Full Text Journal Articles by
Author M Wrigley

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Rapid Assessment of Pepsin Column Activity for Reliable HDX-MS Studies.

Clint Vorauer, Michael S Wrigley, Juan P Rincon Pabon, Michael J Watson, Charlie C Mundorff, David D Weis, Miklos Guttman,

Hydrogen/deuterium exchange with mass spectrometry (HDX-MS) is a widely used technique to probe protein structural dynamics, track conformational changes, and map protein-protein interactions. Most HDX-MS studies employ a bottom-up approach utilizing the acid active protease pepsin to digest the protein of interest, often utilizing immobilized protease in a column format. ... Read more >>

J Am Soc Mass Spectrom (Journal of the American Society for Mass Spectrometry)
[2021, :]

Cited: 0 times

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Statistical Equivalence Testing of Higher-Order Protein Structures with Differential Hydrogen Exchange-Mass Spectrometry (HX-MS).

Tyler S Hageman, Michael S Wrigley, David D Weis,

Hydrogen exchange-mass spectrometry (HX-MS) is widely recognized for its potential utility for establishing the equivalence of the higher-order structures of proteins, particularly in comparability and similarity contexts. However, recent progress in the statistical analysis of HX-MS data has instead placed an emphasis on significance testing to identify regions of proteins ... Read more >>

Anal Chem (Analytical chemistry)
[2021, 93(18):6980-6988]

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Uterine-Artery Embolization or Myomectomy for Uterine Fibroids.

Isaac Manyonda, Anna-Maria Belli, Mary-Ann Lumsden, Jonathan Moss, William McKinnon, Lee J Middleton, Versha Cheed, Olivia Wu, Fusun Sirkeci, Jane P Daniels, Klim McPherson, ,

<h4>Background</h4>Uterine fibroids, the most common type of tumor among women of reproductive age, are associated with heavy menstrual bleeding, abdominal discomfort, subfertility, and a reduced quality of life. For women who wish to preserve their uterus and who have not had a response to medical treatment, myomectomy and uterine-artery embolization ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(5):440-451]

Cited: 4 times

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Use of non-sterile gloves in the ward environment: an evaluation of healthcare workers' perception of risk and decision making.

Ashley Flores, Martha Wrigley, Peter Askew, Rachel Craig, Bernadette Egan, Linda Towey, Jill Shawe,

<h4>Background</h4>Studies have found that inappropriate use of non-sterile gloves (NSG) can affect hand hygiene compliance; the main risks are missing opportunities for hand hygiene and gloves being a vector for microbial transmission.<h4>Aim</h4>The aims of this study were to explore the accuracy of healthcare worker (HCW) risk assessment and decision making ... Read more >>

J Infect Prev (Journal of infection prevention)
[2020, 21(3):108-114]

Cited: 0 times

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Mental health impacts of COVID-19 in Ireland and the need for a secondary care mental health service response.

Karen O'Connor, Margo Wrigley, Rhona Jennings, Michele Hill, Amir Niazi,

The COVID-19 pandemic is a global health emergency, the scale, speed and nature of which is beyond anything most of us have experienced in our lifetimes. The mental health burden associated with this pandemic is also likely to surpass anything we have previously experienced. In this editorial, we seek to ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2021, 38(2):99-107]

Cited: 2 times

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The economic recession and subjective well-being in older adults in the Republic of Ireland.

R M Duffy, K Mullin, S O'Dwyer, M Wrigley, B D Kelly,

<h4>Objective</h4>Subjective well-being in older people is strongly associated with emotional, physical and mental health. This study investigates subjective well-being in older adults in Ireland before and after the economic recession that commenced in 2008.<h4>Methods</h4>Cross-sectional data from the biennial European Social Survey (2002-2012) were analysed for two separate groups of older ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2019, 36(2):99-104]

Cited: 0 times

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Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals.

D J N Wong, S K Harris, S R Moonesinghe, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Cancellation of planned surgery impacts substantially on patients and health systems. This study describes the incidence and reasons for cancellation of inpatient surgery in the UK NHS.<h4>Methods</h4>We conducted a prospective observational cohort study over 7 consecutive days in March 2017 in 245 NHS hospitals. Occurrences and reasons for previous surgical ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2018, 121(4):730-738]

Cited: 13 times

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Contemporary stroke prevention strategies in 11 096 European patients with atrial fibrillation: a report from the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) Long-Term General Registry.

