Full Text Journal Articles by
Author Maciej Maj

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Gene Expression Data Mining Reveals the Involvement of GPR55 and Its Endogenous Ligands in Immune Response, Cancer, and Differentiation.

Artur Wnorowski, Jakub Wójcik, Maciej Maj,

G protein-coupled receptor 55 (GPR55) is a recently deorphanized lipid- and peptide-sensing receptor. Its lipidic endogenous agonists belong to lysoglycerophospholipids, with lysophosphatidylinositol (LPI) being the most studied. Peptide agonists derive from fragmentation of pituitary adenylate cyclase-activating polypeptide (PACAP). Although GPR55 and its ligands were implicated in several physiological and pathological ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(24):]

Cited: 0 times

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Effect of Lacosamide and Ethosuximide Chronic Treatment on Neural Precursor Cells and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice.

Aleksandra Szewczyk, Mirosław Zagaja, Joanna Szala-Rycaj, Maciej Maj, Marta Andres-Mach,

Seizures in about 40% of patients with epilepsy fail to respond to anti-seizure medication (ASM) and may lead to uncontrolled and prolonged seizures often inducing status epilepticus (SE). The aim of the study was to evaluate the impact of a long-term treatment with two different generation ASMs: ethosuximide (ETS, a ... Read more >>

Brain Sci (Brain sciences)
[2021, 11(8):]

Cited: 0 times

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Synthesis of new Hantzsch adducts showing Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power.

Irene Pachón-Angona, Maciej Maj, Artur Wnorowski, Helene Martin, Krzysztof Jóźwiak, Lhassane Ismaili,

<b>Background:</b> Alzheimer's disease is a chronic neurodegenerative chronic disease with a heavy social and economic impact in our developed societies, which still lacks an efficient therapy. <b>Method:</b> This paper describes the Hantzsch multicomponent synthesis of twelve alkyl hexahydro-quinoline-3-carboxylates, <b>4a-l</b>, along with the evaluation of their Ca<sup>2+</sup> channel blockade capacity, cholinesterase inhibition and ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2021, 13(20):1717-1729]

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Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation.

Katarzyna M Targowska-Duda, Barbara Budzynska, Agnieszka Michalak, Artur Wnorowski, Claus J Loland, Maciej Maj, Dina Manetti, Maria Novella Romanelli, Krzysztof Jozwiak, Grazyna Biala, Hugo R Arias,

The aim of this study is to determine whether type I and type II positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) induce antidepressant-like activity in mice after acute, subchronic, and chronic treatments, and to assess whether α7-PAMs inhibit neurotransmitter transporters and activate mTOR (mammalian target of rapamycin) ... Read more >>

Eur Neuropsychopharmacol (European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology)
[2021, 52:31-47]

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Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity.

Paula Zaręba, Kinga Sałat, Georg C Höfner, Kamil Łątka, Marek Bajda, Gniewomir Latacz, Krzysztof Kotniewicz, Anna Rapacz, Adrian Podkowa, Maciej Maj, Krzysztof Jóźwiak, Barbara Filipek, Klaus T Wanner, Barbara Malawska, Katarzyna Kulig,

γ-Aminobutyric acid (GABA) neurotransmission has a significant impact on the proper functioning of the central nervous system. Numerous studies have indicated that inhibitors of the GABA transporters mGAT1-4 offer a promising strategy for the treatment of several neurological disorders, including epilepsy, neuropathic pain, and depression. Following our previous results, herein, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2021, 221:113512]

Cited: 1 time

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Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice.

