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Author Malcolm G Semple

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Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.

Annemarie B Docherty, Ewen M Harrison, Christopher A Green, Hayley E Hardwick, Riinu Pius, Lisa Norman, Karl A Holden, Jonathan M Read, Frank Dondelinger, Gail Carson, Laura Merson, James Lee, Daniel Plotkin, Louise Sigfrid, Sophie Halpin, Clare Jackson, Carrol Gamble, Peter W Horby, Jonathan S Nguyen-Van-Tam, Antonia Ho, Clark D Russell, Jake Dunning, Peter Jm Openshaw, J Kenneth Baillie, Malcolm G Semple, ,

OBJECTIVE:To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave of this outbreak who were enrolled in the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2020, 369:m1985]

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The UK hibernated pandemic influenza research portfolio: triggered for COVID-19.

Colin R Simpson, Benjamin D Thomas, Kirsty Challen, Daniela De Angelis, Ellen Fragaszy, Steve Goodacre, Andrew Hayward, Wei Shen Lim, G James Rubin, Malcolm G Semple, Marian Knight, ,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, :]

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Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration.

Carlo Palmieri, Daniel Palmer, Peter Jm Openshaw, J Kenneth Baille, Malcolm G Semple, Lance Turtle,

ESMO Open (ESMO open)
[2020, 5(3):]

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COVID-19 infection in children.

Ian P Sinha, Rachel Harwood, Malcolm G Semple, Daniel B Hawcutt, Rebecca Thursfield, Omendra Narayan, Simon E Kenny, Russell Viner, Simon Langton Hewer, Kevin W Southern,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(5):446-447]

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Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease.

Paul J Steptoe, Fayiah Momorie, Alimamy D Fornah, Patrick Komba, Elizabeth Emsley, Janet T Scott, Samantha J Williams, Simon P Harding, Matthew J Vandy, Foday Sahr, Nicholas A V Beare, Malcolm G Semple,

Importance:The 2-year ophthalmic sequelae of Ebola virus disease (EVD) in survivors of the 2013 to 2016 epidemic is unknown and may have public health implications for future outbreaks. Objective:To assess the potential for uveitis recurrence, the behavior of dark without pressure, and visual outcomes in a cohort of Sierra Leonean ... Read more >>

JAMA Ophthalmol (JAMA ophthalmology)
[2020, :]

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Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.

Weiyong Liu, Qi Zhang, Junbo Chen, Rong Xiang, Huijuan Song, Sainan Shu, Ling Chen, Lu Liang, Jiaxin Zhou, Lei You, Peng Wu, Bo Zhang, Yanjun Lu, Liming Xia, Lu Huang, Yang Yang, Fang Liu, Malcolm G Semple, Benjamin J Cowling, Ke Lan, Ziyong Sun, Hongjie Yu, Yingle Liu,

N. Engl. J. Med. (The New England journal of medicine)
[2020, 382(14):1370-1371]

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The UK's pandemic influenza research portfolio: a model for future research on emerging infections.

Colin R Simpson, Dan Beever, Kirsty Challen, Daniela De Angelis, Ellen Fragaszy, Steve Goodacre, Andrew Hayward, Wei Shen Lim, G James Rubin, Malcolm G Semple, Marian Knight, ,

The 2009 influenza A H1N1 pandemic was responsible for considerable global morbidity and mortality. In 2009, several research studies in the UK were rapidly funded and activated for clinical and public health actions. However, some studies were too late for their results to have an early and substantial effect on ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2019, 19(8):e295-e300]

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Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Jake Dunning, Simon Blankley, Long T Hoang, Mike Cox, Christine M Graham, Philip L James, Chloe I Bloom, Damien Chaussabel, Jacques Banchereau, Stephen J Brett, , Miriam F Moffatt, Anne O'Garra, Peter J M Openshaw,

In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE project 602525. The error has been corrected in the HTML and PDF version of the article. ... Read more >>

Nat. Immunol. (Nature immunology)
[2019, 20(3):373]

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Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease.

