Full Text Journal Articles by
Author Mamatha Damodarasamy

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The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA).

Mamatha Damodarasamy, Robert B Vernon, Jasmine L Pathan, C Dirk Keene, Anthony J Day, William A Banks, May J Reed,

<h4>Background</h4>The microvasculature (MV) of brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA), in the absence of concurrent pathologies (e.g., infarctions, Lewy bodies), is incompletely understood.<h4>Objective</h4>To analyze microvascular density, diameter and extracellular matrix (ECM) content in association with ADNC and CAA.<h4>Methods</h4>We examined samples of cerebral cortex and ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2020, 17(1):60]

Cited: 0 times

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The extracellular matrix of the blood-brain barrier: structural and functional roles in health, aging, and Alzheimer's disease.

May J Reed, Mamatha Damodarasamy, William A Banks,

There is increasing interest in defining the location, content, and role of extracellular matrix (ECM) components in brain structure and function during development, aging, injury, and neurodegeneration. Studies in vivo confirm brain ECM has a dynamic composition with constitutive and induced alterations that impact subsequent cell-cell and cell-matrix interactions. Moreover, ... Read more >>

Tissue Barriers (Tissue barriers)
[2019, 7(4):1651157]

Cited: 10 times

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Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.

May J Reed, Mamatha Damodarasamy, Jasmine L Pathan, Christina K Chan, Charles Spiekerman, Thomas N Wight, William A Banks, Anthony J Day, Robert B Vernon, C Dirk Keene,

Little is known about the extracellular matrix (ECM) during progression of AD pathology. Brain ECM is abundant in hyaluronan (HA), a non-sulfated glycosaminoglycan synthesized by HA synthases (HAS) 1-3 in a high molecular weight (MW) form that is degraded into lower MW fragments. We hypothesized that pathologic severity of AD ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2019, 67(1):91-102]

Cited: 6 times

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The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells.

Daniella Bianchi-Frias, Mamatha Damodarasamy, Susana A Hernandez, Rui M Gil da Costa, Funda Vakar-Lopez, Ilsa M Coleman, May J Reed, Peter S Nelson,

The incidence of prostate cancer is directly linked to age, but age-associated changes that facilitate prostate cancer development and progression are poorly understood. This study investigated age-related changes in the prostate microenvironment for their influence on prostate cancer behavior. Prostate cancer cells implanted orthotopically into the prostate demonstrated accelerated tumor ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2019, 17(1):321-331]

Cited: 8 times

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The Effects of Normal Aging on Regional Accumulation of Hyaluronan and Chondroitin Sulfate Proteoglycans in the Mouse Brain.

May J Reed, Mamatha Damodarasamy, Jasmine L Pathan, Michelle A Erickson, William A Banks, Robert B Vernon,

The brain changes in volume and composition with normal aging. Cellular components of the brain are supported by an extracellular matrix (ECM) comprised largely of hyaluronan (HA) and HA-associated members of the lectican family of chondroitin sulfate proteoglycans (CSPGs). We examined regional differences in microvascular density, neuronal and glial markers, ... Read more >>

J Histochem Cytochem (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society)
[2018, 66(10):697-707]

Cited: 5 times

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The Effect of Computerized Physician Order Entry Template Modifications on the Administration of High-Risk Medications in Older Adults in the Emergency Department.

Mitchell Kim, Stephen J Kaplan, Steven H Mitchell, Medley Gatewood, Itay Bentov, Katherine A Bennett, Carol A Crawford, Paul R Sutton, Diane Matsuwaka, Mamatha Damodarasamy, May J Reed,

<h4>Background</h4>Older adults are more susceptible to adverse events when administered certain medications at doses appropriate for younger adults.<h4>Objective</h4>The aim of this study was to investigate the effect of default geriatric dosing on computerized physician order entry (CPOE) templates on the subsequent administration of recommended starting doses of opioids, benzodiazepines (BZDs) ... Read more >>

Drugs Aging (Drugs & aging)
[2017, 34(10):793-801]

Cited: 3 times

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Older adults and high-risk medication administration in the emergency department.

Mitchell Kim, Steven H Mitchell, Medley Gatewood, Katherine A Bennett, Paul R Sutton, Carol A Crawford, Itay Bentov, Mamatha Damodarasamy, Stephen J Kaplan, May J Reed,

Background:Older adults are susceptible to adverse effects from opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and benzodiazepines (BZDs). We investigated factors associated with the administration of elevated doses of these medications of interest to older adults (≥65 years old) in the emergency department (ED). Patients and methods:ED records were queried for the ... Read more >>

Drug Healthc Patient Saf (Drug, healthcare and patient safety)
[2017, 9:105-112]

Cited: 2 times

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Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging.

May J Reed, Robert B Vernon, Mamatha Damodarasamy, Christina K Chan, Thomas N Wight, Itay Bentov, William A Banks,

The microvasculature of the aged brain is less dense and more vulnerable to dysfunction than that of the young brain. Brain microvasculature is supported by its surrounding extracellular matrix, which is comprised largely of hyaluronan (HA). HA is continually degraded into lower molecular weight forms that induce neuroinflammation. We examined ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2017, 72(6):740-746]

Cited: 8 times

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Association of Radiologic Indicators of Frailty With 1-Year Mortality in Older Trauma Patients: Opportunistic Screening for Sarcopenia and Osteopenia.

Stephen J Kaplan, Tam N Pham, Saman Arbabi, Joel A Gross, Mamatha Damodarasamy, Itay Bentov, Lisa A Taitsman, Steven H Mitchell, May J Reed,

<h4>Importance</h4>Assessment of physical frailty in older trauma patients admitted to the intensive care unit is often not feasible using traditional frailty assessment instruments. The use of opportunistic computed tomography (CT) scans to assess sarcopenia and osteopenia as indicators of underlying frailty may provide complementary prognostic information on long-term outcomes.<h4>Objective</h4>To determine ... Read more >>

JAMA Surg (JAMA surgery)
[2017, 152(2):e164604]

Cited: 25 times

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Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts.