Marta Andres-Mach, Aleksandra Szewczyk, Mirosław Zagaja, Joanna Szala-Rycaj, Marta Kinga Lemieszek, Maciej Maj, Michał Abram, Krzysztof Kaminski,

Status epilepticus (SE) is a frequent medical emergency that can lead to a variety of neurological disorders, including cognitive impairment and abnormal neurogenesis. The aim of the presented study was the <i>in vitro</i> evaluation of potential neuroprotective properties of a new pyrrolidine-2,5-dione derivatives compound C11, as well as the <i>in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

Cited: 2 times

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Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice

Marta Andres-Mach, Aleksandra Szewczyk, Mirosław Zagaja, Joanna Szala-Rycaj, Marta Kinga Lemieszek, Maciej Maj, Michał Abram, Krzysztof Kaminski,

Status epilepticus (SE) is a frequent medical emergency that can lead to a variety of neurological disorders, including cognitive impairment and abnormal neurogenesis. The aim of the presented study was the in vitro evaluation of potential neuroprotective properties of a new pyrrolidine-2,5-dione derivatives compound C11, as well as the in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

Cited: 0 times

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Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.

Irene Pachón Angona, Helene Martin, Solene Daniel, Ignacio Moraleda, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jozwiak, Isabel Iriepa, Bernard Refouvelet, José Marco-Contelles, Lhassane Ismaili,

We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca<sup>+2</sup> channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl 2,6-dimethyl-4-(4-((5-aminoalkyl)oxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate <b>3a-p</b>, have been obtained via Hantzsch reaction from appropriate and commercially available precursors. Pertinent ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(20):]

Cited: 1 time

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Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels.

Irene Pachòn Angona, Solene Daniel, Helene Martin, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jóźwiak, Tiago Barros Silva, Bernard Refouvelet, Fernanda Borges, José Marco-Contelles, Lhassane Ismaili,

We report herein the design, synthesis and biological evaluation of new antioxidant and neuroprotective multitarget directed ligands (MTDLs) able to block Ca<sup>2+</sup> channels. New dialkyl 2,6-dimethyl-4-(4-(prop-2-yn-1-yloxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate MTDLs <b>3a</b>-<b>t</b>, resulting from the juxtaposition of nimodipine, a Ca<sup>2+</sup> channel antagonist, and rasagiline, a known MAO inhibitor, have been obtained from appropriate and ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(6):]

Cited: 1 time

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Evaluation of the impact of compound C11 a new anticonvulsant candidate on cognitive functions and hippocampal neurogenesis in mouse brain.

Marta Andres-Mach, Aleksandra Szewczyk, Mirosław Zagaja, Jarogniew Luszczki, Maciej Maj, Radoslaw Rola, Michał Abram, Krzysztof Kaminski,

Searching for the new and effective anticonvulsants in our previous study we developed a new hybrid compound C-11 derived from 2-(2,5-dioxopyrrolidin-1-yl) propanamide. C11 revealed high efficacy in acute animal seizure models such as the maximal electroshock model (MES), the pentylenetetrazole model (PTZ) and the 6 Hz (6 Hz, 32 mA) seizure model, as ... Read more >>

Neuropharmacology (Neuropharmacology)
[2020, 163:107849]

Cited: 6 times

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Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy.

Rim Malek, Maciej Maj, Artur Wnorowski, Krzysztof Jóźwiak, Helene Martin, Isabel Iriepa, Ignacio Moraleda, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili,

In this work we describe the synthesis, Ca<sup>+2</sup> channel blockade capacity and antioxidant power of N<sup>3</sup>,N<sup>5</sup>-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxamides 1-9, a number of multi-target small 1,4-dihydropyridines (DHP), designed by juxtaposition of melatonin and nimodipine. As a result, we have identified antioxidant DHP 7 (Ca<sup>2+</sup> channel blockade: 55%, and 8.78 Trolox/Equivalents), the most balanced ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2019, 91:103205]

Cited: 5 times

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Levetiracetam combined with ACEA, highly selective cannabinoid CB1 receptor agonist changes neurogenesis in mouse brain.

