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Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

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Prevalence and clinical correlates of antinuclear antibody in patients with gastroparesis.

Henry P Parkman, Mark L Van Natta, Ashima Makol, Madhusudan Grover, Richard W McCallum, Zubair Malik, Kenneth L Koch, Irene Sarosiek, Braden Kuo, Robert J Shulman, Gianrico Farrugia, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj J Pasricha, Thomas L Abell, ,

<h4>Background</h4>Autoimmunity may play a role in the pathogenesis of gastroparesis in a subset of patients. Antinuclear antibody (ANA) testing is often used to screen for autoimmune disorders.<h4>Aims</h4>1) Determine prevalence of a positive ANA in patients with gastroparesis; 2) Describe characteristics of idiopathic gastroparesis patients with positive ANA.<h4>Methods</h4>Patients were assessed with ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, :e14270]

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Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans.

Stephanie Peters, Ben Pascoe, Zuowei Wu, Sion C Bayliss, Ximin Zeng, Adam Edwinson, Sakteesh Veerabadhran-Gurunathan, Selina Jawahir, Jessica K Calland, Evangelos Mourkas, Robin Patel, Terra Wiens, Marijke Decuir, David Boxrud, Kirk Smith, Craig T Parker, Gianrico Farrugia, Qijing Zhang, Samuel K Sheppard, Madhusudan Grover,

Campylobacter enterocolitis may lead to post-infection irritable bowel syndrome (PI-IBS) and while some C. jejuni strains are more likely than others to cause human disease, genomic and virulence characteristics promoting PI-IBS development remain uncharacterized. We combined pangenome-wide association studies and phenotypic assays to compare C. jejuni isolates from patients who ... Read more >>

Commun Biol (Communications biology)
[2021, 4(1):1015]

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Duodenal Mucosal Barrier in Functional Dyspepsia.

Susrutha Puthanmadhom Narayanan, Daniel R O'Brien, Mayank Sharma, Thomas C Smyrk, Rondell P Graham, Madhusudan Grover, Adil E Bharucha,

<h4>Background and aims</h4>In addition to gastric sensorimotor dysfunctions, functional dyspepsia (FD) is also variably associated with duodenal micro-inflammation and epithelial barrier dysfunction, the pathogenesis and clinical significance of which are unknown. Our hypothesis was that miRNAs and/or inflammation degrade epithelial barrier proteins resulting in increased duodenal mucosal permeability in FD.<h4>Methods</h4>We ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

<h4>Background</h4>Irritable bowel syndrome (IBS) patients often experience meal-associated symptoms. However, the underlying mechanisms are unclear.<h4>Aim</h4>To determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS METHODS: We recruited 26 IBS patients (12 IBS-C, 14 IBS-D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1179-1192]

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Postinfection Irritable Bowel Syndrome Following Clostridioides difficile Infection: A Systematic-review and Meta-analysis.

Srishti Saha, Kanika Sehgal, Sumitabh Singh, Madhusudan Grover, Darrell Pardi, Sahil Khanna,

<h4>Background</h4>Postinfection irritable bowel syndrome (PI-IBS) affects ~14% patients after acute bacterial enterocolitis.<h4>Aim</h4>The aim of this study was to conduct a systematic review and meta-analysis to find the prevalence of PI-IBS following Clostridioides difficile infection (CDI).<h4>Methods</h4>We systematically searched Medline, Embase, and Web of Science from inception through January 20, 2020 for ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, :]

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Effect of Domperidone Therapy on Gastroparesis Symptoms: Results of a Dynamic Cohort Study by NIDDK Gastroparesis Consortium.

Irene Sarosiek, Mark Van Natta, Henry P Parkman, Thomas Abell, Kenneth L Koch, Braden Kuo, Robert J Shulman, Gianrico Farrugia, Madhusudan Grover, Frank A Hamilton, Pankaj J Pasricha, Katherine P Yates, Laura Miriel, Laura Wilson, Goro Yamada, James Tonascia, Richard W McCallum, ,

<h4>Background & aims</h4>The use of domperidone (DOM) for gastroparesis (GP) remains controversial and limited. We aimed to present outcomes of DOM therapy for treatment of patients participating in the multicenter National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium (GpCRC) Registries (GpR).<h4>Methods</h4>The GpCRC cohort consisted of ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Post-infection Irritable Bowel Syndrome.

