO-6950) was generated via isomerization of the core indole and the incorporation of a triple bond into a lead compound. Gemilukast exhibited antagonist activities with IC50 ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2015, 58(15):6093-6113]

Cited: 3 times

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Leukotriene C4 induces bronchoconstriction and airway vascular hyperpermeability via the cysteinyl leukotriene receptor 2 in S-hexyl glutathione-treated guinea pigs.

Yasuo Yonetomi, Tomohiko Sekioka, Michiaki Kadode, Tetsuya Kitamine, Akihiro Kamiya, Naoya Matsumura, Manabu Fujita, Kazuhito Kawabata,

Cysteinyl leukotrienes act through G-protein-coupled receptors termed cysteinyl leukotriene 1 (CysLT1) and cysteinyl leukotriene 2 (CysLT2) receptors. However, little is known about the pathophysiological role of CysLT2 receptors in asthma. To elucidate the possible involvement of CysLT2 receptors in bronchoconstriction and airway vascular hyperpermeability, we have established a novel guinea ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2015, 754:98-104]

Cited: 8 times

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Discovery of a potent, orally available dual CysLT₁ and CysLT₂ antagonist with dicarboxylic acid.

Satoshi Itadani, Shinya Takahashi, Masaki Ima, Tetsuya Sekiguchi, Yoshiyuki Aratani, Hiromu Egashira, Naoya Matsumura, Atsuto Inoue, Yasuo Yonetomi, Manabu Fujita, Yoshisuke Nakayama, Jun Takeuchi,

A potent, orally available dual CysLT₁ and CysLT₂ receptor antagonist with a dicarboxylic acid is described. 4-(3-(Carboxymethyl)-4-{(E)-2-[4-(4-phenoxybutoxy)phenyl]vinyl}-1H-indol-1-yl)butanoic acid (15: ONO-4310321, IC₅₀: CysLT₁=13nM, CysLT₂=25 nM) showed excellent pharmacokinetic profiles (%Frat=100) compared with our previously reported compound 1 (%Frat=1.5). In addition, we describe a new rule for dicarboxylic acid derivatives to show ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2015, 23(9):2079-2097]

Cited: 2 times

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Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist.

Satoshi Itadani, Shinya Takahashi, Masaki Ima, Tetsuya Sekiguchi, Manabu Fujita, Yoshisuke Nakayama, Jun Takeuchi,

The benzoxazine derivative, (2S)-4-(3-carboxypropyl)-8-{[4-(4-phenylbutoxy)benzoyl]amino}-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (19, ONO-2050297), was identified as the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively. ... Read more >>

ACS Med Chem Lett (ACS medicinal chemistry letters)
[2014, 5(11):1230-1234]

Cited: 3 times

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Localization and up-regulation of cysteinyl leukotriene-2 receptor in human allergic nasal mucosa.

Hideaki Shirasaki, Etsuko Kanaizumi, Nobuhiko Seki, Manabu Fujita, Megumi Kikuchi, Tetsuo Himi,

<h4>Background</h4>Cysteinyl leukotrienes (CysLTs) are lipid mediators that have been implicated in the pathogenesis of allergic rhinitis. Pharmacological studies using CysLTs indicate that 2 classes of receptors exist, namely, CysLT1 and CysLT2 receptors. The former class of receptors is sensitive to the CysLT1 antagonists currently used to treat asthma and allergic ... Read more >>

Allergol Int (Allergology international : official journal of the Japanese Society of Allergology)
[2013, 62(2):223-228]

Cited: 9 times

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An updated report of the trends in cancer incidence and mortality in Japan.

Kota Katanoda, Tomohiro Matsuda, Ayako Matsuda, Akiko Shibata, Yoshikazu Nishino, Manabu Fujita, Midori Soda, Akiko Ioka, Tomotaka Sobue, Hiroshi Nishimoto,

<h4>Objective</h4>The analysis of cancer trends in Japan has only been sporadically reported. We present a comprehensive report on the trends in cancer incidence and mortality in Japan using the most recent population-based data.<h4>Methods</h4>National cancer mortality data between 1958 and 2011 were obtained from published vital statistics. Cancer incidence data between ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2013, 43(5):492-507]

Cited: 76 times

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Mechanisims of asthma and allergic disease – 1084. Localization and up-regulation of CysLT2 receptorin perennial allergic rhinitis

Hideaki Shirasaki, Etsuko Kanaizumi, Nobuhiko Seki, Manabu Fujita, Tetsuo Himi,

World Allergy Organ J (The World Allergy Organization journal)
[2013, 6(Suppl 1):P80-P80]

Cited: 0 times

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134 Expression and Localization of CYSLT2 Receptor in Human Nasal Mucosa

Shirasaki Hideaki, Etsuko Kanaizumi, Manabu Fujita, Tetsuo Himi,

<h4>Background</h4> We have previously reported the localization of CysLT1 receptor by using immunohistochemistry and in situ hybridization (Shirasaki H et al. Clin Exp Allergy. 2002;32:1007–1012). <h4>Methods</h4> To clarify the expression of CysLT2 receptor in human nasal mucosa, we investigated CysLT2 receptor mRNA expression and its protein localization in human nasal ... Read more >>

World Allergy Organ J (The World Allergy Organization journal)
[2012, 5(Suppl 2):S61-S62]

Cited: 0 times

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Trend analysis of cancer incidence in Japan using data from selected population-based cancer registries.

