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Author Makoto Saito

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Monitoring Acetylation of the RNA Helicase DDX3X, a Protein Critical for Formation of Stress Granules.

Makoto Saito, Vytautas Iestamantavicius, Daniel Hess, Patrick Matthias,

Stress granules are dynamic structures that assemble in response to various forms of stress, such as heat shock or oxidative stress, among others. We had previously shown that the lysine deacetylase HDAC6 is required for the formation of stress granules, but the substrate important for this function was not known. ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2209:217-234]

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An outbreak of USA300 MRSA among people with HIV in Japan.

Kazuhiko Ikeuchi, Eisuke Adachi, Takashi Sasaki, Masato Suzuki, Lay Ahyoung Lim, Makoto Saito, Michiko Koga, Takeya Tsutsumi, Yasutoshi Kido, Yuki Uehara, Hiroshi Yotsuyanagi,

BACKGROUND:USA300 produces Panton-Valentin leucocidin (PVL), and is known as a predominant community-associated methicillin-resistant Staphylococcus aureus (MRSA) strain in the United States, but it was extremely rare in Japan. We report here an outbreak of USA300 in people with HIV (PWH) in Tokyo, Japan. METHODS:We analyzed the cases of PVL-MRSA infection ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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Phase 2 Clinical Trial of Stereotactic Body Radiation Therapy for Painful Nonspine Bone Metastases.

Kei Ito, Yujiro Nakajima, Tsuyoshi Onoe, Hiroaki Ogawa, Hideyuki Harada, Makoto Saito, Katsuyuki Karasawa,

PURPOSE:The present multicenter, single-arm, phase 2 study aimed to prospectively evaluate the palliative efficacy of stereotactic body radiation therapy (SBRT) in patients with painful nonspine bone metastases. METHODS AND MATERIALS:Patients with painful (≥2 points on a 0-to-10 scale) nonspine bone metastases from a solid tumor were enrolled. The prescribed dose ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2020, :]

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Association of coagulopathy with liver dysfunction in patients with COVID-19.

Takeya Tsutsumi, Makoto Saito, Hiroyuki Nagai, Shinya Yamamoto, Kazuhiko Ikeuchi, Lay Ahyoung Lim, Eisuke Adachi, Michiko Koga, Kazuya Okushin, Hiroyuki Akai, Akira Kunimatsu, Hiroshi Yotsuyanagi,

AIM:Liver dysfunction is sometimes observed in patients with coronavirus disease 2019 (COVID-19), but most studies are from China, and the frequency in other countries is unclear. In addition, previous studies suggested several mechanisms of liver damage, but precise or additional mechanisms are not clearly elucidated. Therefore, we examined COVID-19 patients ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, :]

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Nationwide Survey of Late-onset Hemolysis in Very Low Birth Weight Infants.

Yayoi Miyazono, Junichi Arai, Yu Kanai, Daisuke Hitaka, Daigo Kajikawa, Shusuke Takeuchi, Motomichi Nagafuji, Satoshi Fujiyama, Makoto Saito, Hidetoshi Takada,

BACKGROUND:In Japan, some cases of late-onset acute hemolysis in very low birth weight (VLBW) infants have been reported. These cases had common features, but the cause of hemolysis was unknown. In addition, the incidence and prognosis of this disease are unknown. However, there are only few reports of such hemolytic ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, :]

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Antibody response to SARS-CoV-2 in people living with HIV.

Shinya Yamamoto, Makoto Saito, Etsuko Nagai, Keiko Toriuchi, Hiroyuki Nagai, Hiroshi Yotsuyanagi, Yu Nakagama, Yasutoshi Kido, Eisuke Adachi,

J Microbiol Immunol Infect (Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi)
[2020, :]

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Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs.

Makoto Saito, Valérie Briand, Aung Myat Min, Rose McGready,

All malaria infections are harmful to both the pregnant mother and the developing fetus. One in ten maternal deaths in malaria endemic countries are estimated to result from Plasmodium falciparum infection. Malaria is associated with a 3-4 times increased risk of miscarriage and a substantially increased risk of stillbirth. Current ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(10):761-774]

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Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing.