Antonio Berumen, Adam L Edwinson, Madhusudan Grover,

Epidemiologic data support that acute gastrointestinal infection is one of the strongest risk factors for development of irritable bowel syndrome (IBS). Risk of post-infection IBS (PI-IBS) seems to be greater with bacterial and protozoal than viral enterocolitis. Younger individuals, women, and those with severe enterocolitis are more likely to develop ... Read more >>

Gastroenterol Clin North Am (Gastroenterology clinics of North America)
[2021, 50(2):445-461]

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Colonic expression of Ace2, the SARS-CoV-2 entry receptor, is suppressed by commensal human microbiota.

Adam Edwinson, Lu Yang, Jun Chen, Madhusudan Grover,

Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Angiotensin-converting enzyme 2 (<i>Ace2</i>) is expressed in the gastrointestinal (GI) tract and a receptor for SARS-CoV-2, making the GI tract a potential infection site. This study investigated the effects of commensal intestinal microbiota on colonic <i>Ace2</i> expression ... Read more >>

Gut Microbes (Gut microbes)
[2021, 13(1):1984105]

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Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review.

Nikita Hanning, Adam L Edwinson, Hannah Ceuleers, Stephanie A Peters, Joris G De Man, Leslie C Hassett, Benedicte Y De Winter, Madhusudan Grover,

<h4>Background and aim</h4>Irritable bowel syndrome (IBS) is a complex and heterogeneous disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes of IBS. Our aim is to review studies evaluating barrier dysfunction in adults and children with IBS, as well as to link those changes with IBS symptomatology and ... Read more >>

Therap Adv Gastroenterol (Therapeutic advances in gastroenterology)
[2021, 14:1756284821993586]

Cited: 4 times

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Functional Dyspepsia and Gastroparesis in Tertiary Care are Interchangeable Syndromes With Common Clinical and Pathologic Features.

Pankaj J Pasricha, Madhusudan Grover, Katherine P Yates, Thomas L Abell, Cheryl E Bernard, Kenneth L Koch, Richard W McCallum, Irene Sarosiek, Braden Kuo, Robert Bulat, Jiande Chen, Robert J Shulman, Linda Lee, James Tonascia, Laura A Miriel, Frank Hamilton, Gianrico Farrugia, Henry P Parkman, ,

<h4>Background</h4>The aim of this study was to clarify the pathophysiology of functional dyspepsia (FD), a highly prevalent gastrointestinal syndrome, and its relationship with the better-understood syndrome of gastroparesis.<h4>Methods</h4>Adult patients with chronic upper gastrointestinal symptoms were followed up prospectively for 48 weeks in multi-center registry studies. Patients were classified as having ... Read more >>

Gastroenterology (Gastroenterology)
[2021, 160(6):2006-2017]

Cited: 5 times

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Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson's disease.

Yogesh Bhattarai, Jie Si, Meng Pu, Owen A Ross, Pamela J McLean, Lisa Till, William Moor, Madhusudan Grover, Karunya K Kandimalla, Kara G Margolis, Gianrico Farrugia, Purna C Kashyap,

Parkinson's disease (PD) is a common neurodegenerative disorder characterized primarily by motor and non-motor gastrointestinal (GI) deficits. GI symptoms' including compromised intestinal barrier function often accompanies altered gut microbiota composition and motor deficits in PD. Therefore, in this study, we set to investigate the role of gut microbiota and epithelial ... Read more >>

Gut Microbes (Gut microbes)
[2021, 13(1):1866974]

Cited: 3 times

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Factors that contribute to the impairment of quality of life in gastroparesis.

Henry P Parkman, Laura A Wilson, Katherine P Yates, Kenneth L Koch, Thomas L Abell, Richard W McCallum, Irene Sarosiek, Braden Kuo, Zubair Malik, Ron Schey, Robert J Shulman, Madhusudan Grover, Gianrico Farrugia, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj J Pasricha, ,

<h4>Background</h4>Understanding factors that impair quality of life (QOL) in gastroparesis is important for clinical management.<h4>Aims</h4>(a) Determine QOL in patients with gastroparesis; (b) Determine factors that impair QOL.<h4>Methods</h4>Gastroparetic patientsAQ6 underwent history and questionnaires assessing symptoms (PAGI-SYM and Rome III), QOL (SF-36v2 and PAGI-QOL), depression (Beck Depression Inventory [BDI]), and anxiety (State ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(8):e14087]

Cited: 0 times

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Psychological, physical, and sleep comorbidities and functional impairment in irritable bowel syndrome: Results from a national survey of U.S. adults.

