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Author Maarit Kortesoja

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A platform for studying the transfer of Chlamydia pneumoniae infection between respiratory epithelium and phagocytes.

Maarit Kortesoja, Raluca Elena Trofin, Leena Hanski,

The obligate intracellular bacterium, Chlamydia pneumoniae, has been identified as a risk factor for several chronic inflammatory diseases in addition to respiratory tract infections. The dissemination of C. pneumoniae from respiratory tract to secondary sites of infection occurs via infected monocyte / macrophage line cells, in which C. pneumoniae can ... Read more >>

J. Microbiol. Methods (Journal of microbiological methods)
[2020, 171:105857]

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Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence of Staphylococcus aureus.

Kirsi Savijoki, Ilkka Miettinen, Tuula A Nyman, Maarit Kortesoja, Leena Hanski, Pekka Varmanen, Adyary Fallarero,

The present study investigated Staphylococcus aureus ATCC25923 surfaceomes (cell surface proteins) during prolonged growth by subjecting planktonic and biofilm cultures (initiated from exponential or stationary cells) to label-free quantitative surfaceomics and phenotypic confirmations. The abundance of adhesion, autolytic, hemolytic, and lipolytic proteins decreased over time in both growth modes, while ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(1):]

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Assaying Chlamydia pneumoniae Persistence in Monocyte-Derived Macrophages Identifies Dibenzocyclooctadiene Lignans as Phenotypic Switchers.

Eveliina Taavitsainen, Maarit Kortesoja, Tanja Bruun, Niklas G Johansson, Leena Hanski,

Antibiotic-tolerant persister bacteria involve frequent treatment failures, relapsing infections and the need for extended antibiotic treatment. The virulence of an intracellular human pathogen C. pneumoniae is tightly linked to its propensity for persistence and means for its chemosensitization are urgently needed. In the current work, persistence of C. pneumoniae clinical ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(2):]

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Assaying Chlamydia pneumoniae persistence in monocyte-derived macrophages identifies schisandrin lignans as phenotypic switchers

Eveliina Taavitsainen, Maarit Kortesoja, Leena Hanski,

Abstract Antibiotic-tolerant persister bacteria involve frequent treatment failures, relapsing infections and the need for extended antibiotic treatment. Taking persisters into account in susceptibility assays is thus an essential success factor in antibacterial drug discovery. The virulence of the obligate intracellular bacterium Chlamydia pneumoniae is tightly linked to its propensity for ... Read more >>

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Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells.

Maarit Kortesoja, Elina Karhu, Elin Soffia Olafsdottir, Jona Freysdottir, Leena Hanski,

Redox signaling has been established as an essential component of inflammatory responses, and redox active compounds are of interest as potential immunomodulatory agents. Dibenzocyclooctadiene lignans isolated from Schisandra chinensis, a medicinal plant with widespread use in oriental medicine, have been implicated to possess immunomodulatory properties but their effects on the ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2019, 131:309-317]

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