Full Text Journal Articles by
Author Madhulatha Pantrangi

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Modeling of Effective Antimicrobials to Reduce Staphylococcus aureus Virulence Gene Expression Using a Two-Compartment Hollow Fiber Infection Model.

Sanjay K Shukla, Tonia C Carter, Zhan Ye, Madhulatha Pantrangi, Warren E Rose,

Toxins produced by community-associated methicillin-resistant <i>Staphylococcus aureus</i> (CA-MRSA) contribute to virulence. We developed a statistical approach to determine an optimum sequence of antimicrobials to treat CA-MRSA infections based on an antimicrobial's ability to reduce virulence. In an in vitro pharmacodynamic hollow fiber model, expression of six virulence genes (<i>lukSF</i><i>-PV</i>, <i>sek</i>, ... Read more >>

Toxins (Basel) (Toxins)
[2020, 12(2):]

Cited: 1 time

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A NOVEL LARGE HOMOZYGOUS DELETION IN THE CELLULAR RETINALDEHYDE-BINDING PROTEIN GENE (RLBP1) IN A PATIENT WITH RETINITIS PUNCTATA ALBESCENS.

Saghar Bagheri, Madhulatha Pantrangi, Simrat K Sodhi, Sayeh Bagheri, Patrick Oellers, Hendrik P N Scholl,

<h4>Purpose</h4>To report the phenotypic and genotypic data of a patient with retinitis punctata albescens carrying a novel deletion in the RLBP1 gene.<h4>Results</h4>A woman of Iranian descent in her forties with a history of progressive visual deterioration since early childhood exhibited phenotypic features of retinitis punctata albescens with multiple white dots ... Read more >>

Retin Cases Brief Rep (Retinal cases & brief reports)
[2020, 14(1):85-89]

Cited: 1 time

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A founder deletion in the TRPM1 gene associated with congenital stationary night blindness and myopia is highly prevalent in Ashkenazi Jews.

Yoel Hirsch, David A Zeevi, Byron L Lam, Sholem Y Scher, Rachel Bringer, Bitya Cherki, Cadina C Cohen, Hagit Muallem, John Pei-Wen Chiang, Madhulatha Pantrangi, Josef Ekstein, Martin M Johansson,

Congenital stationary night blindness (CSNB) is a disease affecting the night vision of individuals. Previous studies identified TRPM1 as a gene involved in reduced night vision. Homozygous deletion of TRPM1 was the cause of CSNB in several children in 6 Ashkenazi Jewish families, thereby prompting further investigation of the carrier ... Read more >>

Hum Genome Var (Human genome variation)
[2019, 6:45]

Cited: 1 time

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Virulence factor landscape of a Staphylococcus aureus sequence type 45 strain, MCRF184.

Vijay Aswani, Fares Najar, Madhulatha Pantrangi, Bob Mau, William R Schwan, Sanjay K Shukla,

<h4>Background</h4>We describe the virulence factors of a methicillin-sensitive Staphylococcus aureus sequence type (ST) 45 strain, MCRF184, (spa type t917), that caused severe necrotizing fasciitis in a 72-year-old diabetic male. The genome of MCRF184 possesses three genomic islands: a relatively large type III νSaα with 42 open reading frames (ORFs) that ... Read more >>

BMC Genomics (BMC genomics)
[2019, 20(1):123]

Cited: 0 times

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Regulation of Staphylococcal Superantigen-Like Gene, ssl8, Expression in Staphylococcus aureus strain, RN6390.

Madhulatha Pantrangi, Vineet K Singh, Sanjay K Shukla,

Staphylococcal superantigen-like (SSL) proteins, which are encoded by a cluster of eleven ssl genes, contribute to the Staphylococcus aureus virulence. Recently we reported ssl8 expression profiles in seven clinically important strains-MW2, USA300FPR3757, MSSA476, Newman, RN6390, Mu50, and N315-and showed the differential expression of ssl8 in Newman, RN6390, and USA300FPR3757 strains, ... Read more >>

Clin Med Res (Clinical medicine & research)
[2015, 13(1):7-11]

Cited: 4 times

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Comparative whole-genome mapping to determine Staphylococcus aureus genome size, virulence motifs, and clonality.