Madhusudan Grover, Bhanu Prakash Kolla, Rahul Pamarthy, Meghna P Mansukhani, Margaret Breen-Lyles, Jian-Ping He, Kathleen R Merikangas,

<h4>Background/aims</h4>Patients with irritable bowel syndrome (IBS) in referral practice commonly report mental disorders and functional impairment. Our aim was to determine the prevalence of mental, physical and sleep-related comorbidities in a nationally representative sample of IBS patients and their impact on functional impairment.<h4>Methods</h4>IBS was defined by modified Rome Criteria based ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0245323]

Cited: 1 time

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Constipation in Patients With Symptoms of Gastroparesis: Analysis of Symptoms and Gastrointestinal Transit.

Henry P Parkman, Emily Sharkey, Richard W McCallum, William L Hasler, Kenneth L Koch, Irene Sarosiek, Thomas L Abell, Braden Kuo, Robert J Shulman, Madhusudan Grover, Gianrico Farrugia, Ron Schey, James Tonascia, Frank Hamilton, Pankaj J Pasricha, ,

<h4>Background & aims</h4>Constipation can be an important symptom in some patients with gastroparesis. The aims were to: 1) Determine prevalence of constipation and delayed colonic transit in patients with symptoms of gastroparesis; 2) Correlate severity of constipation to severity of symptoms of gastroparesis; and 3) Relate severity of constipation to ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, :]

Cited: 1 time

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Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome.

Ruben A T Mars, Yi Yang, Tonya Ward, Mo Houtti, Sambhawa Priya, Heather R Lekatz, Xiaojia Tang, Zhifu Sun, Krishna R Kalari, Tal Korem, Yogesh Bhattarai, Tenghao Zheng, Noam Bar, Gary Frost, Abigail J Johnson, Will van Treuren, Shuo Han, Tamas Ordog, Madhusudan Grover, Justin Sonnenburg, Mauro D'Amato, Michael Camilleri, Eran Elinav, Eran Segal, Ran Blekhman, Gianrico Farrugia, Jonathan R Swann, Dan Knights, Purna C Kashyap,

Cell (Cell)
[2020, 183(4):1137-1140]

Cited: 2 times

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Duodenal mucosal secretory disturbances in functional dyspepsia.

Susrutha Puthanmadhom Narayanan, David R Linden, Stephanie A Peters, Anshuman Desai, Saatchi Kuwelker, Daniel O'Brien, Thomas J Smyrk, Rondell P Graham, Madhusudan Grover, Adil E Bharucha,

<h4>Background</h4>There is increased recognition of duodenal disturbances (inflammation, altered mucosal protein expression, and chemosensitivity) in functional dyspepsia (FD). Besides sensorimotor functions, enteric submucosal neurons also regulate epithelial ion transport. We hypothesized that duodenal mucosal ion transport and expression of associated genes are altered in FD.<h4>Methods</h4>Duodenal mucosal ion transport (basal and ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(1):e13955]

Cited: 1 time

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Body weight in patients with idiopathic gastroparesis.

Henry P Parkman, Mark Van Natta, Goro Yamada, Madhusudan Grover, Richard W McCallum, Irene Sarosiek, Gianrico Farrugia, Kenneth L Koch, Thomas L Abell, Braden Kuo, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj J Pasricha,

<h4>Background</h4>The classic clinical picture of gastroparesis is a symptomatic patient losing weight. In addition, a number of patients with delayed gastric emptying are obese and/or gaining weight. Our aim was to investigate the factors impacting body weight in patients with idiopathic gastroparesis.<h4>Methods</h4>In patients with idiopathic gastroparesis, detailed history and weight ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(2):e13974]

Cited: 0 times

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Characteristics and Risk Factors of Post-Infection Irritable Bowel Syndrome After Campylobacter Enteritis.

Antonio Berumen, Ryan Lennon, Margaret Breen-Lyles, Jayne Griffith, Robin Patel, David Boxrud, Marijke Decuir, Gianrico Farrugia, Kirk Smith, Madhusudan Grover,

<h4>Background & aims</h4>Campylobacter is the leading cause of bacterial gastroenteritis in the United States. We investigated the prevalence of postinfection irritable bowel syndrome (PI-IBS) in a cohort with culture-confirmed Campylobacter cases; risk factors for PI-IBS based on clinical factors; and shifts in IBS patterns postinfection in patients with pre-existing IBS.<h4>Methods</h4>The ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, 19(9):1855-1863.e1]

Cited: 2 times

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Comparing Clinical, Imaging, and Physiological Correlates of Intestinal Pseudo-Obstruction: Systemic Sclerosis vs Amyloidosis and Paraneoplastic Syndrome.

