Full Text Journal Articles by
Author Madhavi J Rane


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Loss of NF-E2 expression contributes to the induction of profibrotic signaling in diabetic kidneys.

Shunying Jin, Jia Li, Michelle Barati, Sanjana Rane, Qian Lin, Yi Tan, Zongyu Zheng, Lu Cai, Madhavi J Rane,

AIMS:This study aimed to examine the anti-fibrotic role of Nuclear Factor-Erythroid derived 2 (NF-E2) in human renal tubule (HK-11) cells and in type 1 and type 2 diabetic (T1D, T2D) mouse kidneys. MAIN METHODS:Anti-fibrotic effects of NF-E2 were examined in transforming growth factor-β (TGF-β) treated HK-11 cells by over-expressing/silencing NF-E2 ... Read more >>

Life Sci. (Life sciences)
[2020, 254:117783]

Cited: 0 times

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4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress.

Tianjiao Ma, Zongyu Zheng, Hua Guo, Xin Lian, Madhavi J Rane, Lu Cai, Ki Soo Kim, Kyoung Tae Kim, Zhiguo Zhang, Liqi Bi,

Diabetic nephropathy (DN) is one of the most serious long-term complications of type 2 diabetes (T2D). 4-O-methylhonokiol (MH) is one of the biologically active ingredients extracted from the Magnolia stem bark. In this study, we aim to elucidate whether treatment with MH can ameliorate or slow-down progression of DN in ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and Applied Pharmacology)
[2019, 370:93-105]

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Multiple roles of KLF15 in the heart: Underlying mechanisms and therapeutic implications.

Yuguang Zhao, Wenjing Song, Lizhe Wang, Madhavi J Rane, Fujun Han, Lu Cai,

Although there is an increasing understanding of the signaling pathways that promote cardiac hypertrophy, negative regulatory factors of this process have received less attention. Increasing evidence indicates that Krüppel-like factor 15 (KLF15) plays an important role in maintaining cardiac function by controlling the transcriptional pathways that regulating cardiac metabolism. Recent ... Read more >>

J. Mol. Cell. Cardiol. (Journal of molecular and cellular cardiology)
[2019, 129:193-196]

Cited: 0 times

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A nonapoptotic endothelial barrier-protective role for caspase-3.

Karthik Suresh, Kathleen Carino, Laura Johnston, Laura Servinsky, Carolyn E Machamer, Todd M Kolb, Hong Lam, Steven M Dudek, Steven S An, Madhavi J Rane, Larissa A Shimoda, Mahendra Damarla,

Noncanonical roles for caspase-3 are emerging in the fields of cancer and developmental biology. However, little is known of nonapoptotic functions of caspase-3 in most cell types. We have recently demonstrated a disassociation between caspase-3 activation and execution of apoptosis with accompanying cytoplasmic caspase-3 sequestration and preserved endothelial barrier function. ... Read more >>

Am. J. Physiol. Lung Cell Mol. Physiol. (American journal of physiology. Lung cellular and molecular physiology)
[2019, 316(6):L1118-L1126]

Cited: 0 times

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Krϋppel-like factors (KLFs) in renal physiology and disease.

Madhavi J Rane, Yuguang Zhao, Lu Cai,

Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applications of these KLF proteins. KLF2 is critical to maintaining endothelial barrier integrity and preventing gap formations and in prevention ... Read more >>

EBioMedicine (EBioMedicine)
[2019, 40:743-750]

Cited: 0 times

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Clopidogrel Reduces Fibronectin Accumulation and Improves Diabetes-Induced Renal Fibrosis.

Zongyu Zheng, Tianjiao Ma, Xin Lian, Jialin Gao, Weigang Wang, Wenya Weng, Xuemian Lu, Weixia Sun, Yanli Cheng, Yaowen Fu, Madhavi J Rane, Evelyne Gozal, Lu Cai,

Hyperglycemia-induced renal fibrosis causes end-stage renal disease. Clopidogrel, a platelet inhibitor, is often administered to decrease cardiovascular events in diabetic patients. We investigated whether clopidogrel can reduce diabetes-induced renal fibrosis in a streptozotocin-induced type 1 diabetes murine model and fibronectin involvement in this protective response. Diabetic and age-matched controls were ... Read more >>

Int. J. Biol. Sci. (International journal of biological sciences)
[2019, 15(1):239-252]

Cited: 0 times

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PKA activity exacerbates hypoxia-induced ROS formation and hypoxic injury in PC-12 cells.