Itay Bentov, Mamatha Damodarasamy, Charles Spiekerman, May J Reed,

<h4>Background</h4>The aged are at increased risk of postoperative wound healing complications. Because local anesthetics are infiltrated commonly into the dermis of surgical wounds, we sought to determine whether local anesthetics adversely affect proliferative and biosynthetic functions of dermal fibroblasts. We also evaluated the effect of local anesthetics on insulin-like growth ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2016, 123(3):616-623]

Cited: 2 times

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Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit.

William A Banks, Alicia M Gray, Michelle A Erickson, Therese S Salameh, Mamatha Damodarasamy, Nader Sheibani, James S Meabon, Emily E Wing, Yoichi Morofuji, David G Cook, May J Reed,

<h4>Background</h4>Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain.<h4>Methods</h4>We used lipopolysaccharide (LPS) to induce inflammation and BBB disruption in mice. BBB disruption was measured using ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2015, 12:223]

Cited: 142 times

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Hyaluronan in aged collagen matrix increases prostate epithelial cell proliferation.

Mamatha Damodarasamy, Robert B Vernon, Christina K Chan, Stephen R Plymate, Thomas N Wight, May J Reed,

The extracellular matrix (ECM) of the prostate, which is comprised primarily of collagen, becomes increasingly disorganized with age, a property that may influence the development of hyperplasia and cancer. Collageous ECM extracted from the tails of aged mice exhibits many characteristics of collagen in aged tissues, including the prostate. When ... Read more >>

In Vitro Cell Dev Biol Anim (In vitro cellular & developmental biology. Animal)
[2015, 51(1):50-58]

Cited: 4 times

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Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds.

Mamatha Damodarasamy, Richard S Johnson, Itay Bentov, Michael J MacCoss, Robert B Vernon, May J Reed,

Age-related changes in the extracellular matrix contribute to delayed wound repair in aging. Hyaluronan, a linear nonsulfated glycosaminoglycan, promotes synthesis and assembly of key extracellular matrix components, such as the interstitial collagens, during wound healing. The biological effects of hyaluronan are mediated, in part, by hyaluronan size. We have previously ... Read more >>

Wound Repair Regen (Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society)
[2014, 22(4):521-526]

Cited: 19 times

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Decreased proliferative capacity of aged dermal fibroblasts in a three dimensional matrix is associated with reduced IGF1R expression and activation.

Itay Bentov, Mamatha Damodarasamy, Stephen Plymate, May J Reed,

Skin aging results in increased susceptibility to injury and impaired wound healing. Proliferation of fibroblasts is reduced in aged dermis, which contributes to delays in wound closure. Age-associated differences are regulated, in part, by local or systemic factors such as the IGF-1/IGF1R system. The aim of this study was to ... Read more >>

Biogerontology (Biogerontology)
[2014, 15(4):329-337]

Cited: 12 times

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B16/F10 tumors in aged 3D collagen in vitro simulate tumor growth and gene expression in aged mice in vivo.

Itay Bentov, Mamatha Damodarasamy, Stephen Plymate, May J Reed,

Although the incidence of cancer rises with age, tumor growth is often slowed in older hosts. The B16/F10 melanoma cell line is commonly used in murine models of age-related tumor growth suppression. We wished to determine if the growth pattern and gene expression of B16/10 tumors grown in aged mice ... Read more >>

In Vitro Cell Dev Biol Anim (In vitro cellular & developmental biology. Animal)
[2013, 49(6):395-399]

Cited: 3 times

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Cleavage of hyaluronan is impaired in aged dermal wounds.

May J Reed, Mamatha Damodarasamy, Christina K Chan, Matthew N R Johnson, Thomas N Wight, Robert B Vernon,

Changes in extracellular matrix (ECM) are one of many components that contribute to impaired wound healing in aging. This study examined the effect of age on the glycosaminoglycan hyaluronan (HA) in normal and wounded dermis from young (4-6 month-old) and aged (22-24 month-old) mice. HA content and size were similar ... Read more >>

Matrix Biol (Matrix biology : journal of the International Society for Matrix Biology)
[2013, 32(1):45-51]

Cited: 15 times

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Angiogenesis In Vitro Utilizing Murine Vascular Explants in Miniaturized 3-Dimensional Collagen Gels.

May J Reed, Mamatha Damodarasamy, Robert B Vernon,

Models of angiogenesis in vitro are used to study blood vessel morphogenesis and the effects of compounds that influence vascular growth. Herein, we describe techniques to induce angiogenesis-like sprouting from explants of mouse aortae and microvessels cultured in 3-dimensional gels of native type I collagen. The gels are supported by ... Read more >>

Open Circ Vasc J (The open circulation & vascular journal)
[2011, 4:12-17]

Cited: 2 times

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Collagen extracts derived from young and aged mice demonstrate different structural properties and cellular effects in three-dimensional gels.

Mamatha Damodarasamy, Robert B Vernon, Nathan Karres, Christopher H Chang, Daniella Bianchi-Frias, Peter S Nelson, May J Reed,

Three-dimensional (3D) type I collagen gels are increasingly utilized to simulate extracellular matrix (ECM) in vivo, but little is known about the effects of age on this model. Collagen was extracted from young (4-6 months) and aged (20-24 months) mice tails and compared. The collagens appeared similar by electrophoresis. However, ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2010, 65(3):209-218]

Cited: 17 times

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