Full Text Journal Articles by
Author Mami Miyado

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Similar responsiveness between C57BL/6N and C57BL/6J mouse substrains to superovulation.

Miyuki Shindo, Hideki Tsumura, Kenji Miyado, Woojin Kang, Natsuko Kawano, Tomoko Yoshida, Maki Fukami, Mami Miyado,

Superovulation is a method for the drug-induced release of multiple eggs and useful for <i>in vitro</i> fertilization. Thus, its high efficiency largely reduces the number of mice used per experiment. We compared the responsivity to superovulation between C57BL/6N (B6N) and C57BL/6J (B6J) substrains. The average number of ovulated eggs was ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Neuronal expression of Ca2+ oscillation initiator is linked to rapid neonatal growth in mice.

Woojin Kang, Kenji Yamatoya, Kenji Miyado, Mami Miyado, Yoshitaka Miyamoto,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Quantification of androgens and their precursors in full-term human placenta.

Tomoko Yoshida, Kenji Matsumoto, Mami Miyado, Yoshimichi Miyashiro, Haruhiko Sago, Reiko Horikawa, Maki Fukami,

<h4>Introduction</h4>The two major androgens in humans are testosterone (T) and dihydrotestosterone (DHT). DHT is produced via the classical, backdoor, and alternative steroidogenic pathways. In addition, recent studies have identified C11-oxy C19 steroids as novel human androgens. Although the placenta is known to be involved in steroid metabolism, androgen levels in ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2021, 185(5):K7-K11]

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Structural and numerical Y chromosomal variations in elderly men identified through multiplex ligation-dependent probe amplification.

Yasuko Ogiwara, Mami Miyado, Erina Suzuki, Sumpei Niida, Kouichi Ozaki, Maki Fukami,

Human Y chromosomes frequently acquire structural and numerical alterations. Known alterations include germline copy-number variations (CNVs) in the azoospermia factor (AZF) region and somatic mosaic loss of the Y chromosome (mLOY). Here, we explored Y chromosomal variations in 160 Japanese men aged 75-90 years. Multiplex ligation-dependent probe amplification (MLPA) identified ... Read more >>

J Hum Genet (Journal of human genetics)
[2021, :]

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Suppression of Non-Random Fertilization by MHC Class I Antigens.

Junki Kamiya, Woojin Kang, Keiichi Yoshida, Ryota Takagi, Seiya Kanai, Maito Hanai, Akihiro Nakamura, Mitsutoshi Yamada, Yoshitaka Miyamoto, Mami Miyado, Yoko Kuroki, Yoshiki Hayashi, Akihiro Umezawa, Natsuko Kawano, Kenji Miyado,

Hermaphroditic invertebrates and plants have a self-recognition system on the cell surface of sperm and eggs, which prevents their self-fusion and enhances non-self-fusion, thereby contributing to genetic variation. However, the system of sperm-egg recognition in mammals is under debate. To address this issue, we explored the role of major histocompatibility ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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Circulating steroids and mood disorders in patients with polycystic ovary syndrome.

Tomoko Yoshida, Kazuki Saito, Toshihiro Kawamura, Tomonori Ishikawa, Tsuguhiko Kato, Keiko Matsubara, Naoyuki Miyasaka, Mami Miyado, Maki Fukami,

Aberrant androgen metabolism is a characteristic feature of polycystic ovary syndrome (PCOS). Various androgens as well as their precursors and metabolites can accumulate in the blood of PCOS patients. Although these steroids include neuroactive steroids, such as allopregnanolone and androstenedione (Δ4A), it remains unknown whether altered blood steroid levels contribute ... Read more >>

Steroids (Steroids)
[2021, 165:108748]

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Nonsense-associated altered splicing of MAP3K1 in two siblings with 46,XY disorders of sex development.

Maki Igarashi, Yohei Masunaga, Yuichi Hasegawa, Kenichi Kinjo, Mami Miyado, Hirotomo Saitsu, Yuko Kato-Fukui, Reiko Horikawa, Yomiko Okubo, Tsutomu Ogata, Maki Fukami,

Although splicing errors due to single nucleotide variants represent a common cause of monogenic disorders, only a few variants have been shown to create new splice sites in exons. Here, we report an MAP3K1 splice variant identified in two siblings with 46,XY disorder of sex development. The patients carried a ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):17375]

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Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency.

