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Author Maarten Albersen

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Long-term consequences of bilateral cavernous crush injury in normal and diabetic rats: a functional study.

Fabio Castiglione, Maarten Albersen, Salvatore Fiorenzo, Petter Hedlund, Omer Onur Cakir, Carlo Pavone, Hussain M Alnajjar, Steven Joniau, Asif Muneer, ,

A recent statement from the European-Society-for-Sexual-Medicine has highlighted the limitations of using the rat model for nerve-sparing prostatectomy. The use of young rats with no comorbidities and the early evaluation of the erectile function (EF) are deemed a source of bias. Our aim was to evaluate the long-term consequences in ... Read more >>

Int J Impot Res (International journal of impotence research)
[2021, :]

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Defining High-quality Urological Health Care.

Maarten Albersen,

Eur Urol Focus (European urology focus)
[2021, :]

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Risk factors and survival outcomes for upstaging after inguinal lymph node dissection for cN1 penile squamous cell carcinoma.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

<h4>Objectives</h4>To identify incidence and risk factors for upstaging from cN1 to pN2/N3 at inguinal lymphadenectomy (ILND) for penile cancer (pSCC). Our secondary objective is to assess survival outcomes and associations for cN1 patients undergoing ILND.<h4>Subjects/patients and methods</h4>Patients with pT≥1cN1cM0 pSCC who underwent bilateral ILND and had complete data were identified ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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The use of local therapy in preventing urethral strictures: A systematic review.

Marleen E Jacobs, Vincent F de Kemp, Maarten Albersen, Laetitia M O de Kort, Petra de Graaf,

<h4>Background</h4>Urethral stricture disease is a common problem amongst men in Western countries often leading to a decreased quality of life. Current endoscopic treatment procedure shows an unsatisfying stricture recurrence rate which could be improved by addition of local therapies.<h4>Objectives</h4>To provide an overview of both preclinical and clinical studies in order ... Read more >>

PLoS One (PloS one)
[2021, 16(10):e0258256]

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Supportive care needs and utilization of bladder cancer patients undergoing radical cystectomy: A longitudinal study.

Elke Rammant, Ann Van Hecke, Karel Decaestecker, Maarten Albersen, Steven Joniau, Wouter Everaerts, Femke Jansen, Nihal E Mohamed, Roos Colman, Mieke Van Hemelrijck, Valérie Fonteyne,

<h4>Objectives</h4>Investigating supportive care (SC) needs and utilization/willingness to use SC services from diagnosis to one year after radical cystectomy in bladder cancer (BC) patients. MATERIALS & METHODS: A longitudinal cohort study was conducted in 90 BC patients at Ghent/Leuven University Hospitals between April 2017 and December 2020. The Supportive Care Needs ... Read more >>

Psychooncology (Psycho-oncology)
[2021, :]

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Multitumor Case Series of Germline BRCA1, BRCA2 and CHEK2-Mutated Patients Responding Favorably on Immune Checkpoint Inhibitors.

Lisa Kinget, Oliver Bechter, Kevin Punie, Philip R Debruyne, Hilde Brems, Paul Clement, Eduard Roussel, Yannick Van Herck, Maarten Albersen, Marcella Baldewijns, Patrick Schöffski, Benoit Beuselinck,

In recent years, immune checkpoint inhibitors (ICPI) have become widely used for multiple solid malignancies. Reliable predictive biomarkers for selection of patients who would benefit most are lacking. Several tumor types with somatic or germline alterations in genes involved in the DNA damage response (DDR) pathway harbor a higher tumor ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2021, 28(5):3227-3239]

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Impact of radiation therapy on perineal urethrostomy for penile cancer.

Peter A S Johnstone, Hielke M de Vries, Juan Chipollini, G Daniel Grass, Franklin Boyd, Fernando Korkes, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Viraj Master, Thien-Linh Le, Asif Muneer, Oscar R Brouwer, Philippe E Spiess,

<h4>Objective</h4>A lack of demonstrated clinical benefit precludes radiotherapy (RT) from being recommended for pN1/pN2 penile cancer (PeCa) lesions; but it may be recommended in case of extranodal (pN3) disease or for positive resection margins. Perineal urethrostomy (PU) is a technique of urinary diversion in patients with PeCa requiring total or ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 30:84-87]

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Human and animal fertility studies in cystinosis reveal signs of obstructive azoospermia, an altered blood-testis barrier and a subtherapeutic effect of cysteamine in testis.

