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Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants.

Chunsheng Wu, Xiangting Yi, Renzhi Xu, Maokuan Zhang, Yan Xu, Yan Ma, Li Gao, Zhengbao Zha,

Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose-limiting adverse effects. Local chemotherapy with VP16-loaded drug delivery systems could provide a continuous ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):974-982]

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Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation.

Shuo Zhang, Yan Ma, Juan Feng,

Trans-(-)-ε-viniferin (ε-viniferin) has antioxidative and anti-inflammatory effects. It also has neuroprotective effects in Huntington's disease by activating the SIRT3/LKB1/AMPK signaling pathway; however, it remains unknown whether ε-viniferin also has a neuroprotective role in Parkinson's disease. A Parkinson's disease cell model was induced by exposing SH-SY5Y cells to 3.0 μM rotenone ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(11):2143-2153]

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Drug-coated balloon for vertebral artery origin stenosis: a pilot study.

Yabing Wang, Yiding Feng, Tao Wang, Yan Ma, Peng Gao, Jian Chen, Yanfei Chen, Bin Yang, Liqun Jiao,

BACKGROUND:Drug-coated balloon (DCB) is a potential treatment for patients with low restenosis risk in vertebral artery origin stenosis (VAOS). However, the clinical data of long-term outcome are limited. OBJECTIVE:To evaluate the safety and efficacy of a DCB in patients with severe VAOS. METHODS:A prospective, non-randomized, single-center pilot study enrolled 30 ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2020, :]

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Clinical Significance of Systemic Inflammation Response Index and Platelet–lymphocyte Ratio in Patients with Adenocarcinoma of The Esophagogastric Junction and Upper Gastric Cancer

Xin Yin, Tianyi Fang, Xuan Lin, Xiliang Cong, Yimin Wang, Chunfeng Li, Yan Ma, Yingwei Xue,

Abstract Background: Tumor immunity plays an important role in assessing the tumor progression. The purpose of this study was to investigate the prognostic value of combined systemic inflammation response index (SIRI) and platelet–lymphocyte ratio (PLR) for treatment of gastroesophageal junction cancer (AEG) and upper gastric cancer (UGC). Methods : In ... Read more >>

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The kite flap for reconstructing tumour excision wounds in the middle and lower face: a retrospective study.

Ma Yan, Zhou Xiaobo, Yuan Zhaoqi, Wang Xiuxia, Jin Rui, Liu Fei, Chen Jun, Luo Xusong, Yang Jun, Sun Di,

OBJECTIVE:The aim of this study was to present our experience with a kite flap in reconstruction of facial wounds after malignant tumour excision. METHOD:From October 2008 to September 2017, patients with facial malignant tumour were treated in the Xinjiang Uygur Autonomous Region Bazhou People's Hospital with kite flaps after complete ... Read more >>

J Wound Care (Journal of wound care)
[2020, 29(10):562-566]

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Full-length transcriptome sequencing analysis and development of EST-SSR markers for the endangered species Populus wulianensis.

Qichao Wu, Fengqi Zang, Xiaoman Xie, Yan Ma, Yongqi Zheng, Dekui Zang,

Populus wulianensis is an endangered species endemic to Shandong Province, China. Despite the economic and ornamental value of this species, few genomics and genetic studies have been performed. In this study, we performed a relevant analysis of the full-length transcriptome sequencing data of P. wulianensis and obtained expressed sequence tag ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):16249]

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Transcranial Color-Coded Sonography Criteria for Moderate and Severe Middle Cerebral Artery Stenosis.

Ran Liu, Jingzhi Li, Yang Hua, Jie Yang, Yue Zhao, Xiaojie Tian, Yan Ma, Wenbo Zhao,

This study aimed to establish optimal criteria for evaluation of moderate (50%-69%) and severe (70%-99%) middle cerebral artery (MCA) stenosis with transcranial color-coded sonography (TCCS). A total of 375 cases provided 409 TCCS/digital subtraction angiography vessel pairs. Peak systolic velocity (PSV), end-diastolic velocity (EDV) and mean flow velocity (MFV) of ... Read more >>

Ultrasound Med Biol (Ultrasound in medicine & biology)
[2020, :]

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Effects of Dengzhan Shengmai Capsule combined with butylphthalide soft capsule on oxidative stress indexes and serum Hcy and CRP levels in patients with vascular dementia.

