Full Text Journal Articles by
Author Mahmoud Mosli

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Ovarian Crohn's Disease: A Case Report and Review of the Literature.

Hamza Mohammed, Rana Bokhary, Mohammed Nassif, Mahmoud Mosli,

We present to you a rare case of Crohn's disease involving the ovary in a 28-year-old nulligravida Eritrean patient. This is considered a rare manifestation of Crohn's disease that is believed to be due to fistulization between the ovary and intestines. ... Read more >>

Case Rep Gastrointest Med (Case reports in gastrointestinal medicine)
[2020, 2020:1826469]

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Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches.

Dikhnah Alshehri, Omar Saadah, Mahmoud Mosli, Sherif Edris, Rashad Alhindi, Ahmed Bahieldin,

There is a growing body of evidence reinforcing the unique connections between the host microbiome, health and diseases. Due to the extreme importance of the symbiotic relationship between the intestinal microbiome and the host, it is not surprising that any alteration in the gut microbiota would result in various diseases, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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The Efficacy of Anti-Tumor Necrosis Factor Alpha for Symptomatic Stricturing Small Bowel Crohn's Disease.

Mansour Alourfi, Mahmoud Mosli, Omar I Saadah,

Introduction Crohn's disease (CD) is a chronic inflammatory disease. Current treatment aims to prevent complications and the need for surgical intervention. In patients with symptomatic complications, such as strictures, the possible benefits of anti-tumor necrosis factor-alpha (anti-TNF-α) therapy are currently the subject of considerable debate. This study aims to determine ... Read more >>

Cureus (Cureus)
[2020, 12(9):e10315]

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A cross-sectional survey on the psychological impact of the COVID-19 pandemic on inflammatory bowel disease patients in Saudi Arabia.

Mahmoud Mosli, Mansour Alourfi, Amani Alamoudi, Almoutaz Hashim, Omar Saadah, Eman Al Sulais, Turki AlAmeel, Othman Alharbi, Shakir Bakari, Yaser Meeralam, Seigha Alshobai, Majid Alsahafi, Hani Jawa, Yousif Qari,

Background/Aims:The coronavirus (COVID-19) pandemic has caused significant disruption to patients with chronic illnesses. We explored the emotional state, perception, and concerns of Saudi patients with inflammatory bowel disease (IBD) during the crisis. Materials and Methods:We conducted a cross-sectional survey from 30 March to 5 April, 2020 using a pre-designed questionnaire ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2020, 26(5):263-271]

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Gastrointestinal and liver manifestations of COVID-19.

Janice Cheong, Nichoals Bartell, Thoetchai Peeraphatdit, Mahmoud Mosli, Bandar Al-Judaibi,

The novel coronavirus 2 (SARS-CoV-2) has spread worldwide. While patients typically present with fever and symptoms of a respiratory illness, patients have also presented with gastrointestinal symptoms such as diarrhea, vomiting and abdominal pain. In addition, some patients were reported to have liver injury. In this article, we review gastrointestinal ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2020, 26(5):226-232]

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The psychological impact of COVID-19 pandemic on physicians in Saudi Arabia: A cross-sectional study.

Eman Al Sulais, Mahmoud Mosli, Turki AlAmeel,

Background/Aim:COVID-19 pandemic exposed physicians to extraordinary stress and made them vulnerable to various types of psychological illnesses. The aim of this study was to evaluate the impact that the COVID-19 pandemic had on the psychological well-being of physicians. Materials and Methods:We performed a cross-sectional, survey-based study, targeting physicians in Saudi ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2020, 26(5):249-255]

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The Prevalence of Barrett's Esophagus Among a Saudi Arabian Population.

Majid Alsahafi, Hebah Mimish, Fatma Salem, Mohammed Hijazi, Emad Aljahdli, Hani Jawa, Salim Bazarah, Rana Bokhary, Yousef Qari, Mahmoud Mosli,

BACKGROUND:While gastroesophageal reflux disease (GERD) is common in Middle Eastern countries, little data exists on the epidemiology of Barrett's esophagus (BE). AIMS:We aimed to determine the prevalence of BE among patients undergoing esophagogastroduodenoscopy (EGD) in a cohort of Saudi patients. METHODS:We retrospectively reviewed the endoscopy database at an academic tertiary ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2020, :]

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Prevalence of Celiac Disease in Children and Adolescents With Inflammatory Bowel Disease.