Giuseppe Boriani, Marco Proietti, Cécile Laroche, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Igor Diemberger, Luigi Tavazzi, Aldo P Maggioni, Gregory Y H Lip, , ,

<h4>Aims</h4>Contemporary data regarding atrial fibrillation (AF) management and current use of oral anticoagulants (OACs) for stroke prevention are needed.<h4>Methods and results</h4>The EURObservational Research Programme on AF (EORP-AF) Long-Term General Registry analysed consecutive AF patients presenting to cardiologists in 250 centres from 27 European countries. From 2013 to 2016, 11 096 patients ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2018, 20(5):747-757]

Cited: 17 times

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Developing, implementing and evaluating an end of life care intervention.

Anna Cox, Anne Arber, Fiona Bailey, Sue Dargan, Craig Gannon, Radcliffe Lisk, Barry Quinn, Jane Samarasinghe, Martha Wrigley, Ann Gallagher,

Aim To develop, implement and evaluate a collaborative intervention in care homes seeking to increase the confidence and competence of staff in end of life care and enable more people to receive end of life care in their usual place of residence. Method A two-phase exploratory mixed methods design was ... Read more >>

Nurs Older People (Nursing older people)
[2017, 29(1):27-35]

Cited: 3 times

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A review of mental health recovery programs in selected industrialized countries.

Harold A Pincus, Brigitta Spaeth-Rublee, Grant Sara, Elliot M Goldner, Pamela N Prince, Parashar Ramanuj, Wolfgang Gaebel, Jürgen Zielasek, Isabell Großimlinghaus, Margo Wrigley, Jaap van Weeghel, Mark Smith, Torleif Ruud, John R Mitchell, Lisa Patton,

The concept of recovery has gained increasing attention and many mental health systems have taken steps to move towards more recovery oriented practice and service structures. This article represents a description of current recovery-oriented programs in participating countries including recovery measurement tools. Although there is growing acceptance that recovery needs ... Read more >>

Int J Ment Health Syst (International journal of mental health systems)
[2016, 10:73]

Cited: 14 times

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Mental healthcare for hospitalized older adults: a national survey of consultation-liaison services provided by old age psychiatrists in Ireland.

Damien Gallagher, Colm Cooney, Sinead Murphy, Aideen Freyne, Margo Wrigley,

Int Psychogeriatr (International psychogeriatrics)
[2014, :1-2]

Cited: 0 times

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The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials.

M Dennis, N Mordi, C Graham, P Sandercock, ,

Deep vein thrombosis (DVT) is an important complication of stroke, but the evidence to support commonly used prophylactic strategies is conflicting.To describe the incidence, extent, associated clinical features and evolution of DVT after stroke.The CLOTS trials 1 and 2 together randomized 5632 immobile stroke patients in 135 hospitals in nine ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2011, 9(11):2193-2200]

Cited: 17 times

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Older people and their pets: a final farewell.

C A Lynch, R Loane, O Hally, M Wrigley,

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2010, 25(10):1087-1088]

Cited: 1 time

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Reproducibility of electrocardiographic findings in patients with suspected reflex neurally-mediated syncope.

Angel Moya, Michele Brignole, Richard Sutton, Carlo Menozzi, Roberto Garcia-Civera, Wouter Wieling, Dietrich Andresen, David G Benditt, Jesús F Garcia-Sacristán, Xulio Beiras, Nicoletta Grovale, Panos Vardas, ,

The reproducibility of electrocardiographic (ECG) recordings in syncopal recurrences and the diagnostic role of nonsyncopal arrhythmias are not well known. The objective of this study was to analyse the reproducibility of the ECG findings recorded with implantable loop recorders in 41 patients with suspected neurally-mediated syncope who were included in ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2008, 102(11):1518-1523]

Cited: 18 times

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Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial.

, M Dennis, P A G Sandercock, J Reid, C Graham, G Murray, G Venables, A Rudd, G Bowler,

<h4>Background</h4>Deep vein thrombosis (DVT) and pulmonary embolism are common after stroke. In small trials of patients undergoing surgery, graduated compression stockings (GCS) reduce the risk of DVT. National stroke guidelines extrapolating from these trials recommend their use in patients with stroke despite insufficient evidence. We assessed the effectiveness of thigh-length ... Read more >>

Lancet (Lancet (London, England))
[2009, 373(9679):1958-1965]

Cited: 156 times

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Dabigatran versus warfarin in patients with atrial fibrillation.

