Full Text Journal Articles by
Author Maged W Helmy

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Effect of Regorafenib on P2X7 Receptor Expression and Different Oncogenic Signaling Pathways in a Human Breast Cancer Cell Line: A Potential of New Insight of the Antitumor Effects of Regorafenib.

Muhammed M Salahuddin, Gamal A Omran, Maged W Helmy, Maha E Houssen,

<h4>Background</h4>Breast cancer is the most common malignancy in women worldwide. P2X7 is a transmembrane receptor expressed in breast cancer and activated by the ATP tumor microenvironment, driving cell proliferation, angiogenesis, and metastasis via different signaling pathways. The role of the P2X7 receptor, hypoxia, and autophagy in regulating tumor progression is ... Read more >>

Curr Issues Mol Biol (Current issues in molecular biology)
[2021, 43(3):2199-2209]

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Combinatorial antitumor effects of amino acids and epigenetic modulations in hepatocellular carcinoma cell lines.

Yasmine A Hassan, Maged W Helmy, Asser I Ghoneim,

Hepatocellular carcinoma (HCC) is a highly fatal form of liver cancer. Recently, the interest in using amino acids as therapeutic agents has noticeably grown. The present work aimed to evaluate the possible antiproliferative effects of selected amino acids supplementation or deprivation in human HCC cell lines and to investigate their ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2021, 394(11):2245-2257]

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Omega 3 fatty acids effect on the vascular calcification biomarkers fetuin A and osteoprotegerin in hemodialysis patients.

Rehab H Werida, Sohaila Abou-Madawy, Mohamed Abdelsalam, Maged W Helmy,

Chronic renal failure patients on dialysis are at a high risk of death due to vascular calcification. This study aimed at investigating the effect of omega-3 fatty acids on the vascular calcification biomarkers fetuin-A and osteoprotegerin (OPG) in patients with chronic renal failure who are undergoing hemodialysis. This prospective, open-label, ... Read more >>

Clin Exp Med (Clinical and experimental medicine)
[2021, :]

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Pegylated liquisomes: A novel combined passive targeting nanoplatform of L-carnosine for breast cancer.

Passent M E Gaafar, Noha S El-Salamouni, Ragwa M Farid, Heba A Hazzah, Maged W Helmy, Ossama Y Abdallah,

PEGylated Liquisomes (P-Liquisomes), a novel drug delivery system was designed for the first time by incorporating phospholipid complex in PEGylated liquid crystalline nanoparticles (P-LCNPs). L-carnosine (CN), a challenging dipeptide, has proven to be a promising anti-cancer drug. However, it exhibits high water solubility and extensive in-vivo degradation that halts its ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2021, 602:120666]

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Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers.

Mariam Zewail, Noha Nafee, Maged W Helmy, Nabila Boraie,

Intra-articular drug delivery represents a tempting strategy for local treatment of rheumatoid arthritis. Targeting drugs to inflamed joints bypasses systemic-related side effects. Albeit, rapid drug clearance and short joint residence limit intra-articular administration. Herein, injectable smart hydrogels comprising free/nanoencapsulated leflunomide (LEF) were developed. Nanostructured lipid carriers (NLCs), 200-300 nm, were coated ... Read more >>

Drug Deliv Transl Res (Drug delivery and translational research)
[2021, 11(6):2496-2519]

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Dual Therapeutic Targeting of Lung Infection and Carcinoma Using Lactoferrin-Based Green Nanomedicine.

Marian G Rofeal, Ahmed O Elzoghby, Maged W Helmy, Rowaida Khalil, Heba Khairy, Sanaa Omar,

In view of the promising applications of nanoparticles in drug delivery, this study highlights the fabrication of new bioactive green protein-polysaccharide nanocomplexes with significant antibacterial and antitumor efficacies. We preformulated the water-insoluble drugs Quercetin (Quer) and Resveratrol (Res) as water-soluble nanocrystals to facilitate their entrapment in the electrostatic lactoferrin-chondroitin (Lf-ChS) ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2020, 6(10):5685-5699]

Cited: 0 times

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Dual targeting of Notch and Wnt/β-catenin pathways: Potential approach in triple-negative breast cancer treatment.

Fatma Nasser, Nermine Moussa, Maged W Helmy, Medhat Haroun,

Despite the continuously growing repertoire of new and improved anti-cancer therapies, triple-negative breast cancer (TNBC) remains a clinical challenge to treat. In this sense, targeting signaling pathways such as Notch and Wnt/β-catenin have attracted growing attention. This work aimed at investigating the possible antitumor effects of IMR-1 as a Notch ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2021, 394(3):481-490]

Cited: 0 times

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Lactoferrin-dual drug nanoconjugate: Synergistic anti-tumor efficacy of docetaxel and the NF-κB inhibitor celastrol.