Ahmed Reda, Koenraad Veys, Prashant Kadam, Anna Taranta, Laura Rita Rega, Bianca M Goffredo, Chelsea Camps, Martine Besouw, Daniel Cyr, Maarten Albersen, Carl Spiessens, Liesbeth de Wever, Robert Hamer, Mirian C H Janssen, Kathleen D'Hauwers, Alex Wetzels, Leo Monnens, Lambertus van den Heuvel, Ellen Goossens, Elena Levtchenko,

Cystinosis is an inherited metabolic disorder caused by autosomal recessive mutations in the CTNS gene leading to lysosomal cystine accumulation. The disease primarily affects the kidneys followed by extra-renal organ involvement later in life. Azoospermia is one of the unclarified complications which are not improved by cysteamine, which is the ... Read more >>

J Inherit Metab Dis (Journal of inherited metabolic disease)
[2021, :]

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Reply by Authors.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

J Urol (The Journal of urology)
[2021, 206(4):969]

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Molecular underpinnings of glandular tropism in metastatic clear cell renal cell carcinoma: therapeutic implications.

Eduard Roussel, Lisa Kinget, Annelies Verbiest, Bram Boeckx, Jessica Zucman-Rossi, Gabrielle Couchy, Stefano Caruso, Marcella Baldewijns, Steven Joniau, Hendrik Van Poppel, Diether Lambrechts, Maarten Albersen, Benoit Beuselinck,

<h4>Background</h4>Glandular metastases (GM) have been associated with improved survival in metastatic clear cell renal cell carcinoma (m-ccRCC). We aimed to molecularly characterize m-ccRCC with GM.<h4>Material and methods</h4>We performed a retrospective cohort study on all m-ccRCC patients with available tissue at our institution, diagnosed with metastatic disease from 2000 to 2019. ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2021, 60(11):1499-1506]

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The European Urology Commitment to Gender Equity and Diversity: Expanding Cognitive Diversity through Inclusivity at the Podium.

Sarah P Psutka, Todd Morgan, Maarten Albersen, Jean-Nicolas Cornu, Giacomo Novara, Elizabeth Plimack, Piet Ost, James W F Catto,

Eur Urol (European urology)
[2021, 80(4):450-453]

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Molecular Subtypes and Gene Expression Signatures as Prognostic Features in Fully Resected Clear Cell Renal Cell Carcinoma: A Tailored Approach to Adjuvant Trials.

Eduard Roussel, Annelies Verbiest, Lisa Kinget, Bram Boeckx, Jessica Zucman-Rossi, Gabrielle Couchy, Stefano Caruso, Sylvie Job, Aurélien de Reyniès, Liesbeth De Wever, Marcella Baldewijns, Hendrik Van Poppel, Steven Joniau, Diether Lambrechts, Maarten Albersen, Benoit Beuselinck,

<h4>Background</h4>Trials with adjuvant vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) failed to demonstrate meaningful benefit in clinically high-risk, fully resected clear cell renal cell carcinoma (ccRCC). We evaluated whether the ccrcc1-4 molecular subtypes and gene expression signatures (GES) are associated with outcomes in this setting.<h4>Materials and methods</h4>We determined ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Three Years After CARMENA: What Have We Learned?

Eduard Roussel, Benoit Beuselinck, Maarten Albersen,

Cytoreductive nephrectomy makes way for more effective systemic treatments in the current mRCC treatment paradigm, as disease volume and the number of IMDC risk factors increase. Careful patient selection for upfront or deferred cytoreductive nephrectomy based on these criteria remains key. ... Read more >>

Eur Urol (European urology)
[2021, 80(4):425-427]

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Circulating MicroRNAs, the Next-Generation Serum Biomarkers in Testicular Germ Cell Tumours: A Systematic Review.

Ricardo Leão, Maarten Albersen, Leendert H J Looijenga, Torgrim Tandstad, Christian Kollmannsberger, Matthew J Murray, Stephane Culine, Nicholas Coleman, Gazanfer Belge, Robert J Hamilton, Klaus-Peter Dieckmann,

<h4>Context</h4>Clinical management of testicular germ cell tumours (GCTs) is hampered by low sensitivity and specificity of the biomarkers currently in use. Circulating microRNAs (miRs) might offer the potential to address areas of unmet clinical need.<h4>Objective</h4>To systematically evaluate the evidence for clinical applications of serum levels of miR302/367 and miR371-3 in ... Read more >>

Eur Urol (European urology)
[2021, 80(4):456-466]

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Outcomes of perineal urethrostomy for penile cancer: A 20-year international multicenter experience.