Kenichi Kinjo, Keisuke Nagasaki, Koji Muroya, Erina Suzuki, Keisuke Ishiwata, Kazuhiko Nakabayashi, Atsushi Hattori, Koji Nagao, Ryu-Suke Nozawa, Chikashi Obuse, Kenji Miyado, Tsutomu Ogata, Maki Fukami, Mami Miyado,

Isolated hypogonadotropic hypogonadism (IHH), combined pituitary hormone deficiency (CPHD), and septo-optic dysplasia (SOD) constitute a disease spectrum whose etiology remains largely unknown. This study aimed to clarify whether mutations in SMCHD1, an epigenetic regulator gene, might underlie this disease spectrum. SMCHD1 is a causative gene for Bosma arhinia microphthalmia syndrome ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):10985]

Cited: 1 time

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Correction: Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.

Woojin Kang, Yuichirou Harada, Kenji Yamatoya, Natsuko Kawano, Seiya Kanai, Yoshitaka Miyamoto, Akihiro Nakamura, Mami Miyado, Yoshiki Hayashi, Yoko Kuroki, Hidekazu Saito, Yasuhiro Iwao, Akihiro Umezawa, Kenji Miyado,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2020, 100(4):665]

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Copy-number analysis of Y-linked loci in young men with non-obstructive azoospermia: Implications for the rarity of early onset mosaic loss of chromosome Y.

Erina Suzuki, Yoshitomo Kobori, Momori Katsumi, Kikumi Ushijima, Toru Uchiyama, Hiroshi Okada, Mami Miyado, Maki Fukami,

Purpose:Mosaic loss of chromosome Y (mLOY) is a common feature in elderly men. If mLOY can also occur in young men, it may lead to spermatogenic failure due to loss of spermatogenic genes. Indeed, previous studies detected the 45,X/46,XY karyotype in a few young men with spermatogenic failure. The present ... Read more >>

Reprod Med Biol (Reproductive medicine and biology)
[2020, 19(2):178-181]

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Random X chromosome inactivation in patients with Klinefelter syndrome.

Kenichi Kinjo, Tomoko Yoshida, Yoshitomo Kobori, Hiroshi Okada, Erina Suzuki, Tsutomu Ogata, Mami Miyado, Maki Fukami,

BACKGROUND:X chromosome inactivation (XCI) is an indispensable process in the development of human female embryos. Reportedly, XCI occurs when a blastocyst contains 10-12 embryonic progenitor cells. To date, it remains unclear whether XCI ratios are normally preserved in Klinefelter syndrome (KS) patients with 47,XXY karyotype. METHODS:We examined XCI ratios in ... Read more >>

Mol Cell Pediatr (Molecular and cellular pediatrics)
[2020, 7(1):1]

Cited: 2 times

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Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.

Woojin Kang, Yuichirou Harada, Kenji Yamatoya, Natsuko Kawano, Seiya Kanai, Yoshitaka Miyamoto, Akihiro Nakamura, Mami Miyado, Yoshiki Hayashi, Yoko Kuroki, Hidekazu Saito, Yasuhiro Iwao, Akihiro Umezawa, Kenji Miyado,

Men and women become infertile with age, but the mechanism of declining male fertility, more specifically, the decrease in in sperm quality, is not well known. Citrate synthase (CS) is a core enzyme of the mitochondrial tricarboxylic acid (TCA) cycle, which directly controls cellular function. Extra-mitochondrial CS (eCS) is produced ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2020, 100(4):583-595]

Cited: 1 time

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Reply: Artificial cycle 'per se' or the specific protocol of endometrial preparation as responsible for obstetric complications of frozen cycle?

Kazuki Saito, Akira Kuwahara, Tomonori Ishikawa, Naho Morisaki, Mami Miyado, Kenji Miyado, Maki Fukami, Naoyuki Miyasaka, Osamu Ishihara, Minoru Irahara, Hidekazu Saito,

Hum Reprod (Human reproduction (Oxford, England))
[2019, 34(12):2554-2555]

Cited: 0 times

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Calaxin is required for cilia-driven determination of vertebrate laterality.

Keita Sasaki, Kogiku Shiba, Akihiro Nakamura, Natsuko Kawano, Yuhkoh Satouh, Hiroshi Yamaguchi, Motohiro Morikawa, Daisuke Shibata, Ryuji Yanase, Kei Jokura, Mami Nomura, Mami Miyado, Shuji Takada, Hironori Ueno, Shigenori Nonaka, Tadashi Baba, Masahito Ikawa, Masahide Kikkawa, Kenji Miyado, Kazuo Inaba,

Calaxin is a Ca<sup>2+</sup>-binding dynein-associated protein that regulates flagellar and ciliary movement. In ascidians, calaxin plays essential roles in chemotaxis of sperm. However, nothing has been known for the function of calaxin in vertebrates. Here we show that the mice with a null mutation in <i>Efcab1</i>, which encodes calaxin, display ... Read more >>

Commun Biol (Communications biology)
[2019, 2:226]

Cited: 7 times

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Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus.

