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Author Makoto Yono

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Clinical diagnostic criteria for detrusor underactivity: A report from the Japanese Continence Society working group on underactive bladder.

Masaki Yoshida, Naritoshi Sekido, Yoshihisa Matsukawa, Makoto Yono, Osamu Yamaguchi,

Detrusor underactivity (DU) is a common bladder dysfunction that causes lower urinary tract symptoms (LUTS) in both men and women. Currently DU can only be diagnosed by an invasive urodynamic test. Underactive bladder (UAB) is the symptom-based correlate of DU, as is the case with overactive bladder (OAB) and detrusor ... Read more >>

Low Urin Tract Symptoms (Lower urinary tract symptoms)
[2020, :]

Cited: 0 times

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TAS-303 effects on urethral sphincter function in women with stress urinary incontinence: phase I study.

Makoto Yono, Shin Irie, Momokazu Gotoh,

INTRODUCTION AND HYPOTHESIS:TAS-303, which selectively inhibits noradrenaline reuptake, was developed for treating stress urinary incontinence (SUI). The proximal urethra mainly comprises smooth muscle fibers in which α1 adrenergic receptors are abundant. This study was conducted to evaluate the effect of TAS-303 on urethral function and its safety profile in female ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2020, :]

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Variability of post-void residual urine volume and bladder voiding efficiency in patients with underactive bladder.

Makoto Yono, Kazuya Ito, Megumi Oyama, Takanori Tanaka, Shin Irie, Yoshihisa Matsukawa, Noritoshi Sekido, Masaki Yoshida, Olivier van Till, Osamu Yamaguchi,

OBJECTIVES:Post-void residual urine volume (PVR) and bladder voiding efficiency (BVE) are widely used as clinical parameters to evaluate patients with voiding dysfunction. The present study was conducted to assess the variability of PVR and BVE determinations in patients with underactive bladder (UAB). In addition, we focused on the bladder volume ... Read more >>

Low Urin Tract Symptoms (Lower urinary tract symptoms)
[2020, :]

Cited: 0 times

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Phase I study of KRP-116D, a 50% w/w dimethyl sulfoxide aqueous solution, on the systemic absorption from bladder by intravesical instillation in healthy Japanese subjects.

Hideyo Shimada, Makoto Yono, Yuya Hojo, Yuka Hamamura, Atsushi Ootsuki,

OBJECTIVE:This was a single-institution, single-dose, single-arm phase 1 study in healthy adult males to evaluate the safety and absorption of dimethyl sulfoxide (DMSO) from the bladder into the body when KRP-116D (a 50% w/w DMSO solution) was intravesically administered and allowed to remain in the bladder for 15 minutes. METHODS:Six healthy ... Read more >>

Low Urin Tract Symptoms (Lower urinary tract symptoms)
[2020, 12(2):150-154]

Cited: 1 time

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Clinical characteristics and useful signs to differentiate detrusor underactivity from bladder outlet obstruction in men with non-neurogenic lower urinary tract symptoms.

Yoshihisa Matsukawa, Masaki Yoshida, Osamu Yamaguchi, Shun Takai, Tsuyoshi Majima, Yasuhito Funahashi, Makoto Yono, Noritoshi Sekido, Momokazu Gotoh,

OBJECTIVE:To investigate the clinical characteristics and useful signs to differentiate detrusor underactivity from bladder outlet obstruction in men with non-neurogenic lower urinary tract symptoms. METHODS:A total of 638 treatment-naive men with non-neurogenic lower urinary tract symptoms who underwent subjective and objective evaluations were reviewed retrospectively. We divided the patients into ... Read more >>

Int. J. Urol. (International journal of urology : official journal of the Japanese Urological Association)
[2020, 27(1):47-52]

Cited: 0 times

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Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes.

Tadahiro Shinozawa, Koki Nakamura, Masanobu Shoji, Maya Morita, Maya Kimura, Hatsue Furukawa, Hiroki Ueda, Masanari Shiramoto, Kyoko Matsuguma, Yoshikazu Kaji, Ippei Ikushima, Makoto Yono, Shyh-Yuh Liou, Hirofumi Nagai, Atsushi Nakanishi, Keiji Yamamoto, Seigo Izumo,

To predict drug-induced serious adverse events (SAE) in clinical trials, a model using a panel of cells derived from human induced pluripotent stem cells (hiPSCs) of individuals with different susceptibilities could facilitate major advancements in translational research in terms of safety and pharmaco-economics. However, it is unclear whether hiPSC-derived cells ... Read more >>

Stem Cell Reports (Stem cell reports)
[2017, 8(2):226-234]

Cited: 11 times

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Effect of Duloxetine on Urethral Resting Pressure and on Sphincter Contractility in Response to Coughing and Magnetic Stimulation in Healthy Women.