Evelyne Gozal, Cynthia J Metz, Maurice Dematteis, Leroy R Sachleben, Avital Schurr, Madhavi J Rane,

Hypoxia is a primary factor in many pathological conditions. Hypoxic cell death is commonly attributed to metabolic failure and oxidative injury. cAMP-dependent protein kinase A (PKA) is activated in hypoxia and regulates multiple enzymes of the mitochondrial electron transport chain, thus may be implicated in cellular energy depletion and hypoxia-induced ... Read more >>

Toxicol. Lett. (Toxicology letters)
[2017, 279:107-114]

Cited: 1 time

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Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation.

Rekha Jagadapillai, Madhavi J Rane, Xingyu Lin, Andrew M Roberts, Gary W Hoyle, Lu Cai, Evelyne Gozal,

Diabetes is strongly associated with systemic inflammation and oxidative stress, but its effect on pulmonary vascular disease and lung function has often been disregarded. Several studies identified restrictive lung disease and fibrotic changes in diabetic patients and in animal models of diabetes. While microvascular dysfunction is a well-known complication of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2016, 17(11):]

Cited: 7 times

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Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.

Shu G Chen, Vilius Stribinskis, Madhavi J Rane, Donald R Demuth, Evelyne Gozal, Andrew M Roberts, Rekha Jagadapillai, Ruolan Liu, Kyonghwan Choe, Bhooma Shivakumar, Francheska Son, Shunying Jin, Richard Kerber, Anthony Adame, Eliezer Masliah, Robert P Friedland,

Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-like transmission of protein aggregation. Factors responsible for the initiation of AS aggregation are unknown. To evaluate the role of amyloid proteins made by the microbiota we exposed aged rats and transgenic C. elegans to E. coli producing the extracellular bacterial ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:34477]

Cited: 45 times

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Differential expression of endoplasmic reticulum stress-response proteins in different renal tubule subtypes of OVE26 diabetic mice.

Michelle T Barati, David W Powell, Bobak D Kechavarzi, Susan M Isaacs, Shirong Zheng, Paul N Epstein, Lu Cai, Susan Coventry, Madhavi J Rane, Jon B Klein,

Regulation of the endoplasmic reticulum (ER) stress-response pathway during the course of diabetes specifically in renal tubules is unclear. Since tubule cell dysfunction is critical to progression of diabetic nephropathy, this study analyzed markers of ER stress response and ER chaperones at different stages of diabetes and in different renal ... Read more >>

Cell Stress Chaperones (Cell stress & chaperones)
[2016, 21(1):155-166]

Cited: 6 times

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Macrolide Use and Neutrophil Function/Cytokine Levels in Hospitalized Patients with Community-Acquired Pneumonia: A Pilot Study.

Forest W Arnold, Jose Bordon, Rafael Fernandez-Botran, Madhavi J Rane, Silvia M Uriarte, Robert Kelley, Timothy L Wiemken, Paula Peyrani, Julio A Ramirez, ,

The objective of this study was to measure plasma cytokine levels and blood neutrophil functions as well as clinical outcomes in hospitalized patients with community-acquired pneumonia (CAP) treated with or without macrolide use--a known modulator of inflammatory response.Subjects with CAP had peripheral blood analyzed for some neutrophil functions (degranulation of ... Read more >>

Lung (Lung)
[2016, 194(1):155-162]

Cited: 3 times

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Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.

Shunying Jin, Michael L Merchant, Jeffrey D Ritzenthaler, Kenneth R McLeish, Eleanor D Lederer, Edilson Torres-Gonzalez, Mostafa Fraig, Michelle T Barati, Alex B Lentsch, Jesse Roman, Jon B Klein, Madhavi J Rane,

Immune-complexes play an important role in the inflammatory diseases of the lung. Neutrophil activation mediates immune-complex (IC) deposition-induced acute lung injury (ALI). Components of gamma amino butyric acid (GABA) signaling, including GABA B receptor 2 (GABABR2), GAD65/67 and the GABA transporter, are present in the lungs and in the neutrophils. ... Read more >>

PLoS ONE (PloS one)
[2015, 10(4):e0121637]

Cited: 4 times

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Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation control GABA(B)R-mediated chemotaxis.