Kazuki Saito, Akira Kuwahara, Tomonori Ishikawa, Naho Morisaki, Mami Miyado, Kenji Miyado, Maki Fukami, Naoyuki Miyasaka, Osamu Ishihara, Minoru Irahara, Hidekazu Saito,

<h4>Study question</h4>What were the risks with regard to the pregnancy outcomes of patients who conceived by frozen-thawed embryo transfer (FET) during a hormone replacement cycle (HRC-FET)?<h4>Summary answer</h4>The patients who conceived by HRC-FET had increased risks of hypertensive disorders of pregnancy (HDP) and placenta accreta and a reduced risk of gestational ... Read more >>

Hum Reprod (Human reproduction (Oxford, England))
[2019, 34(8):1567-1575]

Cited: 25 times

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Microexosomes versus exosomes: Shared components but distinct structures.

Mami Miyado, Woojin Kang, Natsuko Kawano, Kenji Miyado,

Regen Ther (Regenerative therapy)
[2019, 11:31-33]

Cited: 1 time

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SHOX far-downstream copy-number variations involving cis-regulatory nucleotide variants in two sisters with Leri-Weill dyschondrosteosis.

Kenichiro Ogushi, Koji Muroya, Hirohito Shima, Tomoko Jinno, Mami Miyado, Maki Fukami,

SHOX haploinsufficiency leading to Leri-Weill dyschondrosteosis (LWD) and idiopathic short stature typically results from intragenic mutations or copy-number variations (CNVs) involving SHOX and/or its putative enhancer regions that are distributed in the genomic interval between 400 kb and 840 kb from Xpter/Ypter. Here, we report two sisters with LWD, who carried a ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2019, 179(9):1778-1782]

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Erratum: Publisher Correction: Calaxin is required for cilia-driven determination of vertebrate laterality.

Keita Sasaki, Kogiku Shiba, Akihiro Nakamura, Natsuko Kawano, Yuhkoh Satouh, Hiroshi Yamaguchi, Motohiro Morikawa, Daisuke Shibata, Ryuji Yanase, Kei Jokura, Mami Nomura, Mami Miyado, Shuji Takada, Hironori Ueno, Shigenori Nonaka, Tadashi Baba, Masahito Ikawa, Masahide Kikkawa, Kenji Miyado, Kazuo Inaba,

[This corrects the article DOI: 10.1038/s42003-019-0462-y.]. ... Read more >>

Commun Biol (Communications biology)
[2019, 2:254]

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DNA Methylation Status of SHOX-Flanking CpG Islands in Healthy Individuals and Short Stature Patients with Pseudoautosomal Copy Number Variations.

Kenichiro Ogushi, Atsushi Hattori, Erina Suzuki, Hirohito Shima, Masako Izawa, Hideaki Yagasaki, Reiko Horikawa, Kimiaki Uetake, Akihiro Umezawa, Tomohiro Ishii, Koji Muroya, Noriyuki Namba, Toshiaki Tanaka, Yasuhiro Hirano, Hitoshi Yamamoto, Shun Soneda, Keiko Matsubara, Masayo Kagami, Mami Miyado, Maki Fukami,

SHOX resides in the short arm pseudoautosomal region (PAR1) of the sex chromosomes and escapes X inactivation. SHOX haploinsufficiency underlies idiopathic short stature (ISS) and Leri-Weill dyschondrosteosis (LWD). A substantial percentage of cases with SHOX haploinsufficiency arise from pseudoautosomal copy number variations (CNVs) involving putative enhancer regions of SHOX. Our ... Read more >>

Cytogenet Genome Res (Cytogenetic and genome research)
[2019, 158(2):56-62]

Cited: 1 time

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Dihydrotestosterone induces minor transcriptional alterations in genital skin fibroblasts of children with and without androgen insensitivity.

Kanako Tanase-Nakao, Kentaro Mizuno, Yutaro Hayashi, Yoshiyuki Kojima, Mariko Hara, Kenji Matsumoto, Yoichi Matsubara, Maki Igarashi, Mami Miyado, Maki Fukami,

Endogenous and exogenous androgens induce masculinization of external genitalia through binding to the androgen receptor (AR). The target genes of androgens in external genitalia remain to be determined, although previous studies have shown that the apolipoprotein D gene (APOD) was significantly upregulated by dihydrotestosterone (DHT), the most potent androgen in ... Read more >>

Endocr J (Endocrine journal)
[2019, 66(4):387-393]

Cited: 2 times

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Losing maleness: Somatic Y chromosome loss at every stage of a man's life.