Makoto Yono, Masayuki Otani, Kazuya Ito, Yumi Inoue, Kohichiro Furukawa, Masaharu Hori, Shigeki Tsuji, Takanori Tanaka, Yukikuni Sakata, Shin Irie,

As a proof-of-mechanism (POM) study of drugs developed to treat stress urinary incontinence (SUI) has not been conducted, this urodynamic study in healthy women was performed to determine an appropriate method to confirm POM, and to evaluate the effect of duloxetine, a serotonin and noradrenaline reuptake inhibitor, on urethral resting ... Read more >>

Low Urin Tract Symptoms (Lower urinary tract symptoms)
[2015, 7(2):93-98]

Cited: 1 time

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A comparison of the expression and contractile function of α1-adrenoceptors in seminal vesicle and vas deferens from normotensive and hypertensive rats.

Makoto Yono, Takanori Tanaka, Shigeki Tsuji, Masaharu Hori, Shin Irie, Yukikuni Sakata, Masayuki Otani, Masaki Yoshida, Jamshid Latifpour,

Because hypertension related alterations occur in the properties of α(1)-adrenoceptor in several mammalian tissues and hypertension may impact ejaculatory function, we investigated hypertension related alterations in the functional, biochemical and molecular properties of α(1)-adrenoceptor in the rat seminal vesicle and vas deferens. Spontaneous seminal emission in male spontaneously hypertensive rats ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2012, 694(1-3):104-110]

Cited: 2 times

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Neuronal Nitric Oxide Synthase Gene Transfer into the Rat Prostate Using In Vivo Electroporation.

Masayuki Otani, Masaki Yoshida, Koichi Masunaga, Takashi Nagata, Makoto Yono, Yukio Homma,

It has been reported that nitric oxide (NO) mainly contributes to prostate or urethral smooth muscles relaxation, and that nitrergic innervation and neuronal NO synthase (nNOS) levels are decreased in benign prostatic hyperplasia. The purpose of the present study was to evaluate the feasibility to gene therapy for benign prostatic ... Read more >>

Low Urin Tract Symptoms (Lower urinary tract symptoms)
[2010, 2(2):83-87]

Cited: 0 times

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The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: pathophysiology and pharmacotherapy of overactive bladder.

Masaki Yoshida, Koichi Masunaga, Takashi Nagata, Makoto Yono, Yukio Homma,

Overactive bladder (OAB) syndrome, which is characterized by a complex of storage symptoms (urinary urgency, frequency, nocturia, and urgency incontinence) is highly prevalent within the general population, causing major distress to patients in terms of their psychosocial and physical functioning. Muscarinic receptors of bladder smooth muscles are involved in both ... Read more >>

J. Pharmacol. Sci. (Journal of pharmacological sciences)
[2010, 112(2):128-134]

Cited: 21 times

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Identification of potential therapeutic targets in hypertension-associated bladder dysfunction.

Makoto Yono, Masaki Yoshida, Yasuhiro Yamamoto, Aya Imanishi, Atsushi Fukagawa, Jamshid Latifpour, Masatoshi Eto,

OBJECTIVE: To investigate differential gene expression profiles in the bladder of spontaneously hypertensive rat (SHR), as the underlying mechanisms involved in hypertension-associated bladder dysfunction remain to be clarified. MATERIALS AND METHODS: SHR and normotensive Wistar-Kyoto (WKY) rats were distributed initially in three groups: group 1 received doxazosin (30 mg/kg/day); group ... Read more >>

BJU Int. (BJU international)
[2010, 105(6):877-883]

Cited: 4 times

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Molecular mechanisms regulating urogenital expression of nitric oxide synthase in spontaneously hypertensive rats.

Makoto Yono, Masaki Yoshida, Yasuhiro Yamamoto, Aya Imanishi, Atsushi Fukagawa, Jamshid Latifpour, Masatoshi Eto,

AIMS: Although doxazosin, but not nifedipine, can partially prevent a decrease in urogenital expression of nitric oxide synthase (NOS) in spontaneously hypertensive rats (SHRs), the mechanisms involved in the regulated expression of NOS are not known. Therefore, we identified differential gene expression profiles in SHRs to elucidate the molecular mechanisms ... Read more >>

Life Sci (Life sciences)
[2009, 85(7-8):334-338]

Cited: 2 times

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Short- and long-term effects of silodosin, a selective alpha 1A-adrenoceptor antagonist, on ejaculatory function in rats.