Julia Joung, Alim Ladha, Makoto Saito, Nam-Gyun Kim, Ann E Woolley, Michael Segel, Robert P J Barretto, Amardeep Ranu, Rhiannon K Macrae, Guilhem Faure, Eleonora I Ioannidi, Rohan N Krajeski, Robert Bruneau, Meei-Li W Huang, Xu G Yu, Jonathan Z Li, Bruce D Walker, Deborah T Hung, Alexander L Greninger, Keith R Jerome, Jonathan S Gootenberg, Omar O Abudayyeh, Feng Zhang,

N Engl J Med (The New England journal of medicine)
[2020, 383(15):1492-1494]

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A high-resolution, spatially explicit estimate of fossil-fuel CO2 emissions from the Tokyo Metropolis, Japan

Richao Cong, Makoto Saito, Tetsuo Fukui, Ryuichi Hirata, Akihiko Ito,

Abstract Background: The quantification of urban greenhouse gas (GHG) emissions is an important task in combating climate change. Emission inventories that include spatially explicit emission estimates facilitate the accurate tracking of emission changes, identification of emission sources, and formulation of policies for climate-change mitigation. Many currently available gridded emission estimates ... Read more >>

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Seroconversion against SARS-CoV-2 occurred after the recovery in patients with COVID-19.

Shinya Yamamoto, Makoto Saito, Etsuko Nagai, Keiko Toriuchi, Hiroyuki Nagai, Hiroshi Yotsuyanagi, Yu Nakagama, Yasutoshi Kido, Eisuke Adachi,

J Med Virol (Journal of medical virology)
[2020, :]

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Semiquantitative assessment of the relative apical sparing pattern of longitudinal strain for cardiac amyloidosis identification.

Makoto Saito, Misaki Imai, Daisuke Wake, Rieko Higaki, Yasuhisa Nakao, Takumi Sumimoto, Yuki Yokomoto, Akiyoshi Ogimoto, Moeko Suzuki, Hideo Kawakami, Go Hiasa, Hideki Okayama, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi,

BACKGROUNDS:The relative apical sparing pattern (RASP) of left ventricular (LV) longitudinal strain (LS) is frequently associated with cardiac amyloidosis (CA). However, the visual assessment of RASP is inconsistent, and the quantitative assessment of RASP is time-consuming. This study aimed to compare assessments of RASP for the identification of CA with ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2020, :]

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Estimation of the effects of inset heights and slit configurations in an acetabular cup on the pull-out behavior of an artificial hip joint with a structure for preventing dislocation using finite element analysis.

Yuki Kawamura, Mitsushi Ohmasa, Takayuki Kobayashi, Yoshihito Matsufuji, Makoto Saito, Yoshinori Uwa, Saiji Washio, Ei Yamamoto,

Joint dislocation is a critical problem of total hip replacement. We have newly proposed an artificial hip joint with a structure that prevents dislocation. The proposed joint has a simple form with a femoral head partially covered with an acetabular cup. In the present study, the effects of inset heights ... Read more >>

Med Biol Eng Comput (Medical & biological engineering & computing)
[2020, 58(10):2587-2601]

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Infiltrative Shadows in COVID-19: Pneumonia or Pulmonary Embolism?

Hiroyuki Nagai, Shinya Yamamoto, Makoto Saito, Eisuke Adachi,

Intern Med (Internal medicine (Tokyo, Japan))
[2020, 59(19):2443-2444]

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Disseminated Gonococcal Infection Associated with Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria: A Case Report and Literature Review.

Makoto Saito, Shinpei Harada, Reiki Ogasawara, Koh Izumiyama, Akio Mori, Masanobu Morioka, Takeshi Kondo,

Eculizumab has been developed as a breakthrough treatment for paroxysmal nocturnal hemoglobinuria (PNH). Not only for breakthroughs, eculizumab therapy is also known to increase the risk of invasive meningococcal infection. It has also been recently reported that, although rarely, administration of eculizumab may result in disseminated gonococcal infection (DGI). We ... Read more >>

Int J Gen Med (International journal of general medicine)
[2020, 13:403-406]

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Relative Bradycardia in Patients with Mild-to-Moderate Coronavirus Disease, Japan.

