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COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes - an ELITA/ELTR multicentre cohort study.

Luca Saverio Belli, Christophe Duvoux, Paolo Angelo Cortesi, Rita Facchetti, Speranta Iacob, Giovanni Perricone, Sylvie Radenne, Sara Conti, Damiano Patrono, Gabriela Berlakovich, Angus Hann, Luisa Pasulo, Lluis Castells, Francois Faitot, Olivier Detry, Federica Invernizzi, Giulia Magini, Paolo De Simone, Ilias Kounis, Maria Cristina Morelli, Fernando Díaz Fontenla, Bo-Göran Ericzon, Carmelo Loinaz, Chris Johnston, Liliana Gheorghe, Mickael Lesurtel, Renato Romagnoli, Dagmar Kollmann, M Thamara Pr Perera, Stefano Fagiuoli, Darius Mirza, Audrey Coilly, Christian Toso, Krzysztof Zieniewicz, Laure Elkrief, Vincent Karam, Rene Adam, Caroline den Hoed, Marco Merli, Massimo Puoti, Luciano De Carlis, Gabriel C Oniscu, Salvatore Piano, Paolo Angeli, Constantino Fondevila, Wojciech G Polak, ,

<h4>Objective</h4>Explore the impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course.<h4>Design</h4>Data from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and were analysed.<h4>Results</h4>From 21 February to 20 November 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 ... Read more >>

Gut (Gut)
[2021, :]

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How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury.

George Clarke, Hynek Mergental, Angus Hann, M Thamara P R Perera, Simon C Afford, Darius F Mirza,

The increasing disparity between the number of patients listed for transplantation and the number of suitable organs has led to the increasing use of extended criteria donors (ECDs). ECDs are at increased risk of developing ischaemia reperfusion injury and greater risk of post-transplant complications. Ischaemia reperfusion injury is a major ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(14):]

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Differences in the platelet mRNA landscape portend racial disparities in platelet function and suggest novel therapeutic targets.

Kaitlin Garofano, C Sehwan Park, Cristina Alarcon, Juan Avitia, April Barbour, David Diemert, Claire M Fraser, Paula N Friedman, Anelia Horvath, Kameron Rashid, Mohammed Shaazuddin, Alfateh Sidahmed, Travis J O'Brien, Minoli A Perera, Norman H Lee,

The African American (AA) population displays a 1.6 to 3-fold higher incidence of thrombosis and stroke mortality compared to European Americans (EA). Current anti-platelet therapies target the ADP-mediated signaling pathway, which displays significant pharmacogenetic variation for platelet reactivity. The focus of this study was to define underlying population differences in ... Read more >>

Clin Pharmacol Ther (Clinical pharmacology and therapeutics)
[2021, :]

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Organ transplantation from deceased donors with vaccine-induced thrombosis and thrombocytopenia.

, George H B Greenhall, Ines Ushiro-Lumb, Sue Pavord, Ian Currie, M Thamara P R Perera, Hermien Hartog, Quentin A Hill, Ismail Mohamed, Muhammad A Khurram, Muhammad A Khurram, Reza Motallebzadeh, Gareth Jones, Aileen Marshall, Joerg-Matthias Pollok, Nicholas Torpey, Gavin J Pettigrew, Sanjay Mehra, Hemant Sharma, Francis Calder, Nicos Kessaris, Jay Nath, Debabrata Roy, Gabriel C Oniscu, Marc Clancy, Karthik Santhanakrishnan, Jorge Mascaro, Sern Lim, Marius Berman, Sue Madden, Lisa Mumford, Darius Mirza, Chris Watson, Olive McGowan, Douglas Thorburn, Rommel Ravanan, Beverley J Hunt, Chris J Callaghan, David J Roberts, John Forsythe,

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, :]

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Fetal echocardiographic assessment: impact of gestational age and maternal obesity.

Malitha Patabendige, S.U. Kodithuwakku, M.N.I. Perera, Tiran Dias,

<h4>Introduction: </h4> To identify the ability to acquire various fetal cardiac views using two-dimensional ultrasound at different gestational age and body mass index (BMI) categories. Material and methods: We performed a prospective observational study among low-risk women with singleton pregnancies attending the University Obstetrics Unit, North Colombo Teaching Hospital, Ragama, ... Read more >>

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Open versus Endovascular Abdominal Aortic Aneurysm Repair in the Australian Private Sector Over Twenty Years.