Yan Ma, Wenping Sun,

This experiment was aimed to investigate the effect of Dengzhan Shengmai capsule combined with butylphthalide soft capsule on oxidative stress indexes and serum homocysteine (Hcy) and C-reactive protein (CRP) levels in patients with vascular dementia (VD). From July 2017 to July 2019, 123 patients with VD in our hospital were ... Read more >>

Cell Mol Biol (Noisy-le-grand) (Cellular and molecular biology (Noisy-le-Grand, France))
[2020, 66(6):8-14]

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Effect of AK098656 on association of hypertension with coronary stenosis severity in coronary heart disease patients

Xin Wang, Ya-li Wu, Yuan-yuan Zhang, Jing Ke, Bao-yu Zhang, Yan Ma, Long-yan Yang, Dong Zhao,

Abstract Background: AK098656 may be an adverse factor for coronary heart disease (CHD), especially in patients with hypertension. This study aimed to analyze the effect of AK098656 on CHD and CHD with various complications. Methods: A total of 117 CHD patients and 27 healthy control subjects were enrolled in the ... Read more >>

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Theoretical study on the catalytic mechanism of human deoxyhypusine hydroxylase.

Junkai Wang, Yan Ma, Xixi Wang, Ying Zhang, Hongwei Tan, Xichen Li, Guangju Chen,

Deoxyhypusine hydroxylase is a critical enzyme for hypusination of eukaryotic translation initiation factor 5A (eIF5A). Human deoxyhypusine hydroxylase (hDOHH) has a nonheme diiron active site that resembles both in structure and function of those found in methane and toluene monooxygenases, bacterial and mammalian ribonucleotide reductases, and stearoyl acyl carrier protein ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(39):22736-22745]

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Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.

Katherine Deland, Bryce F Starr, Joshua S Mercer, Jovita Byemerwa, Donna M Crabtree, Nerissa T Williams, Lixia Luo, Yan Ma, Mark Chen, Oren J Becher, David G Kirsch,

Diffuse intrinsic pontine glioma (DIPG) kills more children than any other type of brain tumor. Despite clinical trials testing many chemotherapeutic agents, palliative radiotherapy remains the standard treatment. Here, we utilized Cre/loxP technology to show that deleting Ataxia telangiectasia mutated (Atm) in primary mouse models of DIPG can enhance tumor ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, :]

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Real-Time fMRI Brain Mapping in Animals.

Sangcheon Choi, Kengo Takahashi, Yuanyuan Jiang, Sascha Köhler, Hang Zeng, Qi Wang, Yan Ma, Xin Yu,

Dynamic fMRI responses vary largely according to the physiological conditions of animals either under anesthesia or in awake states. We developed a real-time fMRI platform to guide experimenters to monitor fMRI responses instantaneously during acquisition, which can be used to modify the physiology of animals to achieve desired hemodynamic responses ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2020, (163):]

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Application of a Prediction Model Based on the Laboratory Index Score in Prelabor Rupture of Membranes with Histologic Chorioamnionitis During Late Pregnancy.

Yan Ma, Yun Xu, Lijuan Jiang, Xiaonan Shao,

BACKGROUND This study aimed to establish a prediction model based on the maternal laboratory index score (Lab-score) for histologic chorioamnionitis (HCA) in patients with prelabor rupture of membranes (PROM) during late pregnancy. MATERIAL AND METHODS Sixty-nine cases of pregnant women with PROM were retrospectively analyzed. The general information and laboratory ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e924756]

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Prognostic significance of Borrmann type combined with vessel invasion status in advanced gastric cancer