Rahul Pamarthy, Antonio Berumen, Margaret Breen-Lyles, Madhusudan Grover, Ashima Makol,

<h4>Introduction</h4>Intestinal pseudo-obstruction is characterized by impaired transit and luminal dilation in the absence of mechanical obstruction. Our study aims to describe the clinical, radiographic, and physiological findings in pseudo-obstruction associated with systemic sclerosis (SSc), amyloidosis, and paraneoplastic syndrome.<h4>Methods</h4>A retrospective cohort of patients evaluated at our institution between January 1, 2008, ... Read more >>

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2020, 11(8):e00206]

Cited: 0 times

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New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter.

Lei Dai, Orhan Sahin, Madhusudan Grover, Qijing Zhang,

Campylobacter is an enteric pathogen and a leading bacterial cause of diarrhea worldwide. It is widely distributed in food animal species and is transmitted to humans primarily through the foodborne route. While generally causing self-limited diarrhea in humans, Campylobacter may induce severe or systemic infections in immunocompromised or young/elderly patients, ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2020, 223:76-88]

Cited: 4 times

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Gastric Biopsies in Gastroparesis: Insights into Gastric Neuromuscular Disorders to Aid Treatment.

Lakshmikanth L Chikkamenahalli, Pankaj J Pasricha, Gianrico Farrugia, Madhusudan Grover,

The cellular and molecular understanding of human gastroparesis has markedly improved due to studies on full-thickness gastric biopsies. A decrease in the number of interstitial cells of Cajal (ICC) and functional changes in ICC constitutes the hallmark cellular feature of gastroparesis. More recently, in animal models, macrophages have also been ... Read more >>

Gastroenterol Clin North Am (Gastroenterology clinics of North America)
[2020, 49(3):557-570]

Cited: 1 time

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Autonomic function in gastroparesis and chronic unexplained nausea and vomiting: Relationship with etiology, gastric emptying, and symptom severity.

Linda Nguyen, Laura A Wilson, Laura Miriel, Pankaj J Pasricha, Braden Kuo, William L Hasler, Richard W McCallum, Irene Sarosiek, Kenneth L Koch, William J Snape, Gianrico Farrugia, Madhusudan Grover, John Clarke, Henry P Parkman, James Tonascia, Frank Hamilton, Thomas L Abell, ,

<h4>Background</h4>Autonomic dysfunction can be present in patients with idiopathic and diabetic gastroparesis. The role of autonomic dysfunction relating to gastric emptying and upper gastrointestinal symptoms in patients with gastroparesis and chronic unexplained nausea and vomiting (CUNV) remains unclear. The aim of our study is to evaluate autonomic function in patients ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(8):e13810]

Cited: 6 times

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Delayed Gastric Emptying Associates With Diabetic Complications in Diabetic Patients With Symptoms of Gastroparesis.

Henry P Parkman, Laura A Wilson, Gianrico Farrugia, Kenneth L Koch, William L Hasler, Linda A Nguyen, Thomas L Abell, William Snape, John Clarke, Braden Kuo, Richard W McCallum, Irene Sarosiek, Madhusudan Grover, Laura Miriel, James Tonascia, Frank A Hamilton, Pankaj J Pasricha, ,

OBJECTIVES:Diabetic gastroparesis (Gp) occurs more often in type 1 diabetes mellitus (T1DM) than in type 2 diabetes mellitus (T2DM). Other diabetic end-organ complications include peripheral neuropathy, nephropathy, and retinopathy (together termed triopathy). This study determines the prevalence of diabetic complications (retinopathy, nephropathy, and peripheral neuropathy) in diabetic patients with symptoms ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2019, 114(11):1778-1794]

Cited: 5 times

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Marijuana Use in Patients with Symptoms of Gastroparesis: Prevalence, Patient Characteristics, and Perceived Benefit.

Henry P Parkman, Emily P Sharkey, Linda A Nguyen, Katherine P Yates, Thomas L Abell, William L Hasler, William Snape, John Clarke, Ron Schey, Kenneth L Koch, Braden Kuo, Richard W McCallum, Irene Sarosiek, Madhusudan Grover, Gianrico Farrugia, James Tonascia, Pankaj J Pasricha, ,

<h4>Background</h4>Marijuana may be used by some patients with gastroparesis (Gp) for its potential antiemetic, orexigenic, and pain-relieving effects.<h4>Aims</h4>The aim of this study was to describe the use of marijuana by patients for symptoms of Gp, assessing prevalence of use, patient characteristics, and patients' perceived benefit on their symptoms of Gp.<h4>Methods</h4>Patients ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2020, 65(8):2311-2320]

Cited: 2 times

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