Michelle T Barati, Janice Scherzer, Rui Wu, Madhavi J Rane, Jon B Klein,

The γ-amino butyric acid (GABA) type B receptors (GABA(B)R) function as chemoattractant receptors in response to GABA(B)R agonists in human neutrophils. The goal of this study was to define signaling mechanisms regulating GABA(B)R-mediated chemotaxis and cytoskeletal rearrangement. In a proteomic study we identified serine/threonine kinase Akt, tyrosine kinases Src and ... Read more >>

Cell. Signal. (Cellular signalling)
[2015, 27(6):1178-1185]

Cited: 5 times

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Contrasting inflammatory responses in severe and non-severe community-acquired pneumonia.

Rafael Fernandez-Botran, Silvia M Uriarte, Forest W Arnold, Lisandra Rodriguez-Hernandez, Madhavi J Rane, Paula Peyrani, Timothy Wiemken, Robert Kelley, Srinivas Uppatla, Rodrigo Cavallazzi, Francesco Blasi, Letizia Morlacchi, Stefano Aliberti, Colleen Jonsson, Julio A Ramirez, Jose Bordon,

The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (PSI ≥ 91 points). Blood and sputum samples ... Read more >>

Inflammation (Inflammation)
[2014, 37(4):1158-1166]

Cited: 18 times

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Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3.

Mahendra Damarla, Ahmad R Parniani, Laura Johnston, Hasina Maredia, Leonid Serebreni, Omar Hamdan, Venkataramana K Sidhaye, Larissa A Shimoda, Allen C Myers, Michael T Crow, Eric P Schmidt, Carolyn E Machamer, Matthias Gaestel, Madhavi J Rane, Todd M Kolb, Bo S Kim, Rachel L Damico, Paul M Hassoun,

Apoptosis is a key pathologic feature in acute lung injury. Animal studies have demonstrated that pathways regulating apoptosis are necessary in the development of acute lung injury, and that activation of p38 mitogen-activated protein kinase (MAPK) is linked to the initiation of the apoptotic cascade. In this study, we assessed ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2014, 50(5):932-941]

Cited: 15 times

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Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats.

Silvia M Uriarte, Madhavi J Rane, Michael L Merchant, Shunying Jin, Alex B Lentsch, Richard A Ward, Kenneth R McLeish,

Exocytosis of neutrophil granules contributes to acute lung injury (ALI) induced by infection or inflammation, suggesting that inhibition of neutrophil exocytosis in vivo could be a viable therapeutic strategy. This study was conducted to determine the effect of a cell-permeable fusion protein that inhibits neutrophil exocytosis (TAT-SNAP-23) on ALI using ... Read more >>

Shock (Shock (Augusta, Ga.))
[2013, 39(3):286-292]

Cited: 21 times

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Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation.

Wenpeng Cui, Yang Bai, Xiao Miao, Ping Luo, Qiang Chen, Yi Tan, Madhavi J Rane, Lining Miao, Lu Cai,

The present study was to investigate whether sulforaphane (SFN) can prevent diabetic nephropathy in type 1 diabetic mouse model induced by multiple low-dose streptozotocin. Diabetic and age-matched control mice were given SFN at 0.5 mg/kg body weight daily for 3 months. At the end of 3-month SFN treatment, the diabetic ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2012, 2012:821936]

Cited: 39 times

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Understanding the roles of cytokines and neutrophil activity and neutrophil apoptosis in the protective versus deleterious inflammatory response in pneumonia.

Jose Bordon, Stefano Aliberti, Rafael Fernandez-Botran, Silvia M Uriarte, Madhavi J Rane, Padmaraj Duvvuri, Paula Peyrani, Letizia Corinna Morlacchi, Francesco Blasi, Julio A Ramirez,

Inflammation is a double-edged sword in the outcome of pneumonia. On the one hand, an effective and timely inflammatory response is required to eliminate the invading respiratory pathogen. On the other, a toxic and prolonged inflammatory response may result in lung injury and poor outcomes, even in those receiving advanced ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2013, 17(2):e76-83]

Cited: 50 times

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Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst.