Mirosław Zagaja, Agnieszka Haratym-Maj, Aleksandra Szewczyk, Radoslaw Rola, Maciej Maj, Jarogniew J Łuszczki, Marta Andres-Mach,

The aim of the study was to evaluate the impact of second generation antiepileptic drug levetiracetam (LEV) with arachidonyl-2'-chloroethylamide (ACEA) on proliferating neural precursor cells in mouse brain. Additionally, we established the relationship between treatment with ACEA in combination with LEV and hippocampal neurogenesis in mouse brain. All experiments were ... Read more >>

Neurosci Lett (Neuroscience letters)
[2019, 696:79-86]

Cited: 3 times

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Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.

Mourad Chioua, Eleonora Buzzi, Ignacio Moraleda, Isabel Iriepa, Maciej Maj, Artur Wnorowski, Catia Giovannini, Anna Tramarin, Federica Portali, Lhassane Ismaili, Pilar López-Alvarado, Maria Laura Bolognesi, Krzysztof Jóźwiak, J Carlos Menéndez, José Marco-Contelles, Manuela Bartolini,

Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to confront Alzheimer's disease (AD), this strategy has been scarcely investigated. To explore this promising line, a series of 5-amino-4-aryl-3,4,6,7,8,9-hexahydropyrimido [4,5-b]quinoline-2(1H)-thiones (tacripyrimidines) (4a-l) were designed by juxtaposition of tacrine, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 155:839-846]

Cited: 9 times

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A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy.

Marta Andres-Mach, Mirosław Zagaja, Agnieszka Haratym-Maj, Radosław Rola, Maciej Maj, Joanna Haratym, Monika Dudra-Jastrzębska, Jarogniew J Łuszczki,

Rational polytherapy in the treatment of refractory epilepsy has been the main therapeutic modality for several years. In treatment with two or more antiepileptic drugs (AEDs), it is of particular importance that AEDs be selected based on their high anticonvulsant properties, minimal side effects, and impact on the formation of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(5):]

Cited: 11 times

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Molecular Epidemiology of Streptococcus pneumoniae Isolates from Children with Recurrent Upper Respiratory Tract Infections.

Izabela Korona-Glowniak, Maciej Maj, Radosław Siwiec, Artur Niedzielski, Anna Malm,

A total of 125 isolates were recovered from adenoids and/or nasopharynx of 170 children aged 2 to 5 from south-east Poland; they had undergone adenoidectomy for recurrent and/or persistent symptoms of upper respiratory tract infections. Pneumococcal isolates were analyzed by phenotyping (serotyping and antimicrobial resistance tests) and genotyping together with ... Read more >>

PLoS One (PloS one)
[2016, 11(7):e0158909]

Cited: 3 times

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ACEA (a highly selective cannabinoid CB1 receptor agonist) stimulates hippocampal neurogenesis in mice treated with antiepileptic drugs.

Marta Andres-Mach, Agnieszka Haratym-Maj, Miroslaw Zagaja, Radoslaw Rola, Maciej Maj, Magdalena Chrościńska-Krawczyk, Jarogniew J Luszczki,

Hippocampal neurogenesis plays a very important role in learning and memory functions. In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. The aim of this study was to ... Read more >>

Brain Res (Brain research)
[2015, 1624:86-94]

Cited: 12 times

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High Viral Loads of Epstein-Barr Virus DNA in Peripheral Blood of Patients with Chronic Lymphocytic Leukemia Associated with Unfavorable Prognosis.

Ewelina Grywalska, Jacek Roliński, Jacek Roliński, Marcin Pasiarski, Izabela Korona-Glowniak, Maciej Maj, Agata Surdacka, Agnieszka Grafka, Agnieszka Stelmach-Gołdyś, Michał Zgurski, Stanisław Góźdź, Anna Malm, Piotr Grabarczyk, Elżbieta Starosławska,

Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus that infects more than 90% of the world population. The potential involvement of EBV in the clinical course of chronic lymphocytic leukemia (CLL) remains unexplained. The aim of this study was to determine whether EBV-DNA load in the peripheral blood mononuclear cells (PBMCs) ... Read more >>

PLoS One (PloS one)
[2015, 10(10):e0140178]

Cited: 11 times

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