Mami Miyado, Maki Fukami,

Mosaic loss of Y chromosome (LOY) is assumed to be among the most common acquired genetic variations in elderly people. Recent studies have linked aging-related mosaic LOY to the risk of Alzheimer's disease, cancer, and early death. Here, we propose that mosaic LOY can present in men at any age. ... Read more >>

FASEB Bioadv (FASEB bioAdvances)
[2019, 1(6):350-352]

Cited: 1 time

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Germline-Derived Gain-of-Function Variants of Gsα-Coding GNAS Gene Identified in Nephrogenic Syndrome of Inappropriate Antidiuresis.

Mami Miyado, Maki Fukami, Shuji Takada, Miho Terao, Kazuhiko Nakabayashi, Kenichiro Hata, Yoichi Matsubara, Yoko Tanaka, Goro Sasaki, Keisuke Nagasaki, Masaaki Shiina, Kazuhiro Ogata, Youhei Masunaga, Hirotomo Saitsu, Tsutomu Ogata,

<h4>Background</h4>The stimulatory G-protein <i>α</i>-subunit encoded by <i>GNAS</i> exons 1-13 (<i>GNAS</i>-Gs<i>α</i>) mediates signal transduction of multiple G protein-coupled receptors, including arginine vasopressin receptor 2 (AVPR2). Various germline-derived loss-of-function <i>GNAS</i>-Gs<i>α</i> variants of maternal and paternal origin have been found in pseudohypoparathyroidism type Ia and pseudopseudohypoparathyroidism, respectively. Specific somatic gain-of-function <i>GNAS</i>-Gs<i>α</i> variants have ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2019, 30(5):877-889]

Cited: 7 times

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Chemotactic behavior of egg mitochondria in response to sperm fusion in mice.

Maki Iwai, Yuichirou Harada, Rinako Miyabayashi, Woojin Kang, Akihiro Nakamura, Natsuko Kawano, Yoshitaka Miyamoto, Mitsutoshi Yamada, Toshio Hamatani, Mami Miyado, Keiichi Yoshida, Hidekazu Saito, Mamoru Tanaka, Akihiro Umezawa, Kenji Miyado,

Mitochondria are the powerhouses of eukaryotic cells and their positioning contributes to fertilization and early developmental processes. We report that sperm fusion triggers Ca<sup>2+</sup> oscillations and mitochondrial movement toward fused sperm (mitochondrial chemotaxis) in mouse eggs. Mitochondria functioned in Ca<sup>2+</sup> storage and were colocalized with endoplasmic reticulum (ER) during Ca<sup>2+</sup> ... Read more >>

Heliyon (Heliyon)
[2018, 4(11):e00944]

Cited: 1 time

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Membrane protein CD9 is repositioned and released to enhance uterine function.

Maki Iwai, Toshio Hamatani, Akihiro Nakamura, Natsuko Kawano, Seiya Kanai, Woojin Kang, Noriko Yoshii, Yasushi Odawara, Mitsutoshi Yamada, Yoshitaka Miyamoto, Takakazu Saito, Hidekazu Saito, Mami Miyado, Akihiro Umezawa, Kenji Miyado, Mamoru Tanaka,

Tetraspanin CD9 is essential for sperm-egg fusion and also contributes to uterine repair through microexosome formation. Microexosomes share CD9 with exosomes and are released from eggs and uterine epithelial cells. However, the mechanism for the formation of microexosomes remains unknown. To address this issue, we examined membrane localization and extracellular ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2019, 99(2):200-209]

Cited: 2 times

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Degradation of phosphate polymer polyP enhances lactic fermentation in mice.

Akihiro Nakamura, Natsuko Kawano, Kei Motomura, Akio Kuroda, Kiyoshi Sekiguchi, Mami Miyado, Woojin Kang, Yoshitaka Miyamoto, Maito Hanai, Maki Iwai, Mitsutoshi Yamada, Toshio Hamatani, Takakazu Saito, Hidekazu Saito, Mamoru Tanaka, Akihiro Umezawa, Kenji Miyado,

In bacteria, a polymer of inorganic phosphate (Pi) (inorganic polyphosphate; polyP) is enzymatically produced and consumed as an alternative phosphate donor for adenosine triphosphate (ATP) production to protect against nutrient starvation. In vertebrates, polyP has been dismissed as a "molecular fossil" due to the lack of any known physiological function. ... Read more >>

Genes Cells (Genes to cells : devoted to molecular & cellular mechanisms)
[2018, 23(10):904-914]

Cited: 2 times

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