Makoto Yono, Yasuhiro Yamamoto, Aya Imanishi, Atsushi Fukagawa, Jamshid Latifpour, Masaki Yoshida,

OBJECTIVE: To investigate the short- and long-term effects of silodosin, a selective alpha(1A)-adrenoceptor antagonist, on spontaneous seminal emission by isolated rats and on the properties of alpha(1)-adrenoceptor subtypes in the rat seminal vesicle, as silodosin produces a relatively high incidence rate of abnormal ejaculation and chronic administration of receptor antagonists ... Read more >>

BJU Int. (BJU international)
[2009, 103(12):1680-1685]

Cited: 3 times

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Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats.

Makoto Yono, Shrikant M Mane, Aiping Lin, Robert M Weiss, Jamshid Latifpour,

We investigated molecular changes in the response to insulin in prostates of spontaneously developed (Bio Breeding) and streptozotocin (STZ)-induced diabetic rats that received sufficient amounts (euglycemic group), or suboptimal doses (hyperglycemic group) of insulin for 32 weeks, using Affymetrix GeneChip analysis of gene expression. Alterations in gene expression levels identified ... Read more >>

Life Sci. (Life sciences)
[2008, 83(5-6):192-197]

Cited: 9 times

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Region and age dependent differences in alpha(1)-adrenergic responsiveness of rat seminal vesicle and vas deferens.

Makoto Yono, Jamshid Latifpour, Yasuhiro Yamamoto, Aya Imanishi, Masaki Yoshida,

Because age dependent differences occur in the incidence of ejaculatory dysfunction with alpha(1)-adrenoceptor antagonists used to treat lower urinary tract symptoms secondary to benign prostatic hyperplasia, we investigated age related changes in the functional, biochemical and molecular properties of alpha(1)-adrenoceptor in the rat seminal vesicle and vas deferens. The characteristics ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2008, 587(1-3):291-295]

Cited: 5 times

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Age related changes in the functional, biochemical and molecular properties of alpha1-adrenoceptors in the rat genitourinary tract.

Makoto Yono, Harris E Foster, Robert M Weiss, Jamshid Latifpour,

PURPOSE: Because age related changes occur in the properties of alpha(1)-adrenoceptor in several mammalian tissues and alpha(1)-adrenoceptor antagonists are extensively used to treat lower urinary tract symptoms secondary to benign prostatic hyperplasia, we investigated age related changes in the functional, biochemical and molecular properties of alpha(1)-adrenoceptor in the rat genitourinary ... Read more >>

J. Urol. (The Journal of urology)
[2006, 176(3):1214-1219]

Cited: 12 times

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Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes.

Makoto Yono, Mehdi Pouresmail, Wataru Takahashi, Joan F Flanagan, Robert M Weiss, Jamshid Latifpour,

To examine the differences between spontaneous and streptozotocin (STZ)-induced diabetes, four parallel studies were performed; three studies of diabetes-prone BB (BBDP/Wor) rats maintained for 8, 16, and 32 weeks and one study of STZ-injected diabetes-resistant BB (BBDR/Wor) rats maintained for 32 weeks. Each diabetic study has three groups of rats: ... Read more >>

Naunyn Schmiedebergs Arch. Pharmacol. (Naunyn-Schmiedeberg's archives of pharmacology)
[2005, 372(3):251-255]

Cited: 15 times

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Effects of chronic administration of doxazosin on alpha1-adrenoceptors in the rat prostate.

Harris E Foster, Makoto Yono, David Shin, Wataru Takahashi, Mehdi Pouresmail, Parviz Afiatpour, Jamshid Latifpour,

PURPOSE:Although the clinical efficacy of alpha1-adrenoceptor (alpha1-AR) antagonists for the treatment of benign prostatic hyperplasia is not disputed, their mechanism of action and ability to maintain long-term effectiveness have only recently been investigated. Since it is known that chronic administration of receptor antagonists causes up-regulation in the targeted receptor, we ... Read more >>

J. Urol. (The Journal of urology)
[2004, 172(6 Pt 1):2465-2470]

Cited: 14 times

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Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract.