Kota Katanoda, Wakiko Ajiki, Tomohiro Matsuda, Yoshikazu Nishino, Akiko Shibata, Manabu Fujita, Hideaki Tsukuma, Akiko Ioka, Midori Soda, Tomotaka Sobue,

Population-based cancer registries are operated by over 80% of prefectures in Japan. However, only a limited proportion of the registries can provide long-term incidence data. Here, we aimed to establish a method for monitoring cancer incidence trends in Japan using data from selected prefectures. Based on the availability of long-term ... Read more >>

Cancer Sci (Cancer science)
[2012, 103(2):360-368]

Cited: 11 times

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Nonfilter and filter cigarette consumption and the incidence of lung cancer by histological type in Japan and the United States: analysis of 30-year data from population-based cancer registries.

Hidemi Ito, Keitaro Matsuo, Hideo Tanaka, Devin C Koestler, Hernando Ombao, John Fulton, Akiko Shibata, Manabu Fujita, Hiromi Sugiyama, Midori Soda, Tomotaka Sobue, Vincent Mor,

Shifts in the histologic type of lung cancer accompanying changes in lung cancer incidence have been observed in Japan and the United States. We examined the association between the shift in tobacco design from nonfilter to filter cigarettes with changes in the incidence of adenocarcinoma (AD) and squamous cell carcinoma ... Read more >>

Int J Cancer (International journal of cancer)
[2011, 128(8):1918-1928]

Cited: 25 times

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Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity.

Satoshi Inoue, Hui Ding, Jose Portilla-Arias, Jinwei Hu, Bindu Konda, Manabu Fujita, Andres Espinoza, Sonal Suhane, Marisa Riley, Marcus Gates, Rameshwar Patil, Manuel L Penichet, Alexander V Ljubimov, Keith L Black, Eggehard Holler, Julia Y Ljubimova,

Biodegradable nanopolymers are believed to offer great potential in cancer therapy. Here, we report the characterization of a novel, targeted, nanobiopolymeric conjugate based on biodegradable, nontoxic, and nonimmunogenic PMLA [poly(β-l-malic acid)]. The PMLA nanoplatform was synthesized for repetitive systemic treatments of HER2/neu-positive human breast tumors in a xenogeneic mouse model. ... Read more >>

Cancer Res (Cancer research)
[2011, 71(4):1454-1464]

Cited: 35 times

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Use of a population-based cancer registry to calculate twenty-year trends in cancer incidence and mortality in Fukui Prefecture.

Masakazu Hattori, Manabu Fujita, Yuri Ito, Akiko Ioka, Kota Katanoda, Yosikazu Nakamura,

<h4>Background</h4>There have been only a limited number of trend analyses of incidence and mortality using population-based cancer registry data in Japan, and the national statistics regarding incidence are estimated data. In the present study, data from the Fukui Prefecture cancer registry, which is the most accurate in Japan, were used ... Read more >>

J Epidemiol (Journal of epidemiology)
[2010, 20(3):244-252]

Cited: 3 times

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[Estimation of the effects of centralization of cancer treatment on mortality reduction by in Fukui Prefecture].

Masakazu Hattori, Manabu Fujita, Yosikazu Nakamura, Akiko Ioka,

<h4>Purpose</h4>This study was conducted to clarify the efficacy of centralization of cancer treatment using population-based cancer registry data in Fukui prefecture, Japan.<h4>Method</h4>Associations between hospital procedure volume and cancer survival were analyzed using the population-based cancer registry survival data for Fukui prefecture between 1994 and 1998. Firstly the cancer patients who ... Read more >>

Nihon Koshu Eisei Zasshi ([Nihon koshu eisei zasshi] Japanese journal of public health)
[2010, 57(4):263-270]

Cited: 1 time

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Ethynylindole compounds

KAZUYUKI OHMOTO, SATOSHI ITADANI, YOSHISUKE NAKAYAMA, JUN TAKEUCHI, MANABU FUJITA,

As a compound having a potent oral activity and a long-lasting cysLT 1 /cysLT 2 receptor antagonistic activity, the compound of the formula (I): which exhibits potent antagonistic activity against the cysLT 1 /cysLT 2 receptor, and have long-lasting effects even in case of oral administration, and therefore is useful ... Read more >>

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Proposal for a cooperative study on population-based cancer survival in selected registries in East Asia.

Hideo Tanaka, Masahiro Tanaka, Wanqing Chen, Sohee Park, Kyu-Won Jung, Chun-Ju Chiang, Mei-Shu Lai, Maria Rica Mirasol-Lumague, Adriano S Laudico, Evlena Suzanna Sinuraya, Yoshikazu Nishino, Akiko Shibata, Manabu Fujita, Midori Soda, Michiko Naito, Hideaki Tsukuma, Malcolm A Moore, Wakiko Ajiki,

Reliable population-based cancer survival data are essential for assessment of the effectiveness of cancer screening programs, distribution of cancer therapy and prevalent cancer cases. International comparisons are useful to allow societies, mass media and health authorities to gain a real appreciation of the cancer problem in their own country and ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2009, 10(6):1191-1198]

Cited: 10 times

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Capsule type endoscope system, and program and method for the system

MANABU FUJITA,

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