Zhao Zhai, Zi-Yu Zhu, Yu Zhang, Xin Yin, Bang-Ling Han, Jia-Liang Gao, Sheng-Han Lou, Tian-Yi Fang, Yi-Min Wang, Chun-Feng Li, Xue-Feng Yu, Yan Ma, Ying-Wei Xue,

BACKGROUND Borrmann classification (types I-IV) for the detection of advanced gastric cancer has been accepted worldwide, and lymphatic and/or blood vessel invasion (LBVI) status is related to the poor prognosis after gastric cancer. AIM To evaluate the significance of Borrmann type combined with LBVI status in predicting the prognosis of ... Read more >>

(World journal of gastrointestinal oncology)
[2020, 12(9):992-1004]

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Sex-Related Differential Whole-Brain Input Atlas of Locus Coeruleus Noradrenaline Neurons.

Pei Sun, Junjun Wang, Meng Zhang, Xinxin Duan, Yunfei Wei, Fuqiang Xu, Yan Ma, Yu-Hui Zhang,

As the most important organ in our bodies, the brain plays a critical role in deciding sex-related differential features; however, the underlying neural circuitry basis remains unclear. Here, we used a cell-type-specific rabies virus-mediated monosynaptic tracing system to generate a sex differences-related whole-brain input atlas of locus coeruleus noradrenaline (LC-NE) ... Read more >>

Front Neural Circuits (Frontiers in neural circuits)
[2020, 14:53]

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Up Regulation of LINC00473 Promotes Cervical Cancer Progression and Predicts Poor Prognosis

Xi Zhou, Xia Zhao, Zhouyi Wu, Yan Ma, Heng Li,

Abstract Objective Long noncoding RNAs imbalance exert momentous effect in cancer. LINC00473 can accelerate the extensive tumors proceeding. Nevertheless, LINC00473 effects in cervical cancer has less reported. This study focused on estimate the LINC00473 effects in the developing process of cervical cancer and its unknown molecular biological regulation mechanism. Methods ... Read more >>

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Implications of Projected Hydroclimatic Change for Tularemia Outbreaks in High-Risk Areas across Sweden.

Yan Ma, Guillaume Vigouroux, Zahra Kalantari, Romain Goldenberg, Georgia Destouni,

Hydroclimatic change may affect the range of some infectious diseases, including tularemia. Previous studies have investigated associations between tularemia incidence and climate variables, with some also establishing quantitative statistical disease models based on historical data, but studies considering future climate projections are scarce. This study has used and combined hydro-climatic ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(18):]

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Discovery and validation of hsa_circ_0001953 as a potential biomarker for proliferative diabetic retinopathy in human blood.

Zheming Wu, Bing Liu, Yan Ma, Haisong Chen, Jing Wu, Jiawei Wang,

PURPOSE:This study aimed to determine whether circular RNAs (circRNAs) in whole blood could be served as novel non-invasive biomarkers for proliferative diabetic retinopathy (PDR). METHODS:This retrospective cross-sectional study comprised 34 healthy participants, 34 PDR patients and 34 non-proliferative DR (NPDR) patients. High-throughput whole transcriptome sequencing was performed to explore the ... Read more >>

Acta Ophthalmol (Acta ophthalmologica)
[2020, :]

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Amplitude spectrum trend-based feature for excitation location classification from snore sounds.

Jingpeng Sun, Xiyuan Hu, Chen Chen, Silong Peng, Yan Ma,

OBJECTIVE:Successful surgical treatment of obstructive sleep apnea (OSA) depends on the precise location of the vibrating tissue. Snoring is the main symptom of OSA and can be utilized to detect the active location of tissues. However, existing approaches are limited, owing to their inability to capture the characteristics of snoring ... Read more >>

Physiol Meas (Physiological measurement)
[2020, 41(8):085006]

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Prognostic significance of Borrmann type combined with vessel invasion status in advanced gastric cancer.