Sanjay K Shukla, Madhulatha Pantrangi, Buffy Stahl, Adam M Briska, Mary E Stemper, Trevor K Wagner, Emily B Zentz, Steven M Callister, Steven D Lovrich, John K Henkhaus, Colin W Dykes,

Despite being a clonal pathogen, Staphylococcus aureus continues to acquire virulence and antibiotic-resistant genes located on mobile genetic elements such as genomic islands, prophages, pathogenicity islands, and the staphylococcal chromosomal cassette mec (SCCmec) by horizontal gene transfer from other staphylococci. The potential virulence of a S. aureus strain is often ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2012, 50(11):3526-3533]

Cited: 15 times

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Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia.

Warren E Rose, Jens C Eickhoff, Sanjay K Shukla, Madhulatha Pantrangi, Suzan Rooijakkers, Sara E Cosgrove, Victor Nizet, George Sakoulas,

<h4>Background</h4>Staphylococcus aureus bacteremia (SaB) carries considerable morbidity and mortality. We examined the predictive value of serum concentrations of interleukin (IL)-10, proinflammatory cytokines, and terminal complement on patient survival and SaB duration.<h4>Methods</h4>Clinical information on consecutive patients with SaB at a tertiary medical center were collected prospectively. Patient serum samples obtained at ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2012, 206(10):1604-1611]

Cited: 62 times

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Simulated antibiotic exposures in an in vitro hollow-fiber infection model influence toxin gene expression and production in community-associated methicillin-resistant Staphylococcus aureus strain MW2.

Solen Pichereau, Madhulatha Pantrangi, William Couet, Cedric Badiou, Gerard Lina, Sanjay K Shukla, Warren E Rose,

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain MW2 harbors a plethora of toxins to mediate its virulence. However, toxin expression and regulation with simulated clinical antimicrobial exposures are unclear. This study evaluated these relationships using an in vitro pharmacodynamic hollow-fiber infection model. Clinical doses of clindamycin, linezolid, minocycline, trimethoprim-sulfamethoxazole (SXT), and ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2012, 56(1):140-147]

Cited: 11 times

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Staphylococcal superantigen-like genes, ssl5 and ssl8, are positively regulated by Sae and negatively by Agr in the Newman strain.

Madhulatha Pantrangi, Vineet K Singh, Christiane Wolz, Sanjay K Shukla,

Some of the staphylococcal superantigen-like (SSL) proteins SSL5, SSL7, SSL9, and SSL11 act as immunomodulatory proteins in Staphylococcus aureus. However, little is known about their regulatory mechanisms. We determined the expression levels of ssl5 and ssl8 in seven clinically important S. aureus strains and their regulatory mechanisms in the Newman ... Read more >>

FEMS Microbiol Lett (FEMS microbiology letters)
[2010, 308(2):175-184]

Cited: 19 times

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Evidence of multiple virulence subtypes in nosocomial and community-associated MRSA genotypes in companion animals from the upper midwestern and northeastern United States.

Yihan Lin, Emily Barker, Jennifer Kislow, Pravin Kaldhone, Mary E Stemper, Madhulatha Pantrangi, Frances M Moore, Matthew Hall, Thomas R Fritsche, Thomas Novicki, Steven L Foley, Sanjay K Shukla,

<h4>Objective</h4>Not much is known about the zoonotic transmission of methicillin-resistant Staphylococcus aureus (MRSA) in companion animals in the United States. We report the rate of prevalence of S. aureus and MRSA recovered from clinical samples of animals requiring treatment at veterinary clinics throughout the upper midwestern and northeastern United States.<h4>Design</h4>We ... Read more >>

Clin Med Res (Clinical medicine & research)
[2011, 9(1):7-16]

Cited: 40 times

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