Mona A Abdelmoneem, Mahmoud M Abd Elwakil, Sherine N Khattab, Maged W Helmy, Adnan A Bekhit, Mohammad A Abdulkader, Amira Zaky, Mohamed Teleb, Kadria A Elkhodairy, Fernando Albericio, Ahmed O Elzoghby,

Despite the progress in cancer nanotherapeutics, some obstacles still impede the success of nanocarriers and hinder their clinical translation. Low drug loading, premature drug release, off-target toxicity and multi-drug resistance are among the most difficult challenges. Lactoferrin (LF) has demonstrated a great tumor targeting capacity via its high binding affinity ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2021, 118:111422]

Cited: 3 times

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Combination of magnetic targeting with synergistic inhibition of NF-κB and glutathione via micellar drug nanomedicine enhances its anti-tumor efficacy.

Kholod A Elhasany, Sherine N Khattab, Adnan A Bekhit, Doaa M Ragab, Mohammad A Abdulkader, Amira Zaky, Maged W Helmy, Hayam M A Ashour, Mohamed Teleb, Nesreen S Haiba, Ahmed O Elzoghby,

Breast cancer is not only one of the most prevalent types of cancer, but also it is a prime cause of death in women aged between 20 and 59. Although chemotherapy is the most common therapy approach, multiple side effects can result from lack of specificity and the use of ... Read more >>

Eur J Pharm Biopharm (European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V)
[2020, 155:162-176]

Cited: 1 time

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Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.

Perihan A Elzahhar, Shrouk M Abd El Wahab, Mohamed Elagawany, Hoda Daabees, Ahmed S F Belal, Ahmed F El-Yazbi, Ali H Eid, Rana Alaaeddine, Rehab R Hegazy, Rasha M Allam, Maged W Helmy, Bahaa Elgendy, Andrea Angeli, Soad A El-Hawash, Claudiu T Supuran,

Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways and molecular targets. To that end, a multi-target design strategy was adopted to develop some 1,2,3-triazoles hybridized with some pharmacophoric anticancer fragments, as first-in-class simultaneous inhibitors of COX-2, 15-LOX and tumor associated carbonic anhydrase enzymes. Results revealed that compounds ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 200:112439]

Cited: 3 times

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Bioassay-guided isolation of potential bioactive constituents from pomegranate agrifood by-product.

Jilan A Nazeam, Walaa A Al-Shareef, Maged W Helmy, Alaadin E El-Haddad,

Food industries are yielding annually plentiful by-products worldwide, these concomitants could be an excellent source of natural functional ingredients. Hence, the antimicrobial and cytotoxic effects of pomegranate husk were examined and chromatographic analyzes were applied for isolation of the bioactive compounds. Lignans; isohydroxymatairesinol, punicatannin C, flavonoids; phloretin, quercetin glycoside, indolamine; ... Read more >>

Food Chem (Food chemistry)
[2020, 326:126993]

Cited: 3 times

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Co-Administration of Tretinoin Enhances the Anti-Cancer Efficacy of Etoposide via Tumor-Targeted Green Nano-Micelles.

Mohamed Gaber, Kholod A Elhasany, Saly Sabra, Maged W Helmy, Jia-You Fang, Sherine N Khattab, Adnan A Bekhit, Mohamed Teleb, Kadria A Elkodairy, Ahmed O Elzoghby,

Herein we report promoted anti-cancer activity via a combination strategy of synergistic chemotherapy/retinoid-based breast cancer therapy with shell-stabilized micellar green nanomedicine. Amphiphilic zein-chondroitin sulfate (ChS)-based copolymeric micelles (PMs) were successfully developed via carbodiimide coupling for concomitant delivery of etoposide (ETP) and all-trans retinoic acid (ATRA) to breast cancer. The micelles ... Read more >>

Colloids Surf B Biointerfaces (Colloids and surfaces. B, Biointerfaces)
[2020, 192:110997]

Cited: 3 times

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Inhalable Lactoferrin/Chondroitin-Functionalized Monoolein Nanocomposites for Localized Lung Cancer Targeting.

Hadeer M Abdelaziz, Ahmed O Elzoghby, Maged W Helmy, Elsayeda-Zeinab A Abdelfattah, Jia-You Fang, Magda W Samaha, May S Freag,

Localized drug delivery to lung cancer can overcome the limitations of systemic nanocarriers including low drug amounts reaching lung tissues and severe off-target toxicity. The current work presented novel inhalable nanocomposites as noninvasive platforms for lung cancer therapy. Nanoparticulate liquid crystals (LCNPs) based on monoolein were developed for synergistic co-encapsulation ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2020, 6(2):1030-1042]

Cited: 2 times

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The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through inhibition of the PI3K/Akt/mTOR/NF-κB axis.