Stuart J Connolly, Michael D Ezekowitz, Salim Yusuf, John Eikelboom, Jonas Oldgren, Amit Parekh, Janice Pogue, Paul A Reilly, Ellison Themeles, Jeanne Varrone, Susan Wang, Marco Alings, Denis Xavier, Jun Zhu, Rafael Diaz, Basil S Lewis, Harald Darius, Hans-Christoph Diener, Campbell D Joyner, Lars Wallentin, ,

<h4>Background</h4>Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor.<h4>Methods</h4>In this noninferiority trial, we randomly assigned 18,113 patients who had atrial fibrillation and a risk of stroke to receive, in ... Read more >>

N Engl J Med (The New England journal of medicine)
[2009, 361(12):1139-1151]

Cited: 4621 times

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Mental capacity: legislation and medical treatment decisions in Ireland.

Vincent Io Agyapong, Margo Wrigley,

This paper examines mental capacity legislation in Ireland and its implications for medical treatment decisions for people whose capacities are believed to be impaired. It draws on inferences from case laws and legislations in other jurisdictions and concludes that there is an urgent need for the enactment of appropriate mental ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2009, 26(1):37-40]

Cited: 0 times

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Older people with enduring or recurrent severe mental illness (graduates): A literature review.

Margo Wrigley, Bernadette Murphy, Martin Farrell, Brendan Cassidy, Jim Ryan,

<h4>Objectives</h4>To review the literature on older people with enduring or recurrent severe mental illness with an onset earlier than 65 years (graduates) and, in particular, to look at the specific features and needs of this group.<h4>Method</h4>A Medline literature search produced 41 relevant papers and reports on the subject.<h4>Results</h4>There are a ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2006, 23(4):151-155]

Cited: 1 time

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Older people with enduring or recurrent severe mental illness in the Eastern Region of Ireland.

Margo Wrigley, Bernadette Murphy, Martin Farrell, Brendan Cassidy, Jim Ryan,

<h4>Objectives</h4>There has been no specific planning for older people with enduring or recurrent severe mental illness in Ireland. This survey aims to identify the number of affected over 65 year olds (graduates) and 55-64 year olds (prospective graduates) in the Health Service Executive, Eastern Region, their diagnoses and their use ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2006, 23(4):145-150]

Cited: 1 time

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A longitudinal study of depression in old age I: outcome and relationship to social networks.

Aideen Freyne, Sabina Fahy, Angela McAleer, Fiona Keogh, Margo Wrigley,

<h4>Objectives</h4>To ascertain the relationship between social network type and depression over time.<h4>Method</h4>A longitudinal outcome study of depressed elderly patients attending an old age psychiatric service was carried out. Subjects were seen at baseline and regular intervals over two years.<h4>Results</h4>Depression severity at baseline and at follow-up times differed according to subjects' ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2005, 22(3):87-93]

Cited: 1 time

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Mania in elderly people.

Zaf Hamzah, Margo Wrigley,

Ir J Psychol Med (Irish journal of psychological medicine)
[2004, 21(2):57-60]

Cited: 0 times

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A longitudinal study of depression in old age II: depression and physical disability.

Aideen Freyne, Fiona Keogh, Maria Kelly, Margo Wrigley,

<h4>Objectives</h4>As part of an outcome study of depression in older people, the relationship between physical disability and depression was explored at baseline and longitudinally. The aims were to identify whether illness in specific body systems or physical disability was associated with a poorer outcome of depression.<h4>Method</h4>Subjects over 65 with depression ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2005, 22(3):94-100]

Cited: 3 times

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An evaluation of the CAGE questionnaire in an elderly psychiatrically ill population.

B M Farragher, S M Fahy, M Wrigley,

Ir Med J (Irish medical journal)
[1998, 91(5):180]

Cited: 0 times

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Screening for depression in elderly patients.

G R Swanwick, M Wrigley,

Am J Psychiatry (The American journal of psychiatry)
[1998, 155(7):994-995]

Cited: 9 times

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A study of aggression among referrals to a community-based psychiatry of old age service.

P Gibbons, M Gannon, M Wrigley,

<h4>Objective</h4>The aims of the study were to examine the prevalence of aggressive behaviour in a non-selected community-based population, to identify clinical and sociodemographic variables associated with aggression and to examine the relationship between aggression and outcome at 2-year follow-up.<h4>Design</h4>Case series, using the Ryden Aggression Scale as a retrospective measure of ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[1997, 12(3):384-388]

Cited: 6 times

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