Zhao Zhai, Zi-Yu Zhu, Yu Zhang, Xin Yin, Bang-Ling Han, Jia-Liang Gao, Sheng-Han Lou, Tian-Yi Fang, Yi-Min Wang, Chun-Feng Li, Xue-Feng Yu, Yan Ma, Ying-Wei Xue,

BACKGROUND:Borrmann classification (types I-IV) for the detection of advanced gastric cancer has been accepted worldwide, and lymphatic and/or blood vessel invasion (LBVI) status is related to the poor prognosis after gastric cancer. AIM:To evaluate the significance of Borrmann type combined with LBVI status in predicting the prognosis of advanced gastric ... Read more >>

(World journal of gastrointestinal oncology)
[2020, 12(9):992-1004]

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Cognitive Rehabilitation Interventions After Stroke: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials

Qing Zhao, Xue Wang, Tao Wang, Adam Dmytriw, Xiao Zhang, Kun Yang, Jichang Luo, Xuesong Bai, Nan Jiang, Bin Yang, Yan Ma, Liqun Jiao, Yunyan Xie,

Abstract Background: Stroke is the second leading cause of deaths worldwide, and 53.4% of the stroke survivors suffer from post-stroke cognitive impairment. Post-stroke cognitive impairment can increase hospitalization rate and cost of care, and decrease the quality of life of stroke patients. To date, multiple cognitive rehabilitation interventions have been ... Read more >>

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Efficacy of cognitive behavioral therapy for insomnia in breast cancer: A meta-analysis.

Yan Ma, Daniel L Hall, Long H Ngo, Qingqing Liu, Paul A Bain, Gloria Y Yeh,

Insomnia is highly prevalent among patients with breast cancer (BC). Although cognitive behavioral therapy for insomnia (CBT-I) is available in integrative oncology settings, it poses unique challenges for BC survivors. Our review aimed to assess the evidence for the therapeutic effects of CBT-I on insomnia in BC. Randomized controlled trials ... Read more >>

Sleep Med Rev (Sleep medicine reviews)
[2020, 55:101376]

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LncRNA DANCR regulates the growth and metastasis of oral squamous cell carcinoma cells via altering miR-216a-5p expression.

Xing-Hui Qu, You-Ling Shi, Yan Ma, Wei-Wei Bao, Lei Yang, Jin-Chao Li, Fan Zhang,

The study aims to investigate how DANCR can alter the growth and metastasis of oral squamous cell carcinoma (OSCC) cells by regulating miR-216a-5p. The expression of DANCR and miR-216a-5p in OSCC patients and cells were measured. SCC15 and CAL-27 cells were selected to divide into Control, sh-NC, DANCR shRNA, DANCR, ... Read more >>

Hum Cell (Human cell)
[2020, 33(4):1281-1293]

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A simple, sustained and sufficient calcium regulation scheme during perioperative period for the secondary hyperparathyroidism

WeiBin Zhang, Jia Dong, YunFei Wu, Bin Zheng, Jin Dai, Yan Ma, Xinsheng Zhang,

Abstract Background: Patients of secondary hyperparathyroidism (SHPT) with chronic renal failure treated by long-term dialysis have received surgical treatment. The severe complications, especially convulsions caused by severe hypocalcemia, would endanger lives during perioperative treatment. Therefore, this study aims to explore a simple, sustained and sufficient calcium regulation scheme during perioperative ... Read more >>

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Increased vegetable and fruit intake is associated with reduced failure rate of tuberculosis treatment: a hospital-based cohort study in China.

Lei Xu, Jinyu Wang, Shanliang Zhao, Jianwen Zhang, Ke Xiong, Jing Cai, Qiuzhen Wang, Song Lin, Yan Ma, Aiguo Ma,

Increased intake of vegetables and fruits has been associated with reduced risk of tuberculosis infection. Vegetables and fruits exert immunoregulatory effects; however, it is not clear whether vegetables and fruits have an adjuvant treatment effect on tuberculosis. Between 2009 and 2013, a hospital-based cohort study was conducted in Linyi, Shandong ... Read more >>

Br J Nutr (The British journal of nutrition)
[2020, :1-8]

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