Kirby R Qin, Marlon Perera, Nathan Papa, David Mitchell, Jason Chuen,

<h4>Purpose</h4>Over the past two decades, the proliferation of endovascular surgery has changed the approach to abdominal aortic aneurysm (AAA) repair. In Australia, close to two-thirds of surgical procedures are performed in the private healthcare system. We aimed to describe the trends in AAA repair in the Australian private sector throughout ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2021, :15266028211028215]

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How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury

George Clarke, Hynek Mergental, Angus Hann, M. Thamara P. R. Perera, Simon C. Afford, Darius F. Mirza,

The increasing disparity between the number of patients listed for transplantation and the number of suitable organs has led to the increasing use of extended criteria donors (ECDs). ECDs are at increased risk of developing ischaemia reperfusion injury and greater risk of post-transplant complications. Ischaemia reperfusion injury is a major ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(14):]

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Changes in prescribing habits for the treatment of metastatic renal clear cell carcinoma (mRCC) in Australia.

Adithya Balasubramanian, Liang Qu, Andrew Weickhardt, Damien Bolton, Marlon Perera,

The availability of efficacious systemic therapies for metastatic clear cell renal cell carcinoma has heralded improved survival for Australians. The Pharmaceutical Benefits Schedule registry was interrogated to assess nation-wide prescribing patterns. Sunitinib remained the most commonly prescribed agent. Prescribing rates were significantly lower in Northern Territory than in other states, ... Read more >>

Intern Med J (Internal medicine journal)
[2021, 51(7):1173-1177]

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Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.

Dami A Collier, Isabella A T M Ferreira, Prasanti Kotagiri, Rawlings P Datir, Eleanor Y Lim, Emma Touizer, Bo Meng, Adam Abdullahi, , Anne Elmer, Nathalie Kingston, Barbara Graves, Emma Le Gresley, Daniela Caputo, Laura Bergamaschi, Kenneth G C Smith, John R Bradley, Lourdes Ceron-Gutierrez, Paulina Cortes-Acevedo, Gabriela Barcenas-Morales, Michelle A Linterman, Laura E McCoy, Chris Davis, Emma Thomson, Paul A Lyons, Eoin McKinney, Rainer Doffinger, Mark Wills, Ravindra K Gupta,

Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age<sup>1</sup>. Here we analysed immune responses following vaccination with the BNT162b2 mRNA vaccine<sup>2</sup> in elderly participants and younger healthcare workers. Serum neutralization and ... Read more >>

Nature (Nature)
[2021, :]

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Hepatocyte necrosis on liver allograft biopsy: Normothermic machine perfusion is the ideal platform for using these grafts in high-risk recipients.

Angus Hann, Hanns Lembach, Mohammad Alzoubi, Siobhan C McKay, Hermien Hartog, Desley A H Neil, Darius F Mirza, M Thamara P R Perera,

Clin Transplant (Clinical transplantation)
[2021, 35(7):e14380]

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Sodium glucose-linked transport protein 2 inhibitors: An overview of genitourinary and perioperative implications.

Mohit Chandrashekar, Stuart Philip, Alexander Nesbitt, Andre Joshi, Marlon Perera,

Sodium glucose-linked transport protein 2 inhibitors are relatively novel drugs, used for the treatment of type 2 diabetes mellitus. Their use since Pharmaceutical Benefits Scheme approval in Australia has increased drastically, possibly due to the low risk of hypoglycemic events and their advertised cardiovascular mortality benefits. However, as with any ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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Commentary on: Short recipient warm ischemia time improves outcomes in deceased donor liver transplantation.

Angus Hann, Dimitri Sneiders, Hermien Hartog, M Thamara P R Perera,

In this issue of Transplantation International, Al Kurdi et al. report that both early liver graft function and long-term survival are affected by recipient warm ischaemic time (rWIT)<sup>1</sup> . The effect temperature has on cellular metabolism is well known, and the period in which the surgeon completes the implantation represents ... Read more >>

Transpl Int (Transplant international : official journal of the European Society for Organ Transplantation)
[2021, :]

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Trends in the uptake of diagnostic multi-parametric MRI of the prostate with Federal funding: Australia population data.