Hielke M de Vries, Juan Chipollini, Julio Slongo, Franklin Boyd, Fernando Korkes, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Viraj Master, Thien-Linh Le, Peter A Johnstone, Asif Muneer, Oscar R Brouwer, Philippe E Spiess,

<h4>Purpose</h4>Perineal urethrostomy (PU) is often the definitive form of urinary diversion in patients with locally-advanced or anatomically unfavorable penile cancer (PC) requiring total penectomy. Here, we report post-operative PU-related complications and PU stenosis rates after total penectomy with PU in a large multicenter cohort of PC patients.<h4>Methods</h4>We retrospectively reviewed the ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(8):500.e9-500.e13]

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Increased Level of Tumor Necrosis Factor-Alpha (TNF-α) Leads to Downregulation of Nitrergic Neurons Following Bilateral Cavernous Nerve Injury and Modulates Penile Smooth Tone.

Hotaka Matsui, Nikolai A Sopko, Jeffrey D Campbell, Xiaopu Liu, Allison Reinhardt, Emmanuel Weyne, Fabio Castiglione, Maarten Albersen, Johanna L Hannan, Trinity J Bivalacqua,

<h4>Background</h4>Erectile dysfunction (ED) after injury to peripheral cavernous nerve (CN) is partly a result of inflammation in pelvic ganglia, suggesting that ED may be prevented by inhibiting neuroinflammation.<h4>Aim</h4>The aim of this study is to examine temporal changes of TNF-α, after bilateral CN injury (BCNI), to evaluate effect of exogenous TNF-α ... Read more >>

J Sex Med (The journal of sexual medicine)
[2021, 18(7):1181-1190]

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MicroRNAs Targeting HIF-2α, VEGFR1 and/or VEGFR2 as Potential Predictive Biomarkers for VEGFR Tyrosine Kinase and HIF-2α Inhibitors in Metastatic Clear-Cell Renal Cell Carcinoma.

Lisa Kinget, Eduard Roussel, Annelies Verbiest, Maarten Albersen, Cristina Rodríguez-Antona, Osvaldo Graña-Castro, Lucía Inglada-Pérez, Jessica Zucman-Rossi, Gabrielle Couchy, Sylvie Job, Aurélien de Reyniès, Annouschka Laenen, Marcella Baldewijns, Benoit Beuselinck,

Metastatic clear-cell renal cell carcinoma (m-ccRCC) is characterized by increased hypoxia-induced factor (HIF)-2α and vascular endothelial growth factor receptor (VEGFR)-dependent angiogenesis through loss of function of the von Hippel-Lindau protein. VEGFR tyrosine kinase inhibitors (VEGFR-TKIs) are a cornerstone of m-ccRCC treatment, and new treatments targeting HIF-2α are currently under investigation. ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(12):]

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Assessment of PI3K/mTOR/AKT Pathway Elements to Serve as Biomarkers and Therapeutic Targets in Penile Cancer.

Anita Thomas, Sascha Reetz, Philipp Stenzel, Katrin Tagscherer, Wilfried Roth, Mario Schindeldecker, Martin Michaelis, Florian Rothweiler, Jindrich Cinatl, Jaroslav Cinatl, Robert Dotzauer, Olesya Vakhrusheva, Maarten Albersen, Stephan Macher-Goeppinger, Axel Haferkamp, Eva Juengel, Andreas Neisius, Igor Tsaur,

The PI3K/mTOR/AKT pathway might represent an intriguing option for treatment of penile cancer (PeCa). We aimed to assess whether members of this pathway might serve as biomarkers and targets for systemic therapy. Tissue of primary cancer from treatment-naïve PeCa patients was used for tissue microarray analysis. Immunohistochemical staining was performed ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(10):]

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Patterns of Recurrence following Inguinal Lymph Node Dissection for Penile Cancer: Optimizing Surveillance Strategies.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

<h4>Purpose</h4>Our primary objective is to detail the incidence, site, and timing of penile squamous cell carcinoma (pSCC) recurrence after inguinal lymph node dissection (ILND).<h4>Materials and methods</h4>We performed a retrospective analysis of 551 patients who underwent ILND for pSCC from 2000 to 2017. The primary outcome was pSCC recurrence after ILND. ... Read more >>

J Urol (The Journal of urology)
[2021, 206(4):960-969]

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Single-cell Transcriptomics Uncover a Novel Role of Myeloid Cells and T-lymphocytes in the Fibrotic Microenvironment in Peyronie's Disease.