Ayman Eskander, Omar I Saadah, Abdelrahman A Abdelrazek, Mahmoud Mosli, Hadeel A Alsufyani, Safa Meshaal, Amera M Hasnoon, Sara Tarek, Abobakr Abdelgalil,

Introduction The association between inflammatory bowel disease (IBD) - particularly its two main subtypes, ulcerative colitis (UC) and Crohn's disease (CD) - and celiac disease (CeD) has been attributed to an overlap in the mechanism of immune dysregulation that characterizes these conditions. Owing to the paucity of studies that have ... Read more >>

Cureus (Cureus)
[2020, 12(8):e9977]

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Patterns of Complementary and Alternative Medicine Use in Saudi Arabian Patients With Inflammatory Bowel Disease: A Cross-Sectional Study.

Albaraa Altunisi, Mahmoud Mosli, Mazen Banweer, Yousif Qari, Faris O Arif, Omar I Saadah,

Background Inflammatory bowel disease (IBD) concerns a group of chronic autoimmune diseases that results in uncontrolled inflammation of the gastrointestinal (GI) tract, which can lead to long-term complications. Conventional treatments for IBD usually target inflammation and include biologics and immunosuppressants, which have been associated with significant adverse effects. Also, non-response ... Read more >>

Cureus (Cureus)
[2020, 12(8):e9687]

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A Rare Case of Adult Dysphagia: Dysphagia Lusoria.

Mansour Alourfi, Mahmoud Mosli,

(ACG case reports journal)
[2020, 7(7):e00428]

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Risk of neutropenia in inflammatory bowel disease patients treated with TNF inhibitors: A single-center, retrospective cohort study.

Dimah AlAskar, Mais AlSardi, Eman Al Sulais, Mahmoud Mosli, Turki AlAmeel,

Background/Aim:Tumor necrosis factor inhibitors (TNFi) have become the mainstay of treatment in moderate-to-severe cases of inflammatory bowel disease (IBD). Neutropenia has been reported in patients receiving TNFi for IBD and other diseases. In this study, we aimed to ascertain the relationship between the use of TNFi and the development of ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2020, :]

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Incorporating Fecal Calprotectin Into Clinical Practice for Patients With Moderate-to-Severely Active Ulcerative Colitis Treated With Biologics or Small-Molecule Inhibitors.

Parambir S Dulai, Robert Battat, Maria Barsky, Nghia H Nguyen, Christopher Ma, Neeraj Narula, Mahmoud Mosli, Niels Vande Casteele, Brigid S Boland, Larry Prokop, M Hassan Murad, Geert DʼHaens, Brian G Feagan, William J Sandborn, Vipul Jairath, Siddharth Singh,

INTRODUCTION:We applied the Grading of Recommendations, Assessment, Development, and Evaluation framework to evaluate the performance of fecal calprotectin (FC) as an alternative to endoscopy in patients with moderate-to-severe ulcerative colitis (UC) treated with a biologic agent or tofacitinib. METHODS:Individual participant data from the trials of infliximab, golimumab, vedolizumab, and tofacitinib ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2020, 115(6):885-894]

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Efficacy of DAAs in the Treatment of Chronic HCV: Real-World Data from the Private Health-Care Sector of the Kingdom of Saudi Arabia.

Almoutaz Hashim, Fadia Almahdi, Emad Aldin Albaba, Ohoud Barkia, Reem Alkasam, Asmaa Almahmoud, Ahmed Nabil, Ayman Alsulaimani, Mahmoud Mosli,

BACKGROUND AND AIM:The hepatitis C virus (HCV) is considered a global health challenge that requires urgent interventions for prevention and control. In this study, we aimed to evaluate the effectiveness of direct-acting antiviral agents (DAAs) for HCV-infected patients in the Kingdom of Saudi Arabia (KSA). PATIENTS AND METHODS:In this retrospective ... Read more >>

J Epidemiol Glob Health (Journal of epidemiology and global health)
[2020, 10(2):178-183]

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Prevalence and Predictors of Reduced Bone Density in Child and Adolescent Patients With Crohn's Disease.