Kazuhiko Ikeuchi, Makoto Saito, Shinya Yamamoto, Hiroyuki Nagai, Eisuke Adachi,

Coronavirus disease is reported to affect the cardiovascular system. We showed that relative bradycardia was a common characteristic for 54 patients with PCR-confirmed mild-to-moderate coronavirus disease in Japan. This clinical sign could help clinicians to diagnose this disease. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2020, 26(10):2504-2506]

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Refractive state and visual acuity of children with extremely low birth weight at 3 years old in Japan.

Takako Tachikawa, Ritsuko Ueno, Tetsuko Mita, Daisuke Yuzurihara, Osamu Katsumi, Toru Noda, Makoto Saito,

PURPOSE:To investigate the refractive status and visual acuity of 3-year-old children with extremely low birth weight (ELBW). STUDY DESIGN:Retrospective cohort study. METHODS:We examined 161 children born between January 2009 and December 2014. The children were divided into five groups for evaluation of visual acuity and refraction: no retinopathy of prematurity ... Read more >>

Jpn. J. Ophthalmol. (Japanese journal of ophthalmology)
[2020, 64(5):539-548]

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Cases of coronavirus disease-2019 in HIV-infected transgender women.

Eisuke Adachi, Makoto Saito, Kazuhiko Ikeuchi, Tokio Hoshina, Hiroshi Yotsuyanagi,

AIDS (AIDS (London, England))
[2020, 34(9):1435-1436]

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Gargle Lavage as a Safe and Sensitive Alternative to Swab Samples to Diagnose COVID-19: A Case Report in Japan.

Makoto Saito, Eisuke Adachi, Seiya Yamayoshi, Michiko Koga, Kiyoko Iwatsuki-Horimoto, Yoshihiro Kawaoka, Hiroshi Yotsuyanagi,

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(15):893-894]

Cited: 5 times

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Prognostic assessment of relative apical sparing pattern of longitudinal strain for severe aortic valve stenosis.

Makoto Saito, Misaki Imai, Daisuke Wake, Rieko Higaki, Yasuhisa Nakao, Hiroe Morioka, Takumi Sumimoto, Katsuji Inoue,

Backgrounds:The relative apical sparing pattern (RASP) of left ventricular (LV) longitudinal strain (LS) is frequently associated with cardiac amyloidosis. Elderly patients with aortic valve stenosis (AS) complicated by transthyretin amyloid cardiomyopathy have poor prognosis. Furthermore, deteriorated basal LS in AS patients has been reported to be associated with adverse outcome. ... Read more >>

Int J Cardiol Heart Vasc (International journal of cardiology. Heart & vasculature)
[2020, 29:100551]

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Transparent dentin region in the tooth root.

Toshiko Inoue, Makoto Saito, Fumio Nishimura, Takashi Miyazaki,

Transparent dentin in the tooth root forms during the aging process. The transparent dentin is weaker than normal opaque dentin, which may explain the occurrence of root dentin fractures in aged individuals. Tooth fractures are caused by the brittleness of the transparent dentin. Clinical procedures in aged persons require modification ... Read more >>

Clin Case Rep (Clinical case reports)
[2020, 8(9):1831-1832]

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Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis.

Makoto Saito, Rashid Mansoor, Kalynn Kennon, Anupkumar R Anvikar, Elizabeth A Ashley, Daniel Chandramohan, Lauren M Cohee, Umberto D'Alessandro, Blaise Genton, Mary Ellen Gilder, Elizabeth Juma, Linda Kalilani-Phiri, Irene Kuepfer, Miriam K Laufer, Khin Maung Lwin, Steven R Meshnick, Dominic Mosha, Atis Muehlenbachs, Victor Mwapasa, Norah Mwebaza, Michael Nambozi, Jean-Louis A Ndiaye, François Nosten, Myaing Nyunt, Bernhards Ogutu, Sunil Parikh, Moo Kho Paw, Aung Pyae Phyo, Mupawjay Pimanpanarak, Patrice Piola, Marcus J Rijken, Kanlaya Sriprawat, Harry K Tagbor, Joel Tarning, Halidou Tinto, Innocent Valéa, Neena Valecha, Nicholas J White, Jacher Wiladphaingern, Kasia Stepniewska, Rose McGready, Philippe J Guérin,