Maged W Helmy, Asser I Ghoneim, Mohamed A Katary, Rana K Elmahdy,

One of the most lethal malignancies worldwide is colorectal cancer (CRC). Alterations in various signalling pathways, including PI3K-mTOR and NF-κB, have been reported in CRC with subsequent dysregulation of proliferation, apoptosis, angiogenesis and, questionably, autophagy processes. BEZ-235 (dactolisib) is a dual PI3K-mTOR inhibitor with potent anti-tumour activity. However, the observed ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2020, 47(3):2217-2230]

Cited: 6 times

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Boronic-targeted albumin-shell oily-core nanocapsules for synergistic aromatase inhibitor/herbal breast cancer therapy.

Mohamed Gaber, Mark Hany, Sarah Mokhtar, Maged W Helmy, Kadria A Elkodairy, Ahmed O Elzoghby,

Multi-modality strategies of albumin-mediated drug accumulation in tumor, boronate-based active tumor targeting and synergistic cancer therapy were combined together for effective treatment of breast cancer. Herein we report the development of albumin-shell oily-core nanocapsules (NCs), loaded with novel combination of hydrophobic drugs, exemestane (EXE) and hesperetin (HES), for targeted breast ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2019, 105:110099]

Cited: 2 times

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Multicompartmental lipid-protein nanohybrids for combined tretinoin/herbal lung cancer therapy.

Nayra M Kamel, Maged W Helmy, Magda W Samaha, Doaa Ragab, Ahmed O Elzoghby,

<b>Aim:</b> Multicompartmental lipid-protein nanohybrids (MLPNs) were developed for combined delivery of the anticancer drugs tretinoin (TRE) and genistein (GEN) as synergistic therapy of lung cancer. <b>Materials & methods:</b> The GEN-loaded lipid core was first prepared and then coated with TRE-loaded zein shell via nanoprecipitation. <b>Results:</b> TRE/GEN-MLPNs demonstrated a size of 154.5 nm. ... Read more >>

Nanomedicine (Lond) (Nanomedicine (London, England))
[2019, 14(18):2461-2479]

Cited: 0 times

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Dual-Targeted Lactoferrin Shell-Oily Core Nanocapsules for Synergistic Targeted/Herbal Therapy of Hepatocellular Carcinoma.

Mona A Abdelmoneem, Manar A Elnaggar, Ruwan S Hammady, Shaza M Kamel, Maged W Helmy, Mohammad A Abdulkader, Amira Zaky, Jia-You Fang, Kadria A Elkhodairy, Ahmed O Elzoghby,

Herein, both strategies of synergistic drug combination together with dual active tumor targeting were combined for effective therapy of hepatocellular carcinoma (HCC). Therefore, based on the tumor sensitizing action, the herbal quercetin (QRC) was co-delivered with the targeted therapeutic drug sorafenib (SFB), preformulated as phospholipid complex, via protein shell-oily core ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2019, 11(30):26731-26744]

Cited: 6 times

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Co-targeting of endothelin-A and vitamin D receptors: a novel strategy to ameliorate cisplatin-induced nephrotoxicity.

Lobna M Abdel Moneim, Maged W Helmy, Hanan S El-Abhar,

<h4>Background</h4>Although modulation of the vitamin D receptor (VDR) and endothelin-<sub>A</sub> receptor (ET<sub>A</sub>R) has previously been reported to offer renoprotection against cisplatin-induced nephrotoxicity, the possible interaction between the ET-1 and vitamin D pathways remains obscure. Therefore, the present study addressed the possible interaction between these signalling pathways using BQ-123 (a selective ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2019, 71(5):917-925]

Cited: 3 times

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Inhalable Dual-Targeted Hybrid Lipid Nanocore-Protein Shell Composites for Combined Delivery of Genistein and All-Trans Retinoic Acid to Lung Cancer Cells.

Nayra M Kamel, Maged W Helmy, Elsayeda-Zeinab Abdelfattah, Sherine N Khattab, Doaa Ragab, Magda W Samaha, Jia-You Fang, Ahmed O Elzoghby,

Localized pulmonary delivery of anticancer agents to lungs has proven to be pioneering approach for lung cancer therapy. Hybrid lipid nanocore-protein shell nanoparticles (HLPNPs) coloaded with all-trans retinoic acid (ATRA) and genistein (GNS) were prepared via sequential solvent evaporation followed by nanoprecipitation of zein shell onto the lipid core. The ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2020, 6(1):71-87]

Cited: 1 time

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Upregulation of cystathionine-γ-lyase/hydrogen sulfide pathway underlies the celecoxib counteraction of cyclosporine-induced hypertension and renal insult in rats.