Omar I Saadah, Vito Annese, Mahmoud H Mosli,

Reduced bone mineral density (BMD) has broadly been found to be associated with inflammatory bowel disease across a number of geographical locations and cultures. We aimed to estimate the prevalence of reduced BMD and identify clinical predictors in a cohort of Crohn's disease patients (CD) in Saudi Arabia. We conducted ... Read more >>

J Clin Densitom (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry)
[2020, :]

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The Impact of the Pharmaceutical Care Management Model of Hepatitis C Medications on the Cost at Health Insurance Level.

Fadia B Almahdi, Almoutaz H Hashim, Emad Aldin M Albaba, Ohoud N Salih, Reem J Alkasam, Mahmoud H Mosli, Ayman F Alsulaimani,

OBJECTIVE:The aim of this study is to evaluate the impact of adopting a pharmaceutical care model on clinical outcomes, patient satisfaction, and cost at a health payer level. METHODS:All patients with hepatitis C virus (HCV) who were insured by Bupa Arabia, with a direct-acting antivirals prior authorization drug request between ... Read more >>

Value Health Reg Issues (Value in health regional issues)
[2020, 21:230-237]

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Metabolic bone disease in children and adolescent patients with ulcerative colitis.

Mahmoud Hisham Mosli, Omar Ibrahim Saadah,

OBJECTIVE:Metabolic bone disease concerns a broad spectrum of conditions related to reduced bone density. Metabolic bone disease has been linked to chronic inflammatory diseases, such as ulcerative colitis. This study examines the prevalence of metabolic bone disease in ulcerative colitis patients and explores possible clinical predictors. METHOD:The authors performed a ... Read more >>

J Pediatr (Rio J) (Jornal de pediatria)
[2020, :]

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Extraintestinal Manifestations of Inflammatory Bowel Disease in Middle Eastern Patients.

Heba Adam, Maryam Alqassas, Omar I Saadah, Mahmoud Mosli,

BACKGROUND AND AIMS:The Inflammatory Bowel Diseases (IBDs), Crohn's Disease (CD) and Ulcerative Colitis (UC), are gastrointestinal autoimmune disorders with many Extraintestinal Manifestations (EIMs). Previously reported incidences of EIMs in IBD patients have ranged from 10% to 50%. The large variation in occurrence of EIMs has been linked to genetic predisposition. ... Read more >>

J Epidemiol Glob Health (Journal of epidemiology and global health)
[2020, :]

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Environmental exposures and the risk of inflammatory bowel disease: a case-control study from Saudi Arabia.

Wafaa Algethmi, Cedric Baumann, Wed Alnajjar, Aaliah Sroji, Majid Alsahafi, Hani Jawa, Yousef Qari, Laurent Peyrin-Biroulet, Omar I Saadah, Mahmoud Mosli,

BACKGROUND AND AIMS:Environmental exposures play a key role in inflammatory bowel disease pathogenesis. The incidence of IBD has increased in the Arabic Peninsula with a disease phenotype that seems to differ from that of Western countries. We aimed to examine the association between environmental exposures and the risk of IBD ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2020, 32(3):358-364]

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Histologically confirmed upper gastrointestinal Crohn's disease: is it rare or are we just not searching hard enough?

Omar Ibrahim Saadah, Kholoud Bakur Fallatah, Cedric Baumann, Abdulrahman Ahmed Elbaradie, Fatimah Talat Howladar, Motaz Tariq Daiwali, Omar Hamad Alshuaibi, Majid Abdulaziz Alsahafi, Rana Yaqoob Bokhary, Yousef Abdulfattah Qari, Laurent Peyrin-Biroulet, Mahmoud Hisham Mosli,

BACKGROUND/AIMS:Crohn's disease (CD) may involve the upper parts of the gastrointestinal (GI) tract including the esophagus, stomach, and duodenum. Clinical features of upper GI CD (UGICD) are not well characterized in the Gulf region. We therefore aimed to assess the prevalence and clinical characteristics of patients diagnosed with UGICD. METHODS:We ... Read more >>

Intest Res (Intestinal research)
[2020, 18(2):210-218]

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Predictors of long-term outcomes of radiologically defined perianal fistulizing Crohn's disease treated with antitumor necrosis factor-alpha agents based on Parks' classification.