BACKGROUND:Malaria in pregnancy, including asymptomatic infection, has a detrimental impact on foetal development. Individual patient data (IPD) meta-analysis was conducted to compare the association between antimalarial treatments and adverse pregnancy outcomes, including placental malaria, accompanied with the gestational age at diagnosis of uncomplicated falciparum malaria infection. METHODS:A systematic review and ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):138]

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Point-of-care testing for COVID-19 using SHERLOCK diagnostics

Julia Joung, Alim Ladha, Makoto Saito, Michael Segel, Robert Bruneau, Meei-li Huang, Nam-Gyun Kim, Xu Yu, Jonathan Li, Bruce Walker, Alexander Greninger, Keith Jerome, Jonathan Gootenberg, Omar Abudayyeh, Feng Zhang,

The recent outbreak of the novel coronavirus SARS-CoV-2, which causes COVID-19, can be diagnosed using RT-qPCR, but inadequate access to reagents and equipment has slowed disease detection and impeded efforts to mitigate viral spread. Alternative approaches based on combinations of isothermal amplification and CRISPR-mediated detection, such as the SHERLOCK ( ... Read more >>

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Comparison of CT-based and MRI-based high-risk clinical target volumes in image guided-brachytherapy for cervical cancer, referencing recommendations from the Japanese Radiation Oncology Study Group (JROSG) and consensus statement guidelines from the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC ESTRO).

Yuma Iwai, Miho Watanabe Nemoto, Takuro Horikoshi, Aki Kanazawa, Marie Kurokawa, Makoto Saito, Rintaro Harada, Hiroki Kobayashi, Takashi Uno,

PURPOSE:The Working Group of the Gynecological Tumor Committee of the Japanese Radiation Oncology Study Group (JROSG) published recommendations for contouring high-risk clinical target volumes (HR-CTV) on CT for 3-dimentional image-guided brachytherapy for cervical cancer. The purpose of this study was to compare HR-CTV delineated on CT, referencing recommendations from JROSG, ... Read more >>

Jpn J Radiol (Japanese journal of radiology)
[2020, 38(9):899-905]

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Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.

Makoto Saito, Rashid Mansoor, Kalynn Kennon, Anupkumar R Anvikar, Elizabeth A Ashley, Daniel Chandramohan, Lauren M Cohee, Umberto D'Alessandro, Blaise Genton, Mary Ellen Gilder, Elizabeth Juma, Linda Kalilani-Phiri, Irene Kuepfer, Miriam K Laufer, Khin Maung Lwin, Steven R Meshnick, Dominic Mosha, Victor Mwapasa, Norah Mwebaza, Michael Nambozi, Jean-Louis A Ndiaye, François Nosten, Myaing Nyunt, Bernhards Ogutu, Sunil Parikh, Moo Kho Paw, Aung Pyae Phyo, Mupawjay Pimanpanarak, Patrice Piola, Marcus J Rijken, Kanlaya Sriprawat, Harry K Tagbor, Joel Tarning, Halidou Tinto, Innocent Valéa, Neena Valecha, Nicholas J White, Jacher Wiladphaingern, Kasia Stepniewska, Rose McGready, Philippe J Guérin,

BACKGROUND:Malaria in pregnancy affects both the mother and the fetus. However, evidence supporting treatment guidelines for uncomplicated (including asymptomatic) falciparum malaria in pregnant women is scarce and assessed in varied ways. We did a systematic literature review and individual patient data (IPD) meta-analysis to compare the efficacy and tolerability of ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(8):943-952]

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Elderly Japanese Standard Data of Echocardiography; From J-LONG study.

Yoshihiro Seo, Tomoko Ishizu, Masaki Ieda, Nobuyuki Ohte, ,

BACKGROUND:Age-related changes in cardiac morphology and function have not been unknown in the elderly. The Japanese eLderly data Of Normal echocardioGraphy (J-LONG) study is a prospective multicenter cohort study and aimed to investigate the echocardiographic data in the healthy Japanese elderly. METHODS:Thirty domestic facilities participated in this study, and 130 ... Read more >>

J Echocardiogr (Journal of echocardiography)
[2020, 18(3):175-182]

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