Mai M Helmy, Maged W Helmy, Mahmoud M El-Mas,

We recently reported that celecoxib, a selective cyclooxygenase-2 (COX2) inhibitor, counteracts the adverse circulatory and renal actions of cyclosporine (CSA). Despite the seemingly advantageous nature of this interaction particularly in clinical settings that necessitate the combined use of the two drugs such as immune-related arthritis, the underlying mechanism remains elusive. ... Read more >>

Prostaglandins Other Lipid Mediat (Prostaglandins & other lipid mediators)
[2019, 141:1-10]

Cited: 2 times

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Lactoferrin-tagged quantum dots-based theranostic nanocapsules for combined COX-2 inhibitor/herbal therapy of breast cancer.

Ahmed S AbdElhamid, Dina G Zayed, Maged W Helmy, Shaker M Ebrahim, Mohammed Bahey-El-Din, Esmat A Zein-El-Dein, Sanaa A El-Gizawy, Ahmed O Elzoghby,

<h4>Aim</h4>Herein, tumor-targeted quantum dots (QDs)-based theranostic nanocapsules (NCs) coloaded with celecoxib and honokiol were developed. Materials & methodology: The anionic CD44-targeting chondroitin sulfate and cationic low density lipoprotein (LDL)-targeting lactoferrin (LF) were sequentially assembled onto the surface of the positively charged oily core. As an imaging probe, highly fluorescent mercaptopropionic acid-capped ... Read more >>

Nanomedicine (Lond) (Nanomedicine (London, England))
[2018, 13(20):2637-2656]

Cited: 9 times

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Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma.

Mona A Abdelmoneem, Mazen Mahmoud, Amira Zaky, Maged W Helmy, Marwa Sallam, Jia-You Fang, Kadria A Elkhodairy, Ahmed O Elzoghby,

<h4>Aim</h4>Lactoferrin (LF)-targeted gliadin nanoparticles (GL-NPs) were developed for targeted oral therapy of hepatocellular carcinoma.<h4>Materials & methods</h4>Celecoxib and diosmin were incorporated in the hydrophobic matrix of GL-NPs whose surface was decorated with LF by electrostatic interaction for binding to asialoglycoprotein receptors overexpressed by liver cancer cells.<h4>Results</h4>Targeted GL-NPs showed enhanced cytotoxic activity ... Read more >>

Nanomedicine (Lond) (Nanomedicine (London, England))
[2018, 13(19):2377-2395]

Cited: 1 time

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Inhalable multi-compartmental phospholipid enveloped lipid core nanocomposites for localized mTOR inhibitor/herbal combined therapy of lung carcinoma.

Dalia M Kabary, Maged W Helmy, Elsayeda-Zeinab A Abdelfattah, Jia-You Fang, Kadria A Elkhodairy, Ahmed O Elzoghby,

Pulmonary delivery of drug nanocarriers can overcome the shortcomings of systemic cancer therapy via the enhanced permeability and retention (EPR) based-nanomedicine. Herein, inhalable multi-compartmental nanocomposites with the capability for both localized and modulated release of the hydrophobic mTOR inhibitor, rapamycin (RAP) and the hydrophilic herbal drug, berberine (BER) have been ... Read more >>

Eur J Pharm Biopharm (European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V)
[2018, 130:152-164]

Cited: 6 times

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Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti-cancer effect of dasatinib in hepatocellular carcinoma.

Ibrahim El Sayed, Maged W Helmy, Hanan S El-Abhar,

<h4>Purpose</h4>Statins extended their hypocholestremic effect to show a promising anticancer activity. Hepatocellular carcinoma (HCC), the third common cause of cancer-related death, responded positively to statins. Some in-vitro studies reveal the rosuvastatin antitumor effect, but barely in-vivo studies. Hence, we evaluated the antitumor potential of rosuvastatin in a HCC model, the ... Read more >>

Life Sci (Life sciences)
[2018, 213:248-257]

Cited: 12 times

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Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy.

Mayada M Elgohary, Maged W Helmy, Elsayeda-Zeinab A Abdelfattah, Doaa M Ragab, Sana M Mortada, Jia-You Fang, Ahmed O Elzoghby,

Etoposide (ETP), as a potential treatment for lung cancer, has limited application due to its poor solubility, and systemic side effects. In the current study, we propose inhalable boronate-targeted HSA nanocomposites for combined delivery of ETP and the herbal drug, berberine (BER) for localized therapy of lung cancer. First, ETP ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2018, 285:230-243]

Cited: 5 times

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