Uros Milenkovic, Bram Boeckx, Diether Lambrechts, Rekin's Janky, Georgios Hatzichristodoulou, Koen van Renterghem, Thomas Gevaert, Selim Cellek, Trinity J Bivalacqua, Dirk De Ridder, Maarten Albersen,

<h4>Background</h4>Peyronie's disease (PD) is an acquired fibrotic disease affecting the penile tunica albuginea that can lead to curvature and deformities, shortening, and erectile dysfunction. Although immunological mechanisms have been suggested for the pathophysiology of PD, these have not been investigated using single-cell transcriptomics.<h4>Objective</h4>To investigate the immunological signature of plaques from ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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AUTHOR REPLY.

Charlotte Maggen, Maarten Albersen, Frédéric Amant, ,

Urology (Urology)
[2021, 151:127-128]

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Reply to Kunlin Yang, Xuesong Li, and Liqun Zhou's Letter to the Editor re: Eduard Roussel, Giovanni Tasso, Riccardo Campi, et al. Surgical Management and Outcomes of Renal Tumors Arising from Horseshoe Kidneys: Results from an International Multicenter Collaboration. Eur Urol 2021;79:133-40.

Eduard Roussel, Giovanni Tasso, Maarten Albersen,

Eur Urol (European urology)
[2021, 80(1):e32]

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Corrigendum to 'Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC)' [European Urology Oncology 3 (2021) 256-263].

Michele Marchioni, Maximilian Kriegmair, Mathias Heck, Thomas Amiel, Francesco Porpiglia, Enrico Checcucci, Riccardo Campi, Andrea Minervini, Andrea Mari, Siska Van Bruwaene, Estefania Linares, Vital Hevia, Mireia Musquera, Mauricio D'Anna, Ithaar Derweesh, Aaron Bradshaw, Riccardo Autorino, Georgi Guruli, Alessandro Veccia, Eduard Roussel, Maarten Albersen, Nicola Pavan, Francesco Claps, Alessandro Antonelli, Carlotta Palumbo, Tobias Klatte, Selcuk Erdem, Maria Carmen Mir, ,

Eur Urol Oncol (European urology oncology)
[2021, 4(3):517]

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Current practices regarding corporotomy localization during penoscrotal inflatable penile implant surgery: a multicenter cohort study.

Koenraad van Renterghem, Brecht Jacobs, Faysal Yafi, Daniar Osmonov, David Ralph, Luca Venturino, John Taylor Barnard, Matthew Ziegelmann, Run Wang, Chris Kannady, Aaron Lentz, Enrique Lledo Garcia, Robert Andrianne, Carlo Bettochi, George Hatzichristodoulou, Martin Gross, Antoine Faix, Javier Romero Otero, Juan Ignacio Martinez Salamanca, Omidreza Sedigh, Maarten Albersen, Marij Dinkelman-Smit, Ioannis Mykoniatis,

Literature concerning corporotomy location in multicomponent inflatable penile prosthetic surgery via a penoscrotal approach is scarce if not nonexistent. Aim of our study was to report practices in low-, moderate-, and high-volume penile implant centers regarding corporotomy location and evaluate its potential impact on intraoperative and short-term postoperative complications. Data ... Read more >>

Int J Impot Res (International journal of impotence research)
[2021, :]

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Focusing on sexual rehabilitation besides penile rehabilitation following radical prostatectomy is important.

Daphné Vanderhaeghe, Maarten Albersen, Emmanuel Weyne,

Erectile dysfunction is commonly reported after radical prostatectomy. Besides the loss of erections, sexual life after prostatectomy is impacted by urinary incontinence, orgasmic dysfunction, and psychological stress. In this review, we describe classical medical therapies used for erectile function rehabilitation such as PDE5 inhibitors and injection therapy. A vast amount ... Read more >>

Int J Impot Res (International journal of impotence research)
[2021, 33(4):448-456]

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