Nahla Azzam, Othman Alharbi, Majid Almadi, Abdulrahman Aljebreen, Turki AlAmeel, Mohammed Alabbas, Salman Bahammam, Ahmed Bashmail, Yasser Alomar, Mahmoud Mosli,

BACKGROUND AND AIMS:Perianal fistulizing Crohn's disease (PFCD) leads to significant disability. Data assessing healing of complex PFCD based on pelvic MRI using Parks' classification remains sparse. We aimed to assess the frequency of closure of fistula tract on MRI in patients treated with antitumor necrosis factor alpha antagonists and identify ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2020, 32(2):187-192]

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A systematic review and meta-analysis of the efficacy of medical treatments for the management of solitary rectal ulcer syndrome.

Yousef Qari, Mahmoud Mosli,

Background/Aim:Solitary rectal ulcer syndrome (SRUS) is a benign, poorly understood disorder that is difficult to manage. Medical interventions such as sucralfate, sulfasalzine, human fibrin, and a high fibre diet are reported as the first line of treatment. The aim of this study is to perform a systematic review and meta-analysis ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2020, 26(1):4-12]

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Ovarian Crohn's Disease: A Case Report and Review of the Literature

Hamza Mohammed, Rana Bokhary, Mohammed Nassif, Mahmoud Mosli,

We present to you a rare case of Crohn's disease involving the ovary in a 28-year-old nulligravida Eritrean patient. This is considered a rare manifestation of Crohn's disease that is believed to be due to fistulization between the ovary and intestines. ... Read more >>

(Case Reports in Gastrointestinal Medicine)
[2020, 2020:]

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Awareness of the first aid management of foreign body aspiration among students: A cross-sectional study.

Khalid A Alshehri, Ahmed A Alharbi, Bassam E Yaghmoor, Anas K Salman, Shahad A Alaydarous, Lujain K Abdalwassie, Mahmoud H Mosli, Hani Z Marzouki,

BACKGROUND:Pediatric foreign body aspiration (FBA) is a life-threatening condition responsible for many deaths every year, especially among children younger than 2 years. OBJECTIVE:This study aimed to determine the level of knowledge among students in Jeddah, Saudi Arabia. SUBJECTS AND METHODS:This observational, cross-sectional study was conducted between December and January 2018 ... Read more >>

J Educ Health Promot (Journal of education and health promotion)
[2019, 8:220]

Cited: 1 time

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Adherence to the Saudi dietary guidelines and its relation to colorectal polyps: A university hospital-based study.

Areej A Alkhaldy, Emad S Aljahdli, Mahmoud H Mosli, Hani A Jawa, Majid A Alsahafi, Yousif A Qari,

Objectives:Colorectal polyps are a known precursor to colorectal cancer (CRC). Using the Saudi dietary guidelines adherence scores, this study evaluated whether dietary intake can lead to the development of colorectal polyps in a Saudi cohort. Methods:In a cross-sectional study, 101 patients of both sexes, aged 30-86 years (40 patients with ... Read more >>

(Journal of Taibah University Medical Sciences)
[2020, 15(1):25-31]

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Declining hospitalisation and surgical intervention rates in patients with Crohn's disease: a population-based cohort.

Adam Rahman, Vipul Jairath, Brian G Feagan, Reena Khanna, Salimah Z Shariff, Britney N Allen, Krista Bray Jenkyn, Christopher Vinden, Jenny Jeyarajah, Mahmoud Mosli, Eric Benchimol,

BACKGROUND:Lifetime risk of surgery in patients with Crohn's disease remains high. AIM:To assess population-level markers of Crohn's disease (CD) in the era of biological therapy. METHODS:Population-based cohort study using administrative data from Ontario, Canada including 45 235 prevalent patients in the Ontario Crohn's and Colitis Cohort (OCCC) from 1 April 2003 ... Read more >>

Aliment. Pharmacol. Ther. (Alimentary pharmacology & therapeutics)
[2019, 50(10):1086-1093]

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