Gavin Wei, Nathan Papa, Brian Kelly, Damien Bolton, Marlon Perera,

Urology (Urology)
[2021, :]

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Basiliximab With Delayed Tacrolimus Improves Short-Term Renal Outcomes Post-Liver Transplantation-a Real-World Experience.

Alexander Boyd, Andrew Brown, Jaimin Patel, Peter Nightingale, M Thamara P R Perera, James Ferguson, James Neuberger, Neil Rajoriya,

<h4>Background</h4>Acute kidney injury (AKI) is common after liver transplantation (LT). Induction with interleukin-2 receptor antagonists is often used as a "renal-sparing" strategy. The aim of this study was to assess this approach in a real-world setting in an LT center.<h4>Methods</h4>A retrospective cohort analysis of LTs between 2011 and 2018 was ... Read more >>

Transplant Proc (Transplantation proceedings)
[2021, 53(5):1541-1547]

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Lactic Acidosis, Hypoglycemia, and Eosinophilia: Novel Markers of Antibody-Mediated Rejection Causing Graft Ischemia.

James M Halle-Smith, Angus Hann, Owen L Cain, M Thamara P R Perera, Desley A H Neil,

Liver Transpl (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2021, :]

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Testing measurement equivalence of neurocognitive assessments across language in the Hispanic Community Health Study/Study of Latinos.

Zachary T Goodman, Maria M Llabre, Hector M González, Melissa Lamar, Linda C Gallo, Wassim Tarraf, Krista M Perreira, Daniel F López-Cevallos, Priscilla M Vásquez, Luis D Medina, Marisa J Perera, Donglin Zeng, Sierra A Bainter,

<h4>Objective</h4>Neuropsychological instruments are often developed in English and translated to other languages to facilitate the clinical evaluation of diverse populations or to utilize in research environments. However, the psychometric equivalence of these assessments across language must be demonstrated before populations can validly be compared.<h4>Method</h4>To test this equivalence, we applied measurement ... Read more >>

Neuropsychology (Neuropsychology)
[2021, 35(4):423-433]

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The understanding, acceptability, and relevance of personalised multidimensional physical activity feedback among urban adults: evidence from a qualitative feasibility study in Sri Lanka.

Carukshi Arambepola, Madhawa Perera, Fiona Gillison, Oliver Peacock, Dylan Thompson,

<h4>Background</h4>Wearable technologies are being used to provide personalised feedback across multiple physical activity dimensions in countries such as the UK, but their feasibility has not been tested in South Asia, where physical inactivity is increasing. This study assessed the understanding, acceptability, and relevance of personalised multidimensional physical activity feedback in ... Read more >>

BMC Public Health (BMC public health)
[2021, 21(1):715]

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Discovery of a Novel Antimicrobial Agent by the Virtual Screening of a Library of Small Molecules.

Satish N Dighe, Suzannah R van Akker, Marina Mathew, Madusha Perera, Trudi A Collet,

A virtual screening approach based upon a combination of docking and pharmacophore methods was utilized on a library of 1.4 million molecules to identify novel antimicrobial agents, which may potentially act via inhibition of the caseinolytic protease. Using this method, compound 6 was found to be bactericidal against three staphylococcal ... Read more >>

Mol Inform (Molecular informatics)
[2021, 40(7):e2100035]

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Single-cell multi-omics analysis of the immune response in COVID-19.

Emily Stephenson, Gary Reynolds, Rachel A Botting, Fernando J Calero-Nieto, Michael D Morgan, Zewen Kelvin Tuong, Karsten Bach, Waradon Sungnak, Kaylee B Worlock, Masahiro Yoshida, Natsuhiko Kumasaka, Katarzyna Kania, Justin Engelbert, Bayanne Olabi, Jarmila Stremenova Spegarova, Nicola K Wilson, Nicole Mende, Laura Jardine, Louis C S Gardner, Issac Goh, Dave Horsfall, Jim McGrath, Simone Webb, Michael W Mather, Rik G H Lindeboom, Emma Dann, Ni Huang, Krzysztof Polanski, Elena Prigmore, Florian Gothe, Jonathan Scott, Rebecca P Payne, Kenneth F Baker, Aidan T Hanrath, Ina C D Schim van der Loeff, Andrew S Barr, Amada Sanchez-Gonzalez, Laura Bergamaschi, Federica Mescia, Josephine L Barnes, Eliz Kilich, Angus de Wilton, Anita Saigal, Aarash Saleh, Sam M Janes, Claire M Smith, Nusayhah Gopee, Caroline Wilson, Paul Coupland, Jonathan M Coxhead, Vladimir Yu Kiselev, Stijn van Dongen, Jaume Bacardit, Hamish W King, , Anthony J Rostron, A John Simpson, Sophie Hambleton, Elisa Laurenti, Paul A Lyons, Kerstin B Meyer, Marko Z Nikolić, Christopher J A Duncan, Kenneth G C Smith, Sarah A Teichmann, Menna R Clatworthy, John C Marioni, Berthold Göttgens, Muzlifah Haniffa,

Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells ... Read more >>

Nat Med (Nature medicine)
[2021, 27(5):904-916]

Cited: 3 times

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What a mesh! An Australian experience using national female continence surgery trends over 20 years.

Aoife McVey, Liang G Qu, Garson Chan, Marlon Perera, Janelle Brennan, Eric Chung, Johan Gani,

<h4>Purpose</h4>To review the evolution of female continence surgical practice in Australia over the last 20 years and observe whether vaginal mesh controversies impacted these trends.<h4>Materials and methods</h4>From January 2000 to December 2019, medicare benefit schedule codes for female continence procedures were identified and extracted for: mesh sling, fascial sling, bulking agent, ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Repetitive Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Meta-analysis of Randomized, Sham-Controlled Trials.

M Prabhavi N Perera, Sudaraka Mallawaarachchi, Aleksandra Miljevic, Neil W Bailey, Sally E Herring, Paul B Fitzgerald,

<h4>Background</h4>Obsessive-compulsive disorder (OCD) is a chronic, disabling mental health condition with limited treatment options available to date. Numerous randomized controlled trials have explored the efficacy of repetitive transcranial magnetic stimulation (rTMS) in OCD. This meta-analysis synthesized data from selected randomized controlled trials and examined the impact of different treatment parameters ... Read more >>

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2021, :]

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Budget impact and cost-effectiveness analyses of the COBRA-BPS multicomponent hypertension management programme in rural communities in Bangladesh, Pakistan, and Sri Lanka.

Eric A Finkelstein, Anirudh Krishnan, Aliya Naheed, Imtiaz Jehan, H Asita de Silva, Mihir Gandhi, Ching Wee Lim, Nantu Chakma, Dileepa S Ediriweera, Jehanzeb Khan, Anuradhani Kasturiratne, Samina Hirani, A K M Solayman, Tazeen H Jafar, ,

<h4>Background</h4>COBRA-BPS (Control of Blood Pressure and Risk Attenuation-Bangladesh, Pakistan, Sri Lanka), a multi-component hypertension management programme that is led by community health workers, has been shown to be efficacious at reducing systolic blood pressure in rural communities in Bangladesh, Pakistan, and Sri Lanka. In this study, we aimed to assess ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2021, 9(5):e660-e667]

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Ex-situ liver preservation with machine preservation.

Hanns Lembach Jahnsen, Hynek Mergental, M Thamara P R Perera, Darius F Mirza,

<h4>Purpose of review</h4>To summarize key studies in liver preservation published over the last 3 years and evaluate benefits and limitations of the different perfusion techniques. Selected experimental applications that may be translated to the clinical use will be also discussed.<h4>Recent findings</h4>Normothermic machine perfusion (NMP) has transitioned into clinical practice. Viability ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(2):121-132]

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Developing critical thinking skills for delivering optimal care.

Ian A Scott, Ruth E Hubbard, Carmel Crock, Thomas Campbell, Michael Perera,

Healthcare systems across the world are challenged with problems of misdiagnosis, non-beneficial care, unwarranted practice variation and inefficient or unsafe practice. In countering these shortcomings, clinicians must be able to think critically, interpret and assimilate new knowledge, deal with uncertainty and change behaviour in response to compelling new evidence. Three ... Read more >>

Intern Med J (Internal medicine journal)
[2021, 51(4):488-493]

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Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities.

Vidyasagar Chinni, John El-Khoury, Marlon Perera, Rinaldo Bellomo, Daryl Jones, Damien Bolton, Joseph Ischia, Oneel Patel,

An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. Patients with COVID-19 are at risk of cytokine storm, acute respiratory distress syndrome (ARDS), reduced blood oxygenation, mechanical ventilation, and a high death rate. Although recent studies have shown remdesivir ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2021, :]

Cited: 2 times

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