Paul J Steptoe, Fayiah Momorie, Alimamy D Fornah, Sahr P Komba, Elizabeth Emsley, Janet T Scott, Simon P Harding, Matthew J Vandy, Foday Sahr, Nicholas A V Beare, Malcolm G Semple,

Importance:Differentiation between Ebola retinal lesions and other retinal pathologies in West Africa is important, and the pathogenesis of Ebola retinal disease remains poorly understood. Objective:To describe the appearance of Ebola virus disease (EVD) retinal lesions using multimodal imaging to enable inferences on potential pathogenesis. Design, Setting, and Participants:This prospective case ... Read more >>

JAMA Ophthalmol (JAMA ophthalmology)
[2018, 136(6):689-693]

Cited: 1 time

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Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Jake Dunning, Simon Blankley, Long T Hoang, Mike Cox, Christine M Graham, Philip L James, Chloe I Bloom, Damien Chaussabel, Jacques Banchereau, Stephen J Brett, Miriam F Moffatt, Anne O'Garra, Peter J M Openshaw, ,

Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data were obtained by MOSAIC investigators. Signatures ... Read more >>

Nat. Immunol. (Nature immunology)
[2018, 19(6):625-635]

Cited: 9 times

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Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone.

Patrick J Howlett, Anna R Walder, Durodami R Lisk, Felicity Fitzgerald, Stephen Sevalie, Marta Lado, Abdul N'jai, Colin S Brown, Foday Sahr, Foday Sesay, Jonathon M Read, Paul J Steptoe, Nicholas A V Beare, Reena Dwivedi, Marylou Solbrig, Gibrilla F Deen, Tom Solomon, Malcolm G Semple, Janet T Scott,

We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2018, 24(8):1412-1421]

Cited: 2 times

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Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE): protocol for a double-blind, randomised, placebo-controlled trial.

Kay Wang, Tricia Carver, Sharon Tonner, Malcolm G Semple, Alastair D Hay, Michael Moore, Paul Little, Christopher Butler, Andrew Farmer, Rafael Perera, Ly-Mee Yu, Susan Mallett, Jane Wolstenholme, Anthony Harnden,

INTRODUCTION:Influenza and influenza-like illness (ILI) create considerable burden on healthcare resources each winter. Children with pre-existing conditions such as asthma, diabetes mellitus and cerebral palsy are among those at greatest risk of clinical deterioration from influenza/ILI. The Antibiotics for at Risk CHildren with InfluEnza (ARCHIE) trial aims to determine whether ... Read more >>

BMJ Open (BMJ open)
[2018, 8(5):e021144]

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Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone.

Richard S Tedder, Dhan Samuel, Steve Dicks, Janet T Scott, Samreen Ijaz, Catherine C Smith, Charlene Adaken, Christine Cole, Samuel Baker, Tansy Edwards, Philip Kamara, Osman Kargbo, Saidia Niazi, Davis Nwakanma, Umberto d'Alessandro, Graham Burch, Heidi Doughty, Colin S Brown, Nick Andrews, Judith R Glynn, Johan van Griensven, , Georgios Pollakis, William A Paxton, Malcolm G Semple,

BACKGROUND:Passive therapy with convalescent plasma provides an early opportunity to intervene in Ebola virus disease (EVD). Methods for field screening and selection of potential donors and quantifying plasma antibody are needed. STUDY DESIGN AND METHODS:Recombinant Ebola virus glycoprotein (EBOV GP) was formatted into immunoglobulin G-capture, competitive, and double-antigen bridging enzyme ... Read more >>

Transfusion (Transfusion)
[2018, 58(5):1289-1298]

Cited: 3 times

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Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children.

Gemma L Saint, Malcolm G Semple, Ian Sinha, Daniel B Hawcutt,

Optimizing the management of children presenting with acute severe asthma is of utmost importance to minimize hospital stays, morbidity, and mortality. Intravenous medications, including theophyllines, are used as second-line treatments for children experiencing a life-threatening exacerbation. For intravenous theophylline (aminophylline), guidelines and formularies recommend a target therapeutic range between 10 ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2018, 20(3):209-214]

Cited: 1 time

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Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (Ophthalmology. 2017;124:170-177).

Paul J Steptoe, Janet T Scott, Foday Sahr, Matthew Vandy, Simon P Harding, Nicholas A V Beare, Malcolm G Semple,

Ophthalmology (Ophthalmology)
[2018, 125(3):e19]

Cited: 0 times

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Visual Disability in Ebola Survivors.