Silvia M Uriarte, Madhavi J Rane, Gregory C Luerman, Michelle T Barati, Richard A Ward, William M Nauseef, Kenneth R McLeish,

The role of exocytosis in the human neutrophil respiratory burst was determined using a fusion protein (TAT-SNAP-23) containing the HIV transactivator of transcription (TAT) cell-penetrating sequence and the N-terminal SNARE domain of synaptosome-associated protein-23 (SNAP-23). This agent inhibited stimulated exocytosis of secretory vesicles and gelatinase and specific granules but not ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2011, 187(1):391-400]

Cited: 51 times

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Attenuation of diabetes-induced cardiac inflammation and pathological remodeling by low-dose radiation.

Chi Zhang, Shunzi Jin, Weiying Guo, Cai Li, Xiaokun Li, Madhavi J Rane, Guanjun Wang, Lu Cai,

In the present study, novel preventive effects of repeated low-dose radiation exposure on diabetes-induced cardiac inflammation and cardiac damage were investigated. C57BL/6J mice were given multiple low doses of streptozotocin (STZ, 60 mg/kg × 6) to generate type 1 diabetes. A week after the last STZ injection, hyperglycemic mice were ... Read more >>

Radiat. Res. (Radiation research)
[2011, 175(3):307-321]

Cited: 24 times

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Simulated microbe removal around finger rings using different hand sanitation methods.

Archana A Alur, Madhavi J Rane, James P Scheetz, Douglas J Lorenz, Lawrence Gettleman,

AIM: It is our opinion that the CDC and the WHO have underestimated cross-contamination under examination gloves in dental clinics while wearing jewelry, such as finger rings. These agencies only "recommend" removing jewelry, and only washing hands for 15 seconds with soap and warm water before donning gloves. This study ... Read more >>

Int J Oral Sci (International journal of oral science)
[2009, 1(3):136-142]

Cited: 2 times

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Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex.

Christina B Clark, Madhavi J Rane, Delphine El Mehdi, Cynthia J Miller, Leroy R Sachleben, Evelyne Gozal,

Heat shock protein 90 (Hsp90) is a chaperone protein regulating PC-12 cell survival by binding and stabilizing Akt, Raf-1, and Cdc37. Hsp90 inhibitor geldanamycin (GA) cytotoxicity has been attributed to the disruption of Hsp90 binding, and the contribution of oxidative stress generated by its quinone group has not been studied ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2009, 47(10):1440-1449]

Cited: 22 times

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Regulation of insulin-response element binding protein-1 in obesity and diabetes: potential role in impaired insulin-induced gene transcription.

Jaspreet Chahal, Ching-Chu Chen, Madhavi J Rane, Joseph P Moore, Michelle T Barati, Ying Song, Betty C Villafuerte,

One of the major mechanisms by which insulin modulates glucose homeostasis is through regulation of gene expression. Therefore, reduced expression of transcription factors that are required for insulin-regulated gene expression may contribute to insulin resistance. We recently identified insulin response element-binding protein-1 (IRE-BP1) as a transcription factor that binds and ... Read more >>

Endocrinology (Endocrinology)
[2008, 149(10):4829-4836]

Cited: 8 times

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Regulation of neutrophil apoptosis by modulation of PKB/Akt activation.

Madhavi J Rane, Jon B Klein,

The serine/threonine kinase, Akt, also known as PKB (Protein Kinase B) is one important signal transduction pathway that mediates the delay of neutrophil apoptosis caused by inflammatory mediators. Proteins controlled by the PKB/Akt pathway have been reported to prevent or reverse apoptotic-signaling pathways and regulate cell survival. In this review ... Read more >>

Front Biosci (Landmark Ed) (Frontiers in bioscience (Landmark edition))
[2009, 14:2400-2412]

Cited: 16 times

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Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway.

Syed J Khundmiri, Vishal Amin, Jeff Henson, John Lewis, Mohamed Ameen, Madhavi J Rane, Nicholas A Delamere,

Endogenous cardiotonic glycosides bind to the inhibitory binding site of the plasma membrane sodium pump (Na(+)/K(+)-ATPase). Plasma levels of endogenous cardiotonic glycosides increase in several disease states, such as essential hypertension and uremia. Low concentrations of ouabain, which do not inhibit Na(+)/K(+)-ATPase, induce cell proliferation. The mechanisms of ouabain-mediated response ... Read more >>

Am. J. Physiol., Cell Physiol. (American journal of physiology. Cell physiology)
[2007, 293(3):C1171-80]

Cited: 33 times

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