Makoto Yono, Harris E Foster, David Shin, Wataru Takahashi, Mehdi Pouresmail, Jamshid Latifpour,

Alpha1-adrenoceptor (AR) antagonists can provide effective treatment of symptoms caused by benign prostatic hyperplasia. However, their mechanisms of action have not been fully elucidated. We previously reported that chronic administration of doxazosin causes an up-regulation in the mRNA expression of all three alpha1-AR subtypes in the rat prostate. As alpha1-AR ... Read more >>

Can. J. Physiol. Pharmacol. (Canadian journal of physiology and pharmacology)
[2004, 82(10):872-878]

Cited: 15 times

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Molecular classification of doxazosin-induced alterations in the rat prostate using gene expression profiling.

Makoto Yono, Harris E Foster, David Shin, Shrikant Mane, Jamshid Latifpour,

We investigated molecular changes that occurred during chronic administration of doxazosin, an alpha1-adrenoceptor (AR) antagonist, using Affymetrix GeneChip analysis of gene expression. Rats were treated with doxazosin (4 mg/kg/day subcutaneously, supplemented with 4 mg/kg/day orally) for 12 weeks. Labeled cRNA was prepared and the subsequent hybridization to rat 230A arrays ... Read more >>

Life Sci (Life sciences)
[2005, 77(4):470-479]

Cited: 9 times

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Age-related alterations in the biochemical and functional properties of the bladder in type 2 diabetic GK rats.

Makoto Yono, Jamshid Latifpour, Masaki Yoshida, Shoichi Ueda,

Previous studies have demonstrated that experimental type 1 diabetes induced by streptozotocin causes alterations in the biochemical and functional properties of several receptor systems in the rat bladder. However, the exact mechanism involved in the pathophysiology of voiding dysfunction in type 2 diabetic patients is unknown. Because the GK rat ... Read more >>

J. Recept. Signal Transduct. Res. (Journal of receptor and signal transduction research)
[2005, 25(3):147-157]

Cited: 12 times

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Doxazosin treatment causes differential alterations of alpha 1-adrenoceptor subtypes in the rat kidney, heart and aorta.

Makoto Yono, Harris E Foster, David Shin, Wataru Takahashi, Mehdi Pouresmail, Jamshid Latifpour,

We have previously demonstrated that long-term administration of doxazosin, an alpha(1)-adrenoceptor (alpha(1)-AR) antagonist, causes an up-regulation in the expression of alpha(1)-AR subtype mRNAs in the rat genitourinary tract and suggested that these changes may affect long-term effectiveness of alpha(1)-AR antagonists when used to treat the lower urinary tract symptoms of ... Read more >>

Life Sci. (Life sciences)
[2004, 75(21):2605-2614]

Cited: 10 times

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Age-related changes in the properties of the endothelin receptor system at protein and mRNA levels in the rat vas deferens.

Makoto Yono, Jamshid Latifpour, Wataru Takahashi, Mehdi Pouresmail, Parviz Afiatpour, Robert M Weiss,

As age-related changes occur in the properties of the endothelin (ET) receptor system in several mammalian tissues, and as there are significant amounts of functional ET receptors in the vas deferens, we investigated the age-related changes in the ET receptor system at the protein and mRNA levels in the rat ... Read more >>

J. Recept. Signal Transduct. Res. (Journal of receptor and signal transduction research)
[2004, 24(1-2):53-66]

Cited: 4 times

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Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors.

Parviz Afiatpour, Jamshid Latifpour, Wataru Takahashi, Makoto Yono, Harris E Foster, Kazuyoshi Ikeda, Mehdi Pouresmail, Robert M Weiss,

The effect of aging on functional, biochemical, anatomical and molecular properties of endothelin (ET) receptors in bladder smooth muscle of the 3-week-, 3-month- and 22-month-old rats was examined using isolated muscle bath techniques, radioligand binding on membrane particulates and slide mounted tissue sections, and real-time reverse transcription polymerase chain reaction ... Read more >>

Naunyn Schmiedebergs Arch. Pharmacol. (Naunyn-Schmiedeberg's archives of pharmacology)
[2003, 367(5):462-472]

Cited: 10 times

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Quantification of endothelins, their receptors, and endothelin-converting enzyme mRNAs in rat genitourinary tract using real-time RT-PCR.

Makoto Yono, Wataru Takahashi, Mehdi Pouresmail, David R Johnson, Harris E Foster, Robert M Weiss, Jamshid Latifpour,

INTRODUCTION:Quantification of mRNA expression is essential for the assessment of endothelin (ET) receptor-mediated mechanisms. Recently, a novel technique for the determination of mRNA expression, termed real-time reverse transcription polymerase chain reaction (RT-PCR), has been developed. We therefore applied real-time PCR using SYBR Green I to quantify ET-1, ET-3, ET-converting enzyme-1 ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2002, 48(2):87-95]

Cited: 19 times

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