Paul J Steptoe, Nicholas A V Beare, Alimamy D Fornah, Fayiah Momorie, Patrick Komba, Matthew Vandy, Malcolm G Semple,

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 66(8):1318-1319]

Cited: 0 times

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Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma.

Rebecca L Cordell, Thalassa S E Valkenburg, Hitesh C Pandya, Daniel B Hawcutt, Malcolm G Semple, Paul S Monks,

OBJECTIVES:A novel gas chromatography-mass spectrometry (GC-MS) method has been developed to quantify salbutamol in micro-volumes (10 µL) of blood. A potential application is paediatric therapeutic dose monitoring (TDM) in acute severe asthma. METHODS:At presentation, the children receive multiple doses of salbutamol (inhaled, nebulised and occasionally intravenous) but it is difficult to ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2018, 55(11):1205-1213]

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Disability Among Ebola Survivors and Their Close Contacts in Sierra Leone: A Retrospective Case-Controlled Cohort Study.

Soushieta Jagadesh, Stephen Sevalie, Richard Fatoma, Foday Sesay, Foday Sahr, Brian Faragher, Malcolm G Semple, Tom E Fletcher, Ralf Weigel, Janet T Scott,

Ebola survivors (21/27 [77.8%]) suffered more disability than their close contacts (6/54 [11.1%]) (adjusted odds ratio, 23.5 [95% confidence interval, 6.5-85.7]; P < .001) when measured by the Washington Group Disability Extended Questionnaire. Major limitations in vision, mobility, cognition, and affect were observed in survivors 1 year following the 2014-2016 ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 66(1):131-133]

Cited: 4 times

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Suction versus no suction for chest drain management.

Clare van Miert, Kerry Dwan, Rebecca Hill, Michel R Hoenig, Russell L Gruen, Malcolm G Semple,

AbstractThis is a protocol for a Cochrane Review (Intervention). The objectives are as follows:In any age group or pathology requiring an intrathoracic chest drain does the addition of suction improve clinical outcomes?In draining the pleural space using underwater seal, one‐way valve (or any other type of drain identified from the ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2017, 2017(11):]

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Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016.

Paul J Steptoe, Janet T Scott, Julia M Baxter, Craig K Parkes, Rahul Dwivedi, Gabriela Czanner, Matthew J Vandy, Fayiah Momorie, Alimamy D Fornah, Patrick Komba, Jade Richards, Foday Sahr, Nicholas A V Beare, Malcolm G Semple,

We conducted a case-control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2017, 23(7):1102-1109]

Cited: 11 times

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Ocular Complications in Survivors of the Ebola Outbreak in Guinea.

Paul J Steptoe, Janet T Scott, Simon P Harding, Nicholas A V Beare, Malcolm G Semple, Matthew J Vandy, Foday Sahr,

Am. J. Ophthalmol. (American journal of ophthalmology)
[2017, 181:180]

Cited: 0 times

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Reply to Lee and colleagues-Viral posterior uveitis.

Paul J Steptoe, Janet T Scott, Malcolm G Semple,

Surv Ophthalmol (Survey of ophthalmology)
[2017, 62(6):886-887]

Cited: 0 times

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Ebola virus disease sequelae: a challenge that is not going away.

Janet T Scott, Malcolm G Semple,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2017, 17(5):470-471]

Cited: 2 times

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Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus.

Judith R Glynn, Hilary Bower, Sembia Johnson, Catherine F Houlihan, Carla Montesano, Janet T Scott, Malcolm G Semple, Mohammed S Bangura, Alie Joshua Kamara, Osman Kamara, Saidu H Mansaray, Daniel Sesay, Cecilia Turay, Steven Dicks, Raoul E Guetiya Wadoum, Vittorio Colizzi, Francesco Checchi, Dhan Samuel, Richard S Tedder,

BACKGROUND:The frequency of asymptomatic infection with Ebola virus is unclear: previous estimates vary and there is no standard test. Asymptomatic infection with Ebola virus could contribute to population immunity, reducing spread. If people with asymptomatic infection are infectious it could explain re-emergences of Ebola virus disease (EVD) without known contact. ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2017, 17(6):645-653]

Cited: 28 times

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Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies.

Johan van Griensven, Tansy Edwards, Sylvain Baize, ,

N. Engl. J. Med. (The New England journal of medicine)
[2016, 375(23):2307-2309]

Cited: 13 times

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